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KR930016109A - 안정한 피브리노겐 용액 - Google Patents

안정한 피브리노겐 용액 Download PDF

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Publication number
KR930016109A
KR930016109A KR1019930001036A KR930001036A KR930016109A KR 930016109 A KR930016109 A KR 930016109A KR 1019930001036 A KR1019930001036 A KR 1019930001036A KR 930001036 A KR930001036 A KR 930001036A KR 930016109 A KR930016109 A KR 930016109A
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South Korea
Prior art keywords
solution
fibrinogen
fibrinogen solution
adsorption
cryoprecipitate
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Application number
KR1019930001036A
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English (en)
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KR100276372B1 (ko
Inventor
혹크 요한
카르게스 헤르만
Original Assignee
부크, 파일
베링베르케 아크티엔게겔샤프트
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Publication of KR930016109A publication Critical patent/KR930016109A/ko
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Publication of KR100276372B1 publication Critical patent/KR100276372B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 조직 접착제에 사용하기에 적합하고 +4℃내지 +25℃의 온도에서 작용할 수 있는 능력의 손실없이, 특히 경도(consistency) 및 응고 특성에 중요한 변화없이 4주 이상 동안 저장될 수 있는 피브리노겐 용액 및 이의 제조방법에 관한 것이다.

Description

안정한 피브리노겐 용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 2회 이상 흡착제로 처리하고 매회 상충액을 획득함으로써 수득될 수 있는, 작용할 수 있는 능력의 손실없이 4주 이상 동안 4내지 25℃에서 저장될 수 있는 피브리노겐 용액.
  2. 제1항에 있어서, 냉동침전물의 용액이 피브리노겐 용액으로서 사용된 피브리노겐 용액.
  3. 제1항에 있어서, 응고가능한 혈장 단백질을 1.5내지 15%, 바람직하게는 5내지 11% 함유하는 피브리노겐 용액.
  4. 제1항에 있어서, 흡착이 알칼리 토금속 그룹을 포함하는 거의 불용성인 금속의 염 또는 알루미늄 하이드록사이드 상에서 수행된 피브리노겐 용액.
  5. 제1항에 있어서, 흡착을 위한 알칼리 토금속염 또는 알루미늄 하이드록사이드의 농도가 0.05내지 2.5%(중량/용적), 바람직하게는 0.05내지 0.5%(중량/용적)인 피브리노겐 용액.
  6. 제1항에 있어서, 흡착이 음이온 교환제 상에서 수행된 피브리노겐 용액.
  7. 제6항에 있어서, 음이온 교환제가 사용되는 냉동침전물 1kg당 0.5내지 20g, 바람직하게는 3내지 10g의 양으로 사용된 피브리노겐 용액.
  8. 제1항에 있어서, 인자 ⅩⅢ을 용액 1ml당 10내지 200유니트, 바람직하게는 60유니트 함유하는 피브리노겐 용액.
  9. 피브리노겐 함유 출발물질을 용해시키고, 흡착제를 사용하여 용액을 처리하고, 용액을 분리한 다음 동일하거나 상이한 흡착제를 사용하여 용액을 다시 처리하고, 용액을 분리시키고, 필요한 경우, 추가로 정제함을 포함함을 특징으로 하여, 응고가능한 혈장 단백질을 1.5내지 15% 함유하고 작용할 수 있는 능력의 손실없이 4주 이상 동안 +4℃내지 +25℃에서 저장될 수 있는 농축 피브리노겐 용액을 제조하는 방법.
  10. 피브리노겐 접착제의 성분으로서의 제1항의 피브리노겐 용액의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930001036A 1992-01-29 1993-01-28 안정한피브리노겐용액 KR100276372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4202667.9 1992-01-29
DEP4202667.90 1992-01-29
DE4202667A DE4202667C1 (ko) 1992-01-29 1992-01-29

Publications (2)

Publication Number Publication Date
KR930016109A true KR930016109A (ko) 1993-08-26
KR100276372B1 KR100276372B1 (ko) 2001-11-22

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Family Applications (1)

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Country Status (10)

Country Link
US (1) US6277961B1 (ko)
EP (2) EP1362595A1 (ko)
JP (1) JP3367698B2 (ko)
KR (1) KR100276372B1 (ko)
AT (1) ATE279202T1 (ko)
AU (1) AU666905B2 (ko)
CA (1) CA2088343C (ko)
DE (2) DE4202667C1 (ko)
ES (1) ES2231766T3 (ko)
NO (1) NO308587B1 (ko)

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* Cited by examiner, † Cited by third party
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KR100411438B1 (ko) * 1994-12-07 2004-04-21 플라스마실 코포레이션 혈장농축물및조직봉합제조성물
KR100867880B1 (ko) * 2001-01-26 2008-11-10 체에스엘 베링 게엠베하 온도 감수성 물질의 온화한 멸균을 위한 과산화수소 플라즈마 멸균 방법

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100411438B1 (ko) * 1994-12-07 2004-04-21 플라스마실 코포레이션 혈장농축물및조직봉합제조성물
KR100867880B1 (ko) * 2001-01-26 2008-11-10 체에스엘 베링 게엠베하 온도 감수성 물질의 온화한 멸균을 위한 과산화수소 플라즈마 멸균 방법

Also Published As

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JPH05286999A (ja) 1993-11-02
JP3367698B2 (ja) 2003-01-14
EP0554570A3 (en) 1993-09-29
DE59210000D1 (de) 2004-11-18
KR100276372B1 (ko) 2001-11-22
CA2088343A1 (en) 1993-07-30
DE4202667C1 (ko) 1993-05-13
EP0554570A2 (de) 1993-08-11
NO930294D0 (no) 1993-01-28
EP1362595A1 (de) 2003-11-19
ATE279202T1 (de) 2004-10-15
ES2231766T3 (es) 2005-05-16
AU3206493A (en) 1993-08-05
EP0554570B1 (de) 2004-10-13
AU666905B2 (en) 1996-02-29
NO930294L (no) 1993-07-30
NO308587B1 (no) 2000-10-02
US6277961B1 (en) 2001-08-21
CA2088343C (en) 2005-01-11

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