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KR850002459A - 디히드록시벤즈아미드 유도체 및 그 제조방법 - Google Patents

디히드록시벤즈아미드 유도체 및 그 제조방법 Download PDF

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Publication number
KR850002459A
KR850002459A KR1019840005572A KR840005572A KR850002459A KR 850002459 A KR850002459 A KR 850002459A KR 1019840005572 A KR1019840005572 A KR 1019840005572A KR 840005572 A KR840005572 A KR 840005572A KR 850002459 A KR850002459 A KR 850002459A
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South Korea
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alkyl group
carbon atoms
group
following general
general formula
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KR1019840005572A
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KR870000545B1 (ko
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히또시(외 9) 다끼따
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스가노 요리쓰구
구레하 가가꾸 고오교오 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

디히드록시벤즈아미드 유도체 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 내지 제5도는 각각 본 발명의 중요한 7화합물의 적외선 흡수 스펙트럼도이다.

Claims (2)

  1. 연화 디아세톡시벤조일을 다음 일반식(Ⅲ)의 일급 또는 이급 아민화합물과 반응시키고, 그 얻어진 디아세틸 유도체를 가수분해하는 것으로 되어 있는것을 특징으로 하는 다음 일반식(Ⅰ)로 표시되는 디히드록시벤즈아미드의 유도체를 제조하는 방법
    상기식에서,
    (1)R1는 수소원자 또는 저급알킬기이고, R2는 탄소원자수 4내지 12의 직쇄알킬기, 탄소원자수 4내지 12의 측쇄알킬기, 탄소원자수 4내지 12의 환상알킬기,(n은 1내지 6의 정수), 또는 치환되거나 되지않은 피리딜기이거나; 또는 (2)R1및 R2는 환형성하여 식 --Y X는 질소원자 또는 메틴이고, Y는 수소원자, 탄소원자수 1내지 6의 알킬기 또는 페닐기로 표시되는 아미노기를 포함하는 복소환을 만든다.
  2. 제1항에 있어서, 디히드록시벤조산을 아세틸화하고 디아세톡시벤조산을 염소화시켜 상기 염화 디아세톡시 벤조일을 제조하는 것을 특징으로 하는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840005572A 1983-09-13 1984-09-13 디히드록시벤즈아미드 유도체의 제조방법 Expired KR870000545B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58168936A JPS6058954A (ja) 1983-09-13 1983-09-13 ジヒドロキシベンズアミド誘導体
JP58-168936 1983-09-13
JP???58-168936 1983-09-13

Publications (2)

Publication Number Publication Date
KR850002459A true KR850002459A (ko) 1985-05-13
KR870000545B1 KR870000545B1 (ko) 1987-03-18

Family

ID=15877283

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005572A Expired KR870000545B1 (ko) 1983-09-13 1984-09-13 디히드록시벤즈아미드 유도체의 제조방법

Country Status (6)

Country Link
US (1) US4725598A (ko)
EP (1) EP0142241B1 (ko)
JP (1) JPS6058954A (ko)
KR (1) KR870000545B1 (ko)
CA (1) CA1244432A (ko)
DE (1) DE3467894D1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140020A (en) * 1983-09-13 1992-08-18 Kureha Kagatu Kogyo Kabushiki Kaisha Derivative of dihydroxybenzamide and a pharmaceutical composition thereof
US4758591A (en) * 1983-12-26 1988-07-19 Kureha Kagaku Kogyo Kabushiki Kaisha Dialkanoyloxybenzylidene dialkanoate
DE3633501A1 (de) * 1986-10-02 1988-04-14 Henkel Kgaa Verwendung von salycilsaeureamiden als antimikrobielle wirkstoffe
DE3822449A1 (de) * 1988-07-02 1990-01-04 Henkel Kgaa Oxidationshaarfaerbemittel mit neuen kupplern
IT1258140B (it) * 1992-09-03 1996-02-20 Gd Spa Dispositivo ottico per il controllo del riempimento di sigarette
DE4436127A1 (de) * 1994-09-27 1996-03-28 Deutsches Rheumaforschungszent Verwendung von aromatischen Amiden und Säuren zur Behandlung von rheumatischen Erkrankungen
JP4189043B2 (ja) * 1996-09-30 2008-12-03 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
RU2130922C1 (ru) * 1996-11-13 1999-05-27 Московская государственная академия тонкой химической технологии им.М.В.Ломоносова Арилалифатические аминоамиды бензойной (замещенной бензойной), циклогексан- и 1-адамантанкарбоновых кислот, обладающие антиаритмической, местноанестезирующей и анальгетической активностью
WO1998047861A1 (en) * 1997-04-24 1998-10-29 Bristol-Myers Squibb Company Retinoid-like compounds
KR100740575B1 (ko) 2006-03-31 2007-07-18 (주)아모레퍼시픽 2,3-디히드록시벤조산 유도체 화합물과 그 제조방법 및이를 함유하는 미백 화장료 조성물
KR101277162B1 (ko) 2007-03-30 2013-06-19 (주)아모레퍼시픽 슬리밍용 화장료 조성물
DE102007035642A1 (de) * 2007-07-30 2009-02-12 Grietje Beck Substanzen zur Protektion von Zellen und Geweben gegen Schädigung durch ungünstige Bedingungen
JP7013375B2 (ja) * 2015-09-04 2022-01-31 シンプン・ファーマシューティカル・カンパニー・リミテッド 血小板凝集阻害効果を有する化合物及びその塩、並びにそれを含む血栓性疾患予防又は治療用組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848335A (en) * 1954-03-25 1958-08-19 Eastman Kodak Co Stabilization of normally oxidizable materials with hydroxybenzamide compounds
US2849480A (en) * 1956-10-05 1958-08-26 Kreuchunas Algird Process for the preparation of 2, 3, 6-trihydroxybenzoic acid and derivatives
AT224644B (de) * 1959-01-23 1962-12-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von neuen Benzoesäure-Derivaten
DE1141986B (de) * 1959-08-12 1963-01-03 Dresden Arzneimittel Verfahren zur Herstellung von tranquillosedativ wirksamen 3, 4, 5-Trimethoxybenzoesaeureamiden
US3873621A (en) * 1972-05-22 1975-03-25 Univ Minnesota Method for preparing amines
US4263322A (en) * 1979-03-01 1981-04-21 Riet Bartholomeus Van T Hydroxy benzohydroxamic acids and benzamides
US4394389A (en) * 1979-03-01 1983-07-19 Riet Bartholomeus Van T Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors
JPS57140754A (en) * 1981-02-24 1982-08-31 Kureha Chem Ind Co Ltd Dihydroxybenzoic acid derivative and physiologically active preparation containing the same
US4448730A (en) * 1981-03-24 1984-05-15 Riet Bartholomeus Van T Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors
JPS6129467A (ja) * 1984-07-20 1986-02-10 Tokico Ltd 磁気デイスク装置

Also Published As

Publication number Publication date
EP0142241B1 (en) 1987-12-02
CA1244432A (en) 1988-11-08
JPH0368854B2 (ko) 1991-10-30
JPS6058954A (ja) 1985-04-05
KR870000545B1 (ko) 1987-03-18
US4725598A (en) 1988-02-16
DE3467894D1 (en) 1988-01-14
EP0142241A1 (en) 1985-05-22

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