KR900007412A - 약제학적 조성물 - Google Patents
약제학적 조성물 Download PDFInfo
- Publication number
- KR900007412A KR900007412A KR1019890016872A KR890016872A KR900007412A KR 900007412 A KR900007412 A KR 900007412A KR 1019890016872 A KR1019890016872 A KR 1019890016872A KR 890016872 A KR890016872 A KR 890016872A KR 900007412 A KR900007412 A KR 900007412A
- Authority
- KR
- South Korea
- Prior art keywords
- component
- pharmaceutical composition
- polyoxyethylene glycol
- group
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 15
- -1 polyoxyethylene Polymers 0.000 claims 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 18
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 9
- 238000010521 absorption reaction Methods 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000004599 antimicrobial Substances 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 238000006386 neutralization reaction Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 150000003952 β-lactams Chemical class 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- JHXOAXMCYMGJLQ-UHFFFAOYSA-N 2,3-dihydro-1,3-thiazol-2-amine Chemical compound NC1NC=CS1 JHXOAXMCYMGJLQ-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 125000003460 beta-lactamyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 1
- 229960004755 ceftriaxone Drugs 0.000 claims 1
- 229940071160 cocoate Drugs 0.000 claims 1
- ODCCQUXDUXHSBP-UHFFFAOYSA-N decanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCC(O)=O ODCCQUXDUXHSBP-UHFFFAOYSA-N 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- PFZCOWLKXHIVII-UHFFFAOYSA-N pyridin-1-ium-1-amine Chemical compound N[N+]1=CC=CC=C1 PFZCOWLKXHIVII-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 229960005480 sodium caprylate Drugs 0.000 claims 1
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004149 thio group Chemical group *S* 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims (14)
- 약제학적으로 불활성인 담체의 존재 또는 부재하에 (a) 항균성 화합물 (b) 흡수 중진량의 2-성분 흡수 중진계를 함유하며, 여기서, 2-성분 흡수 증진계 (b)는 (1)(C6-C18)알콜과 폴리옥시에틸렌 글리콜의 에테르인 제1성분, 및 (2)(ⅰ)폴리옥시에틸렌 글리콜-(C6-C18)카복실산 글리세라이드 에스테르, (ⅱ)(C6-C18)카복실산 또는 약제학적으로 허용되는 이의 염, 및 (ⅲ)2개 이상의 (C6-C18)카복실산, 글리세롤 및 폴리옥시에틸렌 글리콜의 에스테르 중에서 선택된 제2성분으로 이루어짐을 특징으로 하는 약제학적 조성물.
- 제1항에 있어서, 흡수 중진계가 성분 (b)는 (1)(C6-C18)알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b) (2)(ⅰ)폴리옥시에틸렌 글리콜-(C6-C18)카복실산 글리세라이드 에스테르로 이루어지는 약제학적 조성물.
- 제2항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅰ)이 폴리옥시에틸렌글리콜-8 카프릴레이트/카프레이트 글리세라이드 에스테르인 약제학적 조성물.
- 제1항에 있어서, 흡수 중진계가 성분(b)(1)인 (C6-C18) 알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b)(2)(ⅱ)인 (C6-C18)카복실산 또는 약제학적으로 허용되는 이의 염으로 이루어지는 약제학적 조성물.
- 제4항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅱ)가 카프릴산 나트륨이 약제학적 조성물.
- 제1항에 있어서, 흡수 중진계가 성분(b)(1)인 (C6-C18) 알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b)(2)(ⅱ)인 2개 이상의 (C6-C18)카복실산, 글리세롤 및 폴리옥시에틸렌 글리콜의 에스테르로 이루어지는 약재학적 조성물.
- 제6항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅱ)폴리옥시에틸렌 글리콜 글리세롤 코코에이트인 약재학적 조성물.
- 제7항에 있어서, 항균성 화합물이 β-락탐인약제학적 조성물.
- 제8항에 있어서, β-락탐이 하기 일반식의 화합물인 약제학적 조성물.상기식에서, R1은 수소 또는 임의로 치환된 알킬이고, R2는 일반식 SO- 3M+의 그룹이거나, R1과 R2는 이들이 결합된 β-락탐(아제티디논)과 환과 함께 일반식의 화합물을 나타내며,M+는 양성자 또는 양이온이고, R3은 아실아미노 그룹 또는 하이드록시알킬 그룹이며, X는 -S-, -O-, -SO-, -SO2-, -CH2또는 -CH(CH3)이고,Y는 일반식R4는 치환된 티오 그룹(이는 에틸티오, -SCH2CH2NH2,및중에서 선택된다. 임의로 치환된 저급 알킬 그룹(이는 아미노메틸, 아실아미노메틸 및중에서 선택된다) 도는 카바모일옥시O∥(-OCVH2)와 같은 치환된 옥시그룹이고, -COOE그룹과 연결되어있는 탄소원자는 β-락탐환의 질소 원자에 결합되어 있으며, Z는 수소, 할로겐, 알콕시 또는 일반식(CH2T의 그룹이고, T는 수소, 알킬-CO-O-,피리디늄, 카복스아미도 피리디늄, 아미노피리디늄, 카바모일옥시, 아지도, 시아노, 하이드록실, 치환 가능한 -S-페닐 그룹 또는 -S-het그룹(여기서, "het"는 임의로 치환된 5- 또는 6-원 헤테로사이클릭환이다)이며, E는 수소, 약제학적으로 허용되는 에스테르 그룹 또는 염-형성 양이온이다.
- 제8항에있어서, 항균성 화합물이(E)-2-(이소부톡시카보닐)-2-펜테닐(6R,7R)-7-[(Z)-2(2-아미노-4-티아졸린)-2-(메톡시이미노)아세트아미도]-3-(아지도메틸)-8-옥소-5-티아-1-아자비사이클로[4,2,0]옥트-2-엔-2-카복실레이트인 약제학적 조성물.
- 제10항에 있어서, 항균성 화합물이 세프트리악손 또는 약제학적으로 허용되는 이의 염, 에스테르 또는 수화물인 약제학적 조성물.
- 제1항 내지 11항중 어느 한 항에 있어서, 피복된 장용 경구 투여 형태로 존재하는 약제학적 조성물.
- 제1항 내지 11항중 어느 한 항에 있어서, 직장투여 형태로 존재하는 약제학적 조성물.
- 전술된 바와 같은 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27459088A | 1988-11-22 | 1988-11-22 | |
US274,590 | 1988-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900007412A true KR900007412A (ko) | 1990-06-01 |
Family
ID=23048828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890016872A Ceased KR900007412A (ko) | 1988-11-22 | 1989-11-21 | 약제학적 조성물 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0370481B1 (ko) |
JP (1) | JPH0774165B2 (ko) |
KR (1) | KR900007412A (ko) |
AT (1) | ATE94765T1 (ko) |
AU (1) | AU625276B2 (ko) |
CA (1) | CA2003340A1 (ko) |
DE (1) | DE58905681D1 (ko) |
DK (1) | DK585889A (ko) |
HU (1) | HU205713B (ko) |
IE (1) | IE63119B1 (ko) |
IL (1) | IL92357A (ko) |
NZ (1) | NZ231447A (ko) |
PH (1) | PH26390A (ko) |
YU (1) | YU221889A (ko) |
ZA (1) | ZA898331B (ko) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4115849A1 (de) * | 1991-05-15 | 1992-11-19 | Lohmann Therapie Syst Lts | Penetrationsfoerdernde substanz |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
SI9400338A (en) * | 1994-08-31 | 1996-04-30 | Lek D D | Vancomycin hydrochloride suspensions for peroral use and for filling into soft ,gelatine capsules. |
JPH08208510A (ja) * | 1994-11-03 | 1996-08-13 | F Hoffmann La Roche Ag | インターフェロン組成物 |
FR2775188B1 (fr) * | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
IL125244A (en) * | 1998-07-07 | 2002-12-01 | Yissum Res Dev Co | Pharmaceutical compositions containing low-melting waxes |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
AU2681300A (en) * | 1999-02-22 | 2000-09-14 | Elan Corporation, Plc | Solid oral dosage form containing an enhancer |
WO2002092616A1 (en) | 2001-05-11 | 2002-11-21 | Orasense, Ltd. | Antisense permeation enhancers |
US7704977B2 (en) | 2006-04-07 | 2010-04-27 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
US20090280169A1 (en) | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
GB2482810A (en) | 2008-09-17 | 2012-02-15 | Chiasma Inc | Enhanced delivery of exenatide using a medium chain fatty acid and salt thereof |
US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
JP2014501784A (ja) | 2011-01-07 | 2014-01-23 | メリオン・リサーチ・Iii・リミテッド | 経口投与用の鉄の医薬組成物 |
WO2016120378A1 (en) | 2015-01-29 | 2016-08-04 | Novo Nordisk A/S | Tablets comprising glp-1 agonist and enteric coating |
ES3029566T3 (en) | 2015-02-03 | 2025-06-24 | Amryt Endo Inc | Treating acromegaly with oral octreotide |
US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1168949A (en) * | 1979-08-13 | 1984-06-12 | William G. Gorman | Cleansing compositions |
US4525339A (en) * | 1982-10-15 | 1985-06-25 | Hoffmann-La Roche Inc. | Enteric coated oral dosage form |
JPS59212427A (ja) * | 1983-05-19 | 1984-12-01 | Kyoto Yakuhin Kogyo Kk | 直腸投与用組成物 |
EP0126348A2 (en) * | 1983-05-19 | 1984-11-28 | Kyoto Pharmaceutical Industries, Ltd. | Composition for rectal administration and method of promoting rectal drug absorption |
CA1256799A (en) * | 1984-02-22 | 1989-07-04 | Walter Fuller | Suppositories |
EP0179583A1 (en) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | A system for enhancing the water dissolution rate and solubility of poorly soluble drugs |
-
1989
- 1989-11-01 ZA ZA898331A patent/ZA898331B/xx unknown
- 1989-11-20 CA CA002003340A patent/CA2003340A1/en not_active Abandoned
- 1989-11-20 IL IL9235789A patent/IL92357A/en not_active IP Right Cessation
- 1989-11-20 NZ NZ231447A patent/NZ231447A/en unknown
- 1989-11-21 EP EP89121548A patent/EP0370481B1/de not_active Expired - Lifetime
- 1989-11-21 DK DK585889A patent/DK585889A/da not_active Application Discontinuation
- 1989-11-21 IE IE371889A patent/IE63119B1/en not_active IP Right Cessation
- 1989-11-21 DE DE89121548T patent/DE58905681D1/de not_active Expired - Fee Related
- 1989-11-21 PH PH39561A patent/PH26390A/en unknown
- 1989-11-21 KR KR1019890016872A patent/KR900007412A/ko not_active Ceased
- 1989-11-21 AT AT89121548T patent/ATE94765T1/de not_active IP Right Cessation
- 1989-11-21 JP JP1300926A patent/JPH0774165B2/ja not_active Expired - Lifetime
- 1989-11-21 AU AU45384/89A patent/AU625276B2/en not_active Ceased
- 1989-11-22 HU HU896123A patent/HU205713B/hu not_active IP Right Cessation
- 1989-11-22 YU YU02218/89A patent/YU221889A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PH26390A (en) | 1992-07-02 |
IE63119B1 (en) | 1995-03-22 |
JPH0774165B2 (ja) | 1995-08-09 |
HUT52374A (en) | 1990-07-28 |
HU205713B (en) | 1992-06-29 |
DE58905681D1 (de) | 1993-10-28 |
ATE94765T1 (de) | 1993-10-15 |
EP0370481B1 (de) | 1993-09-22 |
YU221889A (en) | 1992-05-28 |
CA2003340A1 (en) | 1990-05-22 |
EP0370481A2 (de) | 1990-05-30 |
HU896123D0 (en) | 1990-02-28 |
AU625276B2 (en) | 1992-07-09 |
IL92357A (en) | 1994-10-07 |
EP0370481A3 (de) | 1991-01-16 |
JPH02180837A (ja) | 1990-07-13 |
DK585889A (da) | 1990-05-23 |
IL92357A0 (en) | 1990-07-26 |
AU4538489A (en) | 1990-05-31 |
NZ231447A (en) | 1992-09-25 |
ZA898331B (en) | 1990-07-25 |
IE893718L (en) | 1990-05-22 |
DK585889D0 (da) | 1989-11-21 |
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