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KR830008997A - Niosin α and its homologue - Google Patents

Niosin α and its homologue Download PDF

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Publication number
KR830008997A
KR830008997A KR1019820000443A KR820000443A KR830008997A KR 830008997 A KR830008997 A KR 830008997A KR 1019820000443 A KR1019820000443 A KR 1019820000443A KR 820000443 A KR820000443 A KR 820000443A KR 830008997 A KR830008997 A KR 830008997A
Authority
KR
South Korea
Prior art keywords
glu
lys
obzl
val
boc
Prior art date
Application number
KR1019820000443A
Other languages
Korean (ko)
Inventor
왕수선
Original Assignee
쿠르트 네셀보슈,볼프강 메쯔거
에프. 호프만-라롯슈 앤드 캄파니
볼프강 메쯔거
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쿠르트 네셀보슈,볼프강 메쯔거, 에프. 호프만-라롯슈 앤드 캄파니, 볼프강 메쯔거 filed Critical 쿠르트 네셀보슈,볼프강 메쯔거
Priority to KR1019820000443A priority Critical patent/KR830008997A/en
Publication of KR830008997A publication Critical patent/KR830008997A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음No content

Description

니모신 α 및 그 동족체의 제조방법Nimosin α and its homologue

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

다음 일반식(II)의 보호시킨 펩라이드로 부터 보호기를 분리시키기고 또 필요에 따라 이 수득화합물을 약리학적 허용염으로 전환시킴을 특징으로 하여 다음 일반식(I)의 펩타이드와 이의 약리학적 허용염을 제조하는 방법.Peptides of formula (I) and their pharmacological tolerances are characterized by isolating a protecting group from the protected pepide of formula (II) and converting the obtained compound to a pharmacologically acceptable salt as necessary. How to prepare a salt. R1-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. (I)R 1 -Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. (I) R2-Glu(OBzl)-Val-Val-Val-Glu(OBzl)-Glu(OBzl)-Ala-Glu(OBzl)-Asn-OBzl. (II)R 2 -Glu (OBzl) -Val-Val-Val-Glu (OBzl) -Glu (OBzl) -Ala-Glu (OBzl) -Asn-OBzl. (II) 상기 일반식에서In the above general formula R1은 수소, H-Glu-Lys-Lys 또는 H-Asp-Leu-Lys-Glu-Lys-Lys이고 R2는 Boc, Boc -Glu(OBzl)-Lys(Z)-Lys(Z) 또는 Boc-Asp(OBzl)-Leu-Lys(Z)-Glu(OBzl)-Lys(Z)-Lys(Z)이며, 또 이때 Boc는 3급-부틸옥시카보닐, Bzl은 벤질 및 Z는 벤질옥시카보닐이다.R 1 is hydrogen, H-Glu-Lys-Lys or H-Asp-Leu-Lys-Glu-Lys-Lys and R 2 is Boc, Boc -Glu (OBzl) -Lys (Z) -Lys (Z) or Boc -Asp (OBzl) -Leu-Lys (Z) -Glu (OBzl) -Lys (Z) -Lys (Z), wherein Boc is tert-butyloxycarbonyl, Bzl is benzyl and Z is benzyloxycarbon Neal. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820000443A 1982-02-03 1982-02-03 Niosin α and its homologue KR830008997A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019820000443A KR830008997A (en) 1982-02-03 1982-02-03 Niosin α and its homologue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019820000443A KR830008997A (en) 1982-02-03 1982-02-03 Niosin α and its homologue

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7801178A Division KR840000054B1 (en) 1978-04-21 1978-04-21 Process for the preparation of thymosin

Publications (1)

Publication Number Publication Date
KR830008997A true KR830008997A (en) 1983-12-16

Family

ID=55025568

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820000443A KR830008997A (en) 1982-02-03 1982-02-03 Niosin α and its homologue

Country Status (1)

Country Link
KR (1) KR830008997A (en)

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PA0107 Divisional application

Comment text: Divisional Application of Patent

Patent event date: 19820203

Patent event code: PA01071R01D

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PE0902 Notice of grounds for rejection

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Patent event date: 19841107

Patent event code: PE09021S01D

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Patent event date: 19850128

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19841107

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I