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KR840001167A - 티아졸리딘알킬렌 피페라진 유도체의 제조방법 - Google Patents

티아졸리딘알킬렌 피페라진 유도체의 제조방법 Download PDF

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Publication number
KR840001167A
KR840001167A KR1019820003482A KR820003482A KR840001167A KR 840001167 A KR840001167 A KR 840001167A KR 1019820003482 A KR1019820003482 A KR 1019820003482A KR 820003482 A KR820003482 A KR 820003482A KR 840001167 A KR840001167 A KR 840001167A
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South Korea
Prior art keywords
pyrimidinyl
pharmaceutically useful
thiazolidinedione
piperazinyl
butyl
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KR1019820003482A
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English (en)
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KR880001478B1 (ko
Inventor
엘. 팅플. 쥬니어(외 1) 데이비스
Original Assignee
원본미기재
브리스톨 마이어즈 컴페니
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Publication of KR840001167A publication Critical patent/KR840001167A/ko
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Publication of KR880001478B1 publication Critical patent/KR880001478B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

내용 없음

Description

티아졸리딘알킬렌 피페라진 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 구조식(Ⅱ)의 티아졸리디온과 하기 구조식(Ⅲ)의 피페라진을, 충분한 시간동안 약 50℃ 내지 200℃의 온도에서 염기 존재하에 또는 않이, 불활성 반응매체에서 반응시키는, 하기 구조식(Ⅰ)의 화합물의 제조방법.
    R1은 저급알킬 또는 수소, n은 2내지 5의 정수, Z는인 R2치환된 페닐라디칼, R2는 수소, 할로겐, 저급알킬, 저급알콕시 또는 트리플루오로메틸, n은 3,4 또는 5Z는 2-피리미디닐 또는인 R3치환된 2-피리미디닐라디칼, R3은 수소, 시아노 또는 그로 인한 약학적인 수용성 비독성상 부가염, A는 독자적으로 수소, 알칼리 금속염 또는 X-(CH2)n-라디칼인데, X는 반응성 에스테르기의 산 잔여기 n은 2내지 5의 정수, 및/또한 만일 필요하다면 구조식(Ⅰ)의 생성된 화합물은 유리화합물 또는 그외의 염으로 전환될 수 있는 염으로 전환된다.
  2. 제1항에 있어서, 충분한 시간동안 불활성 용매의 환류 상태에서 염기의 존재하에 3-(4-브로모부틸-2,4-티아졸리딘디온과 1-(2-피리미디닐)피페라진을 반응시 켜 3-[4-[4-(2-피리미디닐)-1-피페라지닐]-부틸]-2,4-티아졸리딘디온의 유리된 염기를 생성한후, 상기 유리된 염기를 약학적으로 유용한 산과 약학적으로 유용한 산부가염으로 전환시키는 것으로 이루어진 3-[4-[4-(2-피리미디닐)-1-피페라지닐]-부틸]-2,4-티아졸리딘디온과 그의 약학적으로 유용한 산부가염의 제조방법.
  3. 제1항에 있어서, 충분한 시간동안 불활성용매의 환류상태에서, 염기의 존재하에 3-(4-브로모부틸)-2,4-티아졸리딘 디온과 1-(3｜트리플루오로메틸페닐)-피페라진을 반응시켜 3-[4-[4-[3-(트리플루오로메틸)-페닐]-1-피페라지닐]-부틸]-2,4-티아졸리딘의 유리염기를 생성한뒤 상기 유리된 염기를 약학적으로 유용한산과 약학적으로 유용한 산부가염으로 전환시키는 것으로 이루어진 3-[4-[4-[3-(트리플루오로메틸)-페닐]-1-피페라지닐]-부틸]-2,40티아졸리딘디온과 그의 학적으로 유용한 산부가염의 제조방법.
  4. 실시예 1,2,3과 4-14에 서술된 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8203482A 1981-08-03 1982-08-03 티아졸리디닐 알킬렌 피페라진 유도체의 제조방법 KR880001478B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US289352 1981-08-03
US06/289,352 US4367335A (en) 1981-08-03 1981-08-03 Thiazolidinylalkylene piperazine derivatives
US289.352 1981-08-03

Publications (2)

Publication Number Publication Date
KR840001167A true KR840001167A (ko) 1984-03-28
KR880001478B1 KR880001478B1 (ko) 1988-08-13

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KR8203482A KR880001478B1 (ko) 1981-08-03 1982-08-03 티아졸리디닐 알킬렌 피페라진 유도체의 제조방법

Country Status (28)

Country Link
US (1) US4367335A (ko)
JP (2) JPS5826877A (ko)
KR (1) KR880001478B1 (ko)
AT (1) AT381705B (ko)
AU (1) AU560655B2 (ko)
BE (1) BE894022A (ko)
CA (1) CA1172636A (ko)
CH (1) CH652398A5 (ko)
DE (1) DE3228990A1 (ko)
DK (1) DK162991C (ko)
ES (1) ES8307800A1 (ko)
FI (1) FI76793C (ko)
FR (1) FR2510572B1 (ko)
GB (1) GB2106104B (ko)
GR (1) GR76172B (ko)
HU (1) HU191187B (ko)
IE (1) IE53641B1 (ko)
IL (1) IL66434A0 (ko)
IT (1) IT1149329B (ko)
LU (1) LU84316A1 (ko)
NL (1) NL8203034A (ko)
NZ (1) NZ201159A (ko)
OA (1) OA07172A (ko)
PH (1) PH18220A (ko)
PT (1) PT75366B (ko)
SE (1) SE452320B (ko)
YU (1) YU44074B (ko)
ZA (1) ZA825479B (ko)

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Also Published As

Publication number Publication date
GB2106104A (en) 1983-04-07
NL8203034A (nl) 1983-03-01
OA07172A (fr) 1984-04-30
FR2510572A1 (fr) 1983-02-04
NZ201159A (en) 1985-10-11
PT75366A (en) 1982-09-01
ZA825479B (en) 1983-04-27
CA1172636A (en) 1984-08-14
SE452320B (sv) 1987-11-23
IL66434A0 (en) 1982-12-31
YU44074B (en) 1990-02-28
JPH02270821A (ja) 1990-11-05
SE8204550D0 (sv) 1982-08-02
AT381705B (de) 1986-11-25
ATA299482A (de) 1986-04-15
ES514264A0 (es) 1983-08-01
IE53641B1 (en) 1989-01-04
IE821852L (en) 1983-02-03
DE3228990A1 (de) 1983-03-03
LU84316A1 (fr) 1983-06-07
PT75366B (en) 1985-11-20
GB2106104B (en) 1985-05-09
IT8248909A0 (it) 1982-07-29
AU8566382A (en) 1983-02-10
KR880001478B1 (ko) 1988-08-13
SE8204550L (sv) 1983-02-04
FI76793B (fi) 1988-08-31
CH652398A5 (de) 1985-11-15
JPH0235754B2 (ko) 1990-08-13
ES8307800A1 (es) 1983-08-01
HU191187B (en) 1987-01-28
DK162991C (da) 1992-06-01
FI822667A0 (fi) 1982-07-30
FI822667L (fi) 1983-02-04
GR76172B (ko) 1984-08-03
FI76793C (fi) 1988-12-12
JPH0371410B2 (ko) 1991-11-13
YU158682A (en) 1985-04-30
IT1149329B (it) 1986-12-03
US4367335A (en) 1983-01-04
DK162991B (da) 1992-01-06
AU560655B2 (en) 1987-04-16
DK343682A (da) 1983-02-04
PH18220A (en) 1985-04-30
JPS5826877A (ja) 1983-02-17
FR2510572B1 (fr) 1986-05-09
BE894022A (fr) 1983-02-03

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