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KR880002793A - 항 마이코플라즈마제 - Google Patents

항 마이코플라즈마제 Download PDF

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Publication number
KR880002793A
KR880002793A KR870009130A KR870009130A KR880002793A KR 880002793 A KR880002793 A KR 880002793A KR 870009130 A KR870009130 A KR 870009130A KR 870009130 A KR870009130 A KR 870009130A KR 880002793 A KR880002793 A KR 880002793A
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KR
South Korea
Prior art keywords
tropolone
oxo
agent according
methyl
salt
Prior art date
Application number
KR870009130A
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English (en)
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KR950006804B1 (ko
Inventor
에이지 곤도
요시유끼 하야시
다까오 고니시
데루오 하또리
주니찌 쇼오지
Original Assignee
요시또시 가즈오
시오노기 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 요시또시 가즈오, 시오노기 세이야꾸 가부시끼 가이샤 filed Critical 요시또시 가즈오
Publication of KR880002793A publication Critical patent/KR880002793A/ko
Application granted granted Critical
Publication of KR950006804B1 publication Critical patent/KR950006804B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/29—Saturated compounds containing keto groups bound to rings
    • C07C49/307—Saturated compounds containing keto groups bound to rings to a seven- to twelve-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

항 마이코플라즈마제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 활성 성분으로서 하기 일반식으로 나타내는, 하나 또는 그 이상의 화합물 및 그의 염으로 구성된 항마이코플라즈마제 ;
    [상기식중, R1은 히드록시, 지방족 아실옥시, 아릴아실옥시, 아리술포닐옥시, 카르복시알킬옥시, 또는 그의 에스테르, 벤조일알킬옥시, 알케닐옥시, 1,3-디히드로-3-옥소-1-이소벤조푸라닐옥시,(2-옥소-5-메틸-1,3-디옥솔-4-일)메틸 옥시 또는 티오시아나토이고, R2는 수소,할로겐, 히드록시, 알킬 또는 알콕시이다.]
  2. 제1항에 있어서, 상기의 염이 중 금속 착체인 항 마이코플라즈마제.
  3. 제2항에 있어서, 상기의 중 금속이 철, 구리 코발트 또는 니켈인 항 마이코플라즈마제.
  4. 제1항에 있어서, 상기의 염이 중 금속 염인 항 마이코 플라즈마제.
  5. 제4항에 있어서, 상기의 금속이 칼슘,마그네슘,아연 또는 나트륨인 항 마이코플라즈마제.
  6. 제1항에 있어서, 상기의 염이 유기염기의 염인 항 마이코플라즈마제.
  7. 제6항에 있어서, 상기의 유기염기가 에탄올아민,n-프로필아민,리진 또는 아르기닌인 항 마이코플라즈마제.
  8. 제 1항에 있어서, 상기의 화합물이 0-아세틸트로폴론, 0-벤조일트로폴론, 0-(P-톨루엔술포닐)트로폴론, 0-(1-카르복시에틸)트로폴론, 0-(3차-부틸옥시카르보닐메틸)트로폴론, 0-(3차-부틸카르보닐옥시메틸)트로폴론, 0-(1-에톡시카르보닐에틸)트로폴론, 0-(벤조일메틸)트로폴론, 0-알릴트로폴론, 0-(1,3-디히드로-3-옥소-1-이소벤조푸라닐)트로폴론, 7-브로모트로폴론, 0-{(2-옥소-5-메틸-1,3-디옥솥-4-일)메틸} 트로폴론, 7-메톡시트로폴론, 7-히드록시트로폴론, 7-메틸트로폴론 또는 2-티오시아나토트로폰인 항 마이코플라즈마제.
  9. 하기 일반식으로 나타내는 화합물 ;
    [상기식중, R1은 1-카르복시에틸옥시,3차-부틸옥시카르보닐 메틸옥시,1-에톡시카르보닐에틸옥시,1,3-디히드로-3-옥소-1-이소벤조푸라닐옥시 또는(2-옥소-5-메틸-1,3-디옥솥-4-일)메틸옥시이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870009130A 1986-08-21 1987-08-20 항마이코플라즈마제 KR950006804B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19653586 1986-08-21
JP196535/1986 1986-08-21
JP196535 1986-08-21

Publications (2)

Publication Number Publication Date
KR880002793A true KR880002793A (ko) 1988-05-11
KR950006804B1 KR950006804B1 (ko) 1995-06-22

Family

ID=16359355

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009130A KR950006804B1 (ko) 1986-08-21 1987-08-20 항마이코플라즈마제

Country Status (7)

Country Link
US (1) US4950686A (ko)
EP (1) EP0267378B1 (ko)
JP (1) JP2552870B2 (ko)
KR (1) KR950006804B1 (ko)
AT (1) ATE81969T1 (ko)
DE (1) DE3782484T2 (ko)
PH (1) PH24191A (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689342B1 (en) * 2002-07-29 2004-02-10 Warner-Lambert Company Oral care compositions comprising tropolone compounds and essential oils and methods of using the same
US6787675B2 (en) * 2002-07-29 2004-09-07 Warner-Lambert Company Substituted tropolone compounds, oral care compositions containing the same and methods of using the same
ES2393114T3 (es) * 2005-06-17 2012-12-18 Symrise Ag Mezclas sinérgicas de alcoholes aromáticos y derivados de los mismos con tropolona
JP2010105961A (ja) * 2008-10-30 2010-05-13 Asahi Kasei E-Materials Corp トロポロン誘導体のエーテル類の製造方法
EP2864311A4 (en) * 2012-06-22 2015-12-02 Univ Connecticut SUBSTITUTED TROPOLON DERIVATIVES AND METHODS OF USE
US20180169083A1 (en) 2015-06-11 2018-06-21 Saint Louis University Inhibitors of nucleotidyl transferases and use in herpes and hepatitis viral infections therefor
EP3307256B1 (en) 2015-06-11 2023-06-07 Saint Louis University Hydroxylated tropolone inhibitors of nucleotidyl transferases in herpesvirus and hepatitis b
US20200147086A1 (en) * 2017-05-17 2020-05-14 Saint Louis University Inhibitors of nucleotidyltransferase superfamily enzymes as antibiotics
EP3773900A4 (en) * 2018-04-13 2022-03-30 The Board of Trustees of the University of Illinois HINOKITIOL ANALOGUES, PROCESSES FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
CN109776357A (zh) * 2018-08-29 2019-05-21 湖北工业大学 一种含环庚三烯酚酮小分子抑制剂及在抑制鸟氨酸脱羧酶（odc）上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3448155A (en) * 1965-04-05 1969-06-03 Ppg Industries Inc Process for the hydrolysis of 7,7-dihalobicyclo - (3.2.0) - 2 - heptene - 6 - ones to tropolones
US4569944A (en) * 1984-06-21 1986-02-11 Warner-Lambert Company Dibenzosuberone as a non-steroidal anti-inflammatory compound and compositions thereof

Also Published As

Publication number Publication date
ATE81969T1 (de) 1992-11-15
KR950006804B1 (ko) 1995-06-22
PH24191A (en) 1990-03-22
JP2552870B2 (ja) 1996-11-13
US4950686A (en) 1990-08-21
DE3782484T2 (de) 1993-03-18
DE3782484D1 (de) 1992-12-10
JPS63159343A (ja) 1988-07-02
EP0267378A3 (en) 1990-04-25
EP0267378B1 (en) 1992-11-04
EP0267378A2 (en) 1988-05-18

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