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KR930007457A - Method for preparing herbal extract granules and solid extract-containing solid preparations - Google Patents

Method for preparing herbal extract granules and solid extract-containing solid preparations Download PDF

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Publication number
KR930007457A
KR930007457A KR1019910018025A KR910018025A KR930007457A KR 930007457 A KR930007457 A KR 930007457A KR 1019910018025 A KR1019910018025 A KR 1019910018025A KR 910018025 A KR910018025 A KR 910018025A KR 930007457 A KR930007457 A KR 930007457A
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South Korea
Prior art keywords
granules
herbal extract
mixture
extract
present
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KR1019910018025A
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Korean (ko)
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KR960002178B1 (en
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도시히로 이시하라
히로까즈 구리따
다께시 오꾸야마
노부유끼 히또미
아끼라 스즈끼
Original Assignee
이시자와 가즈또모
가네보오 가부시끼가이샤
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Publication of KR930007457A publication Critical patent/KR930007457A/en
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Publication of KR960002178B1 publication Critical patent/KR960002178B1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 한방 엑기스 그래뉼 및 한방 엑기스 함유 고형제제의 제조방법에 관한 것으로서, 그 구성은, 한방 엑기스분말 100 중량부와 부형제 2~20 중량부로 이루어지는 혼합물을 부유선회 유동시켜, 그 혼합물의 함수율(Y)을 아래식(Ⅰ)The present invention relates to a method for producing herbal extract granules and herbal extract-containing solid preparations, the composition of which is characterized in that the mixture consisting of 100 parts by weight of the herbal extract powder and 2 to 20 parts by weight of excipients is suspended in a flow flow, and the moisture content of the mixture (Y ) In the following formula (Ⅰ)

0.9X-9.8??Y??1.1X-6.8 ……(Ⅰ)0.9X-9.8 ?? Y ?? 1.1X-6.8... … (Ⅰ)

(식중, X는 한방 엑기스 분말과 부형제에 의해 이루어지는 혼합물의 소성 한계를 나타낸다. 단, 14??X??40)로 표시되는 범위내로 제어하면서 그 혼합물에 물 또는 결합제 수용액을 분무하는 것을 특징으로 하고, 한방 엑기스와 부형제로 이루어지는 그래뉼 제조방법 및 그 방법으로 얻어지는 그래뉼을 제제화하는 것을 특징으로 한다.(Wherein X represents the calcination limit of the mixture formed by the herbal extract powder and the excipient, except that the mixture is sprayed with an aqueous solution of water or binder while controlling within the range represented by 14 ?? X ?? 40). And it is characterized in that the granules production method and the granules obtained by the method comprising a herbal extract and an excipient.

본 발명의 방법에 의해 엑기스 함유율이 높은 한방 엑기스 그래뉼이 효율좋게 생산될 수 있으며, 더구나, 본 발명의 그래뉼 제조방법은 유기용매를 사용하지 않기 때문에 제조상 안전하며, 또 그래뉼중의 잔류 용매의 염려도 없다.Herbal extract granules with high extract content can be produced efficiently by the method of the present invention. Moreover, the method of producing granules of the present invention is safe in manufacturing because no organic solvent is used, and there is also concern about residual solvent in the granules. none.

나아가, 본 발명으로 얻어지는 그래뉼에서 제조되는 세립제, 과립제, 캅셀제, 정제등의 한방 엑기스 함유 고형제제는 한방 엑기스 함유율이 높고, 게다가 용출성 붕해성등의 제제특성이 우수하다는 등의 효과가 있다.Furthermore, the herbal extract-containing solid preparations such as the granules, granules, capsules, tablets and the like prepared in the granules obtained by the present invention have high herbal extract content, and also have excellent formulation properties such as dissolution disintegrating properties.

Description

한방 엑기스 그래뉼 및 한방 엑기스 함유 고형제제의 제조방법Method for preparing herbal extract granules and solid extract-containing solid preparations

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

한방 엑기스 분발 100 중량부와 부형제 2~20 중량부로 이루어지는 혼합물을 부유 선회 유동시켜 그 혼합물을 함수율(Y)을, 아래식(Ⅰ)The mixture consisting of 100 parts by weight of the herbal extract powder and 2 to 20 parts by weight of the excipient is suspended in a swirling flow, and the mixture is converted into a water content (Y) by the following formula (I). 0.9X-9.8≤Y≤1.1X-6.8 ……(Ⅰ)0.9X-9.8≤Y≤1.1X-6.8... … (Ⅰ) (식중, X는 한방 엑기스 분말과 부형제에 의해 이루어지는 혼합물의 소성 한계를 나타낸다. 단, 14≤X≤40)로 표시되는 범위내로 제어하면서 그 혼합물에 물 또는 결합제 수용액을 분무하는 것을 특징으로 하고, 한방 엑기스와 부형제로 이루어지는 그래뉼 제조방법.(Wherein X represents a calcination limit of the mixture formed by the herbal extract powder and the excipient, except that the mixture is sprayed with water or binder aqueous solution while controlling within the range represented by 14 ≦ X ≦ 40), Granules manufacturing method consisting of herbal extracts and excipients. 제1항에 있어서, 상기 방법으로 얻어지는 그래뉼을 제제화하는 것을 특징으로 하는 한방 엑기스 함유 고형제제의 제조방법.The method of producing a herbal extract-containing solid preparation according to claim 1, wherein the granule obtained by the method is formulated. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910018025A 1990-10-22 1991-10-14 Method for preparing herbal extract granules and solid extract-containing solid preparations Expired - Fee Related KR960002178B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP90-284657 1990-10-22
JP28465790 1990-10-22

Publications (2)

Publication Number Publication Date
KR930007457A true KR930007457A (en) 1993-05-20
KR960002178B1 KR960002178B1 (en) 1996-02-13

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KR1019910018025A Expired - Fee Related KR960002178B1 (en) 1990-10-22 1991-10-14 Method for preparing herbal extract granules and solid extract-containing solid preparations

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KR (1) KR960002178B1 (en)
CN (1) CN1045161C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004160165A (en) * 2002-09-17 2004-06-10 Pauretsuku:Kk Granulation method for galenical component preparation
CN115770286A (en) * 2022-12-22 2023-03-10 浙江赞生药业有限公司 Method for preparing bupleurum tenue capsules by fluidized bed granulation drying method

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CN1045161C (en) 1999-09-22
CN1061904A (en) 1992-06-17
KR960002178B1 (en) 1996-02-13

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