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KR830005237A - Electrolytic Reduction Method of Separosporin P-Nitrobenzyl Ester - Google Patents

Electrolytic Reduction Method of Separosporin P-Nitrobenzyl Ester Download PDF

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Publication number
KR830005237A
KR830005237A KR1019810000929A KR810000929A KR830005237A KR 830005237 A KR830005237 A KR 830005237A KR 1019810000929 A KR1019810000929 A KR 1019810000929A KR 810000929 A KR810000929 A KR 810000929A KR 830005237 A KR830005237 A KR 830005237A
Authority
KR
South Korea
Prior art keywords
potential
electrolytic reduction
pnb ester
separosporin
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019810000929A
Other languages
Korean (ko)
Inventor
알프레드 할 데비드
Original Assignee
아더 알. 웨일
일라일 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아더 알. 웨일, 일라일 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR830005237A publication Critical patent/KR830005237A/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Cephalosporin Compounds (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

내용 없음No content

Description

세파로스포린 P-니트로벤질에스테르의 전기분해적 환원방법Electrolytic Reduction Method of Separosporin P-Nitrobenzyl Ester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도 : 전형적 전압전류도 곡선을 나타낸 도면.FIG. 1 shows a typical voltammogram curve.

Claims (1)

환원되는 화합물 몰당 4몰이상의 산을 가한, 0내지 50%의 물이 함유된 산성액체매질(물중에서 측정한 산의 Pka는 0 또는 이 이하임) 및 전해적 환원에 실제로 불활성인 유기용매중에서 전해조내의 탄소, 수은, 주석, 알미늄, 은, 구리, 납, 크롬, 아연, 닉켈 또는 카드뮴으로 구성된 전극을 사용하여 0내지 75℃의 온도에서 1차 환원에 흐른 전류의 초기개시 전위내지 2차 환원에 흐른 전류의 초기개시 전위내의 전위에서 PNB에스테르를 전기분해적으로 환원시킴을 특징으로 하는 세파로스포린 4-카복실산 PNB에스테르로부터 PNB에스테르 보호그룹을 제거하여 유리세파로스포린 4-카복실산을 분리시키는 방법.Electrolysers in acidic liquid media containing 0 to 50% of water (more than 4 moles of acid per mole of reduced compound) (pka of the acid measured in water is 0 or less) and organic solvents that are actually inert to electrolytic reduction. In the initial initiation potential to secondary reduction of the current flowing in the primary reduction at a temperature of 0 to 75 ° C using an electrode composed of carbon, mercury, tin, aluminum, silver, copper, lead, chromium, zinc, nickel or cadmium A method for separating free cephalosporin 4-carboxylic acid by removing the PNB ester protecting group from the cephalosporin 4-carboxylic acid PNB ester characterized by electrolytically reducing the PNB ester at a potential within the initial starting potential of the flowing current. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810000929A 1980-03-31 1981-03-20 Electrolytic Reduction Method of Separosporin P-Nitrobenzyl Ester Ceased KR830005237A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13582980A 1980-03-31 1980-03-31
US135829 1993-10-14

Publications (1)

Publication Number Publication Date
KR830005237A true KR830005237A (en) 1983-08-03

Family

ID=22469892

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000929A Ceased KR830005237A (en) 1980-03-31 1981-03-20 Electrolytic Reduction Method of Separosporin P-Nitrobenzyl Ester

Country Status (7)

Country Link
EP (1) EP0038626A1 (en)
JP (1) JPS56152982A (en)
KR (1) KR830005237A (en)
CA (1) CA1164402A (en)
GB (1) GB2074607B (en)
HU (1) HU185631B (en)
IL (1) IL62427A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632850A (en) * 1969-03-18 1972-01-04 Lilly Co Eli Cephalexin synthesis
US4042472A (en) * 1976-04-12 1977-08-16 Eli Lilly And Company Electrolytic process for 7-methoxy-3-exomethylenecepham compounds

Also Published As

Publication number Publication date
EP0038626A1 (en) 1981-10-28
CA1164402A (en) 1984-03-27
JPS56152982A (en) 1981-11-26
HU185631B (en) 1985-03-28
GB2074607A (en) 1981-11-04
IL62427A (en) 1984-07-31
GB2074607B (en) 1983-02-16

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19810320

PG1501 Laying open of application
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19840827

Patent event code: PE09021S01D

PE0601 Decision on rejection of patent

Patent event date: 19841107

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19840827

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I