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KR920002137A - Percutaneous Absorption Steroid Hormones - Google Patents

Percutaneous Absorption Steroid Hormones Download PDF

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Publication number
KR920002137A
KR920002137A KR1019900010365A KR900010365A KR920002137A KR 920002137 A KR920002137 A KR 920002137A KR 1019900010365 A KR1019900010365 A KR 1019900010365A KR 900010365 A KR900010365 A KR 900010365A KR 920002137 A KR920002137 A KR 920002137A
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KR
South Korea
Prior art keywords
delivery system
steroid hormone
polymer
transdermal absorption
hormone delivery
Prior art date
Application number
KR1019900010365A
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Korean (ko)
Inventor
조경일
Original Assignee
조경일
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Publication date
Application filed by 조경일 filed Critical 조경일
Priority to KR1019900010365A priority Critical patent/KR920002137A/en
Publication of KR920002137A publication Critical patent/KR920002137A/en

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Abstract

내용 없음No content

Description

경피흡수용 스테로이드 호르몬 제제Percutaneous Absorption Steroid Hormones

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 본 발명의 바람직한 예의 실물크기의 사시도1 is a perspective view of a life-size of a preferred example of the present invention

제2도 제1도의 2-2선의 단면도2 2 is a cross-sectional view taken along the line 2-2 of FIG.

제3도 인체의 사체 피부 침투율을 연구한 결과를 나타낸 그래프Fig. 3 Graph showing the results of the study of carcass skin penetration rate of the human body

Claims (13)

불침투성 지지체, 및 이 불침투성 지지체에 부착되고 다음의 조성을 가지는 폴리머 접착성 메트릭스로 이루어진 경피흡수용 스테로이드 호르몬 전달시스템, 중량%기준으로 활성성분 0.1-10%, 부형제 약4-30%, 피부침투 촉진제 약0.1-20%, 피부 자극감소 또는 방지제 약 2-20%및 활성성분의 담체(접착성 폴리머)약 50-92%로 이루어지거나 또는, 여기에 비율을 조절하기 않은 다공성 막을 폴리머층 사이에 가진다.Percutaneous absorption steroid hormone delivery system consisting of an impermeable support and a polymer adhesive matrix attached to the impermeable support, having the following composition, 0.1-10% active ingredient by weight, about 4-30% excipient, skin penetration A porous membrane consisting of about 0.1-20% of an accelerator, about 2-20% of a skin irritant or preventive agent, and about 50-92% of a carrier (adhesive polymer) of an active ingredient, or an uncontrolled proportion between the polymer layers Have 제1항에서, 활성성분이 여성 호르몬인 에스트로젠류, 에스트로젠유도체류 또는 이들의 혼합물로 이루어진 그룹에서 선택된 경피흡수용 스테로이드 호르몬 전달 시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the active ingredient is a female hormone selected from the group consisting of estrogens, estrogen derivatives, or mixtures thereof. 제1항 또는 제 2항에서, 활성 성분이 17-β-에스트라이올인 경피흡수용 스테로이드 호르몬 전달 시스템.The transdermal absorption steroid hormone delivery system according to claim 1 or 2, wherein the active ingredient is 17-β-estradiol. 제1항에서, 접착성 폴리머가 아크릴 멀티폴리머인 경피흡수용 스테로이드 호르몬 전달 시스템.The transdermal absorption steroid hormone delivery system of claim 1 wherein the adhesive polymer is an acrylic multipolymer. 제 1항에서, 접착성 폴리머가 아크릴폴리머 및 실리콘폴리머의 혼합폴리머인 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the adhesive polymer is a mixed polymer of an acrylic polymer and a silicone polymer. 제1항에서 접착성 폴리머가 합성고무폴리머 및 폴리우레탄폴리머의 혼합폴리머인 경피흡수용 스테로이드 호르몬 전달 시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the adhesive polymer is a mixed polymer of a synthetic rubber polymer and a polyurethane polymer. 제1항에서 부형제가 폴리에틸렌글리콜, 폴리에틸렌글리콜 유도체류 및 이들의 혼합물로 이루어진 그룹에서 선택된 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the excipient is selected from the group consisting of polyethylene glycol, polyethylene glycol derivatives, and mixtures thereof. 제1항에서 부형체가 프로필렌글리콜, 프로필렌글리콜 유도체류 및 이들의 혼합물로 이루어진 그룹에서 선택된 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the excipient is selected from the group consisting of propylene glycol, propylene glycol derivatives, and mixtures thereof. 제1항에서 피부 저항 감소제가 라우릴 디에탄올아민 또는 그유도체류인 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin resistance reducing agent is lauryl diethanolamine or its derivative. 제1항에서 피부저항감소제가 소디움 라우릴 설페이트 및 그 유도체류인 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin resistance reducing agent is sodium lauryl sulfate and derivatives thereof. 제1항에서, 피부자극 감소 또는 방지제가 슈크로즈 코코에이트 또는 슈크로즈 유도체류 및 그 혼합물인 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin irritation reducing or preventing agent is sucrose cocoate or sucrose derivatives and mixtures thereof. 제 1항에서 박리 라이너를 더 포함하여 사용전에는 메트릭스가 상기 지지체와 박리 라이너 사이에 샌드위치 되어 있는 경피흡수용 스테로이드 호르몬 전달시스템.The transdermal absorption steroid hormone delivery system of claim 1, further comprising a release liner, wherein a matrix is sandwiched between the support and the release liner before use. 불침투성 지지체 및 이 불침투성 지지체에 부착되고 다음의 조성을 가지는 폴리머 접착성 메트릭스로 이루어진 경피흡수용 여성 스테로이드 호르몬 전달시스템, 중량%기준으로 활성성분 0.1-10%, 부형체 약4-30%, 피부침투 촉진제 약 0.1-20%,피부자극감소 또는 방지제 약 2-20% 및 활성성분의 담체(점착성 폴리머) 약 50-92%로 이루어지거나 또는, 여기에 비율이 조절되지 않은 다공성 막을 폴리머층 사이에 가진다.Percutaneous absorption female steroid hormone delivery system comprising an impermeable support and a polymer adhesive matrix attached to the impermeable support, having the following composition, 0.1-10% by weight of active ingredient, about 4-30% of excipient, skin A porous membrane consisting of about 0.1-20% of penetration promoter, about 2-20% of skin irritant or inhibitor and about 50-92% of carrier (adhesive polymer) of active ingredient Have ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900010365A 1990-07-09 1990-07-09 Percutaneous Absorption Steroid Hormones KR920002137A (en)

Priority Applications (1)

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KR1019900010365A KR920002137A (en) 1990-07-09 1990-07-09 Percutaneous Absorption Steroid Hormones

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Application Number Priority Date Filing Date Title
KR1019900010365A KR920002137A (en) 1990-07-09 1990-07-09 Percutaneous Absorption Steroid Hormones

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KR920002137A true KR920002137A (en) 1992-02-28

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