[go: up one dir, main page]

KR910020013A - 피롤로[2,3, -b]인 돌-케톤 및 동족체, 이들의 제조방법 및 약제로서의 이들의 용도 - Google Patents

피롤로[2,3, -b]인 돌-케톤 및 동족체, 이들의 제조방법 및 약제로서의 이들의 용도 Download PDF

Info

Publication number
KR910020013A
KR910020013A KR1019910007463A KR910007463A KR910020013A KR 910020013 A KR910020013 A KR 910020013A KR 1019910007463 A KR1019910007463 A KR 1019910007463A KR 910007463 A KR910007463 A KR 910007463A KR 910020013 A KR910020013 A KR 910020013A
Authority
KR
South Korea
Prior art keywords
lower alkyl
hydrogen
aryl
compound
alkylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019910007463A
Other languages
English (en)
Other versions
KR100197328B1 (ko
Inventor
씨. 알렌 리챠드
엠. 플라나간 데니즈
Original Assignee
원본미기재
훽스트-러셀 파마슈티칼즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 훽스트-러셀 파마슈티칼즈 인코포레이티드 filed Critical 원본미기재
Publication of KR910020013A publication Critical patent/KR910020013A/ko
Application granted granted Critical
Publication of KR100197328B1 publication Critical patent/KR100197328B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

피롤로[2,3, -b]인 돌-케톤 및 동족체, 이들의 제조방법 및 약제로서의 이들의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 다음 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용되는 이의 부가염 및, 적용가능할 경우, 이의 기하 이성체와 광학 이성체 및 라세미 혼합물.
  3. 상기식에서, R1은 저급알킬, 아릴 또는 아릴저급알킬이고, R2는 수소, 할로겐 또는 저급알킬이며, R3은 수소 또는 저급알킬이고, R4는 저급알킬 또는 아릴저급알킬이며, R5는 수소, 저급알킬, 저급알케닐, 저급알키닐, 아릴저급알킬, 포밀, 저급알킬카보닐, 아릴저급알킬카보닐 또는 저급알콕시카보닐이고, Y는 수소, 할로겐, 저급알킬 또는 저급알콕시이다.
  4. 제1항에 있어서, R1이 저급알킬이고, R2가 수소이며, R3, R4및 R5가 각각 독립적으로 저급알킬이고 Y가 수소인 화합물.
  5. 제2항에있어서, 1-[1,2,3,3a,8,8a-헥사하이드로-1,3a,8-트리메틸피롤로[2,3-b]인돌-5-일]-2-프로판온, 디-톨루오일-L-타프타르산 염인 화합물.
  6. 기억 장애를 치료하는 유효한 양의 제1항 따는 화합물 및 이에 적합한 담체를 포함하는 약제학적 조성물.
  7. 기억 장애 치료활성을 지닌 약제를 제조하기 위한 제1항에 따르는 화합물의 용도.
  8. 다음 일반식(Ⅲ)의 화합물을 촉매량의 팔라듐 아세테이트 및 트리-0-톨릴포스핀의 존재하에 트리부틸주석 메톡사이드 및 이소프로페닐 아세테이트와 반응시킴을 특징으로하여, 제1항에 따르는 화합물의 제조하는 방법.
  10. 상기식에서, R3은 수소 또는 저급알킬이고, R4는 저급알킬 또는 아릴저급알킬이며, R5는 수소, 저급알킬, 저급알케닐, 저급알키닐, 아릴저급알킬, 포밀, 저급알킬카보닐, 아릴저급알킬카보닐 또는 저급 알콕시카보닐이다.
  11. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007463A 1990-05-11 1991-05-09 피롤로(2,3-bz)인돌-케톤 동족체, 이의 제조방법 및 이를 함유하는 약제학적 조성물 Expired - Fee Related KR100197328B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52195390A 1990-05-11 1990-05-11
US521,953 1990-05-11

Publications (2)

Publication Number Publication Date
KR910020013A true KR910020013A (ko) 1991-12-19
KR100197328B1 KR100197328B1 (ko) 1999-06-15

Family

ID=24078810

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910007463A Expired - Fee Related KR100197328B1 (ko) 1990-05-11 1991-05-09 피롤로(2,3-bz)인돌-케톤 동족체, 이의 제조방법 및 이를 함유하는 약제학적 조성물

Country Status (18)

Country Link
EP (1) EP0456196A1 (ko)
JP (1) JP3061442B2 (ko)
KR (1) KR100197328B1 (ko)
AR (1) AR248025A1 (ko)
AU (1) AU634654B2 (ko)
CA (1) CA2042327C (ko)
CZ (1) CZ286092B6 (ko)
FI (1) FI94760C (ko)
HU (1) HUT61309A (ko)
IE (1) IE911606A1 (ko)
IL (1) IL98094A (ko)
MX (1) MX25721A (ko)
NO (1) NO178890C (ko)
NZ (1) NZ238094A (ko)
PL (1) PL290200A1 (ko)
PT (1) PT97622A (ko)
RU (1) RU2015979C1 (ko)
ZA (1) ZA913534B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983616A (en) * 1990-02-01 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
FR2772516B1 (fr) 1997-12-12 2003-07-04 Ela Medical Sa Circuit electronique, notamment pour un dispositif medical implantable actif tel qu'un stimulateur ou defibrillateur cardiaque, et son procede de realisation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
US5077289A (en) * 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US4983616A (en) * 1990-02-01 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
KR100197328B1 (ko) 1999-06-15
NO911810D0 (no) 1991-05-10
JPH04226987A (ja) 1992-08-17
IL98094A (en) 1996-01-31
FI94760B (fi) 1995-07-14
NO178890B (no) 1996-03-18
HUT61309A (en) 1992-12-28
HU911574D0 (en) 1991-11-28
ZA913534B (en) 1992-03-25
RU2015979C1 (ru) 1994-07-15
CA2042327C (en) 2001-12-04
CA2042327A1 (en) 1991-11-12
PL290200A1 (en) 1992-07-27
PT97622A (pt) 1992-02-28
NZ238094A (en) 1994-05-26
AU7622891A (en) 1991-11-14
IL98094A0 (en) 1992-06-21
AU634654B2 (en) 1993-02-25
NO911810L (no) 1991-11-12
CZ286092B6 (cs) 2000-01-12
AR248025A1 (es) 1995-05-31
JP3061442B2 (ja) 2000-07-10
FI912247L (fi) 1991-11-12
EP0456196A1 (en) 1991-11-13
IE911606A1 (en) 1991-11-20
FI94760C (fi) 1995-10-25
MX25721A (es) 1993-10-01
FI912247A0 (fi) 1991-05-09
NO178890C (no) 1996-06-26
CS138391A3 (en) 1991-12-17

Similar Documents

Publication Publication Date Title
NO821494L (no) Terapeutisk nyttige 1-alkyl-2-aminotetralinderivater
KR910009706A (ko) 피소스티그민과 관련된 4- 및 6-카바메이트, 이의 제조방법 및 중간 생성물, 및 이의 약제로서의 용도
FI875229A0 (fi) Menetelmä uusien farmakologisesti aktiivisten katekolijohdoksien valmistamiseksi
RU93005057A (ru) Фармацевтические соединения, производные тиенобензодиазепина, способ их получения, фармкомпозиция и их использование
AU3060197A (en) Aryl substituted cyclic amines as selective dopamine d3 ligands
MX21088A (es) N-heteroanil-purin-6-aminas, y un proceso para su preparacion y su uso como medicamentos.
KR900016203A (ko) 신규 화합물들
NO924949D0 (no) Piperidylsubstituerte indoler
ES2111352T3 (es) Uso de diester fosfato para el tratamiento de enfermedades retinianas.
KR950702563A (ko) 테트라시클릭 화합물, 이것의 제조방법 및 중간체와, 항암제로서의 이들의 사용방법(tetracyclic compounds process and intermediates for their preparation and their use as antitumour agents)
KR910000647A (ko) 나프틸아미노-및 나프틸옥시- 피리딘아민 및 관련된 화합물, 이의 제조방법 및 이의 피부소염제로서의 용도
KR910020013A (ko) 피롤로[2,3, -b]인 돌-케톤 및 동족체, 이들의 제조방법 및 약제로서의 이들의 용도
KR960703912A (ko) 중추신경계 활성을 갖는 헤테로사이클 아민(heterocyclic amines having central nervous system activity)
RU95120819A (ru) Наружное средство и способ лечения неврологических заболеваний и заболеваний опорно-двигательного аппарата с болевым синдромом и отечностью
PT1025101E (pt) Derivados de nafto-imidazo¬1,2-a|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central
KR880004810A (ko) 소화성 궤양 치료제
AR029259A1 (es) Compuestos 1,1'(1,2 etendiilo) bis (benceno) sustituidos, un proceso para su preparacion composiciones farmaceuticas y el uso de dichos compuestos para preparar agentes intensificadores de la absorcion de glucosa
KR890002168A (ko) 디하이드로-1,4-옥사지노[2,3-c]퀴놀린, 그의 제조방법 및 중간생성물 및 약제로서의 용도
ES2036539T3 (es) Un procedimiento para preparar derivados de ergolina.
IE790108L (en) Isoquinoline compounds
KR900007811A (ko) 1-아미노알킬-3옥시치환된-4-아릴-1,3,4,5-테트라하이드로-2h-1.3-벤조디아제핀-2-은, 이의 제조방법 및 이의 약제로서의 용도
JPS57193461A (en) Benzazepine derivative
KR910000739A (ko) 7H-벤조[b] 피라지노[1,2-d] 피롤로[3,2, 1-jk][1,4] 벤조디아제핀, 이의 제조방법 및 약제로서의 이의 용도
DE59103080D1 (de) 9-Amino-2-phenylbicyclo[3.3.1]nonane und 9-Amino-2-phenylbicyclo[3.3.1]-non-2-ene und diese enthaltende therapeutische Mittel.
KR927003580A (ko) 제약학적으로 활성인 노르모닐 화합물

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20030214

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20040225

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20040225