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KR910019612A - 옥살릴아미노산 유도체, 이의 제조방법 및 프롤린 하이드록실라제 억제용 약제로서의 이의 용도 - Google Patents

옥살릴아미노산 유도체, 이의 제조방법 및 프롤린 하이드록실라제 억제용 약제로서의 이의 용도 Download PDF

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Publication number
KR910019612A
KR910019612A KR1019910007532A KR910007532A KR910019612A KR 910019612 A KR910019612 A KR 910019612A KR 1019910007532 A KR1019910007532 A KR 1019910007532A KR 910007532 A KR910007532 A KR 910007532A KR 910019612 A KR910019612 A KR 910019612A
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South Korea
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compound
formula
medicament
hydrogen
alkyl
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KR1019910007532A
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English (en)
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바아더 엑케하르트
부르그하르트 하랄트
귄즐러-푸칼 볼크마르
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오일러, 라피체
훽스트 아크티엔게젤샤프트
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Publication of KR910019612A publication Critical patent/KR910019612A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

내용 없음

Description

옥살릴아미노산 유도체, 이의 제조방법 및 프롤린 하이드록실라제 억제용 약제로서의 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 약제로서 사용하기 위한, 하기 일반시(I)의 옥살릴 아미노산 유도체, 및 이의 상당히 순수한 D- 및 L-형으로 존재하는 화합물 및 생리학적으로 허용되는 염.
    상기식에서, R및 R'는 동일하거나 상이하며 C1-C6-알킬 또는 수소이고, R1은 수소이거나C1-C4-알킬이며, R2는 수소, C1-C6-알킬(여기서, 알킬 라디칼은 비치환 되거나 아릴, OH,SH또는 NH2에 의해 치환된다), C1-C3-알콕시, 카복실, C1-C6-알콕시 카보닐, 아릴, SH,NH2또는 할로겐이거나, R1및 R2는 함께 C2-C|4-알킬렌 쇄를 형성한다.
  2. 제1항에 있어서, R 및 R'가 동일하거나 상이하며 C1-C3-알킬, Na 또는 K이고, R1이 수소, 메틸 또는 에틸이며, R2가 수소또는 C1-C4-알킬(여기서, 알킬 라디칼은 비치환 되거나 페닐 또는 SH에 의해 치환된다)이거나, R1과 R2가 함께 C2또는 C3-알킬렌 쇄를 형성하는, 약제로서 사용하기 위한 일반식(I)의 화합물.
  3. 제1또는 2항에 있어서, R및R'가 동일하고 메틸, 에틸, Na또는 K이고, R1이 수소 또는 메틸이며, R2가 수소, C1-C3-알킬, 벤질 또는 티오메틸이거나, R1과R2가 함께 에틸렌 쇄를 형성하는, 약제로서 사용하기 위한 일반식(I)의 화합물.
  4. 제1 내지 3항중 어느 한 항에 있어서, 효소 프폴린 하이드록실라제 또는 리신 하이드록실라제를 억제하기 위한 일반식(I)의 화합물.
  5. 제1 내지 3항중 어느 한 항에 있어서, 섬유형성 억제제 및 면역형성억제제로서 사용하기 위한 일반식(I)의 화합물.
  6. 제 1내지 3항중 어느 한 항에 따른 일반식(I)의 화합물을 혼합가능한 약제학적 담체와 함께 함유하는 약제.
  7. 섬유형성억제 및/또는 면역형성억제활성을 갖는 약제를 제조하기 위한, 제1 내지 3항중 어느 한 항에 따른 일반식(I)의 화합물의 용도.
  8. 콜라겐 및 콜라겐-유사 물질의 신진대사에 영향을 미치거나 Clq를 생합성시키기 위한, 제1 내지 3항중 어느 한 항에 따른 일반식(I)의 화합물의 용도.
  9. 콜라겐 및 콜라겐-유사 물질의 신진대사에 질환을 치료하거나 Clq를 생합성시키기 위한, 제1 내지 3항중 어느 한 항에 따른 일반식(I)의 화합물의 용도.
  10. 제1 내지 3항중 어느 한 항에 따른 일반식(I)의 화합물을 약제에 가함을 특징으로 하여, 콜라겐 및 콜라겐-유사 물질의 신진대사에 영향을 미치거나 Clq를 생합성시키기 위한 약제를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007532A 1990-05-12 1991-05-10 옥살릴아미노산 유도체, 이의 제조방법 및 프롤린 하이드록실라제 억제용 약제로서의 이의 용도 KR910019612A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4015255A DE4015255A1 (de) 1990-05-12 1990-05-12 Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase
DEP4015255.3 1990-05-12

Publications (1)

Publication Number Publication Date
KR910019612A true KR910019612A (ko) 1991-12-19

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KR1019910007532A KR910019612A (ko) 1990-05-12 1991-05-10 옥살릴아미노산 유도체, 이의 제조방법 및 프롤린 하이드록실라제 억제용 약제로서의 이의 용도

Country Status (28)

Country Link
US (1) US5204338A (ko)
EP (1) EP0457163B1 (ko)
JP (1) JP2504874B2 (ko)
KR (1) KR910019612A (ko)
CN (1) CN1032253C (ko)
AT (1) ATE108177T1 (ko)
AU (1) AU641760B2 (ko)
BR (1) BR9101927A (ko)
CA (1) CA2042282A1 (ko)
CZ (1) CZ279939B6 (ko)
DE (2) DE4015255A1 (ko)
DK (1) DK0457163T3 (ko)
EG (1) EG19762A (ko)
ES (1) ES2057655T3 (ko)
HR (1) HRP940695B1 (ko)
HU (1) HU217974B (ko)
IE (1) IE65298B1 (ko)
IL (1) IL98109A (ko)
LT (1) LT3953B (ko)
LV (1) LV10387B (ko)
MA (1) MA22152A1 (ko)
MX (1) MX25723A (ko)
MY (1) MY108608A (ko)
NZ (1) NZ238112A (ko)
PT (1) PT97642B (ko)
RU (1) RU2025123C1 (ko)
TW (1) TW225988B (ko)
ZA (1) ZA913538B (ko)

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Also Published As

Publication number Publication date
CA2042282A1 (en) 1991-11-13
LV10387A (lv) 1995-02-20
BR9101927A (pt) 1991-12-17
HUT57581A (en) 1991-12-30
DE4015255A1 (de) 1991-11-14
MY108608A (en) 1996-10-31
CN1056683A (zh) 1991-12-04
MA22152A1 (fr) 1991-12-31
JP2504874B2 (ja) 1996-06-05
HU157291D0 (en) 1991-11-28
EG19762A (en) 1996-01-31
IL98109A (en) 1995-07-31
CN1032253C (zh) 1996-07-10
ZA913538B (en) 1992-02-26
LT3953B (en) 1996-05-27
AU641760B2 (en) 1993-09-30
ATE108177T1 (de) 1994-07-15
EP0457163A1 (de) 1991-11-21
DK0457163T3 (da) 1994-10-17
PT97642B (pt) 1998-08-31
MX25723A (es) 1993-04-01
JPH04226913A (ja) 1992-08-17
PT97642A (pt) 1992-02-28
HU217974B (hu) 2000-05-28
LTIP1460A (en) 1995-05-25
IE911608A1 (en) 1991-11-20
AU7622191A (en) 1991-11-14
TW225988B (ko) 1994-07-01
RU2025123C1 (ru) 1994-12-30
HRP940695A2 (en) 1997-02-28
ES2057655T3 (es) 1994-10-16
DE59102102D1 (de) 1994-08-11
NZ238112A (en) 1993-12-23
IE65298B1 (en) 1995-10-18
IL98109A0 (en) 1992-06-21
US5204338A (en) 1993-04-20
HRP940695B1 (en) 1999-04-30
CZ279939B6 (cs) 1995-09-13
LV10387B (en) 1996-02-20
EP0457163B1 (de) 1994-07-06

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