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KR880011173A - Method for producing cephalosporin derivatives - Google Patents

Method for producing cephalosporin derivatives Download PDF

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Publication number
KR880011173A
KR880011173A KR870001884A KR870001884A KR880011173A KR 880011173 A KR880011173 A KR 880011173A KR 870001884 A KR870001884 A KR 870001884A KR 870001884 A KR870001884 A KR 870001884A KR 880011173 A KR880011173 A KR 880011173A
Authority
KR
South Korea
Prior art keywords
general formula
cephalosporin derivatives
producing cephalosporin
iii
organic base
Prior art date
Application number
KR870001884A
Other languages
Korean (ko)
Other versions
KR890002216B1 (en
Inventor
장문호
최경일
김성각
Original Assignee
이정오
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 이정오, 한국과학기술원 filed Critical 이정오
Priority to KR1019870001884A priority Critical patent/KR890002216B1/en
Publication of KR880011173A publication Critical patent/KR880011173A/en
Application granted granted Critical
Publication of KR890002216B1 publication Critical patent/KR890002216B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세팔로스포린 유도체의 제조방법Method for producing cephalosporin derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (2)

일반식(Ⅳ)의 세펨화합물을 실리화한 후 일반식(Ⅲ)의 카르복실산과 일반식(Ⅱ)의 포스페이트를 유기염기 존재하에 반응시켜 일반식(I)의 세팔로스포린 유도체를 제조하는 방법.A method of preparing a cephalosporin derivative of the general formula (I) by reacting a cephem compound of the general formula (III) with a phosphate of the general formula (II) in the presence of an organic base after silylating the cephem compound of the general formula (IV) . 일반식(I)에서 R1은 C1-4인 지방족 알킬기를 표시하며, 일반식(Ⅱ)에서 R2는 메틸, 에틸, 프로필 또는 페닐기를 표시한다, 그리고 일반식(Ⅲ)에서의 R1은 일반식(I)에서의 R1과 동일하다.In the general formula (I), R 1 represents an aliphatic alkyl group of C 1-4 , R 2 in the general formula (II) represents a methyl, ethyl, propyl or phenyl group, and R 1 in the general formula (III) Is the same as R 1 in the general formula (I). 제 1항에 있어서, 유기염기가 트리에틸아민, 피리딘, 디메틸아민, 이소프로필아민 또는 디메틸아미노 피리딘 중에서 선택됨을 특징으로 하는 일반식(I)이 세팔로스포린 유도체의 제조방법.The process according to claim 1, wherein the organic base is selected from triethylamine, pyridine, dimethylamine, isopropylamine or dimethylaminopyridine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019870001884A 1987-03-03 1987-03-03 Method for preparing cephalosporin derivative KR890002216B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870001884A KR890002216B1 (en) 1987-03-03 1987-03-03 Method for preparing cephalosporin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870001884A KR890002216B1 (en) 1987-03-03 1987-03-03 Method for preparing cephalosporin derivative

Publications (2)

Publication Number Publication Date
KR880011173A true KR880011173A (en) 1988-10-27
KR890002216B1 KR890002216B1 (en) 1989-06-23

Family

ID=19259819

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870001884A KR890002216B1 (en) 1987-03-03 1987-03-03 Method for preparing cephalosporin derivative

Country Status (1)

Country Link
KR (1) KR890002216B1 (en)

Also Published As

Publication number Publication date
KR890002216B1 (en) 1989-06-23

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