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KR880001615A - 5,6-치환-2,4-퀴나졸인디아민 및 신규의 중간 생성물을 제조하는 향상된 방법 - Google Patents

5,6-치환-2,4-퀴나졸인디아민 및 신규의 중간 생성물을 제조하는 향상된 방법 Download PDF

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Publication number
KR880001615A
KR880001615A KR1019870007685A KR870007685A KR880001615A KR 880001615 A KR880001615 A KR 880001615A KR 1019870007685 A KR1019870007685 A KR 1019870007685A KR 870007685 A KR870007685 A KR 870007685A KR 880001615 A KR880001615 A KR 880001615A
Authority
KR
South Korea
Prior art keywords
methyl
amino
quinazoleindiamine
substituted
improved methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1019870007685A
Other languages
English (en)
Inventor
미라 버만 엘렌
제임스 수토 마크
Original Assignee
크리스틴 에이.트라우트웨인
워너-람버트 컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 크리스틴 에이.트라우트웨인, 워너-람버트 컴퍼니 filed Critical 크리스틴 에이.트라우트웨인
Publication of KR880001615A publication Critical patent/KR880001615A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

5,6-치환-2,4-퀴나졸인디아민 및 신규의 중간 생성물을 제조하는 향상된 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 구조식 화합물
    을 150℃ 및 250℃사이의 온도에서 클로로포름아미딘 하이드로클로라이드와 반응시키고, 다음에 통상적인 방법으로 생성물을 분리하여 정제하는 것으로 구성되는, 다음 구조식 화합물의 제조방법.
    식중, R1은 C1-3의 알킬,
    R2는 브롬, 염소 또는 시아노
  2. 제 1항에 있어서, 상기반응이 에틸렌 글로콜 디메틸 에테르, 비스-에틸렌 글리콜 디메틸 에테르, 디메틸 설폭사이드, 및 디메텔설폰으로 부터 선택된 고온에서 비등하는 불활성 용매에서 실행되는 방법.
  3. 제 2항에 있어서, 상기 고온에서 비등하는 불활성 용매가 디메틸설폰인 방법.
  4. 2-메틸-4-니트로-1,3-벤조디니트릴.
  5. 4-아미노-2-메틸-1,3-벤조디니트릴.
  6. 6-아미노-3-브로모-2-메틸-벤조니트릴.
  7. 6-아미노-3-클로로-2-메틸-벤조니트릴.
  8. 6-아미노-5-메틸-2,4-퀴나졸인디아민.
  9. 6-클로로-5-메틸-2,4-퀴나졸인다아민.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870007685A 1986-07-17 1987-07-16 5,6-치환-2,4-퀴나졸인디아민 및 신규의 중간 생성물을 제조하는 향상된 방법 Abandoned KR880001615A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/886,463 US4677219A (en) 1986-07-17 1986-07-17 Substituted benzonitriles
US886463 1986-07-17

Publications (1)

Publication Number Publication Date
KR880001615A true KR880001615A (ko) 1988-04-25

Family

ID=25389079

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870007685A Abandoned KR880001615A (ko) 1986-07-17 1987-07-16 5,6-치환-2,4-퀴나졸인디아민 및 신규의 중간 생성물을 제조하는 향상된 방법

Country Status (16)

Country Link
US (1) US4677219A (ko)
EP (1) EP0253396B1 (ko)
JP (1) JPS6330474A (ko)
KR (1) KR880001615A (ko)
AT (1) ATE86984T1 (ko)
AU (1) AU591305B2 (ko)
CA (1) CA1282078C (ko)
DE (1) DE3784795T2 (ko)
DK (1) DK368587A (ko)
ES (1) ES2053478T3 (ko)
FI (1) FI873125L (ko)
NO (1) NO872971L (ko)
NZ (1) NZ221020A (ko)
PH (1) PH23781A (ko)
PT (1) PT85345B (ko)
ZA (1) ZA874651B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818753A (en) * 1987-09-18 1989-04-04 Sri International Synthesis and method of use for 2, 4 diaminoquinazoline
US4886936A (en) * 1988-08-15 1989-12-12 Ici Americas Inc. Process for the production of ortho-nitrobenzonitriles
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
US5716960A (en) * 1995-01-13 1998-02-10 U.S. Bioscience Inc. And Individuals Crystalline trimetrexate salts and the process for making the same
US6017922A (en) 1998-05-18 2000-01-25 U.S. Bioscience, Inc. Thermally stable trimetrexates and processes for producing the same
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1345502A (en) * 1916-11-23 1920-07-06 John G Livingston Switch or receptacle box
GB1345502A (en) * 1972-07-06 1974-01-30 Parke Davis & Co Quinazoline compounds and processes for their production
US4900859A (en) * 1987-12-03 1990-02-13 Hoffman-La Roche Inc. Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde

Also Published As

Publication number Publication date
DE3784795T2 (de) 1993-06-24
NO872971D0 (no) 1987-07-16
FI873125A0 (fi) 1987-07-15
EP0253396B1 (en) 1993-03-17
AU591305B2 (en) 1989-11-30
ES2053478T3 (es) 1994-08-01
NZ221020A (en) 1990-06-26
PH23781A (en) 1989-11-03
NO872971L (no) 1988-01-18
ZA874651B (en) 1989-02-22
EP0253396A3 (en) 1989-04-19
DK368587D0 (da) 1987-07-15
US4677219A (en) 1987-06-30
FI873125L (fi) 1988-01-18
EP0253396A2 (en) 1988-01-20
AU7501287A (en) 1988-01-21
DK368587A (da) 1988-01-18
CA1282078C (en) 1991-03-26
PT85345B (pt) 1990-04-30
ATE86984T1 (de) 1993-04-15
PT85345A (en) 1987-08-01
DE3784795D1 (de) 1993-04-22
JPS6330474A (ja) 1988-02-09

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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19870716

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Patent event code: PA02012R01D

Patent event date: 19920711

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Patent event date: 19950524

Patent event code: PE09021S01D

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