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KR910015558A - 개선된 류코트라이인 길항물질 - Google Patents

개선된 류코트라이인 길항물질 Download PDF

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Publication number
KR910015558A
KR910015558A KR1019910002539A KR910002539A KR910015558A KR 910015558 A KR910015558 A KR 910015558A KR 1019910002539 A KR1019910002539 A KR 1019910002539A KR 910002539 A KR910002539 A KR 910002539A KR 910015558 A KR910015558 A KR 910015558A
Authority
KR
South Korea
Prior art keywords
leukotriine
antagonist
improved
hydroxy
phenyl
Prior art date
Application number
KR1019910002539A
Other languages
English (en)
Inventor
마크 가핀스키 다렐
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR910015558A publication Critical patent/KR910015558A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음

Description

개선된 류코트라이인 길항물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식 Ⅰ 의 화합물 또는 약학적으로 허용될 수 있는 그의 염기 부가염
    여기에서, Y는 -CO-, -C(=NOH)-, -CHOH-, -CH2-, 혹은 -C(=CH2)- 이고; A는 결합 혹은 -O-이며; R1과 R2중 하나는 수소이고 다른 하나는 -CH2CH2COOH이고, p는 1 내지 16이며, Z는 -H혹은 -G-Q이고 여기서 G는 결합, -O-, -S(O)t-, -NH-, -CH=CH- 혹은 -C≡C- 이고 Q는 페닐 혹은 할로, C1-C3알킬, C1-C3알콕시, 아세틸, 니트로, 아미노, 트리플루오로메틸, 하이드록시 및 -S(O)t-(C1-C3알킬) (여기서 t는 각각 독립적으로 0 내지 2이다)로 구성된 군으로부터 선택된 하나 또는 두 치환체로 치환된 페닐이다.
  2. 튜코트라이인의 과다 방출을 특징으로 하는 어떤 질병에 걸렸거나 걸리기 쉬운 동물을 치료하는데 사용하기 위한 제1항에 청구한 일반식 Ⅰ 의 화합물 또는 약학적으로 허용될 수 있는 그의 염기 부가염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910002539A 1990-02-16 1991-02-13 개선된 류코트라이인 길항물질 KR910015558A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/481,413 US4996230A (en) 1990-02-16 1990-02-16 Leukotriene antagonists
US07/481,413 1990-02-16

Publications (1)

Publication Number Publication Date
KR910015558A true KR910015558A (ko) 1991-09-30

Family

ID=23911845

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910002539A KR910015558A (ko) 1990-02-16 1991-02-13 개선된 류코트라이인 길항물질

Country Status (20)

Country Link
US (1) US4996230A (ko)
EP (1) EP0442748B1 (ko)
JP (1) JPH04211037A (ko)
KR (1) KR910015558A (ko)
CN (1) CN1028639C (ko)
AR (1) AR247205A1 (ko)
AT (1) ATE116980T1 (ko)
AU (1) AU631482B2 (ko)
CA (1) CA2036523A1 (ko)
DE (1) DE69106545T2 (ko)
FI (1) FI910728L (ko)
HU (1) HU208431B (ko)
IE (1) IE910531A1 (ko)
IL (1) IL97242A0 (ko)
NO (1) NO177097C (ko)
NZ (1) NZ237124A (ko)
PT (1) PT96760A (ko)
RU (1) RU2007401C1 (ko)
YU (1) YU27691A (ko)
ZA (1) ZA911111B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
CA2142735A1 (en) * 1993-06-18 1995-01-05 Tatsuyoshi Tanaka Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
CN1166834A (zh) * 1994-10-13 1997-12-03 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物，其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
CA2201742A1 (en) * 1994-10-13 1996-04-25 Anthony Daniel Piscopio Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists
US5977077A (en) * 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
CA2199104A1 (en) 1996-03-05 1997-09-05 Tsuneaki Hida Xanthene derivatives, their production and use
US6613797B2 (en) 1999-12-02 2003-09-02 Interlab, Inc. Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN112285355B (zh) * 2020-10-20 2023-01-13 四川大学华西医院 Viridiflorin检测试剂在制备COPD诊断试剂盒中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7008627A (ko) * 1969-06-25 1970-12-29
US3987088A (en) * 1971-09-08 1976-10-19 Burroughs Wellcome Co. Cyclic carbonyl compounds
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
GB1543964A (en) * 1976-04-08 1979-04-11 Ici Ltd Method of antagonising herbicides on soyabean and cotton
NZ204003A (en) * 1982-04-27 1986-05-09 Wellcome Found Substituted xanthenes and xanthones and pharmaceutical compositions
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4661607A (en) * 1984-09-21 1987-04-28 Chugai Seiyaku Kabushiki Kaisha Furoxanthone derivatives useful as diuretics
DE3789299T2 (de) * 1986-12-23 1994-08-04 Warner Lambert Co Verbindungen mit antitumoralen und antibakteriellen Eigenschaften.
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US5242121A (en) * 1991-08-23 1993-09-07 Roto-Mix Enterprises, Ltd. Bale support and cutter

Also Published As

Publication number Publication date
DE69106545T2 (de) 1995-06-01
US4996230A (en) 1991-02-26
IL97242A0 (en) 1992-05-25
AU631482B2 (en) 1992-11-26
PT96760A (pt) 1991-11-29
CN1054066A (zh) 1991-08-28
HUT56359A (en) 1991-08-28
HU208431B (en) 1993-10-28
NO177097C (no) 1995-07-19
NO177097B (no) 1995-04-10
CN1028639C (zh) 1995-05-31
CA2036523A1 (en) 1991-08-17
NZ237124A (en) 1992-04-28
ATE116980T1 (de) 1995-01-15
AR247205A1 (es) 1994-11-30
JPH04211037A (ja) 1992-08-03
NO910608L (no) 1991-08-19
FI910728A0 (fi) 1991-02-14
IE910531A1 (en) 1991-08-28
YU27691A (sh) 1994-04-05
ZA911111B (en) 1992-10-28
NO910608D0 (no) 1991-02-15
FI910728L (fi) 1991-08-17
EP0442748A1 (en) 1991-08-21
AU7110391A (en) 1991-08-22
EP0442748B1 (en) 1995-01-11
RU2007401C1 (ru) 1994-02-15
DE69106545D1 (de) 1995-02-23

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19910213

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid