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KR920700690A - α-입자 방출을 이용하는 방사선 면역치료제 - Google Patents

α-입자 방출을 이용하는 방사선 면역치료제

Info

Publication number
KR920700690A
KR920700690A KR1019910700189A KR910700189A KR920700690A KR 920700690 A KR920700690 A KR 920700690A KR 1019910700189 A KR1019910700189 A KR 1019910700189A KR 910700189 A KR910700189 A KR 910700189A KR 920700690 A KR920700690 A KR 920700690A
Authority
KR
South Korea
Prior art keywords
antibody
radiation
immune complex
radionuclide
immunotherapeutics
Prior art date
Application number
KR1019910700189A
Other languages
English (en)
Other versions
KR0179645B1 (en
Inventor
빌렘 기어링스 마우리츠
마이클카스피젠 프란시스
Original Assignee
에프. 지. 엠. 헤르만스·에이. 지. 제이. 베르미렌
악조 엔. 브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 지. 엠. 헤르만스·에이. 지. 제이. 베르미렌, 악조 엔. 브이 filed Critical 에프. 지. 엠. 헤르만스·에이. 지. 제이. 베르미렌
Publication of KR920700690A publication Critical patent/KR920700690A/ko
Application granted granted Critical
Publication of KR0179645B1 publication Critical patent/KR0179645B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

α-입자 방출을 이용한 방사선 면역치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 입자를 방출하는 방사성 핵종, 킬레이트제 및 종양특이성 항체를 함유하며, 상기 방사성 핵종은 225악티늄동위원소 또는 그것의 딸원자중 하나이고, 상기 항체는 천천히 국소분포하는 항체인 것을 특징으로 하는 방사선 면역 복합체.
  2. 제1항에 있어서, IgM-항체인 것을 특징으로 하는 방사선 면역 복합체.
  3. 제1항 또는 제2항에 있어서, 상기 항체는 인체-또는 인체화된 항체인 것을 특징으로 하는 방사성 면역 복합체.
  4. 제3항에 있어서, 상기 항체는 모노클론 항체 16.88인 것을 특징으로 하는 방사선 면역 복합체.
  5. 제3항에 있어서, 상기 항체는 모노클론 항체 28A32인 것을 특징으로 하는 방사선 면역 복합체.
  6. 전술한 항중 어느 한 항에 의한 방사선 면역 복합체를 함유하는 약학조성물.
  7. 제6항에 있어서, 일종 이상의 스카벤징제(scavenging agents)를 함유하는 것을 특징으로 하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910700189A 1989-06-19 1991-02-18 Radioimmunotherapy using -g(a)-particles emission KR0179645B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP892015918 1989-06-19
EP89201591 1989-06-19

Publications (2)

Publication Number Publication Date
KR920700690A true KR920700690A (ko) 1992-08-10
KR0179645B1 KR0179645B1 (en) 1999-03-20

Family

ID=8202415

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910700189A KR0179645B1 (en) 1989-06-19 1991-02-18 Radioimmunotherapy using -g(a)-particles emission

Country Status (11)

Country Link
US (1) US5246691C1 (ko)
EP (1) EP0429624B1 (ko)
JP (1) JPH089553B2 (ko)
KR (1) KR0179645B1 (ko)
AU (1) AU629367B2 (ko)
CA (1) CA2034484C (ko)
DE (1) DE69007430T2 (ko)
DK (1) DK0429624T3 (ko)
ES (1) ES2053196T3 (ko)
FI (1) FI98707C (ko)
WO (1) WO1990015625A1 (ko)

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US6403771B1 (en) * 1991-02-19 2002-06-11 Actinium Pharmaceuticals, Limited Method and means for site directed therapy
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
WO1994020839A1 (en) * 1993-03-12 1994-09-15 Akzo America Inc. Process for stripping radon-220 from radioactive isotope mixture
LU88636A1 (de) * 1995-07-03 1997-01-03 Euratom Verfahren zur Erzeugung von Actinium-225
LU88637A1 (de) * 1995-07-03 1997-01-03 Euratom Verfahren zur Erzeugung von Actinium-225 und Wismut-213 durch Bestrahlung von Radium-226 mit hochenergetischen Gammaquanten
DK0842668T3 (da) * 1996-11-15 2003-01-06 Euratom Fremgangsmåde til ex-corpore-behandling af humane blodceller
US5809394A (en) * 1996-12-13 1998-09-15 Battelle Memorial Institute Methods of separating short half-life radionuclides from a mixture of radionuclides
US6117413A (en) * 1997-11-12 2000-09-12 Battelle Memorial Institute Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide
EP1047457A2 (en) * 1998-01-16 2000-11-02 MCA Development B.V. USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE
DE19911329A1 (de) * 1998-03-27 2000-09-21 Benes Ivan Friedrich Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung
US6696551B1 (en) 1999-03-23 2004-02-24 The United States Of America As Represented By The Department Of Health And Human Services 225Ac-HEHA and related compounds, methods of synthesis and methods of use
ATE407702T1 (de) * 2000-06-16 2008-09-15 Sloan Kettering Inst Cancer Liposomale einkapselung von alphastrahlern, und deren verwendung
US6852296B2 (en) * 2001-06-22 2005-02-08 Pg Research Foundation Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine
US7087206B2 (en) * 2002-04-12 2006-08-08 Pg Research Foundation Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
US20030086868A1 (en) * 2002-08-12 2003-05-08 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy
US20040141916A1 (en) * 2003-01-08 2004-07-22 George Sgouros Prevention of systemic toxicity during radioimmunotherapy for intravascularly disseminated cancers
KR20060015507A (ko) * 2003-04-15 2006-02-17 알게타 에이에스 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227
DE102004022200B4 (de) * 2004-05-05 2006-07-20 Actinium Pharmaceuticals, Inc. Radium-Target sowie Verfahren zu seiner Herstellung
WO2005117976A2 (en) * 2004-06-03 2005-12-15 The Regent Of The University Of California Method of increasing radiation sensitivity by inhibition of beta one integrin
US7736610B2 (en) * 2004-09-24 2010-06-15 Battelle Energy Alliance, Llc Actinium radioisotope products of enhanced purity
US7157061B2 (en) * 2004-09-24 2007-01-02 Battelle Energy Alliance, Llc Process for radioisotope recovery and system for implementing same
DE102006008023B4 (de) * 2006-02-21 2008-05-29 Actinium Pharmaceuticals, Inc. Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets
CA2662932C (en) 2006-09-08 2017-06-06 Actinium Pharmaceuticals, Inc. Method for the purification of radium from different sources
CN104710504B (zh) 2009-07-22 2019-09-13 锕医药股份有限公司 用于制备放射性免疫缀合物的方法
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
US20150157742A1 (en) * 2013-12-11 2015-06-11 The European Atomic Energy Community (Euratom), Represented By The European Commission SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225
EP3409297A1 (en) 2017-05-30 2018-12-05 AlfaRim Medial Holding B.V. The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy
US20200230266A1 (en) 2017-09-20 2020-07-23 Alfarim Medical Holding B.V. The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy

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US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
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US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates

Also Published As

Publication number Publication date
FI910772A0 (fi) 1991-02-18
DK0429624T3 (da) 1994-05-30
KR0179645B1 (en) 1999-03-20
WO1990015625A1 (en) 1990-12-27
CA2034484C (en) 2000-08-15
CA2034484A1 (en) 1990-12-20
US5246691C1 (en) 2001-10-09
FI98707B (fi) 1997-04-30
EP0429624B1 (en) 1994-03-16
EP0429624A1 (en) 1991-06-05
US5246691A (en) 1993-09-21
FI98707C (fi) 1997-08-11
AU5857490A (en) 1991-01-08
DE69007430T2 (de) 1994-07-07
ES2053196T3 (es) 1994-07-16
DE69007430D1 (de) 1994-04-21
JPH04500366A (ja) 1992-01-23
JPH089553B2 (ja) 1996-01-31
AU629367B2 (en) 1992-10-01

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