KR920002599A - 플루오르화 퓨린핵산의 제조방법 - Google Patents
플루오르화 퓨린핵산의 제조방법 Download PDFInfo
- Publication number
- KR920002599A KR920002599A KR1019900011010A KR900011010A KR920002599A KR 920002599 A KR920002599 A KR 920002599A KR 1019900011010 A KR1019900011010 A KR 1019900011010A KR 900011010 A KR900011010 A KR 900011010A KR 920002599 A KR920002599 A KR 920002599A
- Authority
- KR
- South Korea
- Prior art keywords
- nucleic acid
- fluorine
- purine nucleic
- general formula
- group
- Prior art date
Links
- -1 fluorinated purine nucleic acid Chemical class 0.000 title claims 6
- 102000039446 nucleic acids Human genes 0.000 title claims 6
- 108020004707 nucleic acids Proteins 0.000 title claims 6
- 238000000034 method Methods 0.000 title claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 239000001257 hydrogen Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- KJAHHUSTNYUGRJ-IEBDPFPHSA-N (4S,5R)-4-acetyl-5-[(1R)-1,2-dihydroxyethyl]-4,5-dihydroxyheptane-2,3,6-trione Chemical group C(C)(=O)[C@@]([C@](C(=O)C(C)=O)(O)C(C)=O)(O)[C@H](O)CO KJAHHUSTNYUGRJ-IEBDPFPHSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (3)
- 일반식(Ⅱ)의 퓨린핵산에 테트라플루오로붕소나트륨, 티부틸티오나이트라이트(또는 티부틸티오나이트레이트)를 사용하여 아세토니트릴 존재하에서 탈 아미노-치환반응시키는 것을 특징으로 하는 일반식(Ⅰ)의 플루오르호 퓨린핵산의 제조방법.일반식(Ⅰ)에 있어서 R은 트리아세틸 리보스나 에틸기를 표시하고 X는 메틸아민, 수소 또는 불소기를 표시하고 Y는 히드록시, 불소기를 나타내고 Z는 수소, 브롬을 나타낸다.일반식(Ⅱ)에 있어서, X'는 메틸아민, 수소, 아민기를 표시하고 Y'는 히드록시, 아민기를 표시한다.
- 제1항에 있어서, R이 트리아세틸 리보스기인경우 X가 메틸아민일때는 Y는 불소이고, X가 수소인 경우 Y는 불소이며, X가 불소인 경우 Y는 히드록시인것이 특징인 일반식(Ⅰ)의 플루오르호 퓨린핵산의 제조방법.
- 제1항에 있어서, 테트라플루오로붕소나트륨과 티부틸티오나이트라이트(혹은 티부틸티오나이트레이트)의 첨가량이 일반식(Ⅱ)의 퓨린핵산에 대해 1:2:2의 몰비를 가지는 것을 특징으로 하는 일반식(Ⅰ)의 플루오르화퓨린핵산의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019900011010A KR920005743B1 (ko) | 1990-07-19 | 1990-07-19 | 플루오르화 퓨린핵산의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019900011010A KR920005743B1 (ko) | 1990-07-19 | 1990-07-19 | 플루오르화 퓨린핵산의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR920002599A true KR920002599A (ko) | 1992-02-28 |
| KR920005743B1 KR920005743B1 (ko) | 1992-07-18 |
Family
ID=19301451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900011010A KR920005743B1 (ko) | 1990-07-19 | 1990-07-19 | 플루오르화 퓨린핵산의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR920005743B1 (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100324956B1 (ko) * | 1999-12-31 | 2002-02-28 | 이계안 | 차량용 시트의 마운팅 구조 |
-
1990
- 1990-07-19 KR KR1019900011010A patent/KR920005743B1/ko not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100324956B1 (ko) * | 1999-12-31 | 2002-02-28 | 이계안 | 차량용 시트의 마운팅 구조 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR920005743B1 (ko) | 1992-07-18 |
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