KR830005245A - Method for preparing cephalosporin derivative - Google Patents

Abstract

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Description

Method for preparing cephalosporin derivative

As this is a public information case, the full text was not included.

Claims (1)

The lactam of general formula (II) is reacted with the carboxylic acid of general formula (III) or an active derivative thereof to give a compound of general formula (IV), and when R ¹ is a protecting group, the radical is separated and X ¹ is X If not switch the X ¹ to X, and separated, and X X and the switching sequence to Z ¹ and Z ¹ a R ¹ sikimyeo switch Z ¹ when the Z ¹ other than Z a and Z is characterized in that the change in the bar intended To prepare the compound of formula (I). In the above structural formula X is hydrogen, optionally substituted alkyl of 1 to 4 carbon atoms, carboxymethyl, which may be present in the optionally substituted, physiologically toxic salt form, optionally substituted alkoxycarbonylmethyl of 1 to 4 carbon atoms, optionally substituted in the alkyl site Aminocarbonylmethyl or optionally substituted cyanomethyl Y is halogen Z is an azide, optionally substituted pyridinium or S-Het, wherein Het contains one or more nitrogen atoms and is an optionally substituted 5 or 6 heterocycle ring A is hydrogen, easily decomposable ester radical or physiologically toxic cation Z ¹ is Z, acyloxy or halogen of 1 to 4 carbon atoms in the acyl moiety R ¹ is an aminoprotective group known in hydrogen or peptide chemistry X ¹ is X, a group that can be easily decomposed or a -CH ₂ CO ₂ R ³ group R ³ is a radical capable of decomposition under mild conditions. ※ Note: The disclosure is based on the initial application.