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KR890008121A - 로다닌 유도체 및 약제학적 조성물 - Google Patents

로다닌 유도체 및 약제학적 조성물 Download PDF

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Publication number
KR890008121A
KR890008121A KR1019880014869A KR880014869A KR890008121A KR 890008121 A KR890008121 A KR 890008121A KR 1019880014869 A KR1019880014869 A KR 1019880014869A KR 880014869 A KR880014869 A KR 880014869A KR 890008121 A KR890008121 A KR 890008121A
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South Korea
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group
substituted
alkyl
phenyl
compound
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KR1019880014869A
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KR960009424B1 (en
Inventor
히또시 이노우에
히로야스 고야마
레이꼬 구보다
히로히꼬 고마쯔
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원본미기재
니신 세이훈 가부시끼가이샤
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Publication of KR890008121A publication Critical patent/KR890008121A/ko
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Publication of KR960009424B1 publication Critical patent/KR960009424B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

로다닌 유도체 및 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅰ)의 로다닌 유도체 및 이의 약제학적으로 허용되는 염.
    상기식에서, R1은 C1-C6알킬 또는 그룹 -(CH2)nCOOR3[여기에서, n은 1 내지 4의 정수이고, R3는 수소 또는 C1-C6알킬이다]이고 ; R2는 그룹 -CH=CH-R4또는 -CH2-CH2-R4[여기에서, R4는 치환되거나 비치환된 페닐 또는 치환되거나 비치환된 5-원 헤테로사이클릭 그룹이다.]이다.
  2. 제 1 항에 있어서, R1이 그룹 -(CH2)nCOOR3이고, n은 2 또는 3이며, R3는 수소 또는 C1-C4알킬인 화합물.
  3. 제 1 항에 있어서, R2가 그룹 -CH=CH-R4이고, R4는 페닐이거나, 또는 C1-C6알킬, C1-C6알콕시, 하이드록실, 할로겐, 카복실 및 카복실-, 알콕시카보닐- 또는 테트라졸릴-치환된 알콕시중에서 선택된 하나이상의 치환체를 갖는 치환된 페닐인 화합물.
  4. 제 1 항에 있어서, R2가 그룹 -CH=CH-R4이고, R4는 티에닐, 할로겐-치환된 티에닐 또는 피롤릴인 화합물.
  5. 제 1 항에 있어서, R2가 그룹 -CH2-CH2-R4이고, R4는 C1-C6알킬, C1-C6알콕시 또는 하이드록실에 의해 임의로 치환된 페닐인 화합물.
  6. 하나이상의 약제학적으로 허용되는 첨가제 또는 부형제와 함께, 활성성분으로서 하기 일반식(Ⅰ)의 로다닌 유도체 또는 이의 약제학적으로 허용되는 염을 함유함을 특징으로 하는, 화학적 전달물질 억제 활성을 지니는 약제학적 조성물.
    상기식에서, R1은 C1-C6알킬 또는 그룹 -(CH2)nCOOR3[여기에서, n은 1 내지 4의 정수이고, R3는 수소 또는 C1-C6알킬이다]이고 ; R2는 그룹 -CH=CH-R4또는 -CH2-CH2-R4[여기에서, R4는 치환되거나 비치환된 페닐 또는 치환되거나 비치환된 5-원 헤테로사이클릭 그룹이다.]이다.
  7. 제 6 항에 있어서, R1이 그룹 -(CH2)nCOOR3이고, n은 2 또는 3이며, R3는 수소 또는 C1-C4알킬인 조성물.
  8. 제 6 항에 있어서, R2가 그룹 -CH=CH-R4이고, R4는 페닐이거나, 또는 C1-C4알킬,C1-C6알콕시, 하이드록실, 할로겐, 카복실 및 카복실-, 알콕시카보닐- 또는 테트라조릴-치환된 알콕시중에서 선택된 하나이상의 치환체를 갖는 치환된 페닐의 조성물.
  9. 제 6 항에 있어서, R2가 그룹 -CH=CH-R4이고, R4는 티에닐, 할로겐-치환된 티에닐 또는 피롤릴인 조성물.
  10. 제 6 항에 있어서, R2가 그룹 -CH2-CH2-R4이고, R4는 C1-C6알킬, C1-C6알콕시 또는 하이드록실에 의해 임의로 치환된 페닐인 조성물.
  11. 하기 일반식(Ⅱ)의 로다닌을 일반식(Ⅲ)의 케톤과 반응시킴을 특징으로 하여, 제 1 항의 화합물 및 이의 약제학적으로 허용되는 염을 제조하는 방법.
    상기식에서, R1은 C1-C6알킬 또는 그룹 -(CH2)nCOOR3[여기에서, n은 1 내지 4의 정수이고, R3는 수소 또는 C1-C6알킬이다]이고 ; R2는 그룹 -CH=CH-R4또는 -CH2-CH2-R4[여기에서, R4는 치환되거나 비치환된 페닐 또는 치환되거나 비치환된 5-원 헤테로사이클릭 그룹이다.]이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR88014869A 1987-11-13 1988-11-12 Rhodanine derivatives and pharmaceutical compositions KR960009424B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28899887 1987-11-13
JP62-288998 1987-11-13

Publications (2)

Publication Number Publication Date
KR890008121A true KR890008121A (ko) 1989-07-08
KR960009424B1 KR960009424B1 (en) 1996-07-19

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KR88014869A KR960009424B1 (en) 1987-11-13 1988-11-12 Rhodanine derivatives and pharmaceutical compositions

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US (1) US4897406A (ko)
EP (1) EP0316790B1 (ko)
KR (1) KR960009424B1 (ko)
CA (1) CA1336837C (ko)
DE (1) DE3883164T2 (ko)
ES (1) ES2059471T3 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933355A (en) * 1988-04-14 1990-06-12 Sankyo Company Limited Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
DE69024843T2 (de) * 1989-05-19 1996-05-30 Nisshin Flour Milling Co., Ltd., Tokio/Tokyo Rhodanin-Derivate und pharmazeutische Zusammensetzungen
MX9705557A (es) * 1995-01-23 1997-10-31 Lilly Co Eli Metodo y composiciones para el tratamiento de la esclerosis multiple.
WO2000018746A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
AU2009249589A1 (en) * 2008-05-19 2009-11-26 Microbiotix, Inc. Inhibitors of bacterial biofilm formation
FR2965730B1 (fr) * 2010-10-08 2013-03-29 Oreal Utilisation de derives de methoxyalcoxyphenyl-alkyle substitues comme conservateur, procede de conservation, composes et composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604530A (ko) * 1967-06-06 1971-11-29
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
US4791126A (en) * 1980-08-22 1988-12-13 Ono Pharmaceutical Co., Ltd. Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredients
ES537999A0 (es) * 1983-11-29 1985-12-01 Kaken Pharma Co Ltd Un procedimiento para preparar un derivado de rodanina
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
JPS6212776A (ja) * 1985-07-10 1987-01-21 Taiho Yakuhin Kogyo Kk ロ−ダニン誘導体
JPS6229570A (ja) * 1985-07-29 1987-02-07 Kanegafuchi Chem Ind Co Ltd ３，５−ジイソプロピルベンジリデン複素環式化合物
GR862081B (en) * 1985-08-09 1986-12-24 Lilly Co Eli Di-t-butylphenol compounds

Also Published As

Publication number Publication date
EP0316790B1 (en) 1993-08-11
DE3883164D1 (de) 1993-09-16
KR960009424B1 (en) 1996-07-19
DE3883164T2 (de) 1993-12-02
ES2059471T3 (es) 1994-11-16
US4897406A (en) 1990-01-30
EP0316790A1 (en) 1989-05-24
CA1336837C (en) 1995-08-29

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