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KR830007514A - 두고리 화합물의 제조방법 - Google Patents

두고리 화합물의 제조방법 Download PDF

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Publication number
KR830007514A
KR830007514A KR1019810004142A KR810004142A KR830007514A KR 830007514 A KR830007514 A KR 830007514A KR 1019810004142 A KR1019810004142 A KR 1019810004142A KR 810004142 A KR810004142 A KR 810004142A KR 830007514 A KR830007514 A KR 830007514A
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KR
South Korea
Prior art keywords
formula
compound
alkyl
hydrogen
hydroxyl
Prior art date
Application number
KR1019810004142A
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English (en)
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KR880000890B1 (ko
Inventor
요시까즈 오까
고헤이 니시가와
아끼오 미야께
Original Assignee
구라바야시 이꾸시로
다께다야꾸힝 고오교 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55154394A external-priority patent/JPS5777651A/ja
Priority claimed from JP56064371A external-priority patent/JPS57179141A/ja
Application filed by 구라바야시 이꾸시로, 다께다야꾸힝 고오교 가부시끼 가이샤 filed Critical 구라바야시 이꾸시로
Publication of KR830007514A publication Critical patent/KR830007514A/ko
Priority to KR1019860009085A priority Critical patent/KR880001007B1/ko
Application granted granted Critical
Publication of KR880000890B1 publication Critical patent/KR880000890B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

두고리 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 하기식(Ⅱ)의 화합물 및 하기식(Ⅲ)의 화합물을 환원 조건하 축합 시키거나,
    (b) 식(Ⅰ)의 화합물〔여기서, R3는 수소이거나 또는 R6가 히드록실이며, R3가 수소이고, 기타 모든 상징은 하기 정의한 바와 같음.〕을 제공하기 위하여 식(Ⅰ)의 에스테르 화합물〔여기서, R3는 C1∼4알킬이거나 또는 R6가 C1∼4알콕시이며, R3가 C1∼4알킬이고, 기타 모든 상징은 하기 정의한 바와 같음〕을 가수분해 하거나,
    (c) 식(Ⅰ)의 화합물〔여기서, R3는 수소이거나 또는 R6가 히드록실이며, R3가 수소이고, 기타 모든 상징은 하기 정의한 바와 같음.〕을 제공하기 위하여 식(Ⅰ)〔여기서, R3는 벤질이거나 또는 R6가 벤질옥시이며 R3가 벤질이고, 기타 모든 상징은 하기 정의한 바와 같음〕의 화합물의 벤질 에스테르를 촉매 환원 시키거나,
    (d) 하기식(Ⅳ)의 화합물 가수분해 또는 촉매 환원 시키거나,
    (e) 식(Ⅱ)의 화합물을 하기식(Ⅴ)의 화합물과 반응시키고, 그리고
    (f) 원한다면, 이와 같이 얻은 식(Ⅰ)의 화합물을 약학적으로 무독한 그의 염으로 전환 시킴을 특징으로 하는 하기식(Ⅱ)의 두고리 화합물 또는 약학적으로 무독한 그의 염의 제조방법.
    (식중,
    R1및 R2는 독립적으로 수소, 히드록실 또는 C1-4알킬렌 디옥시를 나타내고,
    R3는 수소 또는 C1-4알킬이고,
    R4는 비치환 또는 C2-4알카노일, 벤조일, C2-4알콕시카르보닐 또는 벤질옥시카르보닐로 이루어진 종류의 아실에 의하여 치환된 C1-4알킬, 아미노 C1-4알킬, 또는 수소이고,
    R5는 비치환 또는 할로겐, C1-4알킬, C1-4알콕시, 아미노, 니트로 및 히드록실 중 1내지 3개로 치환된 C1-4알킬, 페닐 C1-4알킬 또는 할로겐이고,
    R6는 히드록실, C1-4알킬시, 아미노 또는 모노-또는 디 C1-4알킬아미노이고,
    X는 할로겐 또는 R7는 C1-4알킬, 페닐 또는 p-톨릴인 식 R7SO2-0-의 기이고.
    Y는 가수분해 또는 촉매 환원에 의하여 제거될 수 있는 보호기이고, 그리고 m 및 n은 각각 1 또는 2를 의미함).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004142A 1980-10-31 1981-10-29 두고리 화합물의 제조방법 KR880000890B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860009085A KR880001007B1 (ko) 1980-10-31 1986-10-29 비사이클릭 화합물의 제조 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US154394/1980 1980-10-31
JP55154394A JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation
JP56064371A JPS57179141A (en) 1981-04-28 1981-04-28 Bicyclic compound and its preparation
US64371/1981 1981-04-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019860009085A Division KR880001007B1 (ko) 1980-10-31 1986-10-29 비사이클릭 화합물의 제조 방법

Publications (2)

Publication Number Publication Date
KR830007514A true KR830007514A (ko) 1983-10-21
KR880000890B1 KR880000890B1 (ko) 1988-05-30

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Country Status (19)

Country Link
US (3) US4822818A (ko)
EP (1) EP0051391B1 (ko)
KR (1) KR880000890B1 (ko)
AU (1) AU543804B2 (ko)
CA (1) CA1287444C (ko)
DE (1) DE3165862D1 (ko)
DK (1) DK164917C (ko)
ES (3) ES8306710A1 (ko)
FI (1) FI73698C (ko)
GB (1) GB2086393B (ko)
GR (1) GR75368B (ko)
HK (1) HK19887A (ko)
HU (1) HU183652B (ko)
IE (1) IE51918B1 (ko)
MY (1) MY8500500A (ko)
NO (1) NO155133C (ko)
NZ (1) NZ198826A (ko)
PH (2) PH18357A (ko)
PT (1) PT73912B (ko)

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Also Published As

Publication number Publication date
CA1287444C (en) 1991-08-06
KR880000890B1 (ko) 1988-05-30
ES506714A0 (es) 1983-06-01
US4474692A (en) 1984-10-02
AU543804B2 (en) 1985-05-02
FI73698B (fi) 1987-07-31
GB2086393A (en) 1982-05-12
PH18357A (en) 1985-06-05
ES515269A0 (es) 1983-12-01
DE3165862D1 (en) 1984-10-11
EP0051391A1 (en) 1982-05-12
NO155133C (no) 1987-02-18
PH21390A (en) 1987-10-15
NZ198826A (en) 1984-07-06
HK19887A (en) 1987-03-13
AU7652181A (en) 1982-05-06
US4822818A (en) 1989-04-18
ES524148A0 (es) 1985-05-01
US5098892A (en) 1992-03-24
PT73912A (en) 1981-11-01
IE51918B1 (en) 1987-04-29
DK164917C (da) 1993-02-01
ES8504671A1 (es) 1985-05-01
HU183652B (en) 1984-05-28
PT73912B (en) 1983-01-25
DK478181A (da) 1982-05-01
GB2086393B (en) 1984-01-11
IE812471L (en) 1982-04-30
NO813662L (no) 1982-05-03
ES8306710A1 (es) 1983-06-01
NO155133B (no) 1986-11-10
GR75368B (ko) 1984-07-13
ES8401445A1 (es) 1983-12-01
FI813383L (fi) 1982-05-01
DK164917B (da) 1992-09-07
EP0051391B1 (en) 1984-09-05
FI73698C (fi) 1987-11-09
MY8500500A (en) 1985-12-31

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