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KR870006084A - N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법 - Google Patents

N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법 Download PDF

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Publication number
KR870006084A
KR870006084A KR860011117A KR860011117A KR870006084A KR 870006084 A KR870006084 A KR 870006084A KR 860011117 A KR860011117 A KR 860011117A KR 860011117 A KR860011117 A KR 860011117A KR 870006084 A KR870006084 A KR 870006084A
Authority
KR
South Korea
Prior art keywords
formyl
methyl ester
phenylalanine methyl
aspartyl
preparing
Prior art date
Application number
KR860011117A
Other languages
English (en)
Other versions
KR930004054B1 (ko
Inventor
도시히데 유가와
하루오 가와사끼
마사오 나까무라
다까시 야마시따
도시아끼 쯔찌
Original Assignee
우다다 가쯔히로
아지노모도 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우다다 가쯔히로, 아지노모도 가부시끼가이샤 filed Critical 우다다 가쯔히로
Publication of KR870006084A publication Critical patent/KR870006084A/ko
Application granted granted Critical
Publication of KR930004054B1 publication Critical patent/KR930004054B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 실시예 사용하기 위한 반응기의 한 예이다.

Claims (3)

  1. N-포르밀-L-아스파트산무수물과 L-페닐알라닌 메틸 에스테르와의 반응을 아세트산 또는 아세트산과 포름산의 존재하에 반응용매 중에서 완전혼합형 연속반응 방식으로 수행함을 특징으로 하여 N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸에스테르를 제조하는 방법.
  2. 제1항에 있어서, 반응용매가 톨루엔 또는 에틸 아세테이트인 방법.
  3. 제1항에 있어서, 존재하는 아세트산 또는 아세트산과 포름산의 양이 반응용매를 기준하여 10 내지 150중량%인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860011117A 1985-12-24 1986-12-23 N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법 KR930004054B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP291180 1985-12-24
JP291180/1985 1985-12-24
JP60291180A JPH0680075B2 (ja) 1985-12-24 1985-12-24 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法

Publications (2)

Publication Number Publication Date
KR870006084A true KR870006084A (ko) 1987-07-09
KR930004054B1 KR930004054B1 (ko) 1993-05-19

Family

ID=17765492

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860011117A KR930004054B1 (ko) 1985-12-24 1986-12-23 N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법

Country Status (6)

Country Link
US (1) US4820861A (ko)
EP (1) EP0227301B1 (ko)
JP (1) JPH0680075B2 (ko)
KR (1) KR930004054B1 (ko)
CA (1) CA1302648C (ko)
IE (1) IE59388B1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH085912B2 (ja) * 1986-09-04 1996-01-24 味の素株式会社 Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
BR9007646A (pt) * 1988-02-12 1992-09-15 Nutrasweet Co Processo em recipiente unico de preparacao de hidrocloreto de -apm,processo de copulacao de anidrido n-formil-l-aspartico com l-fenilalanina e processo de preparacao de isomeros de / -n-formil-l-aspartil-l-fenilalanina
US5053532A (en) * 1988-02-12 1991-10-01 The Nutra Sweet Company One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
EP0471833B1 (en) * 1990-03-12 1995-06-14 The Nutrasweet Company Method for increasing the alpha to beta ratio in an aspartame coupling reaction
JP2910228B2 (ja) * 1990-11-20 1999-06-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩の製法
JP3144430B2 (ja) * 1991-08-27 2001-03-12 味の素株式会社 有機溶媒の分離方法
JPH05178889A (ja) * 1991-10-30 1993-07-20 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析方法
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
NL1013404C2 (nl) * 1999-10-27 2001-05-01 Dsm Nv Werkwijze voor de bereiding van een dipeptide en tussenproduct in een dergelijke werkwijze.
AU2019415174B2 (en) * 2018-12-25 2022-08-11 Tokyo Institute Of Technology Method for producing amide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833553A (en) * 1970-01-31 1974-09-03 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters
US3901871A (en) * 1973-09-21 1975-08-26 American Cyanamid Co Process of preparing ' -l-aspartyl-l-phenylalanine methyl ester
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS51113841A (en) * 1975-03-28 1976-10-07 Ajinomoto Co Inc Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
IE810577L (en) * 1983-05-31 1982-09-16 Prendergast Angela Apparatus for fermentation
US4440677A (en) * 1983-06-20 1984-04-03 G. D. Searle & Co. Method and intermediates for producing α-L-aspartyl-L-phenylalanine

Also Published As

Publication number Publication date
EP0227301A3 (en) 1989-04-26
EP0227301B1 (en) 1992-05-13
IE59388B1 (en) 1994-02-23
JPS62149699A (ja) 1987-07-03
JPH0680075B2 (ja) 1994-10-12
IE863082L (en) 1987-06-24
CA1302648C (en) 1992-06-02
KR930004054B1 (ko) 1993-05-19
EP0227301A2 (en) 1987-07-01
US4820861A (en) 1989-04-11

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