KR890001969A - 황화합물, 이들의 제법 및 이들을 함유하는 제약학적 조성물 - Google Patents
황화합물, 이들의 제법 및 이들을 함유하는 제약학적 조성물 Download PDFInfo
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- KR890001969A KR890001969A KR1019880009567A KR880009567A KR890001969A KR 890001969 A KR890001969 A KR 890001969A KR 1019880009567 A KR1019880009567 A KR 1019880009567A KR 880009567 A KR880009567 A KR 880009567A KR 890001969 A KR890001969 A KR 890001969A
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- KR
- South Korea
- Prior art keywords
- alkyl
- compound
- group
- general formula
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title 1
- 150000003464 sulfur compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 18
- -1 cyano, nitro, amino Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 125000004754 (C2-C12) dialkylamino group Chemical group 0.000 claims 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 150000002596 lactones Chemical class 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Eye Examination Apparatus (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 일반식(Ⅰ)의 화합물과 이들의 약리학적으로 수용가능한 염, 에스테르 및 아미드 :상기식에서 R1은 C1-C6-알킬, C2-C6-알케닐 또는 C3-C5-시클로알킬기이거나 또는, 각 경우에 그 아릴부가 한번 또는 그 이상 할로겐, C1-C6-알킬, C1-C6-알콜시, 히드록실, 트리플루오로메틸, 시아노, 니트로, 아미노, C1-C6-아킬아미노, C2-C12-디알킬아미노, C1-C6-아실아미노, C6-C16-아실 또는 아지도에 의해 치환될 수 있으며, 알킬 또는 알케닐부는 각각 C1-C5및 C2또는 C3를 함유할 수 있는 아랄킨, 아랄케닐 또는 아릴기이며, m은 0.1또는 2이며, B는 C6이하를 함유하는 직쇄 또는 측쇄의 포화 알킬렌사슬리며, W는 1,2-, 1-3-또는 1,4-페닐렌기이며, A는 C1-C6-알킬, C2-C6-알케닐, 포르밀 C1-C5-알킬, 히드록시 C0-C6-알킬, 카복시 C0-C5-알킬 또는 옥시아세트산이거나 또는 D가또는그룹이고 R2가 수소원자 또는 C1-C5-알킬, 히드록시C1-C5-알킬 또는 카복시 -C4알킬기인 -D-R2기이며, 임으로 이들의 락톤이다.
- 앞에서 특이적으로 예시한 제 1항에 따르는 화합물.
- a) 다음 일반식(Ⅱ)의 화합물을, 다음 일반식(Ⅲ)의 머켑탄과 또는 다음 일반식(Ⅳ)의 술핀산 또는 이들의 염과 반응시키고 이후에 얻어진 술페닐화합물을 임의로 대응되는 술피닐 또는 술포닐화합물로 산화시키거나 또는 얻어진 술포닐화합물을 대응되는 술피닐 또는 술페닐화합물로 환원시키거나 또는 얻어진 술피닐화합물을 대응되는 술페닐화합물로 환원시키거나, 또는 b) R1이 알킬, 알케닐, 시클로알킬 또는 아릴킬일때, 다음일반식(Ⅳ)의 머켑탄을, 다음 일반식(Ⅴ)의 화합물과 반응시키거나, 또는 c) 다음 일반식(Ⅶ)의 화합물을, 다음 일반식(Ⅷ) 또는 (Ⅷa)의 화합물과 반응시키거나, 또는 d) A가 OCH2COOH기일때, 다음 일반식(Ⅸ)의 화합물을, 클로로-또는 브로모아세트산 또는 이들의 에스테르와 반응시키고, 그 다음에, 만약 필요하다면, 얻어진 일반식(Ⅰ)의 화합물을 기지의 방법으로 일반식(Ⅰ)의 다른 화합물로 전환시키거나 또는 얻어진 유리산을 약리학적으로 수용가능한 염, 에스테르 또는 아미드로 전환시키거나 또는 얻어진 에스테르 또는 아미드를 유리산으로 전환시켜서, 다음 일반식(Ⅰ)의 화합물과 이들의 약리학적으로 수용가능한 염, 에스테르 및 아미드를 제조하는 방법 :상기식에서 R1은 C1-C6-알킬, C2-C6-알케닐 또는 C3-C7-시클로알킬기이거나 또는, 각 경우에 그 아릴부가 한번 또는 그 이상 할로겐, C1-C6-알킬, C1-C6-알콕시, 히드록실, 트리플루오로메틸, 시아노, 니토로, 아미노, C1-C6-알킬아미노, C2-C12-디알킬아미노, C1-C6-아실아미노, C1-C16-아실 또는 아지도에 의해 치환될 수 있으며, 알킬 또는 알케닐 부는 각각 C1-C5및 Ct 또는 C3를 함유할 수 있는 아랄킬, 아랄케닐 또는 아릴기이며, m은 0,1 또는 2이며, B는 C6이하는 함유하는 직쇄 또는 축쇄의 포화 알킬렌사슬이며, W는 1,2-, 1,3-또는 1,4-페닐렌기이며, A는 C1-C6-알킬, C2-C6-알케닐, 포르밀 -C1-C5-알킬, 히드록시 -C0-C6-알킬, 카복시 -C0-C5-알킬 또는 옥시아세트산기이거나 또는 D가또는그룹이고 R2가 수소원자 또는 C1-C5-알킬, 히드록시 -C1-C5-알킬 또는 카복시 -C0-C4-알킬기인 D-R2기이며 임의로 이들의 락톤이고, 일반식(Ⅱ)와(Ⅴ)에서 X는 잔기이고 일반식(Ⅷ)에서X는 할로겐원자이다.
- 본질적으로 앞에서 기술 및 예시한, 일반식(Ⅰ)에 따르는 화합물의 제조방법.
- 제3또는 4항에 따라서 언제나 제조되는, 제1항에 따르는 화합물.
- 종레의 담체 및 보조물질 뿐아니라, 제1,2 및 5항중의 어느항에 따르는 적어도 하나의 화합물을 함유하는 약리학적 조성물.
- 약리학적 조성물을 제조하기 위해 제1,2 및 5항중의 어느항에 따르는 화합물의 사용방법.
- 대사질환의 치료를 위해 제1,2 및 5항중의 어느항에 따르는 화합물의 사용방법.
- 순환계이상의 치료를 위해 제1,2 및 5항중 어느 항에 따르는 화합물의 사용방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873724923 DE3724923A1 (de) | 1987-07-28 | 1987-07-28 | Neue schwefelverbindungen, verfahren zu ihrer herstellung sowie arzneimittel |
| DEP3724923.1 | 1987-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890001969A true KR890001969A (ko) | 1989-04-07 |
Family
ID=6332503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880009567A Withdrawn KR890001969A (ko) | 1987-07-28 | 1988-07-28 | 황화합물, 이들의 제법 및 이들을 함유하는 제약학적 조성물 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0301421B1 (ko) |
| JP (1) | JPS6447758A (ko) |
| KR (1) | KR890001969A (ko) |
| AT (1) | ATE66672T1 (ko) |
| AU (1) | AU2015088A (ko) |
| DD (1) | DD285976A5 (ko) |
| DE (2) | DE3724923A1 (ko) |
| DK (1) | DK423188A (ko) |
| ES (1) | ES2040294T3 (ko) |
| FI (1) | FI883538L (ko) |
| HU (1) | HU199408B (ko) |
| IL (1) | IL87176A0 (ko) |
| PT (1) | PT88095B (ko) |
| ZA (1) | ZA885474B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170026280A (ko) | 2015-08-28 | 2017-03-08 | 신성금형 주식회사 | 전기매트용 전원 커넥터 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006542A (en) * | 1988-10-31 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use |
| US5070099A (en) * | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| GB8921221D0 (en) * | 1989-09-20 | 1989-11-08 | Ici Plc | Compound,preparation and use |
| CN1159277C (zh) | 1993-06-25 | 2004-07-28 | 默里尔药物公司 | 用于制备抗组胺哌啶衍生物的新中间体 |
| US6147216A (en) * | 1993-06-25 | 2000-11-14 | Merrell Pharmaceuticals Inc. | Intermediates useful for the preparation of antihistaminic piperidine derivatives |
| US6930197B2 (en) | 1998-07-02 | 2005-08-16 | Aventis Pharmaceuticals Inc. | Antihistaminic piperidine derivatives and intermediates for the preparation thereof |
| US6683094B2 (en) | 1998-07-02 | 2004-01-27 | Aventis Pharmaceuticals Inc. | Antihistaminic piperidine derivatives and intermediates for the preparation thereof |
| TW200904329A (en) * | 2007-05-18 | 2009-02-01 | Sumitomo Chemical Co | Organic sulfur compound and its use for controlling harmful arthropod |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB790199A (en) * | 1954-02-18 | 1958-02-05 | Boots Pure Drug Co Ltd | Benzyl phenyl sulphides and acaricidal compositions thereof |
| GB780520A (en) * | 1955-03-11 | 1957-08-07 | Boots Pure Drug Co Ltd | New sulphur containing compounds |
| US4752616A (en) * | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
-
1987
- 1987-07-28 DE DE19873724923 patent/DE3724923A1/de not_active Withdrawn
-
1988
- 1988-07-21 IL IL87176A patent/IL87176A0/xx unknown
- 1988-07-22 ES ES198888111808T patent/ES2040294T3/es not_active Expired - Lifetime
- 1988-07-22 DE DE8888111808T patent/DE3864474D1/de not_active Expired - Lifetime
- 1988-07-22 AT AT88111808T patent/ATE66672T1/de not_active IP Right Cessation
- 1988-07-22 EP EP88111808A patent/EP0301421B1/de not_active Expired - Lifetime
- 1988-07-25 PT PT88095A patent/PT88095B/pt not_active IP Right Cessation
- 1988-07-26 DD DD88318302A patent/DD285976A5/de unknown
- 1988-07-26 JP JP63184765A patent/JPS6447758A/ja active Pending
- 1988-07-27 ZA ZA885474A patent/ZA885474B/xx unknown
- 1988-07-27 FI FI883538A patent/FI883538L/fi not_active Application Discontinuation
- 1988-07-27 HU HU884002A patent/HU199408B/hu not_active IP Right Cessation
- 1988-07-28 DK DK423188A patent/DK423188A/da not_active Application Discontinuation
- 1988-07-28 KR KR1019880009567A patent/KR890001969A/ko not_active Withdrawn
- 1988-07-28 AU AU20150/88A patent/AU2015088A/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170026280A (ko) | 2015-08-28 | 2017-03-08 | 신성금형 주식회사 | 전기매트용 전원 커넥터 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3864474D1 (de) | 1991-10-02 |
| DE3724923A1 (de) | 1989-02-09 |
| DK423188D0 (da) | 1988-07-28 |
| HU199408B (en) | 1990-02-28 |
| ZA885474B (en) | 1989-04-26 |
| ATE66672T1 (de) | 1991-09-15 |
| JPS6447758A (en) | 1989-02-22 |
| DK423188A (da) | 1989-01-29 |
| AU2015088A (en) | 1989-02-02 |
| ES2040294T3 (es) | 1993-10-16 |
| EP0301421A2 (de) | 1989-02-01 |
| FI883538L (fi) | 1989-01-29 |
| HUT47901A (en) | 1989-04-28 |
| IL87176A0 (en) | 1988-12-30 |
| EP0301421B1 (de) | 1991-08-28 |
| PT88095A (pt) | 1989-06-30 |
| DD285976A5 (de) | 1991-01-10 |
| PT88095B (pt) | 1995-03-01 |
| FI883538A0 (fi) | 1988-07-27 |
| EP0301421A3 (en) | 1989-05-10 |
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