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KR850004484A - N6-(1-및 2-벤조싸이클로알킬)아데노신의 제법 - Google Patents

N6-(1-및 2-벤조싸이클로알킬)아데노신의 제법 Download PDF

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Publication number
KR850004484A
KR850004484A KR1019840007662A KR840007662A KR850004484A KR 850004484 A KR850004484 A KR 850004484A KR 1019840007662 A KR1019840007662 A KR 1019840007662A KR 840007662 A KR840007662 A KR 840007662A KR 850004484 A KR850004484 A KR 850004484A
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South Korea
Prior art keywords
hydrogen
lower alkyl
hydroxy
alkoxy
phenyl
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KR1019840007662A
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English (en)
Inventor
트리베디 배렛
Original Assignee
에드워드 에프. 엘스라져
워너 램버트 컴페니
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Publication of KR850004484A publication Critical patent/KR850004484A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

N6―(1―및 2―벤조싸이클로알킬)아데노신의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 불활성 또는 중성용매내에서 다음 일반식(2)의 6―할로푸린리보사이드를 다음 일반식(3a) 또는 (3b)의 인다닐 아민과 25―150℃에서 1―48시간동안 반응시켜 다음 일반식(1)의 화합물을 제조하는 방법.
    식중,
    R1은
    n은 0 또는 1; X는 수소, 저급알킬, 말단부가 하이드록시, 알콕시, 카복실로 치환된 저급알킬, OR(R은 수소, 저급알킬, 저급알카노일이나 벤조일), 페닐 또는 수소, 하이드록시, 저급알콕시, 아미노, 트리플루오로메틸로 치환된 페닐; Y는 수소, 저급알킬, 말단부가 하이드록시, 저급알콕시 또는 카복실로 치환된 저급알킬, OR(R은 수소 또는 저급알킬)또는 저급알카노일이나 벤조일; Z 및 Z′는 각각 수소, 할로겐, 질소, 트리플루오로메틸, 아미노, 저급알킬, 하이드록시 또는 저급알콕시; R3는 수소 또는 저급알킬; R1는 수소 아세틸 또는 벤조일; R2는 수소, 할로겐, NR′,R2′(R1′및 R2′는 각각 수소, 저급알킬, 페닐 또는 할로겐, 하이드록시, 저급알콕시, 아미노, 트리플루오로메틸로 치환 페닐) 또는 SR(R은 수소 또는 저급알킬); Hal은 염소 또는 브롬.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007662A 1983-12-05 1984-12-05 N6-(1-및 2-벤조싸이클로알킬)아데노신의 제법 KR850004484A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/558,144 US4501735A (en) 1983-12-05 1983-12-05 N6-(1- and 2-benzocycloalkyl) adenosines
US558144 1990-07-25

Publications (1)

Publication Number Publication Date
KR850004484A true KR850004484A (ko) 1985-07-15

Family

ID=24228400

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007662A KR850004484A (ko) 1983-12-05 1984-12-05 N6-(1-및 2-벤조싸이클로알킬)아데노신의 제법

Country Status (18)

Country Link
US (1) US4501735A (ko)
EP (1) EP0144235A3 (ko)
JP (1) JPS60136592A (ko)
KR (1) KR850004484A (ko)
AU (1) AU562690B2 (ko)
CA (1) CA1230595A (ko)
DK (1) DK573484A (ko)
ES (1) ES538238A0 (ko)
FI (1) FI77667C (ko)
GR (1) GR81144B (ko)
HU (1) HUT36482A (ko)
IL (1) IL73700A (ko)
NO (1) NO159384C (ko)
NZ (1) NZ210428A (ko)
OA (1) OA07883A (ko)
PH (1) PH21367A (ko)
PT (1) PT79613B (ko)
ZA (1) ZA849337B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1239397A (en) * 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
US4683223A (en) * 1985-09-09 1987-07-28 Warner-Lambert Company N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
AU577743B2 (en) * 1984-10-26 1988-09-29 Warner-Lambert Company N6-benzopyrano and benzothiopyrano adenosines
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
US4833273A (en) * 1986-02-03 1989-05-23 Warner-Lambert Company Process for the resolution of 1-aminoindanes
DE3782427T2 (de) * 1986-10-06 1996-07-18 Univ Virginia Verwendung einer adenosin, hypoxanthin und ribose enthaltender lösung zur schonung des herzens während chirurgischer eingriffe.
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
FI880405A (fi) * 1987-02-04 1988-08-05 Ciba Geigy Ag Adenosin-5'-karboxamidderivat.
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US4837207A (en) * 1987-05-13 1989-06-06 Warner-Lambert Company Diastereoisomers of n6 -endo-bicyclo[2.2.1]heptyladenosine as antihypertensives with selective action
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
EP0550631B1 (en) * 1990-09-25 1997-01-02 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
ES2219033T3 (es) 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
JP2015172077A (ja) * 2015-06-24 2015-10-01 中国医学科学院葯物研究所 Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670175A1 (de) * 1966-12-21 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Derivaten
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
JPS4826038B1 (ko) * 1970-09-25 1973-08-03
DE2059922A1 (de) * 1970-12-05 1972-06-15 Boehringer Mannheim Gmbh Neue N(6)-Aralkyl-adenosin-Derivate und Verfahren zur Herstellung derselben
DE2136624A1 (de) * 1971-07-22 1973-02-08 Boehringer Mannheim Gmbh N (6)-substituierte adenosin-derivate und verfahren zur herstellung derselben
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
US4090021A (en) * 1971-10-08 1978-05-16 Schering Aktiengesellschaft Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
US3922261A (en) * 1972-06-21 1975-11-25 Merck Patent Gmbh Adenosine derivative
JPS5046689A (ko) * 1972-07-24 1975-04-25
DE2249397A1 (de) * 1972-10-09 1974-05-02 Merck Patent Gmbh Adenosinester und -aether
DE2406587A1 (de) * 1974-02-12 1975-08-21 Klinge Co Chem Pharm Fab Hypolipaemisch wirksame adenosinderivate
DE3019322A1 (de) * 1980-05-21 1981-12-03 Merck Patent Gmbh, 6100 Darmstadt Psychopharmakon sowie verwendung von adenosinderivaten
US4388308A (en) * 1980-06-09 1983-06-14 G.D. Searle & Co. N6 -[(2-Hydroxypropyl)aryl]adenosines
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten

Also Published As

Publication number Publication date
DK573484A (da) 1985-06-06
NO844830L (no) 1985-06-06
EP0144235A2 (en) 1985-06-12
AU3621684A (en) 1985-06-13
NO159384C (no) 1988-12-21
FI77667B (fi) 1988-12-30
EP0144235A3 (en) 1986-07-30
OA07883A (en) 1986-11-20
AU562690B2 (en) 1987-06-18
IL73700A (en) 1988-09-30
FI844750L (fi) 1985-06-06
ES8602033A1 (es) 1985-11-01
JPS60136592A (ja) 1985-07-20
NZ210428A (en) 1989-05-29
FI77667C (fi) 1989-04-10
PH21367A (en) 1987-10-15
PT79613B (en) 1986-12-12
HUT36482A (en) 1985-09-30
PT79613A (en) 1985-01-01
ZA849337B (en) 1986-07-30
FI844750A0 (fi) 1984-12-03
DK573484D0 (da) 1984-12-03
ES538238A0 (es) 1985-11-01
CA1230595A (en) 1987-12-22
IL73700A0 (en) 1985-02-28
GR81144B (en) 1985-04-04
US4501735A (en) 1985-02-26
NO159384B (no) 1988-09-12

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