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KR880009006A - Method for preparing 1,2-dithiol-3-thione derivative - Google Patents

Method for preparing 1,2-dithiol-3-thione derivative Download PDF

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Publication number
KR880009006A
KR880009006A KR870009838A KR870009838A KR880009006A KR 880009006 A KR880009006 A KR 880009006A KR 870009838 A KR870009838 A KR 870009838A KR 870009838 A KR870009838 A KR 870009838A KR 880009006 A KR880009006 A KR 880009006A
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KR
South Korea
Prior art keywords
dithiol
thione
butadienyl
formula
derivative
Prior art date
Application number
KR870009838A
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Korean (ko)
Other versions
KR900000968B1 (en
Inventor
이타루 야마모도
아기라 마쯔바라
간지 도미야
오사무 미즈노
미쯔히로 사까구찌
미끼오 구마구라
Original Assignee
사와무라 하루오
미쯔이 도아쯔 가가꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of KR880009006A publication Critical patent/KR880009006A/en
Application granted granted Critical
Publication of KR900000968B1 publication Critical patent/KR900000968B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.No content.

Description

1,2-디티올-3-티온 유도체의 제조방법Method for preparing 1,2-dithiol-3-thione derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

하기식 (I)의 1,2-디티올-3-티온 유도체.1,2-dithiol-3-thione derivatives of the formula (I). 상기식에서 R은 수소, 할로겐, 저급알콕시, 저급알킬, 아미노, 저급-알킬치환된 아미노 또는 저급알콕시 카르보닐기.Wherein R is hydrogen, halogen, lower alkoxy, lower alkyl, amino, lower-alkyl substituted amino or lower alkoxy carbonyl group. 제1항에 있어서, 5-(4-페닐-1,3-부타디에닐)-1,2-디티올-3-티온, 5-{4-(4-클로로페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(4-메톡시페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(p-톨루일)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(O-클로로페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(m-메틸페닐)-1,3-부타디에닐}-1,2-디티올-3-티온인 유도체.The method of claim 1, wherein 5- (4-phenyl-1,3-butadienyl) -1,2-dithiol-3-thione, 5- {4- (4-chlorophenyl) -1,3-buta Dienyl} -1,2-dithiol-3-thione, 5- {4- (4-methoxyphenyl) -1,3-butadienyl} -1,2-dithiol-3-thione, 5- {4- (p-toluyl) -1,3-butadienyl} -1,2-dithiol-3-thione, 5- {4- (O-chlorophenyl) -1,3-butadienyl} Derivatives which are -1,2-dithiol-3-thione, 5- {4- (m-methylphenyl) -1,3-butadienyl} -1,2-dithiol-3-thione. 염기존재하의 유기용매내에서 하기식 (II)의 알데하이드 화합물을 5-메틸-1,2-디티올-3-티온 유도체와 축합하는 것으로 구성된 하기식 (I)의 1,2-디티올-3-티온 유도체의 제조방법.1,2-dithiol-3 of formula (I) consisting of condensing an aldehyde compound of formula (II) with a 5-methyl-1,2-dithiol-3-thione derivative in an organic solvent in the presence of a base -Method of preparing a thion derivative. 상기식에서 R은 수소, 할로겐, 저급알콕시, 저급알킬, 아미노, 저급알킬 치환된 아미노 또는 저급알콕시 카르보닐.Wherein R is hydrogen, halogen, lower alkoxy, lower alkyl, amino, lower alkyl substituted amino or lower alkoxy carbonyl. 청구범위 제1항의 식 (I)의 1,2-디티올-3-티온 유도체의 유효량과 약학적으로 허용가능한 담체로 구성된 면역조절 조성물.An immunomodulatory composition comprising an effective amount of a 1,2-dithiol-3-thione derivative of formula (I) of claim 1 and a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870009838A 1986-03-05 1987-09-04 1,2-dithiol-3-thione derivative composition and their preparation KR900000968B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP4631886 1986-03-05
JP?61-46318 1986-03-05
JP62-018295 1987-01-30
JP?62-18295 1987-01-30
JP62018295A JPS6310785A (en) 1986-03-05 1987-01-30 Novel 1,2-dithiol-3-thione derivative, production thereof and immunoregulating agent containing said compound as active ingredient

Publications (2)

Publication Number Publication Date
KR880009006A true KR880009006A (en) 1988-09-13
KR900000968B1 KR900000968B1 (en) 1990-02-23

Family

ID=12743812

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009838A KR900000968B1 (en) 1986-03-05 1987-09-04 1,2-dithiol-3-thione derivative composition and their preparation

Country Status (2)

Country Link
JP (1) JPS6310785A (en)
KR (1) KR900000968B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (en) * 2002-11-13 2005-04-20 씨제이 주식회사 Thione derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089611B2 (en) * 1988-06-20 1996-01-31 三井東圧化学株式会社 Novel 1,2-dithiole-3-thione derivative and immunomodulator containing the same as active ingredient
JPH0816059B2 (en) * 1993-05-21 1996-02-21 三井東圧化学株式会社 Immunomodulator

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (en) * 2002-11-13 2005-04-20 씨제이 주식회사 Thione derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
JPH0440356B2 (en) 1992-07-02
JPS6310785A (en) 1988-01-18
KR900000968B1 (en) 1990-02-23

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