KR890701732A - 개량형 조직 플라스미노겐 활성화 인자 - Google Patents

개량형 조직 플라스미노겐 활성화 인자

Info

Publication number: KR890701732A
Authority: KR; South Korea
Prior art keywords: plasminogen activator; tissue plasminogen; improved tissue; improved; thrombus
Prior art date: 1987-10-29

Application number

KR1019890701197A

Other languages

English (en)

Other versions

KR970005046B1 (ko

Inventor

야스시 가와우찌

도시유끼 다께모또

마코또 다까아마

마사미 요코타

마사오 가토

기미오 가쯔타

히로시 구시마

Original Assignee

야마노우찌 세이야꾸 가부시끼가이샤

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-29

Filing date

1989-06-29

Publication date

1989-12-21

1988-10-28 Application filed by 야마노우찌 세이야꾸 가부시끼가이샤 filed Critical 야마노우찌 세이야꾸 가부시끼가이샤

1989-12-21 Publication of KR890701732A publication Critical patent/KR890701732A/ko

1997-04-11 Application granted granted Critical

1997-04-11 Publication of KR970005046B1 publication Critical patent/KR970005046B1/ko

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Adhesives Or Adhesive Processes (AREA)
Graft Or Block Polymers (AREA)
External Artificial Organs (AREA)
Pens And Brushes (AREA)
Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

KR1019890701197A 1987-10-29 1988-10-28 개량형 조직 플라스미노겐 활성화 인자 KR970005046B1 (ko)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
JP27477087		1987-10-29
JP62-274770		1987-10-29
JP62-320785		1987-12-18
JP32078587		1987-12-18
JP7012688		1988-03-23
JP63-70126		1988-03-23
JP18935188		1988-07-27
JP63-189351		1988-07-27
PCT/JP1988/001098 WO1989003874A1 (en)	1987-10-29	1988-10-28	Novel polypeptide compounds

Publications (2)

Publication Number	Publication Date
KR890701732A true KR890701732A (ko)	1989-12-21
KR970005046B1 KR970005046B1 (ko)	1997-04-11

Family

ID=27465213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019890701197A KR970005046B1 (ko)	1987-10-29	1988-10-28	개량형 조직 플라스미노겐 활성화 인자

Country Status (10)

Country	Link
US (2)	US5556621A (ko)
JP (1)	JP2534332B2 (ko)
KR (1)	KR970005046B1 (ko)
AT (1)	ATE125294T1 (ko)
DE (1)	DE3854195T2 (ko)
DK (1)	DK104390A (ko)
FI (1)	FI102844B1 (ko)
HU (2)	HU217100B (ko)
NO (1)	NO301174B1 (ko)
WO (1)	WO1989003874A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2007364A1 (en) *	1989-01-17	1990-07-17	David J. Livingston	Gene sequences encoding modified residues situated in the protease domain of tpa
US6497877B1 (en)	1997-01-29	2002-12-24	University Technology Corporation	Plasminogen activator as an anti-inflammatory agent
JP3956272B2 (ja)	1997-09-22	2007-08-08	敏男宮田	メグシンタンパク質

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4753879A (en) *	1984-08-27	1988-06-28	Biogen N.V.	Modified tissue plasminogen activators
FR2581652B1 (fr) *	1985-04-22	1989-12-22	Genentech Inc	Nouveaux mutants de l'activateur tissulaire du plasminogene humain
US5073494A (en) *	1985-04-22	1991-12-17	Genentech, Inc.	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
NZ217331A (en) *	1985-08-26	1989-05-29	Lilly Co Eli	Tissue plasminogen activator derivatives and genetically engineered product
KR950000303B1 (ko) *	1985-12-20	1995-01-13	디 엎죤 캄파니	조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법
DK43387A (da) *	1986-01-29	1987-07-30	Beecham Group Plc	Fibrinolytisk enzym
AU7090887A (en) *	1986-04-02	1987-10-08	Beecham Group Plc	Plasminogen activators modified in first kringle domain
JPH02504102A (ja) *	1987-06-30	1990-11-29	ジェネンテク，インコーポレイテッド	血管障害治療のための改良法
US4935237A (en) *	1988-03-21	1990-06-19	Genentech, Inc.	Processes for the preparation of t-PA mutants
US5094953A (en) *	1988-03-21	1992-03-10	Genentech, Inc.	Human tissue plasminogen activator variants
US5037646A (en) *	1988-04-29	1991-08-06	Genentech, Inc.	Processes for the treatment of vascular disease
JP2793462B2 (ja) *	1993-02-23	1998-09-03	山陽特殊製鋼株式会社	超耐食Ｎｉ基合金

1988
- 1988-10-28 JP JP63272020A patent/JP2534332B2/ja not_active Expired - Lifetime
- 1988-10-28 AT AT88909384T patent/ATE125294T1/de not_active IP Right Cessation
- 1988-10-28 DE DE3854195T patent/DE3854195T2/de not_active Expired - Lifetime
- 1988-10-28 WO PCT/JP1988/001098 patent/WO1989003874A1/ja active IP Right Grant
- 1988-10-28 KR KR1019890701197A patent/KR970005046B1/ko not_active IP Right Cessation
- 1988-10-28 HU HU886304A patent/HU217100B/hu not_active IP Right Cessation
1990
- 1990-04-25 FI FI902066A patent/FI102844B1/fi not_active IP Right Cessation
- 1990-04-27 NO NO901920A patent/NO301174B1/no not_active IP Right Cessation
- 1990-04-27 DK DK104390A patent/DK104390A/da not_active Application Discontinuation
1994
- 1994-05-04 US US08/237,249 patent/US5556621A/en not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00671P patent/HU211335A9/hu unknown
1996
- 1996-09-10 US US08/712,999 patent/US5739012A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO301174B1 (no)	1997-09-22
FI102844B (fi)	1999-02-26
HUT58811A (en)	1992-03-30
DE3854195T2 (de)	1995-12-21
WO1989003874A1 (en)	1989-05-05
HU211335A9 (en)	1995-11-28
ATE125294T1 (de)	1995-08-15
NO901920D0 (no)	1990-04-27
JP2534332B2 (ja)	1996-09-11
DK104390A (da)	1990-06-21
DE3854195D1 (de)	1995-08-24
FI902066A0 (fi)	1990-04-25
KR970005046B1 (ko)	1997-04-11
DK104390D0 (da)	1990-04-27
NO901920L (no)	1990-04-27
JPH02167076A (ja)	1990-06-27
US5739012A (en)	1998-04-14
FI102844B1 (fi)	1999-02-26
HU886304D0 (en)	1991-11-28
US5556621A (en)	1996-09-17
HU217100B (hu)	1999-11-29

Publication	Publication Date	Title
DE3684680D1 (de)	1992-05-07	Peptidplasminogenaktivatoren.
EP0217379A3 (en)	1988-08-31	Thrombolytic composition and a process for production thereof
NO922237D0 (no)	1992-06-05	Proteiner og nukleinsyrer
ATE172359T1 (de)	1998-11-15	Kalt-sterilisermittel mit verlängerter aktivät
EP0278696A3 (en)	1989-07-26	An arg-serpin human plasminogen activator inhibitor designated pai-2
ES8801551A1 (es)	1987-12-16	Un procedimiento para preparar un vector de expresion replicable.
DK0506791T3 (da)	1994-03-21	Enzymholdigt præparat og detergent indeholdende et sådant præparat
SE8701921L (sv)	1987-11-13	Ny farmaceutisk anvendning
GB1533205A (en)	1978-11-22	Plasmin fractions and complexes thereof
MX169931B (es)	1993-08-02	Procedimiento para determinar la catividad de serinproteasas inhibidores de serinproteasas
KR890701732A (ko)	1989-12-21	개량형 조직 플라스미노겐 활성화 인자
EP0576038A3 (en)	1994-06-08	Method for measuring tissue plasminogen activator, antithrombin iii and soluble fibrin
EP0218479A3 (en)	1989-09-06	Reagent and process
DE3888619D1 (de)	1994-04-28	Modifizierter Gewebeplasminogenaktivator.
DE3780357D1 (de)	1992-08-20	Plasminogen-aktivator und thrombolytische zusammensetzung.
EP0386240A4 (en)	1990-10-24	Novel polypeptide compounds
DE3881953D1 (de)	1993-07-29	Expression von fremden genen in drosophila-zellen.
RU95115761A (ru)	1997-09-10	4-(n,n,n-триметиламино)-циннамоильные производные фибринолитических ферментов в качестве пролонгированного тромболитического средства и способ их получения

Legal Events

Date	Code	Title	Description
1989-06-29	PA0109	Patent application	Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19890629
1989-12-21	PG1501	Laying open of application
1993-08-23	A201	Request for examination
1993-08-23	PA0201	Request for examination	Patent event code: PA02012R01D Patent event date: 19930823 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19890629 Comment text: Patent Application
1996-10-24	E902	Notification of reason for refusal
1996-10-24	PE0902	Notice of grounds for rejection	Comment text: Notification of reason for refusal Patent event date: 19961024 Patent event code: PE09021S01D
1997-03-08	G160	Decision to publish patent application
1997-04-11	PG1605	Publication of application before grant of patent	Comment text: Decision on Publication of Application Patent event code: PG16051S01I Patent event date: 19970308
1997-06-24	E701	Decision to grant or registration of patent right
1997-06-24	PE0701	Decision of registration	Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19970624
1997-07-28	GRNT	Written decision to grant
1997-07-28	PR0701	Registration of establishment	Comment text: Registration of Establishment Patent event date: 19970728 Patent event code: PR07011E01D
1997-07-28	PR1002	Payment of registration fee	Payment date: 19970728 End annual number: 3 Start annual number: 1
1999-04-13	FPAY	Annual fee payment	Payment date: 19990413 Year of fee payment: 15
1999-04-13	PR1001	Payment of annual fee	Payment date: 19990413 Start annual number: 4 End annual number: 15
2012-04-12	EXPY	Expiration of term
2012-04-12	PC1801	Expiration of term