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KR840006633A - 벤족사졸리논 유도체의 제조방법 - Google Patents

벤족사졸리논 유도체의 제조방법 Download PDF

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Publication number
KR840006633A
KR840006633A KR1019830005578A KR830005578A KR840006633A KR 840006633 A KR840006633 A KR 840006633A KR 1019830005578 A KR1019830005578 A KR 1019830005578A KR 830005578 A KR830005578 A KR 830005578A KR 840006633 A KR840006633 A KR 840006633A
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KR
South Korea
Prior art keywords
hydrogen
radical
piperazinyl
compound
nitrogen atom
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KR1019830005578A
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KR910000416B1 (ko
Inventor
엉리 깨냐르 다니엘 (외 3)
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리옹 라보라 또 와레-세르 에스·아
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음

Description

벤족사졸리논 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 아민 HNR1R2을 6-(2-할로게노에틸)-벤족사졸리논과 반응시킴을 특징으로 하는 하기 일반식(I)의 화합물 또는 약학적으로 알맞은 이것의 염의 제조방법.
    상기 식중,
    R은 수소 또는 저급 알킬 라디칼 또는 메틸라디칼이고,
    R1및 R2는 각각 수소, 저급알킬, 시클로알킬 또는 벤질이거나 또는 여기에 결합된 질소원자와 함께 복소환 라디칼을 나타내거나, 여기에 결합된 질소원자와 함께 몰폴리노, 4-(피페리딘-2-일)-피페라지닐 및 4-페질피페라지닐 라디칼,할로겐, 저급알콕시 내지 트리플루오로메틸로 선택적으로 치환된 페닐라디칼이거나, 여기에 결합된 질소원자와 함께 4-(2-메톡시페닐)-피페라지닐, 4-(3-트리플루오로페닐)피페라지닐 또는 4-(4-플루오로페닐)-피페라지닐 라디칼이거나, R1은 수소이고, R2는 메틸, 이소프로필 또는 시클로프로필 라디칼이거나, R1및 R2모두 수소임.
  2. 제1항에 있어서, 할로겐 유도체가 6-(2-브로모에틸)-벤족사졸리논에 사용됨을 특징으로 하는 제제방법.
  3. 제1항에 있어서, 헥사메틸렌 테트라민이 6-(2-할로끼노에틸)-벤족사졸리논과 반응함을 특징으로 하는 R1및 R2가 수소인 화합물의 제조방법.
  4. 제1항에 있어서, 디벤질아민이 6-(2-할로게노에틸)-벤졸사졸리논과 반응하고 환원됨을 특징으로 하는 R1및 R2가 수소인 화합물(I)의 제조방법.
  5. 제1항의 화합물중 어느 하나를 활성 주성분으로 하고 알맞은 부형제를 함께 함유하는 제약조성물.
  6. R1및 R2가 수소인 화합물(I)을 활성 주성분으로 하고 통상의 제약학적 담체와 혼합되어 심기능 부전에 사용되는 제약조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005578A 1982-11-25 1983-11-25 벤족사졸리논 유도체의 제조방법 Expired KR910000416B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR19812 1982-11-25
FR8219812A FR2536749A1 (fr) 1982-11-25 1982-11-25 (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique
FR8219821 1982-11-25

Publications (2)

Publication Number Publication Date
KR840006633A true KR840006633A (ko) 1984-12-01
KR910000416B1 KR910000416B1 (ko) 1991-01-25

Family

ID=9279533

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005578A Expired KR910000416B1 (ko) 1982-11-25 1983-11-25 벤족사졸리논 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4558060A (ko)
EP (1) EP0110781B1 (ko)
JP (1) JPS59112976A (ko)
KR (1) KR910000416B1 (ko)
AT (1) ATE26270T1 (ko)
AU (1) AU562113B2 (ko)
CA (1) CA1208220A (ko)
DE (1) DE3370624D1 (ko)
DK (1) DK539983A (ko)
ES (1) ES527521A0 (ko)
FI (1) FI78079C (ko)
FR (1) FR2536749A1 (ko)
GR (1) GR81294B (ko)
HU (1) HU190635B (ko)
IE (1) IE56285B1 (ko)
PT (1) PT77735B (ko)
ZA (1) ZA838684B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
FR2637286A1 (fr) * 1988-10-04 1990-04-06 Adir Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5182278A (en) * 1989-02-28 1993-01-26 Adir Et Compagnie Analgesic benzoxazolinones having at the 6-position a 1-hydroxy-3-morpholinopropyl side chain
FR2643634A1 (fr) * 1989-02-28 1990-08-31 Adir Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2667068B1 (fr) * 1990-09-26 1994-09-09 Adir Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5268381A (en) * 1990-09-26 1993-12-07 Adir Et Compagnie Aminoalkyl-benzothiazolinone and -benzoxazolinone compounds having a high 5-HT1A affinity
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
FR2674524B1 (fr) * 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
FR2717810B1 (fr) * 1994-03-22 1996-04-26 Adir Nouvelles aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP0957080B1 (en) * 1997-08-07 2006-06-21 Fujimoto Brothers Co., Ltd. Novel ethylamine derivatives
US7213005B2 (en) * 1999-12-09 2007-05-01 International Business Machines Corporation Digital content distribution using web broadcasting services
US7794761B2 (en) * 2000-04-13 2010-09-14 Seroctin Research & Technology, Inc. Methods for inducing anti-anxiety and calming effects in animals and humans
US20040192669A1 (en) 2000-04-13 2004-09-30 Rosenfeld Mark J. Novel compounds for use in weight loss and appetite suppression in humans
US7524877B2 (en) 2003-11-20 2009-04-28 Seroctin Research & Technology, Inc. Compounds for use in weight loss and appetite suppression in humans
WO2005054235A1 (en) * 2003-11-28 2005-06-16 Wockhardt Limited Process for the preparing ziprasidone monohydrochloride hydrate
KR100812310B1 (ko) * 2005-12-27 2008-03-10 주식회사이에스이 위치제어용 얼라인 장치
RU2714893C2 (ru) 2014-12-05 2020-02-20 Земмельвайс Юнивёрсити Арилалкиламиновые соединения для применения для профилактики или лечения рака

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034100A (en) * 1976-02-13 1977-07-05 Merck & Co., Inc. Antihypertensive agents
FR2491066A1 (fr) * 1980-09-29 1982-04-02 Cerm Cent Europ Rech Mauvernay Benzoxazolinones substituees en 6 par une chaine aminoalcool ou aminocetone, leur preparation et leur application en therapeutique
FR2491471A1 (fr) * 1980-10-03 1982-04-09 Cerm Cent Europ Rech Mauvernay Benzoxazolinones substituees, leur preparation et leur application en therapeutique
JPS57123103A (en) * 1981-01-26 1982-07-31 Hokko Chem Ind Co Ltd Agricultural and horticultural fungicide
JPS61231548A (ja) * 1985-04-05 1986-10-15 Konishiroku Photo Ind Co Ltd 写真廃液の処理方法及び写真自動現像機

Also Published As

Publication number Publication date
CA1208220A (en) 1986-07-22
AU2161283A (en) 1984-05-31
JPS59112976A (ja) 1984-06-29
ES8501233A1 (es) 1984-12-01
PT77735B (fr) 1986-03-27
GR81294B (ko) 1984-12-11
FR2536749B1 (ko) 1985-04-26
FI834315A0 (fi) 1983-11-24
ZA838684B (en) 1984-07-25
ATE26270T1 (de) 1987-04-15
DE3370624D1 (en) 1987-05-07
KR910000416B1 (ko) 1991-01-25
FI834315L (fi) 1984-05-26
FR2536749A1 (fr) 1984-06-01
US4558060A (en) 1985-12-10
FI78079C (fi) 1989-06-12
PT77735A (fr) 1983-12-01
HU190635B (en) 1986-09-29
EP0110781A1 (fr) 1984-06-13
DK539983D0 (da) 1983-11-25
IE832756L (en) 1984-05-25
ES527521A0 (es) 1984-12-01
DK539983A (da) 1984-05-26
FI78079B (fi) 1989-02-28
IE56285B1 (en) 1991-06-05
EP0110781B1 (fr) 1987-04-01
AU562113B2 (en) 1987-05-28

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