KR910002666B1 - Hair growth promoting composition - Google Patents

Abstract

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Description

Hair growth promoting composition

The present invention relates to a hair growth promoting composition, more particularly a hair growth promoting composition consisting of a blood flow increasing agent and / or hair cell activator and a carbon dioxide gas.

As a known hair growth promoting composition, a substance extracted from a synthetic material or natural product having a blood flow increasing action or a hair cell activity is usually used. However, when only a small amount of such a substance or extract is used, a satisfactory effect cannot be obtained. Although the use of a large amount of material or extract may have some effect, there is a fear of undesirably stimulating the site where the growth promoting composition is used. Continued use of such growth promoting compositions can cause dermatitis.

On the other hand, it is known that carbon dioxide has a vasodilating action. Carbon dioxide baths are used clinically for rehabilitation.

With the above facts in mind, the present inventors have conducted extensive research to properly apply carbon dioxide to hair growth promoting compositions. As a result, it has been found that the use of carbon dioxide in combination with blood flow enhancers and / or parental cell activators is very effective. More particularly, the use of carbon dioxide with a blood flow increasing agent has been shown to increase blood flow through the scalp and maintain an increase in blood flow. Similarly, when carbon dioxide is used in combination with parental cell activators, the parental cell activators reach the matrix cells efficiently, activating the cells and at the same time expanding the capillaries of the scalp. As such, combined use reduces hair decline and promotes growth. The present invention has been completed based on the above findings.

The present invention provides a hair growth promoting composition which contains a blood flow increasing agent and / or parental cell activator in a mixture with carbon dioxide and is completely sealed in an internal pressure vessel.

-α-토코페릴 아세테이트, 피리독신 디카프릴레이트, 비오틴, 니코틴산 및 이들의 유도체, 톨라졸린 히드로클로라이드, 글리세릴 글리시르헤티네이트, 히노키티올과 같은 합성물진 또는 천연물에서 유도된 물질, 및 스웨르티아 자포니카, 마늘, 안젤리카 아쿠틸로바 키타가와, 천궁(Chidium), 건조된 오렌지 껍질, 카모밀 및 박하와 같은 다양한 식물의 추출물이다. 이들 중에서 d

-α-토코페릴 아세테이트와 스웨르티아 자포니카, 안젤리카 아쿠틸로바 키타가와 및 천궁 추출물이 바람직하다.Examples of blood flow increasing agents used in the present invention are d

substances derived from synthetic or natural products, such as -α-tocopheryl acetate, pyridoxine dicaprylate, biotin, nicotinic acid and derivatives thereof, tolazoline hydrochloride, glyceryl glycyrhetate, hinokthiol, and Swertia japonica It is an extract of various plants, such as garlic, angelica acutylova kitagawa, chidium, dried orange peel, chamomile and peppermint. Of these d

Preference is given to -α-tocopheryl acetate with Swertia japonica, angelica acutylova kitagawa and celestial extract.

-아스파르트산 및 이들의 유도체, 광감응소 제301번, 에티닐에스트라디올, 태반 추출물, 철 클로로필 등과 같은 합성 물질 또는 천연물이다. 이들 중에서, 비타민 A산, 칼륨 판토테네이트, 판토테닐 알코올과 태반 추출물이 바람직하다.Examples of parental cell activators include vitamin A acid, pantothenic acid and derivatives thereof, pantothenyl alcohol and derivatives thereof,

-Aspartic acid and derivatives thereof, photosensitizer No. 301, ethynylestradiol, placental extract, iron chlorophyll and the like, or natural products. Among them, vitamin A acid, potassium pantothenate, pantothenyl alcohol and placental extract are preferred.

Such blood flow increasing agents and / or parental cell activators are usually used dissolved in water or a mixture of water and lower alcohol. Preferably the blood flow increasing agent and / or hair cell activator is used in an amount of 0.001 to 5% by weight (simplified to% below) of the hair growth promoting composition. Small amounts are undesirable because no satisfactory effect can be obtained, while excessive amounts cause undesirable irritation to the scalp.

Carbon dioxide is known to exist as CO ₂ molecules and have vasodilation when dissolved in acidic solutions. In this sense, the hair growth promoting composition of the present invention is generally adjusted to pH7 or below, preferably 4.5 to 6.5. It can be noted that the hair growth promoting composition of the present invention is more acidified when the carbon dioxide is charged under pressure and dissolved in the growth promoting composition. The final PH range is adjusted as defined above. For the adjustment of pH, organic acids such as citric acid, tartaric acid, lactic acid and the like or salts thereof and phosphoric acid and salts thereof are used.

Various methods can be readily used to incorporate carbon dioxide into the hair growth promoting composition. In one method, the hair growth promoting composition is placed in a pressure-resistant container into which a high pressure gas is introduced. Another method is to add a hair growth promoting composition containing a carbonate, such as sodium hydrogen carbonate, to which a pH regulator is added to generate carbon and immediately seal the container completely. Another method is to use dry ice pellets for carbon dioxide generation. Among these, the method of using a high pressure gas is preferable.

By this method, some of the carbon dioxide is dissolved in the hair growth promoting composition and some is present as a solid in the container. In carrying out the present invention, it is important that carbon dioxide is dissolved and incorporated in the hair growth promoting composition. The amount of carbon dioxide incorporated is preferably 60 ppm or more. Small amounts are undesirable because no desired vasodilating action can be expected. The content of carbon dioxide can be adjusted according to the charge of the incorporated carbon dioxide (charged under pressure). In general, the pressure in the vessel is preferably 1.2 to 8 Kg / cm 2 · G at 35 ° C.

The pressure-resistant container used to practice the present invention should be a container capable of withstanding the pressure from the time of sealing to use in order to keep the hair growth promoting composition closed. Examples of such containers are metal containers such as aluminum and tin, resin containers such as acetal resins, polycarbonate resins, and glass containers.

The vessel has a discharge nozzle. If the diameter of the discharge nozzle is small, the filling liquid is sprayed in a mist state, and if the diameter is large, the spray liquid is sprayed with bubbles or drops. As a result, the spraying state may change depending on the internal pressure of the container. Known aerosol atomizers have a diameter of the discharge nozzle of 0.3 mm or less. Use of such a discharge nozzle in the hair growth promoting composition of the present invention does not yield satisfactory results because the filling liquid is sprayed in a mist and carbon dioxide is immediately separated from the liquid. In order to avoid this, it is necessary to maintain a long residence time of carbon dioxide in the hair growth promoting composition. In this sense, it is preferable to use the composition directly on the scalp in the form of bubbles or drops, while precipitating the hair growth promoting composition to the hair in as little amount as possible. In use, it can generate carbon dioxide on the scalp. For this purpose, the discharge nozzle preferably has a diameter of 0.3 to 1.5 mm and a length of 1 to 15 cm. In order to avoid a decrease in the content of dissolved carbon dioxide and to maintain constant spray conditions, it is preferable to use the aerosol syringe described in Japanese Patent Laid-Open No. 57-153752, which is equipped with a small carbon dioxide bomb. When the pressure of carbon dioxide is lowered, it is possible to provide fresh carbon dioxide while maintaining a consistent concentration of carbon dioxide from the initial use state to the end.

Except for the above basic ingredients, the hair growth promoting composition of the present invention is usually an oil substrate, an emollient, a gelling agent, various emulsifiers, cosmetics such as perfumes, preservatives such as parahydroxybenzoate, and butyl hydroxyanisol. It may further contain antioxidants, coloring agents such as dyes, freezing agents such as menthol, fungicides, moisturizing agents such as propylene glycol, and the like as other components.

As described above, the hair growth promoting composition of the present invention consisting of a blood flow increasing agent and / or parental cell activator and carbon dioxide increases to the blood flow in a short time and maintains an increase in the blood flow to some extent. Blood flow increasing agents and / or parental cell activators can effectively reach parental cells. As a result, a good effect of preventing hair deterioration is obtained. The use of carbon dioxide reduces the amount of blood flow enhancers and / or hair cell activators and allows the hair growth promoting composition to continue to be used in anticipation of further improved effects. Moreover, when the carbon dioxide dissolved in the hair growth promoting composition vaporizes, it provides the scalp with the desired irritation and a kind of massage. The hair growth promoting composition itself is weakly acidic and thus the pH is expected to have a desirable effect on the skin since the pH of human skin is close to that of human skin.

The invention is specifically illustrated by the following examples.

Reference Example 1

The hair of each back skin is cut | disconnected without damaging the back skin of resting C ₃ H rat (male). In the next stage of growth, the growth of the hair is observed. The location of hair growth on the skin surface is checked as a function of time. Calculate the ratio (r) of the hair growth position to the area of the cutout. The results are shown in the first table.

TABLE 1

As can be seen from Table 1, the area of the location where the onset of hair growth is delayed increases with age.

Example 1

The hair of each dorsal skin is cut without damaging the skin of 108 days C ₃ H mice (males) during the resting period. The rats are divided into seven groups and the hair growth promoting composition indicated in Table 2 is used for the cut hair every day. Observe the hair growth of each rat. The area of the hair growth site shown on the skin surface is measured and its ratio (r) to the cutout is calculated. The results are shown in Table 3.

TABLE 2

TABLE 3

As can be seen from Table 3, the hair growth promoting composition of the present invention, which is composed of carbon dioxide, is effective to facilitate the onset of hair growth.

Example 2

The hair growth promoting compositions indicated in Table 4 are prepared in the same manner as in Table 1 to determine their effects. The results are shown in Table 5.

TABLE 4

TABLE 5

* Same as Table 1

As can be seen from Table 5, the hair growth promoting composition of the present invention consisting of carbon dioxide is effective to facilitate the onset of hair growth.

Reference Example 2

The periodic distribution of hair at the top of the head of a 30 to 40 year old male with a genetic tendency to baldness is measured. For comparison, the cyclic distribution of hairs of the same generation of normal men and bald men is measured equally. The results are shown in Table 6.

TABLE 6

As shown in Table 6, men who are bald and men who are bald tend to have a higher proportion of hair at rest than normal men.

Example 3

The hair growth promoting composition of Table 7 is used for men who have a tendency to bald for more than one year, and the increase rate of the hair in the resting state and the ratio of the hair in the resting state before and after using the bald head are checked. The results are shown in Table 7.

TABLE 7

TABLE 8

As can be seen from the results of Table 8, the hair growth promoting composition of the present invention composed of carbon dioxide reduces the proportion of hair in the resting state.

Example 4

The general procedure of Example 3 is repeated using the hair growth promoting composition indicated in Table 9. The results are shown in Table 10.

TABLE 9

[Composition]

TABLE 10

[result]

As in Table 10, the hair growth promoting composition of the present invention consisting of carbon dioxide reduces the proportion of hair in the resting state.

Claims (4)

A hair growth promoting composition comprising a solution of a blood flow increasing agent and / or hair cell activator in a mixture with carbon dioxide gas and completely sealed in a pressure resistant container. The hair growth promoting composition according to claim 1, wherein the pH of the hair growth promoting composition is 7 or less. The hair growth promoting composition according to claim 1, wherein the blood flow increasing agent is used at a concentration of 0.001 to 5% by weight of the total composition. The hair growth promoting composition according to claim 1, wherein carbon dioxide gas is used in an amount of 60 ppm or more.