KR930005634A - Mk 단백질을 사용하여 세포성장을 억제하는 방법 - Google Patents
Mk 단백질을 사용하여 세포성장을 억제하는 방법 Download PDFInfo
- Publication number
- KR930005634A KR930005634A KR1019920017538A KR920017538A KR930005634A KR 930005634 A KR930005634 A KR 930005634A KR 1019920017538 A KR1019920017538 A KR 1019920017538A KR 920017538 A KR920017538 A KR 920017538A KR 930005634 A KR930005634 A KR 930005634A
- Authority
- KR
- South Korea
- Prior art keywords
- protein
- human
- animal
- alkylated
- cell growth
- Prior art date
Links
- 230000010261 cell growth Effects 0.000 title claims abstract description 6
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 13
- 102000004169 proteins and genes Human genes 0.000 title claims abstract 13
- 238000000034 method Methods 0.000 claims abstract 11
- 230000002401 inhibitory effect Effects 0.000 claims abstract 6
- 241001465754 Metazoa Species 0.000 claims 6
- 101001046529 Homo sapiens Mevalonate kinase Proteins 0.000 claims 4
- 101000990990 Homo sapiens Midkine Proteins 0.000 claims 4
- 102000053521 human MDK Human genes 0.000 claims 4
- 241000251468 Actinopterygii Species 0.000 claims 3
- 101001046523 Bos taurus Mevalonate kinase Proteins 0.000 claims 3
- 241000282326 Felis catus Species 0.000 claims 3
- 241001494479 Pecora Species 0.000 claims 3
- 241000195493 Cryptophyta Species 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 241000271566 Aves Species 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 108700021154 Metallothionein 3 Proteins 0.000 claims 1
- 102100028708 Metallothionein-3 Human genes 0.000 claims 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
본 발명은 MK 단백질을 사용함으로써 내피세포같은 세포의 세포 성장을 억제하는 방법에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BHK 세포의 높은 친화성 수용기에 대한 bFGF 결합에 미치는 MK의 효과이다. 분석은 실시예 8에서 설명된다.
제2도는 소의 ABAE 세포성장에 미치는 MK의 효과이다.
제3도는 사람의 HUVE 세포성장에 미치는 MK의 효과이다.
Claims (10)
- 세포성장 억제량의 MK 단백질, 알킬화 MK 단백질 또는 이의 조합물을 동물에게 투여함으로 구성되는, 세포성장을 억제하는 방법.
- 제1항에 있어서, 상기 MK 단백질은 사람 MK, 소MK, 양MK, 개MK, 돼지MK, 고양이MK, 말MK, 조류MK, 어류MK 단백질 또는 이의 알킬화 형태인 방법.
- 맥관형성 억제량의 MK 단백질, 알킬화MK 단백질 또는 이의 조합물을 동물에게 투여함으로 구성되는, 동물에서 맥관형성을 억제하는 방법.
- 제3항에 있어서, 상기 MK 단백질은 사람MK, 소MK, 양MK, 개MK, 돼지MK, 고양이MK, 말MK, 조류MK, 어류MK 단백질 또는 이의 알킬화 형태의 방법.
- 반응성 세포 조사에서 MK를 이용함으로 구성되는 세포성장 억제인자인 선별방법.
- 외과 수술후 출혈 억제량의 MK를 사람 또는 온형 동물에게 투여함으로 구성되는, 외곽수술후 출혈을 억제하는 방법.
- 제6항에 있어서, 상기 MK는 사람 MK인 방법.
- MK 단백질, 알킬화 MK 단백질 또는 이의 조합물을 동물에게 투여함으로 구성되는, 종양 성장을 억제하는 방법.
- 제10항에 있어서, 상기 MK 단백질은 사람MK, 소MK, 양MK, 개MK, 돼지MK, 고양이MK, 말MK, 조류MK, 어류MK 단백질 또는 이의 알킬화 형태인 방법.
- 제9항에 있어서, 상기 동물은 사람인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76902991A | 1991-09-30 | 1991-09-30 | |
| US07/769,029 | 1991-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930005634A true KR930005634A (ko) | 1993-04-20 |
Family
ID=25084204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920017538A KR930005634A (ko) | 1991-09-30 | 1992-09-25 | Mk 단백질을 사용하여 세포성장을 억제하는 방법 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0535336A3 (ko) |
| JP (1) | JPH05229957A (ko) |
| KR (1) | KR930005634A (ko) |
| AU (1) | AU650786B2 (ko) |
| CA (1) | CA2079290A1 (ko) |
| TW (1) | TW255827B (ko) |
| ZA (1) | ZA927468B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001151A1 (fr) | 1996-07-10 | 1998-01-15 | Meiji Milk Products Co., Ltd. | Nouvelle utilisation de la famille mk comme facteur hematopoietique |
| AU738923C (en) | 1997-03-12 | 2003-02-20 | Takashi Muramatsu | Preventive and therapeutic compositions for drug induced nephropathy and hepatopathy |
| EP0998941B9 (en) * | 1997-07-14 | 2007-03-14 | Takashi Muramatsu | Use of midkine or of anti-midkine antibodies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO175594C (no) * | 1988-01-25 | 1994-11-02 | American Cyanamid Co | Fremgangsmåte for isolering av heparin-bindende hjerne-mitogen |
-
1992
- 1992-08-10 EP EP19920113631 patent/EP0535336A3/en not_active Withdrawn
- 1992-08-11 TW TW081106327A patent/TW255827B/zh active
- 1992-09-25 KR KR1019920017538A patent/KR930005634A/ko not_active Application Discontinuation
- 1992-09-28 CA CA002079290A patent/CA2079290A1/en not_active Abandoned
- 1992-09-29 ZA ZA927468A patent/ZA927468B/xx unknown
- 1992-09-29 JP JP4283717A patent/JPH05229957A/ja active Pending
- 1992-09-29 AU AU26042/92A patent/AU650786B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0535336A2 (en) | 1993-04-07 |
| EP0535336A3 (en) | 1993-05-19 |
| CA2079290A1 (en) | 1993-03-31 |
| AU2604292A (en) | 1993-04-01 |
| TW255827B (ko) | 1995-09-01 |
| JPH05229957A (ja) | 1993-09-07 |
| AU650786B2 (en) | 1994-06-30 |
| ZA927468B (en) | 1993-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920925 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |