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KR880007462A - 빈뇨치료용 프로피오페논 유도체 - Google Patents

빈뇨치료용 프로피오페논 유도체 Download PDF

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Publication number
KR880007462A
KR880007462A KR870014977A KR870014977A KR880007462A KR 880007462 A KR880007462 A KR 880007462A KR 870014977 A KR870014977 A KR 870014977A KR 870014977 A KR870014977 A KR 870014977A KR 880007462 A KR880007462 A KR 880007462A
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KR
South Korea
Prior art keywords
alkyl group
group
propiophenone
lower alkyl
pyrrolidinopropiophenone
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Application number
KR870014977A
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English (en)
Other versions
KR920006907B1 (ko
Inventor
야스오 이토
히데오 가토
에이이치 고시나카
고지 모리키와
도시에 야마우치
Original Assignee
이토 겐지
호쿠리쿠 세이야꾸 가부시키가이샤
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17984801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR880007462(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 이토 겐지, 호쿠리쿠 세이야꾸 가부시키가이샤 filed Critical 이토 겐지
Publication of KR880007462A publication Critical patent/KR880007462A/ko
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Publication of KR920006907B1 publication Critical patent/KR920006907B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

내용 없음.

Description

빈뇨치료용 프로피오페논 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)의 프로피오페논 유도체 및 그의 약리학적으로 허용되는 산부가염을 유효성분으로 하는 빈뇨치료제.
    식중, R1, R2및 R3은 동일 또는 상이하고, 각각 수소, 할로겐, 직쇄 또는 분지쇄의 탄소쇄를 가진 저급알킬기 또는 할로게노-저급 알킬기, 저급알콕시기 또는 탄소원자수 3-8개의 시클로알킬기이고, 또는 R1, R2및 R3중 두 개가 결합하여 형성하는 메틸렌디옥시 또는 에틸렌옥시이고, R4는 수소, 또는 직쇄나 분지쇄의 탄소쇄를 가진 저급알킬기이고, A는 피롤리디닐기, 피페리디닐기, 모르폴리닐기, 또는 아제피닐기이다.
  2. 제1항에 있어서, 프로피오페논은 약3-500㎎의 양이 함유되는 상기 빈뇨치료제.
  3. 제1항에 있어서, 프로피오페논은 약15-100㎎의 양이 경구 투여되는 상기 빈뇨치료제.
  4. 제1항에 있어서, 프로피오페논은 약리학적으로 허용되는 희석제 또는 담체와 결합하여 약리학적 조성물의 형태로 투여되는 상기 빈뇨치료제.
  5. 제4항에 있어서, 약리학적 조성물은 경구 투여용으로 적합하며, 경구 투여되는 상기 빈뇨치료제.
  6. 제1항에 있어서, 프로피오페논은 하기 화합물 및 그의 약리학적으로 허용되는 염에서 선택되는 상기 빈뇨치료제. 4′-n-부틸-2-메틸-3-피롤리디노프로피오페논, 4′-터트-부틸-2-메틸-3-피롤리디노프로피오페논, 및 4′-메톡시-2, 2′, 3′-트리메틸-3-피롤리디노프로피오페논.
  7. 하기 일반식(I)의 프로피오페논 유도체 및 그의 약리학적으로 허용되는 산부 가염에 의한 빈뇨질환의 치료방법.
    식중, R1, R2및 R3은 동일 또는 상이하고, 각각 수소, 할로겐, 직쇄 또는 분지쇄의 탄소쇄를 가진 저급 알킬기 또는 할로게노-저급 알킬기, 저급 알콕시기, 또는 탄소원자수 3-8개의 시클로알킬기이고, 또는 R1, R2및 R3중 두 개가 결합하여 형성하는 메틸렌디옥시 또는 에킬렌옥시이고, R4는 수소, 또는 직쇄나 분지쇄의 탄소쇄를 가진 저급알킬기이고, A는 피롤리디닐기, 피페리디닐기, 모르폴리닐기, 또는 아제피닐기이다.
  8. 식(Ⅰ)의 유효량의 화합물과 약리학적으로 허용되는 담체와 결합하여 이루어지는 배뇨장애 치료용 약리학적 조성물.
  9. 제8항에 있어서, 일반식(Ⅰ)의 프로피오페논은 하기 화합물 및 그의 약리학적으로 허용되는 염에서 선택되는 상기 조성물. 4′-에틸-2-메틸-3-피롤리디노프로피오페논, 4′-시클로헥실-2-메틸-3-피롤리디노프로피오페논, 4′-에틸-2-메틸-3-피페리디노프로피오페논, 및 2,4′-디메틸-3-피페리디노프로피오페논.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870014977A 1986-12-26 1987-12-26 빈뇨치료용 프로피오페논 유도체 Expired KR920006907B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61308747A JPH0637389B2 (ja) 1986-12-26 1986-12-26 頻尿治療剤
JP61-308747 1986-12-26
JP86-308747 1986-12-26

Publications (2)

Publication Number Publication Date
KR880007462A true KR880007462A (ko) 1988-08-27
KR920006907B1 KR920006907B1 (ko) 1992-08-22

Family

ID=17984801

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870014977A Expired KR920006907B1 (ko) 1986-12-26 1987-12-26 빈뇨치료용 프로피오페논 유도체

Country Status (10)

Country Link
US (1) US4912116A (ko)
EP (1) EP0273375B2 (ko)
JP (1) JPH0637389B2 (ko)
KR (1) KR920006907B1 (ko)
AT (1) ATE78685T1 (ko)
CA (1) CA1295251C (ko)
DE (1) DE3780787T2 (ko)
DK (1) DK685787A (ko)
HU (1) HU202752B (ko)
ZA (1) ZA879663B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1233715B (it) * 1989-07-14 1992-04-14 Menarini Farma Ind Uso in terapia della 10-ammino-5,6diidro-11h= dibenzo (b,e) azepina-6,11-dione e derivati, quali farmaci utili per il trattamento dell'incontinenza urinaria
DE69017794T2 (de) * 1989-08-04 1995-08-03 Mitsui Toatsu Chemicals Aminoketonderivate und ihre Verwendung.
US5338857A (en) * 1989-08-04 1994-08-16 Mitsui Toatsu Chemicals Incorporated Aminoketone derivatives of 1,2-oxazole and use thereof
AT409083B (de) * 1999-04-01 2002-05-27 Sanochemia Pharmazeutika Ag Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung
DE10341923A1 (de) * 2003-09-11 2005-04-07 Heinl, Alexander, Dr.med. Verwendung von Tolperison
AT500144A1 (de) * 2004-03-05 2005-11-15 Sanochemia Pharmazeutika Ag Tolperison enthaltende, pharmazeutische zubereitung mit steuerbarer wirkstofffreisetzung zur oralen verabreichung
WO2006112565A1 (en) * 2005-04-21 2006-10-26 Dreampharma Corp. Therapeutic drugs for pollakiuria and urinary incontinence containing optical active propiophenon and its salts
WO2008004127A2 (en) * 2006-04-20 2008-01-10 Sanochemia Pharmazeutika Ag Method for administering tolperisone
US8604031B2 (en) * 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
CN103450077B (zh) 2007-06-08 2016-07-06 满康德股份有限公司 IRE-1α抑制剂
WO2009038771A2 (en) * 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
JPS5933276A (ja) * 1982-08-20 1984-02-23 Hokuriku Seiyaku Co Ltd ３−ピロリジノ置換プロピオフエノン誘導体
HU33131A (ko) * 1984-01-26 1984-10-29

Also Published As

Publication number Publication date
EP0273375B2 (en) 1995-05-10
KR920006907B1 (ko) 1992-08-22
JPH0637389B2 (ja) 1994-05-18
EP0273375A3 (en) 1990-05-16
EP0273375B1 (en) 1992-07-29
DK685787D0 (da) 1987-12-23
ATE78685T1 (de) 1992-08-15
DK685787A (da) 1988-06-27
DE3780787D1 (de) 1992-09-03
CA1295251C (en) 1992-02-04
ZA879663B (en) 1988-06-23
HUT45400A (en) 1988-07-28
JPS63162621A (ja) 1988-07-06
US4912116A (en) 1990-03-27
HU202752B (en) 1991-04-29
DE3780787T2 (de) 1995-08-24
EP0273375A2 (en) 1988-07-06

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