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KR840009115A - 세펨 화합물의 제조방법 - Google Patents

세펨 화합물의 제조방법 Download PDF

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Publication number
KR840009115A
KR840009115A KR1019840002446A KR840002446A KR840009115A KR 840009115 A KR840009115 A KR 840009115A KR 1019840002446 A KR1019840002446 A KR 1019840002446A KR 840002446 A KR840002446 A KR 840002446A KR 840009115 A KR840009115 A KR 840009115A
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South Korea
Prior art keywords
optionally substituted
group
alkyl
substituted
mono
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KR1019840002446A
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English (en)
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KR910004331B1 (ko
Inventor
키르스테테르(외 3) 라이너
Original Assignee
하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
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Application filed by 하인리히 벡커, 베른하르트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR840009115A publication Critical patent/KR840009115A/ko
Application granted granted Critical
Publication of KR910004331B1 publication Critical patent/KR910004331B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Soil Working Implements (AREA)
  • Saccharide Compounds (AREA)
  • Eye Examination Apparatus (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Cosmetics (AREA)
  • Tea And Coffee (AREA)

Abstract

내용 없음

Description

세펨 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 일반(Ⅱ)의 화합물 또는 이들의 염을 트리-C1-C4알킬 요오드실란 존재하에 일반식(Ⅰ)의 라디칼 A에 상응하는 염기와 반응시키고,
    a) 존재하는 보호그룹을 제거시키고,
    b) 만일 필요하면, 생성물을 생리학적으로 허용되는 산부가염으로 전환시킴을 특징으로 하여 다음 일반식의 세펨화합물 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
    상기식에서
    R은 티아졸릴 라디칼또는 1,2,4-
    티아디아졸릴 라디칼이며
    여기에서 R3는 수소 또는 할로겐이고 B는 임의로 치환된 아미노그룹이고,
    R1은 수소 또는 메톡시이고,
    R2는 수소, 임의로 치환된 C1-C6-알킬, 임으로 치환된 C2-C6알케닐, C2-C6알키닐, C3-C7시클로알킬, C3-C7시클로알킬-C1-C6알킬, C4-C7시클로알케닐 또는그룹이며, 여기에서 m 및 n은 각기 0 또는 1이고, R4및 R5는 같거나 또는 다르며, 수소, 아릴 또는 C1-C4알킬 그룹이거나 또는 이들이 결합된 탄소와 함께 메틸렌 또는 C3-C7시클로 알킬이덴 그룹을 형성하며, 이때 C1-C4알킬 및 C3-C7시킬로알킬이덴 그룹은 또한 더 일치환 또는 다치환 될수 있으며, R6은 COOH, CN 또는 CONH2그룹이며, 이때 CONH2그룹은 질소상에서 일치환 또는 이치환될 수 있고,
    A는 퀴놀리늄또는 이소퀴놀 리늄라디칼(이들 각각은 또한 임의로 치환된 C1-C6알킬, C1-C6알콕시, 할로겐, 트리플루오로메틸 및 하이드록실로 이루어진 그룹중의 같거나 또는 다른 치환체로 일치환 또는 다치환될 수 있다)또는 펜안트리디늄 라디칼 또는 피리디늄라디칼(이때 이 라디칼은 오르토 위치의 2알칼그룹이 결합되어 한개의 환상 탄소원자가 헤테로원자로 치환될 수 있고 또한 하나 또는 두개의 이중결합을 지닐 수 있는 임의로 치환된 디-내지 데카-메틸렌환을 형성할 수 있는 임의로 치환된 C1-C6알킬;임의로 치환된 C2-C|6알케닐, C2-C6알키닐, C3-C7-시클로알킬 및 C3-C7, C4-C7시클로 알킬메틸(이때 나중의 두 치환체중의 환은 또한 치환될 수 있다), C1-C6시클로알케닐, 임의로 치환된 C2-C|6알콕시, C2-C6알케닐옥시 및 C2-C6알키닐옥시, 할로겐, 트리플루오로메틸 및 하이드록실, 임의로 치환된 페닐, 벤질 및 헤테로아릴, 포르밀 및 케탈화된 포르밀, 또한 케탈화된 형태로 존재할수도 있는 임의로 치환된 C1-C6알킬 카보닐, 아릴카보닐 및 카바모일로 이루어진 그룹중의 같거나 또는 다른 치환체로 일치환 또는 다치환 될 수 있다)이고;
    R2O그룹은 신-위치에 있으며 R7은 일반식(Ⅰ)의 라디칼 A에 상응하는 염기로 치환될 수 있는 그룹이다.
  2. 제1항에 있어서, 트리 C1-C4알킬요오도 실란이 트리메틸-또는 트리에틸-요오도실란인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002446A 1983-05-07 1984-05-04 세펨화합물의 제조방법 KR910004331B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3316797.4 1983-05-07
DE19833316797 DE3316797A1 (de) 1983-05-07 1983-05-07 Verfahren zur herstellung von cephemverbindungen

Publications (2)

Publication Number Publication Date
KR840009115A true KR840009115A (ko) 1984-12-24
KR910004331B1 KR910004331B1 (ko) 1991-06-26

Family

ID=6198461

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002446A KR910004331B1 (ko) 1983-05-07 1984-05-04 세펨화합물의 제조방법

Country Status (27)

Country Link
US (1) US4692516A (ko)
EP (1) EP0125576B1 (ko)
JP (1) JPH0723379B2 (ko)
KR (1) KR910004331B1 (ko)
AT (1) ATE42296T1 (ko)
AU (1) AU575826B2 (ko)
CA (1) CA1224458A (ko)
CS (1) CS247080B2 (ko)
DD (1) DD219195A5 (ko)
DE (2) DE3316797A1 (ko)
DK (1) DK165836C (ko)
ES (1) ES8502120A1 (ko)
FI (1) FI82056C (ko)
GR (1) GR81610B (ko)
HU (1) HU192984B (ko)
IE (1) IE57355B1 (ko)
IL (1) IL71772A (ko)
MA (1) MA20109A1 (ko)
MT (1) MTP948B (ko)
MX (1) MX7281A (ko)
NO (1) NO841793L (ko)
NZ (1) NZ208065A (ko)
OA (1) OA07767A (ko)
PH (1) PH20953A (ko)
PT (1) PT78545B (ko)
YU (1) YU45966B (ko)
ZA (1) ZA843339B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74822A (en) * 1984-04-17 1989-06-30 Daiichi Seiyaku Co Cephalosporin derivatives and salts thereof and their preparation
KR930007260B1 (ko) * 1984-11-23 1993-08-04 바이오케미 게젤샤프트 엠. 비. 에취 세팔로스포린 유도체의 제조방법
GB8504072D0 (en) * 1985-02-18 1985-03-20 Fujisawa Pharmaceutical Co Cephem compounds
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim
DE3775798D1 (de) * 1986-03-19 1992-02-20 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
DE4440141A1 (de) * 1994-11-10 1996-05-15 Hoechst Ag Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
US6303705B1 (en) 1998-05-08 2001-10-16 Sumitomo Special Metals Co., Ltd. Method for using rubber product or rubber member
TW200305422A (en) * 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
ES2348299T3 (es) 2003-04-16 2010-12-02 Sandoz Ag Procedimientos para la preparación de cefepime.
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
WO2006008749A1 (en) 2004-07-16 2006-01-26 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
CN103601738A (zh) * 2013-12-04 2014-02-26 哈药集团制药总厂 一种头孢匹罗氢碘酸盐的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4266049A (en) * 1980-02-20 1981-05-05 Eli Lilly And Company Process for 3-iodomethyl cephalosporins
US4367228A (en) * 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
EP0070706B1 (en) * 1981-07-17 1987-12-23 Glaxo Group Limited Cephalosporin compounds
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
ZA826538B (en) * 1981-09-08 1984-04-25 Lilly Co Eli Thieno and furopyridinium-substituted cephalosporin derivatives
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics

Also Published As

Publication number Publication date
PH20953A (en) 1987-06-10
IL71772A (en) 1988-11-30
EP0125576A3 (en) 1985-10-16
DE3477784D1 (en) 1989-05-24
AU2770684A (en) 1984-11-08
GR81610B (ko) 1984-12-11
FI82056C (fi) 1991-01-10
IL71772A0 (en) 1984-09-30
DK224384A (da) 1984-11-08
MA20109A1 (fr) 1984-12-31
MX7281A (es) 1993-11-01
DK165836C (da) 1993-06-21
CS247080B2 (en) 1986-11-13
YU76784A (en) 1986-12-31
EP0125576A2 (de) 1984-11-21
OA07767A (fr) 1985-08-30
EP0125576B1 (de) 1989-04-19
PT78545B (pt) 1986-07-17
IE57355B1 (en) 1992-08-12
CA1224458A (en) 1987-07-21
HU192984B (en) 1987-08-28
IE841109L (en) 1984-11-07
NZ208065A (en) 1986-10-08
HUT34507A (en) 1985-03-28
YU45966B (sh) 1992-12-21
DD219195A5 (de) 1985-02-27
FI841765A0 (fi) 1984-05-03
AU575826B2 (en) 1988-08-11
DE3316797A1 (de) 1984-11-08
US4692516A (en) 1987-09-08
JPH0723379B2 (ja) 1995-03-15
FI82056B (fi) 1990-09-28
ES532176A0 (es) 1984-12-16
ATE42296T1 (de) 1989-05-15
DK165836B (da) 1993-01-25
JPS6034973A (ja) 1985-02-22
ES8502120A1 (es) 1984-12-16
NO841793L (no) 1984-11-08
ZA843339B (en) 1984-12-24
KR910004331B1 (ko) 1991-06-26
PT78545A (pt) 1984-06-01
MTP948B (en) 1985-01-23
DK224384D0 (da) 1984-05-04
FI841765A (fi) 1984-11-08

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