KR900700079A - 누출방지 리포좀 제제 - Google Patents
누출방지 리포좀 제제Info
- Publication number
- KR900700079A KR900700079A KR1019890701687A KR890701687A KR900700079A KR 900700079 A KR900700079 A KR 900700079A KR 1019890701687 A KR1019890701687 A KR 1019890701687A KR 890701687 A KR890701687 A KR 890701687A KR 900700079 A KR900700079 A KR 900700079A
- Authority
- KR
- South Korea
- Prior art keywords
- liposome
- water
- leak
- liposome formulation
- liposome preparation
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title claims description 8
- 238000009472 formulation Methods 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 102000057041 human TNF Human genes 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 동결 용해후의 사람 TNF 포함율에 대한, 외수상에 가한 트레할로오스 농도의 영향을 표시하고 있으며, 제2도는 외수상에 가한 젤라틴 농도의 영향을 표시하고 있다. 도면에서 ●는 본 발명의 리포좀제제를 ○는 대조 리포좀 제제를 나타낸다.
Claims (4)
- 리포좀의 내수상에 젤라틴, 알부민 혹은 폴리에틸렌글리콜을 함유함을 특징으로 하는 수용성 고분자 물질을 유효성분으로 하는 동결 또는 동결 건조 리포좀 제제.
- 제1항에 있어서, 외수상에 당 또는 아미노산을 함유하는 동결 리포좀 제제.
- 제1항에 있어서, 수용성 고분자 물질이 단백질인 리포좀 제제.
- 제1항에 있어서, 단백질이 사람 암 괴사인자 또는 인터류킨 1인 리포좀 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1988/000022 WO1988004974A1 (en) | 1987-01-12 | 1988-01-12 | Method and apparatus for processing circumference of spectacle lens |
| JP5361/88 | 1988-01-13 | ||
| JP536188 | 1988-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR900700079A true KR900700079A (ko) | 1990-08-11 |
Family
ID=11609035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890701687A KR900700079A (ko) | 1988-01-12 | 1989-01-11 | 누출방지 리포좀 제제 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0395765A4 (ko) |
| KR (1) | KR900700079A (ko) |
| WO (1) | WO1989006532A1 (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740375A (en) * | 1985-02-25 | 1988-04-26 | Technology Unlimited, Inc. | Gelcores |
| EP0437479B1 (en) * | 1988-10-05 | 1994-06-22 | Vestar, Inc. | Method of making liposomes with improved stability during drying |
| US6805879B2 (en) * | 2000-06-23 | 2004-10-19 | Biopharm Solutions Inc. | Stable polymer aqueous/aqueous emulsion system and uses thereof |
| TWI388344B (zh) * | 2005-08-23 | 2013-03-11 | Celsion Corp | 儲存奈米微粒調合物之方法 |
| US8962015B2 (en) * | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| US20110020428A1 (en) * | 2007-11-15 | 2011-01-27 | Qun Zeng | Gel-stabilized liposome compositions, methods for their preparation and uses thereof |
| KR101685218B1 (ko) * | 2008-11-14 | 2016-12-09 | 아처 다니엘 미드랜드 캄파니 | 유기젤 조성물 및 이의 생산 공정 |
| BR112012029040A2 (pt) | 2010-05-14 | 2016-08-02 | Archer Daniels Midland Co | composição de organogel de fosfolipideo estruturado termorreversível comestível para uso em produto alimentício, método de estruturar uma fase orgânica comestível, produto ou ingrediente alimentício, composição, método de carregar um organogel de fosfolipídeo estruturado termorreversível comestível, método de revestir um alimento e composição de organogel de fosfolipídeo estruturado termorreversivel comestível para uso em um produto alimentício |
| KR20150047336A (ko) | 2013-10-24 | 2015-05-04 | 삼성전자주식회사 | 나노입자, 이를 제조하는 방법, 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS574913A (en) * | 1980-06-11 | 1982-01-11 | Green Cross Corp:The | Urokinase preparation for oral administration |
| JPS58174330A (ja) * | 1982-04-07 | 1983-10-13 | Asahi Chem Ind Co Ltd | ガン壊死因子の安定化法 |
| EP0172007B1 (en) * | 1984-08-10 | 1991-05-22 | Syntex (U.S.A.) Inc. | Stable liposomes with aqueous-soluble medicaments and methods for their preparation |
| DE3621828A1 (de) * | 1986-06-28 | 1988-01-14 | Biotest Pharma Gmbh | Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff |
| JP2501336B2 (ja) * | 1987-07-02 | 1996-05-29 | 第一製薬株式会社 | 安定なリポソ−ム製剤 |
| JPS6447443A (en) * | 1987-08-13 | 1989-02-21 | Nippon Shoe | Liposome |
-
1989
- 1989-01-11 WO PCT/JP1989/000022 patent/WO1989006532A1/ja not_active Application Discontinuation
- 1989-01-11 EP EP19890901311 patent/EP0395765A4/en not_active Withdrawn
- 1989-01-11 KR KR1019890701687A patent/KR900700079A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0395765A1 (en) | 1990-11-07 |
| WO1989006532A1 (en) | 1989-07-27 |
| EP0395765A4 (en) | 1991-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19890911 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |