[go: up one dir, main page]

KR920004340A - 술폰아미드 유도체 - Google Patents

술폰아미드 유도체 Download PDF

Info

Publication number
KR920004340A
KR920004340A KR1019910013235A KR910013235A KR920004340A KR 920004340 A KR920004340 A KR 920004340A KR 1019910013235 A KR1019910013235 A KR 1019910013235A KR 910013235 A KR910013235 A KR 910013235A KR 920004340 A KR920004340 A KR 920004340A
Authority
KR
South Korea
Prior art keywords
group
carbon atoms
hydrogen atom
alkyl
alkyl group
Prior art date
Application number
KR1019910013235A
Other languages
English (en)
Other versions
KR100194993B1 (ko
Inventor
마사까즈 사또
유따까 가와시마
준 고또
요시유끼 지바
미끼오 사따께
쥬조 이와따
다께시 이마니시
Original Assignee
우에하라 아끼라
다이쇼 세이야꾸 가부시끼가이샤
원본미기재
닛뽕 스이산 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우에하라 아끼라, 다이쇼 세이야꾸 가부시끼가이샤, 원본미기재, 닛뽕 스이산 가부시끼가이샤 filed Critical 우에하라 아끼라
Publication of KR920004340A publication Critical patent/KR920004340A/ko
Application granted granted Critical
Publication of KR100194993B1 publication Critical patent/KR100194993B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Surgical Instruments (AREA)

Abstract

내용 없음

Description

술폰아미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식의 술폰아미드 유도체 또는 그의 염.
    상기 식중, A는 나프틸기, 피리딜기, 페닐기, 할로겐원자, 1내지 4개의 탄소 원자를 갖는 알킬기, 1 내지 4개의 탄소 원자를 갖는 알콕시기, 니트로기 및아세트아미도기로 이루어진 군 중에서 선택되는 1 내지 5개의 치환체로 치환된 페닐기, 또는 1 내지 20개의 탄소 원자를 갖는 알킬기이고, B는 1 내지 3개의 탄소 원자를 알킬렌기, -CH=CH-기이고, X 및 Y는 동일하거나 또는 상이할 수 있으며, 각각 수소 원자 또는 불소 원자이고, R은 카르복시기,2 내지 5개의 원자를 갖는 알콕시 카르보닐기, 히드록시메틸기 또는기(이때,R1은 수소 원자 또는 1 내지 3개의 탄소 원자를 갖는 알킬기이고, R2는 수소원자, 히드록실기, 1 내지 3개의 탄소 원자를 갖는 알킬기, 카르복시 메틸기 또는 3 내지 6개의 탄소 원자를 갖는 알콕시카르보닐메틸기임)이고, m은 0내지 2의 정수이고, n은 0내지 3의 정수이다.
  2. 하기 일반식의 술폰아미드 유도체 또는 그의 염.
    상기 식, A는 할로겐 원자, 1 내지 4개의 탄소 원자를 갖는 알킬기, 1 내지
    4개의 탄소 원자를 갖는 알콕시기, 니트로기, 및 아세트아미도기로 이루어진
    군 중에서 선택된 1 내지 5개의 치환체로 치환된 페닐기이고, B는 1 내지 3
    개의 탄소 원자를 갖는 알킬렌기 또는 -OCH2-기이고, X 및 Y는 동일하거나
    또는 상이할 수 있으며, 각각 수소 원자 또는 불소원자이고, R은 카르복시기
    또는 2 내지 4개의 탄소 원자를 갖는 알콕시 카르보닐기이고, m은 0 내지 2
    의 정수이다.
  3. 하기 일반식의 티오페놀 유도체.
    상기 식중, X 및 Y는 동일하거나 또는 상이할 수 있으며, 각각 수소 원자 또는 불소 원자이고, R은 카르복시기, 2 내지 5개의 원자를 갖는 알콕시 카르보닐기, 히드록시메틸기 또는기(이때, R1은 수소 원자 또는 1 내지 3개의 탄소 원자를 갖는 알킬기이고, R2는 수소 원자, 히드록실기, 1 내지 3개의 탄소 원자를 갖는 알킬기, 카르복시 메틸기 또는 3 내지 6개의 탄소 원자를 갖는 알콕시카르보닐케틸기임)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910013235A 1990-08-01 1991-07-31 술폰아미드 유도체 KR100194993B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20473290 1990-08-01
JP90-204732 1990-08-01

Publications (2)

Publication Number Publication Date
KR920004340A true KR920004340A (ko) 1992-03-27
KR100194993B1 KR100194993B1 (ko) 1999-06-15

Family

ID=16495399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910013235A KR100194993B1 (ko) 1990-08-01 1991-07-31 술폰아미드 유도체

Country Status (8)

Country Link
US (1) US5189211A (ko)
EP (1) EP0469901B1 (ko)
JP (1) JP3110515B2 (ko)
KR (1) KR100194993B1 (ko)
AT (1) ATE113032T1 (ko)
CA (1) CA2048212C (ko)
DE (1) DE69104668T2 (ko)
DK (1) DK0469901T3 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69611437T2 (de) * 1995-02-21 2001-08-23 Nippon Suisan Kaisha, Ltd. Gluteminsäurerezeptor agonisten
PT896533E (pt) * 1996-02-22 2004-02-27 Tularik Inc Pentafluorobenzenosulfonamidas e analogos
EP0939627B1 (en) 1996-07-19 2003-09-10 Tularik, Inc. Pentafluorobenzenesulfonamides and analogs
AU763687B2 (en) 1998-06-25 2003-07-31 Tularik Inc. Arylsulfonanilide phosphates
US6153585A (en) * 1998-07-20 2000-11-28 Tularik Inc. Arylsulfonanilide derivatives
EP1115701B1 (en) * 1998-09-23 2003-05-21 Tularik Inc. Arylsulfonanilide ureas
RU2268054C2 (ru) 1999-07-29 2006-01-20 Амджен Инк. Сочетанная терапия с использованием пентафторбензолсульфонамидов
PT1249233E (pt) 1999-11-26 2008-10-21 Shionogi & Co Antagonistas de y5 de npy
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AU2002234165A1 (en) 2000-11-03 2002-05-27 Tularik, Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
SG11201800071PA (en) * 2015-07-06 2018-02-27 Public Univ Corp Yokohama City Univ Novel compound that specifically binds to ampa receptor
JP2020045285A (ja) * 2017-01-11 2020-03-26 公立大学法人横浜市立大学 Ａｍｐａ受容体に関連する疾患の予防及び／又は治療剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4717736A (en) * 1984-01-23 1988-01-05 Merck Frosst Canada, Inc. Antagonists of slow reacting substances of anaphylaxis
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3821540A1 (de) * 1988-06-25 1989-12-28 Boehringer Mannheim Gmbh Neue sulfonamide, verfahren zu ihrer herstellung sowie solche sulfonamide enthaltende arzneimittel

Also Published As

Publication number Publication date
CA2048212A1 (en) 1992-02-02
EP0469901A1 (en) 1992-02-05
EP0469901B1 (en) 1994-10-19
KR100194993B1 (ko) 1999-06-15
ATE113032T1 (de) 1994-11-15
US5189211A (en) 1993-02-23
CA2048212C (en) 2002-07-09
DE69104668D1 (de) 1994-11-24
JP3110515B2 (ja) 2000-11-20
JPH04364158A (ja) 1992-12-16
DK0469901T3 (da) 1994-11-21
DE69104668T2 (de) 1995-03-16

Similar Documents

Publication Publication Date Title
SE7607201L (sv) Forfarande for framstellning av nya tienopyridinderivat
KR980003842A (ko) 중합체 및 레지스트 물질
KR830009054A (ko) 아미노피리미딘 유도체의 제조방법
KR870006072A (ko) 라파마이신 전구체의 제조방법
KR920004340A (ko) 술폰아미드 유도체
KR890005084A (ko) 퀴놀린 유도체
KR930700106A (ko) 혈전증 치료제 및 포스포 디에스테라제 저해제
SE7707341L (sv) 4-hydroxifenylalkanolamin-derivat och forfarande for framstellning derav
UST984005I4 (en) Yellow-dye-forming couplers
SE7710873L (sv) Nya 1h-pyrazolo(3,4-b)pyridiner
FI911615A0 (fi) Nya 4-kinolyl-dihydropyridiner, foerfaranden foer deras framstaellning och deras anvaendning i laekemedel.
SE7905608L (sv) 4-substituerade tiazoloxamsyror samt salter och estrar derav
AU643290B2 (en) Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
KR920702685A (ko) 4,6-o- 히드록시포스포릴글루코사민 유도체
KR840005105A (ko) 의약용 피리다지논류 유도체의 제조방법
KR950704252A (ko) N-치환 이미다졸 유도체
ES384182A1 (es) Procedimiento para la preparacion de nuevos butanoles ter- ciarios basicamente sustituidos.
ES468586A1 (es) Procedimiento para la preparacion de nuevas piridobenzodia- zepinonas.
KR890016006A (ko) 피롤 유도체
KR920007680A (ko) 분말의 응집 방지방법
ES443357A1 (es) Un procedimiento de preparacion de benzodioxanos-1,4.
KR840006967A (ko) N-알킬-피페리디닐 벤조에이트 유도체의 제조방법
KR890005096A (ko) 빈카민산 유도체
KR830005188A (ko) 혈당강하성 구아닐 아미딘의 제조방법
KR850000034A (ko) 테트라하이드로-β-카르보린 유도체의 제조방법

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19910731

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 19960425

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19960621

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19910731

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19980929

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19981230

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19990210

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19990211

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20020130

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20030121

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20030121

Start annual number: 5

End annual number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

Termination category: Default of registration fee

Termination date: 20050111