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KR850004482A - 인돌-3-카르복사미드 유도체의 제조방법 - Google Patents

인돌-3-카르복사미드 유도체의 제조방법 Download PDF

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KR850004482A
KR850004482A KR1019840007753A KR840007753A KR850004482A KR 850004482 A KR850004482 A KR 850004482A KR 1019840007753 A KR1019840007753 A KR 1019840007753A KR 840007753 A KR840007753 A KR 840007753A KR 850004482 A KR850004482 A KR 850004482A
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KR910006863B1 (ko
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데쓰야 다하라
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하기하라 후미오
요시또미 세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S47/00—Plant husbandry
    • Y10S47/01—Methods of plant-breeding and including chromosome multiplication

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

인돌-3-카르복사미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (1) 다음식(Ⅱ)의 화합물 또는 그의 작용 유도체와 다음 식(Ⅱ)의 화합물을 반응시키고; (2) 다음식(Ⅳ)의 화합물을 브롬화 수소산으로 처리하고; (3) 다음식 (Ⅴ)의 화합물을 촉매 수소화시키고; (4) 다음식(Ⅵ)의 화합물을 다음식(Ⅶ)의 화합물과 반응시키고; (5) 다음식(Ⅶ)의 화합물과 알킬화제를 반응시키고; 및 (6) 바람직하다면, 얻어진 화합물을 그의 제약에 수용할 수 있는 산부가염으로 전환함을 특징으로 하는 다음식(Ⅰ)의 인돌-3-카르복사미드유도체, 제약에 수용할 수 있는 산부가염 및/또는 그의 수화물의 제조방법.
    상기식에서, R1은 수소원자, C1-4알킬기, 벤젠 고리 위에 할로겐원자로 임의로 치환될 수 있는 페닐기 또는 벤젠고리 위에 할로겐원자로 임의로 치환될 수 있는 페닐-C14알킬기이고; R2는 수소원자 또는 C1-4알킬기이고, C1-4알킬기, C1-7시클로알킬기, 알릴기 또는 벤젠고리 위에 할로겐원자 또는 α-탄소 위에 메틸기로 임의로 치환될 수 있는 벤질기이고;R5는 수소원자 또는 C1-4알킬기이고;m은 0 또는 1이고;n은 1내지 3의 정수이다.
    상기식에서 각 기호는 상기에 정의한 바와같다.
    상기식에서, R4가 수소원자인 경우를 제외하고 각 기호는 상기에 정의한 바와같다.
    상기식에서,는 메틸기 또는 벤질기이고, 다른 기호들은 상기에 정의한 바와같다.
    상기식에서 각 기호는 상기에 정의한 바와같다.
    상기식에서 각 기호는 상기에 정의한 바와같다.
    상기식에서는 수소원자를 제외하고 상기의 정의와 같고, X는 반응성 원자 또는 기이다.
    상기식에서 각 기호는 상기에 정의한 바와같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007753A 1983-12-08 1984-12-07 인돌-3-카르복사미드 유도체의 제조방법 Expired KR910006863B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP232514 1983-12-08
JP232514/83 1983-12-08
JP58232514A JPS60123485A (ja) 1983-12-08 1983-12-08 インド−ル−３−カルボキサミド誘導体

Publications (2)

Publication Number Publication Date
KR850004482A true KR850004482A (ko) 1985-07-15
KR910006863B1 KR910006863B1 (ko) 1991-09-09

Family

ID=16940520

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007753A Expired KR910006863B1 (ko) 1983-12-08 1984-12-07 인돌-3-카르복사미드 유도체의 제조방법

Country Status (8)

Country Link
US (1) US4616009A (ko)
EP (1) EP0144986B1 (ko)
JP (1) JPS60123485A (ko)
KR (1) KR910006863B1 (ko)
AT (1) ATE25682T1 (ko)
CA (1) CA1279319C (ko)
DE (1) DE3462504D1 (ko)
ES (1) ES8604571A1 (ko)

Families Citing this family (25)

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GB8814277D0 (en) * 1988-06-16 1988-07-20 Glaxo Group Ltd Chemical compounds
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
JPH0255357U (ko) * 1988-10-07 1990-04-20
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
JPH03206584A (ja) * 1990-01-09 1991-09-09 Nec Home Electron Ltd Ｉｃカードのロック機構
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
JP3037108U (ja) * 1996-10-22 1997-05-06 カシオ計算機株式会社 電子機器におけるロック機構
EP1433782A4 (en) * 2001-09-10 2005-04-27 Mercian Corp PROCESS FOR PREPARING A PIPECOLAMID DERIVATIVE
WO2005005378A2 (en) * 2003-07-02 2005-01-20 Sugen, Inc. Indolinone hydrazides as c-met inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US20070219206A1 (en) * 2005-11-04 2007-09-20 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
CN101331117B (zh) * 2005-11-04 2012-09-05 阿米拉制药公司 5-脂氧合酶活化蛋白（flap）抑制剂
US20070244128A1 (en) * 2005-11-04 2007-10-18 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
EP2285803A4 (en) * 2008-05-23 2011-10-05 Amira Pharmaceuticals Inc Inhibitor of 5-Lipoxygenase Activating Protein
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
RS59473B1 (sr) 2015-09-10 2019-12-31 Suven Life Sciences Ltd Fluoroindol derivati kao pozitivni alosterički modulatori muskarinskog m1 receptora

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1173148A (fr) * 1956-03-19 1959-02-20 Rhone Poulenc Sa Nouveaux dérivés de l'indole et leur préparation
US3136770A (en) * 1960-04-01 1964-06-09 Neisler Lab Inc Indolyl substituted piperidines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
GB1273563A (en) * 1968-07-24 1972-05-10 Wyeth John & Brother Ltd Indoles
GB1345872A (en) * 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
GB1543619A (en) * 1976-03-12 1979-04-04 Wyeth John & Brother Ltd Process for preparing 3-(heterocycloalkyl)-indole derivatives

Also Published As

Publication number Publication date
EP0144986B1 (en) 1987-03-04
EP0144986A3 (en) 1985-07-24
JPS60123485A (ja) 1985-07-02
US4616009A (en) 1986-10-07
CA1279319C (en) 1991-01-22
ES538418A0 (es) 1986-02-01
ATE25682T1 (de) 1987-03-15
EP0144986A2 (en) 1985-06-19
DE3462504D1 (de) 1987-04-09
ES8604571A1 (es) 1986-02-01
KR910006863B1 (ko) 1991-09-09
JPS6348272B2 (ko) 1988-09-28

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