KR20240063010A - Functionality patch for whitening comprising an ozonated oil - Google Patents

Abstract

The present invention is characterized by using ozonated oil as an active ingredient of a whitening patch. according to the present invention, it is possible to stably implement a whitening patch containing ozonated oil, and the patch has a reduced unique odor of ozonated oil, less skin irritation, and a whitening effect as well as a moisturizing effect.

Description

Functional patch for whitening containing ozonated oil {FUNCTIONALITY PATCH FOR WHITENING COMPRISING AN OZONATED OIL}

The present invention relates to a functional patch for whitening. Specifically, it is about uncovering the whitening function of ozonated oil and developing a functional patch for whitening using it.

[Whitening care]

Human skin color is determined by melanin, and when physiological function declines due to aging or excessive exposure to ultraviolet rays from sunlight, melanin is synthesized excessively, causing pigmentation.

Demand in the field of skin whitening to suppress or improve pigmentation is growing as the general public's interest in beauty increases.

[Whitening active ingredients]

Existing whitening substances that inhibit melanin production are, depending on their mechanism of action, one of three types: ultraviolet ray absorber; ultraviolet scattering agent; Tyrosinase inhibitors such as vitamin C, hyperlipidic acid, and arbutin; There are tocopherols that scavenge active oxygen.

Existing research on whitening was based on chemical synthetic substances, and research on extracting whitening ingredients from natural plants using biotechnology has also been attempted. For example, research on the whitening effect of herbal medicine extracts such as quince, apricot, baekjain, safflower, hyangbuja, hyeonggae, tosaja, bokbunja, and peony.

[Ozonized oil]

The present inventor focused on ozonated oil as a whitening active ingredient.

Ozone is an unstable gas that is highly chemically active and is known to attack bacteria, viruses, fungi, and organic substances harmful to the human body and oxidize them by causing a chemical reaction with them. For example, using these properties, water can be made clean and sterile. According to reports, ozone is known to have better sterilizing power than chlorine-based disinfectants but is non-residual. This is because the remaining ozone gas is gradually completely decomposed into oxygen.

Ozone has been developed as a product for treating skin diseases by utilizing its sterilizing power.

However, if ozone is used in gaseous form or dissolved in water, it is difficult to contain it for a long time, so it cannot be produced as a product that can fully demonstrate ozone's sterilizing function. There have been attempts to capture ozone in creams, etc., but since ozone easily escapes from hydrophilic materials and is released into the air, the function of ozone cannot be fully utilized.

Then, ozonized oil, which introduced ozone gas into oil, appeared. The manufacturing process of ozonated oil is described in Kim, D.S., "The Study on the Development of Ozone Water Diffusion Device by Ozonated Olive Oil Mix Ratio that will Increase", J. Korean Oil chem. It is disclosed in papers such as Soc, Vol.31, NO.9, pp.688~693, 2014.

According to research, ozonized oil has little skin irritation and is evaluated as a non-irritating substance, and is currently being attempted to treat various skin diseases using its sterilizing power. For example, Republic of Korea Patent Publication No. 10-1657088 applies ozonated oil to men in their late 20s or early 30s with skin problems and discloses the improvement effect.

However, the present inventor found that ozonated oil not only has sterilizing power but also has a whitening effect. The present invention is characterized by using ozonized oil as an active ingredient for whitening function.

[Whitening patch]

The patch formulation has the advantage of being able to stably inject the active ingredient into the target skin area by applying it topically to the skin for a long period of time. In cases where the active ingredient needs to be absorbed into the skin for a sufficient period of time, a patch formulation is more effective than a cream-like formulation.

However, patch formulations are more difficult to design than cream formulations, and cream formulations are currently more dominant than patches in the whitening cosmetics market.

For example, in the case of ozonized oil, if you look at the formulation of the product currently being distributed as a skin sterilization product, it is a cream formulation.

However, the present inventor succeeded in developing a formulation design that can optimize ozonated oil into a patch formulation.

Meanwhile, ozonated oil is known to have a unique odor and is not convenient to use. For example, Republic of Korea Patent Publication No. 10-2016-0137797 discloses a process of preparing ozonated oil by adding essential oil to reduce the specific odor of ozonated oil in a cream formulation containing ozonated oil. .

In contrast, the present invention is characterized by removing unusual odors by implementing ozonated oil in a patch formulation using ionic ingredients, herbal extracts, and/or tea tree oil.

Republic of Korea Patent Publication No. 10-1657088 Republic of Korea Patent Publication No. 10-2016-0137797

First, the present invention is characterized by attempting to change the perception of ozonized oil as a whitening product rather than a sterilizing product.

Second, the effect of whitening products can be expressed satisfactorily only when the active ingredients are absorbed into the target skin area for a long period of time, and a patch formulation is better than a cream formulation for long-term absorption of active ingredients. However, in the past, there was no successful case of using ozonated oil in a patch formulation, so most products were released in a cream formulation, but the present invention is characterized by implementing this patch formulation.

Third, ozonated oil has a unique odor, so it is not convenient for users who are sensitive to odor. The present invention is characterized by eliminating such unusual odors.

The present invention solves the above-described problem by means of the following means.

1. Functional patch for whitening containing ozonated oil.

2. The water-based functional patch according to item 1, further comprising partially neutralized polyacrylate as a specific odor reducer and/or ozonated oil collector.

3. The water-based functional patch according to item 1 or 2, further comprising extract of Cypress chinensis and/or tea tree oil as an odor reducing agent. In one embodiment, the preferred content of the Trifolia extract and/or tea tree oil is 5 to 20 (ozonized oil) : 1 (trifoliate extract and/or tea tree oil) based on the total weight of the composition.

4. The water-based functional patch according to any one of items 1 to 3 above, further comprising vitamin E as a whitening improving agent.

5. The water-based functional patch according to any one of items 1 to 4 above, further comprising niacinamide as a whitening improving agent.

6. The water-based functional patch according to any one of 1 to 5 above, characterized in that it contains 20% or more of purified water based on the total weight of the composition.

The present invention has a skin whitening effect.

According to the present invention, ozonated oil can be stably implemented in a patch formulation.

In the present invention, the peculiar odor characteristic of ozonated oil is reduced.

Typically, ozonated oils use insoluble solvents to capture stable ozone, but in contrast, the present invention can be implemented as an aqueous patch that can contain more than 20% of purified water based on the total weight of the composition, providing not only skin whitening but also a moisturizing effect. The characteristic is that it can also be achieved.

The present invention may further include vitamin E or niacinamide to enhance the skin whitening effect. However, vitamin E or niacinamide is an ingredient known to cause skin irritation. However, the present invention is characterized by being non-irritating without skin irritation even though it contains both types of vitamin E and niacinamide.

Figure 1 is a diagram showing the change in average skin pigmentation melanin concentration before the test, 2 weeks after the test, and 4 weeks after the test.
Figure 2 is an image taken to check skin pigmentation using Antera 3D before the test, 2 weeks after the test, and 4 weeks after the test.

[Active ingredient]

The present invention is characterized by including ozonated oil as an active ingredient for skin whitening. Ozonated oil is commercially available as an active ingredient for skin sterilization, and suitable ozonated oils available on the market can be prepared and used in the present invention. Ozonized oil can be mixed in an amount of 5 to 50 mg per unit dosage form. If the content is small, there may be a limit to the skin whitening function, while if the content is excessive, ozone's unique odor is generated and convenience is reduced.

The present invention may further include vitamin E and/or niacinamide as a whitening improver, if necessary. Vitamin E and/or niacinamide can usually be mixed in an appropriate amount selected from products for skin whitening.

[Formulation]

The present invention is characterized in that it is a patch in formulation. Specifically, it is characterized as a water-based patch that can contain moisture. The present invention may contain 20% or more of purified water based on the total weight of the composition.

Typically, patches are implemented in a matrix form where the active ingredients are dispersed in an adhesive layer. Matrix-type patches have a support layer impregnated with an adhesive or an adhesive applied to one side of the support layer, and when attached to the skin, active ingredients come out from the adhesive and penetrate into the skin. The support layer may be made of, for example, a non-woven fabric. The support layer of the present invention is not particularly limited.

The present invention uses hydrogel as an adhesive. Hydrogel is an insoluble material with a three-dimensional network structure in which homopolymers or copolymers of water-soluble polymers are physicochemically cross-linked. It can contain a large amount of moisture or biological fluids, similar to biological tissue, and has excellent biocompatibility.

So far, ozonized oil has been studied only as a cream, and there has been no research on the value and optimizable composition of patches, specifically water-based patches. The reason is that it was recognized that the patch would have limitations in stably capturing ozonated oil.

However, the present inventor has implemented a water-based patch that can stably collect ozonated oil.

The water-based patch manufacturing method is described by T.W. Lee, J.C. Kim and S.J. Hwang, Hydrogel patches containing triclosan for acne treatment, Eur. J. Pharm. Biopharm., 56, 407-412 (2003), etc., and an example manufacturing method is as follows.

Completely dissolve the active ingredients, methylparaben and PEG-40 in Transcutol CG, add glycerin while stirring slowly and mix until a homogeneous phase is formed, then add dihydroxy aluminum aminoacetate, sodium carboxymethyl cellulose and sodium polyacrylate. Disperse to produce Phase A. Tartaric acid is dissolved in purified ionized water, and sorbitol and polyacrylic acid are added and dissolved to prepare a homogeneous phase B. Prepare a homogeneous gel by slowly adding Phase B to Phase A and mixing to prevent bubbles from forming. This is spread on the surface of the non-woven fabric to produce a patch.

The present invention can also be manufactured by a general manufacturing method such as the example above. However, unlike the above, the adhesive composition is made of a new composition.

[Furtherance]

The representative problems of the present invention are as follows.

First, it must be possible to stably collect ozonated oil, and second, it must be possible to reduce the specific odor of ozonated oil. Additionally, since the present invention is a water-based patch, it must have adequate skin adhesion and must not cause skin irritation. Additionally, since the basic purpose is skin whitening, the skin whitening effect must be excellent.

First, the stable capture of ozonated oil will be explained.

In cases where the active ingredient needs to be absorbed into the skin for a sufficient period of time, a patch formulation is more effective than a cream-like formulation. Nevertheless, patch formulations are more difficult to design than cream formulations, and cream formulations are currently more dominant than patches in the whitening cosmetics market.

Additionally, ozone, which has an unstable structure, has the ability to instantly kill strains by dissociating and stealing electrons from the fundamental RNN/DNN structure of viruses or bacteria on the skin. Additionally, the oxygen atoms produced when ozone is decomposed are involved in the formation of unstable tissues, have strong oxidizing power, and easily react with other compounds to oxidize and decompose those compounds. Accordingly, there have been attempts to treat skin diseases by trapping ozone with these characteristics in hydrophilic creams, etc., but there is a problem that the function of ozone cannot be fully used because ozone easily escapes from hydrophilic materials and is released into the air.

However, in the present invention, the stability of ozone was secured by collecting ozonated oil with partially neutralized polyacrylate with a three-dimensional network structure.

The present invention is characterized by comprising a partially neutralized polyacrylate. Partially neutralized refers to neutralization by replacing the H ion of COOH of polyacrylic acid with Na ion, etc., and can be selected from commercially available raw materials, preferably 50% neutralized or 70% neutralized. there is.

In the present invention, an aqueous patch is manufactured through an emulsion process in which ozonated oil is loaded onto the partially neutralized polyacrylate polymer, and the ozonated oil is stably captured in the polymer. Accordingly, according to the present invention, there is an advantage that the active ingredient can be stably injected into the target skin area.

The content of neutralized polyacrylate is preferably 3-7% based on the total weight of the composition for stability of ozonated oil and removal of specific odors described below.

The present invention is characterized in that it contains neutralized polyacrylate, Cypress extract and/or tea tree oil as an odor reducer.

Ozonated oil is an ingredient that has a specific odor and is not very convenient to use. There have been studies on improving the specific odor of ozonated oil in the past, such as in Korean Patent Publication No. 10-2016-0137797, but research on improving the specific odor of patches was insufficient.

The present invention uses ionic ingredients, herbal extracts, and/or tea tree oil as odor reducers for ozonated oil. Ionic components refer to neutralized polyacrylate polymers that are also used for gastric collection purposes. A representative example of a herbal medicine extract is Sambaekcho extract. Sambaekcho is called an all-purpose herb because it is effective in strengthening blood vessels, detoxifying, and regulating the intestines. Before it is dried, the ginseng root has a unique and strong scent, but the dried extract has a much lighter scent. However, the ginseng extract also has a slightly astringent scent. Surprisingly, however, when this extract of Campanula angiosperm was mixed with ozonated oil at a ratio of 5 to 20 (ozonated oil): 1 (extract of Campanula angiosperm) based on the total weight of the composition, the unique odors of the extract and ozonated oil complemented each other, creating an unpleasant sensation. It was confirmed that the scent was removed. In the case of tea tree oil, it can be mixed at a ratio of 5 to 20 (ozonized oil):1 (tea tree oil) based on the total weight of the composition.

The present invention may further contain excipients, cross-linking agents, cross-linking accelerators, etc., as necessary.

Examples of excipients include, but are not limited to, copolymers such as kaolin, PVP, sodium alginate, sodium CMC, etc. Examples of crosslinking agents include, but are not limited to, aluminum glycinate. Examples of crosslinking accelerators include, but are not limited to, tartaric acid. The content of each excipient, cross-linking agent, and cross-linking accelerator can be appropriately adjusted to the range generally considered in the composition of an aqueous patch.

The following examples supplement further explanation of the present invention. Meanwhile, the examples merely introduce a preferred embodiment of the present invention and should not limit the scope of the present invention.

[Example]

[Manufacturing example]

Prepare a water-based patch that satisfies the composition below.

Furtherance test product % 342.00mg One glycerin 38.00% 129.96mg TiO2 0.20% 0.68mg aluminum glycinate 0.12% 0.41mg Partially neutralized polyacrylate (Aronvis 105X) 4.50% 15.39 mg Vitamin E 0.20% 0.68mg sodium polyacrylate 1.00% 3.42mg CMC-Na 1.20% 4.10 mg Twin 80 0.30% 1.03 mg ozonated oil 7.00% 23.94mg 2 1,2-hexanediol 0.50% 1.71 mg Butylhydroxytuluene (BHT) 0.05% 0.17 mg 3 tartaric acid 0.15% 0.51mg Trifolium prickly pear extract 0.50% 1.71 mg PVP 1.00% 3.42mg Niacinamide 2.00% 6.84mg lactic acid 0.30% 1.03mg EDTA-2Na 0.04% 0.12mg Purified water 42.95% 146.87mg total amount 100.00% 342.00mg

[Test Example 1]

We requested the Human Skin Clinical Test Center Co., Ltd. to confirm the degree of relief of skin pigmentation (spots, freckles, blemishes, and age spots) after using the above patch (hereinafter also referred to as test product) for 2 and 4 weeks. The experiment was performed according to standard operating procedures (SOP).

The test method involves having a test subject visit the test facility, wash and wash the test area with lukewarm water, wait at least 30 minutes under constant temperature and humidity (22±2°C, 50±5%) conditions, sufficiently stabilize the skin, and then participate in the test. did. The efficacy of alleviating skin pigmentation was evaluated by analyzing the average concentration of melanin in the cheek area before and after using the test product for 2 and 4 weeks.

As a result, as shown in Table 2, Figures 1 and 2, the average melanin concentration in the cheek area significantly decreased after using the test product for 2 and 4 weeks, confirming that it helps alleviate skin pigmentation.

(As a result of Antera 3D melanin average concentration analysis, significance probability is p<0.05)

Below are the results of the analysis on the ease of use of the test product.

After using the test product for two weeks, a questionnaire was administered to the test subjects regarding efficacy and quality, and the results of the analysis are as follows.

After using the test product for 4 weeks, a questionnaire was administered to the test subjects regarding efficacy and quality, and the results of the analysis are as follows.

During this test period, no adverse reactions such as contact dermatitis or irritant contact dermatitis were reported or observed after using the test product in test subjects.

In addition, as a result of a questionnaire evaluation of test subjects separately from the adverse reaction evaluation by the test person, no special adverse reactions were observed.

[Test Example 2]

Below are the stability results of the test product under typical acceleration and harsh conditions. Even if the test product contains 42.95% purified water, that is, even if it contains a lot of water-soluble solvents, ozone can be collected for a long time without being blown away.

pH peroxide value iodine value Early 5.98 1212 2.4 Accelerated 1 week 5.90 1082 4.2 accelerated 2 weeks 6.04 1068 8.3 Accelerated 4 weeks 5.77 771 4.8 Accelerated 6 weeks 5.74 636 7.7 Accelerated 8 weeks 5.75 467 5.9 Accelerated 10 weeks 5.72 524 5.6

pH peroxide value iodine value Early 5.98 1212 2.4 Harsh 1 week 5.73 168 6.3 harsh 2 weeks 5.65 69 10.8 harsh 4 weeks 5.35 50 11.4

[Production Example 2 and Test Example 3]

Below, tea tree leaf oil, a naturally derived essential oil that can eliminate the specific odor of ozonated oil, is mixed with ozonated oil at a ratio of 5 to 20 (ozonized oil) : 1 (tea tree oil) based on the total weight of the composition. As a result, it was confirmed that the unique odors of tea tree leaf oil and ozonized oil were combined to eliminate unpleasant odors.

Furtherance test product % 342.00mg



One glycerin 38.00% 129.96mg TiO2 0.20% 0.68mg aluminum glycinate 0.12% 0.41mg Partially neutralized polyacrylate (Aronvis 105X) 4.50% 15.39mg Vitamin E 0.20% 0.68mg sodium polyacrylate 1.00% 3.42mg CMC-Na 1.20% 4.10 mg Twin 80 0.30% 1.03mg ozonized oil 7.00% 23.94mg
2 1,2-hexanediol 0.50% 1.71 mg Butylhydroxytuluene (BHT) 0.05% 0.17mg


3 tartaric acid 0.15% 0.51mg Tea tree oil 0.50% 1.71mg PVP 1.00% 3.42mg Niacinamide 2.00% 6.84mg lactic acid 0.30% 1.03mg EDTA-2Na 0.04% 0.12mg Purified water 42.95% 146.87mg total amount 100.00% 342.00mg

Claims (5)

Water-based functional patch for whitening containing ozonated oil. The water-based functional patch according to claim 1, comprising partially neutralized polyacrylate as a specific odor reducer or ozonated oil collector, and further comprising an extract of Cypress chinensis. The water-based functional patch according to claim 1, comprising partially neutralized polyacrylate as a specific odor reducer or ozonated oil collector, and further comprising tea tree leaf oil. The water-based functional patch according to claim 1, further comprising at least one whitening improving agent selected from the group consisting of vitamin E and niacinamide. The water-based functional patch according to claim 1, wherein the water-based functional patch contains 20% or more of purified water based on the total weight of the composition.