KR880001428B1 - 치환된 3-아미노-시드논-이민의 제조방법 - Google Patents
치환된 3-아미노-시드논-이민의 제조방법 Download PDFInfo
- Publication number
- KR880001428B1 KR880001428B1 KR8200898A KR820000898A KR880001428B1 KR 880001428 B1 KR880001428 B1 KR 880001428B1 KR 8200898 A KR8200898 A KR 8200898A KR 820000898 A KR820000898 A KR 820000898A KR 880001428 B1 KR880001428 B1 KR 880001428B1
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- formula
- compound
- radicals
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyrane Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Epoxy Compounds (AREA)
- Seasonings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims (10)
- 일반식(Ⅱ)의 화합물을 폐환시킴을 특징으로 하여 일반식(Ⅰ)의 치환된 3-아미노-시드논이민 및 그의 약리학적 허용되는 산부가염을 제조하는 방법.상기식에서 R1은 라디칼이고, R2는 수소 또는 라디칼 - COR4이며, R3은 메틸, 에틸, 프로필 또는 이소프로필이고, R4는 탄소수 1 내지 3의 알콕시로 치환된 수도 있는 탄소수 1내지 4의 지방족 라디칼을 나타내거나, 탄소수 5 내지 7의 사이클로지방족 라디칼, 탄소수 7 내지 14의 비사이크롤지방족 라디칼, 탄소수 7 내지 16의 트리사이클로지방족 라디칼, 탄소수 1 내지 6의 알콕시라디칼, 탄소수 6 내지 12의 아릴옥시 라디칼, 총 탄소수 2 내지 7의 알콕시카보닐 라디칼, 또느,ㄴ 탄소수 6 내지 12의 아릴라디칼을 나타내거나, 또는 할로겐 원자 1개 내지 3개 및/또는 탄소수 1 내지 3의 알킬 라디칼 1개 내지 3개 및/또는 탄소수 1 내지 3의 알콕시 라디칼 1개 내지 3개 및/또는 니트로 그룹 1개 또는 2개로 일치환, 이치환 또는 심치환되는 탄소수 6내지 12의 라디칼을 나타낸다.
- 제1항에 있어서, 폐환반응을 용매 또는 분산제중 0내지 40℃의 온도에서, 수용액의 pH치를 3이하로 조정하는 폐환제의 보조하에 수행함을 특징으로 하는 방법.
- 제1항에 있어서, R3가메틸 또는 에틸이고,R4는 탄소수 1 내지 4의 알킬, 메톡시메틸, 탄소수 5 내지 7의 사이클로알킬, 2,6,6-트리메틸-비사이클로 [3.1.1]헵틸, 트리사이클로[3.3.1.13,7]데실, 메톡시, 에톡시, 페녹시, 에톡시카보닐, 페닐, 메틸페닐, 니트로페닐, 또는 클로로페닐인 일반식(Ⅰ)의 화합물이 제조됨을 특징으로 하는 방법.
- 제1항에 있어서, R1이 N-메틸-N-(테트라하이드로-3-티에닐-s,s-디옥사이드)-아미노 그룹임을 특징으로 하는 방법.
- 제1항에 있어서, R2가 수소, 또는 그룹 -COR4이고 R4는 메틸, 에틸, 사이클로헥실, 페닐, 4-클로로페닐 또는 4-니트로페닐임을 특징으로 하는 방법.
- 제1또는 2항에 있어서, 생성된 일반식(Ⅰ)의 화합물이 3-(N-메틸-N-(테트라하이드로-3-티에닐-S,S-디옥사이드)-아미노)-시드논-이민 또는 그의 산부가염임을 특징으로 하는 방법.
- 제1항에 있어서, 생성된 일반식(Ⅰ)의 화합물이 3-(N-메틸-N-(테트라하이드로-3-티에닐-S,S-디옥사이드)-아미노)-N6-니트로벤조일-시드논-이민 또는 그의 산부가염임을 특징으로 하는 방법.
- 제9항에 있어서, 생성된 유리화합물을 그의 상응하는 산부가염을 전환시킴을 특징으로 하는 방법.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019880007345A KR880001429B1 (ko) | 1981-03-02 | 1988-06-17 | 치환된 3-아미노-시드논-이민의 제조방법 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3107933.4 | 1981-03-02 | ||
DE19813107933 DE3107933A1 (de) | 1981-03-02 | 1981-03-02 | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3107933 | 1981-03-02 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880007345A Division KR880001429B1 (ko) | 1981-03-02 | 1988-06-17 | 치환된 3-아미노-시드논-이민의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830009062A KR830009062A (ko) | 1983-12-17 |
KR880001428B1 true KR880001428B1 (ko) | 1988-08-08 |
Family
ID=6126174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8200898A Expired KR880001428B1 (ko) | 1981-03-02 | 1982-03-02 | 치환된 3-아미노-시드논-이민의 제조방법 |
Country Status (23)
Country | Link |
---|---|
US (2) | US4436743A (ko) |
EP (1) | EP0059356B1 (ko) |
JP (1) | JPS57158768A (ko) |
KR (1) | KR880001428B1 (ko) |
AT (1) | ATE13055T1 (ko) |
AU (1) | AU545292B2 (ko) |
CA (1) | CA1192905A (ko) |
CS (1) | CS224645B2 (ko) |
DD (1) | DD208617A5 (ko) |
DE (2) | DE3107933A1 (ko) |
DK (1) | DK149852C (ko) |
ES (1) | ES8303404A1 (ko) |
FI (1) | FI820518A7 (ko) |
HU (1) | HU190683B (ko) |
IL (1) | IL65141A (ko) |
NO (1) | NO820476L (ko) |
NZ (1) | NZ199862A (ko) |
PH (1) | PH18696A (ko) |
PL (1) | PL136818B1 (ko) |
PT (1) | PT74507B (ko) |
RO (1) | RO84816B (ko) |
SU (1) | SU1097197A3 (ko) |
ZA (1) | ZA821327B (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なn−アシルシドノンイミン誘導体およびその製法 |
US4517179A (en) * | 1983-04-29 | 1985-05-14 | Pennwalt Corporation | Rapid dissolving, uniform drug compositions and their preparation |
DK243084A (da) * | 1983-05-26 | 1984-11-27 | Takeda Chemical Industries Ltd | Perkutane farmaceutiske praeparater til udvortes brug |
DE3526068A1 (de) * | 1985-07-20 | 1987-01-22 | Cassella Ag | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische praeparate |
DE3702083A1 (de) * | 1987-01-24 | 1988-08-04 | Cassella Ag | Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3732174A1 (de) * | 1987-09-24 | 1989-04-06 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
US5221680A (en) * | 1988-01-14 | 1993-06-22 | Cassella Aktiengesellschaft | Substituted 3-aminosydnonimines |
FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
US5120732A (en) * | 1988-06-14 | 1992-06-09 | Cassella Aktiengesellschaft | Substituted 3-aminosyndone imines, a process for their preparation and their use |
DE4025604A1 (de) * | 1990-08-13 | 1992-02-20 | Cassella Ag | 3-dicyclohexylamino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE4028679A1 (de) * | 1990-09-10 | 1992-03-19 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE4031373A1 (de) * | 1990-10-04 | 1992-04-09 | Cassella Ag | 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
WO1997017334A1 (fr) * | 1995-11-06 | 1997-05-15 | Chugai Seiyaku Kabushiki Kaisha | Derives d'imine de sydnone |
FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6531158B1 (en) | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1695897C3 (de) | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US3833580A (en) | 1966-08-09 | 1974-09-03 | Boehringer Sohn Ingelheim | 3-morpholino-n6-cyclohexylcarbonyl sydnonimine |
BE788052A (fr) * | 1971-08-26 | 1973-02-26 | Science Union & Cie Societe Fr | Nouveaux derives de la sydnone imine |
US3833589A (en) * | 1972-07-31 | 1974-09-03 | Sandoz Ag | Substituted sydnonimine nitrate esters |
DE2930736A1 (de) * | 1979-07-28 | 1981-02-12 | Cassella Ag | Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
JPS5832870A (ja) * | 1981-08-24 | 1983-02-25 | Hiroyoshi Hidaka | 新規なシドノンイミン誘導体及びその製法 |
JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なn−アシルシドノンイミン誘導体およびその製法 |
-
1981
- 1981-03-02 DE DE19813107933 patent/DE3107933A1/de not_active Withdrawn
-
1982
- 1982-02-15 DE DE8282101091T patent/DE3263342D1/de not_active Expired
- 1982-02-15 AT AT82101091T patent/ATE13055T1/de not_active IP Right Cessation
- 1982-02-15 EP EP82101091A patent/EP0059356B1/de not_active Expired
- 1982-02-16 FI FI820518A patent/FI820518A7/fi not_active Application Discontinuation
- 1982-02-16 DK DK67682A patent/DK149852C/da not_active IP Right Cessation
- 1982-02-16 NO NO820476A patent/NO820476L/no unknown
- 1982-02-19 US US06/350,366 patent/US4436743A/en not_active Expired - Fee Related
- 1982-02-26 DD DD82237741A patent/DD208617A5/de unknown
- 1982-02-26 RO RO106750A patent/RO84816B/ro unknown
- 1982-02-26 CA CA000397186A patent/CA1192905A/en not_active Expired
- 1982-03-01 IL IL65141A patent/IL65141A/xx unknown
- 1982-03-01 SU SU823398796A patent/SU1097197A3/ru active
- 1982-03-01 HU HU82616A patent/HU190683B/hu unknown
- 1982-03-01 NZ NZ199862A patent/NZ199862A/en unknown
- 1982-03-01 PT PT74507A patent/PT74507B/pt unknown
- 1982-03-01 JP JP57030669A patent/JPS57158768A/ja active Pending
- 1982-03-01 ZA ZA821327A patent/ZA821327B/xx unknown
- 1982-03-01 ES ES510015A patent/ES8303404A1/es not_active Expired
- 1982-03-01 AU AU80966/82A patent/AU545292B2/en not_active Ceased
- 1982-03-01 PL PL1982235274A patent/PL136818B1/pl unknown
- 1982-03-01 PH PH26931A patent/PH18696A/en unknown
- 1982-03-02 CS CS821412A patent/CS224645B2/cs unknown
- 1982-03-02 KR KR8200898A patent/KR880001428B1/ko not_active Expired
-
1983
- 1983-05-06 US US06/477,146 patent/US4551454A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI820518L (fi) | 1982-09-03 |
EP0059356A1 (de) | 1982-09-08 |
NZ199862A (en) | 1985-04-30 |
RO84816B (ro) | 1984-09-30 |
CA1192905A (en) | 1985-09-03 |
SU1097197A3 (ru) | 1984-06-07 |
JPS57158768A (en) | 1982-09-30 |
DD208617A5 (de) | 1984-04-04 |
CS224645B2 (en) | 1984-01-16 |
AU545292B2 (en) | 1985-07-11 |
PL136818B1 (en) | 1986-03-31 |
PT74507B (de) | 1983-11-08 |
FI820518A7 (fi) | 1982-09-03 |
PH18696A (en) | 1985-09-05 |
US4551454A (en) | 1985-11-05 |
ES510015A0 (es) | 1983-02-01 |
RO84816A (ro) | 1984-08-17 |
US4436743A (en) | 1984-03-13 |
DE3107933A1 (de) | 1982-09-16 |
ZA821327B (en) | 1983-01-26 |
NO820476L (no) | 1982-09-03 |
HU190683B (en) | 1986-10-28 |
KR830009062A (ko) | 1983-12-17 |
DE3263342D1 (en) | 1985-06-05 |
IL65141A (en) | 1984-10-31 |
DK67682A (da) | 1982-09-03 |
IL65141A0 (en) | 1982-05-31 |
AU8096682A (en) | 1982-09-16 |
PT74507A (de) | 1982-04-01 |
PL235274A1 (ko) | 1982-10-25 |
ATE13055T1 (de) | 1985-05-15 |
EP0059356B1 (de) | 1985-05-02 |
ES8303404A1 (es) | 1983-02-01 |
DK149852B (da) | 1986-10-13 |
DK149852C (da) | 1987-06-01 |
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