KR20230138769A - Method of reading biosensor information for distinguishing biosensor and device thereof - Google Patents

Abstract

The biosensor measurement system according to an embodiment of the present invention includes an integrated strip type and body composition concentration reading unit that senses the combination of biosensors, determines the type of biosensor, and obtains a detection signal from the biosensor based on the type of biosensor. ; It may include a biosensor reading device including an output unit that outputs measurement information based on a detection signal, and a plurality of biosensors with different electrode configurations.

Description

Method for reading biosensor information for distinguishing biosensors and device therefor {METHOD OF READING BIOSENSOR INFORMATION FOR DISTINGUISHING BIOSENSOR AND DEVICE THEREOF}

The present invention relates to a method for identifying various types of biosensors from each other and a biosensor reading device for performing and reading other measurements using the identified information.

In general, biological substances such as blood sugar, ketones, uric acid, cholesterol, and nucleic acids are measured, or enzymes, cofactors (FAD, FAD, FMN), antigens, antibodies, immune reactions, nucleic acids, Products used in industries such as medical, environmental, and agricultural industries that utilize the specific selective reactions of biological receptors such as peptides, avidin, biotin, and target proteins are called biosensors.

In particular, electrochemical measurement methods have recently been in the spotlight due to their simplicity and miniaturization. The medical blood glucose monitoring system (BGMS) is a representative commercialized product.

Biosensors that operate using electrochemical measurement methods have one or more essential elements: a two-electrode system consisting of a working electrode, a counter electrode, or a three-electrode system consisting of a working electrode, a counter electrode, and a reference electrode. do.

Looking at the basic operation of a biosensor, a sample is applied and an electrochemical cell operates. The CPU reads the flow of oxidation or reduction current induced in the sample through appropriate adjustment of the potential. The electrochemical measurement method indirectly measures the amount of the target substance by quantifying the change and flow of the current.

Meanwhile, when reading biosensor information, if the type of biosensor is not recognized in advance, the biosensor reading may be inaccurate. In other words, it is necessary to immediately determine the type of biosensor to ensure measurement is appropriate for the target substance in the sample and to accurately quantify the measured current value as the concentration of the analyte.

Existing portable electrochemical biosensors are usually paired with a reader and are designed to measure only one target analyte (substrate). In order to measure two or more different target objects, a separate means is needed. This can be done by inserting a code chip or barcode containing biosensor information into a separate slot for recognition (setting), or by another method. was able to read the type of biosensor by changing the shape of the connector inside the reading device to a separate form or changing the design of the PCB connection circuit connected to the connector.

However, these methods involve the use of a separate code chip, a separate slot, a separate or modified connector, and a change in the PCB circuit, which has the disadvantages of increased unit cost, difficulty in component compatibility, and reduced convenience of use. You may have problems.

The purpose of the present invention is to provide a biosensor reading method and device to solve the above problems.

The biosensor reading device according to an embodiment of the present invention is characterized by identifying the type of biosensor in a connector connected to one PCB type and acquiring a detection signal according to the type of the identified biosensor. In other words, it features an integrated reading device that recognizes the type of biosensor and measures body composition concentration through one connector. It does not require a separate code chip or code card to read the biosensor type, and does not require a separate connector to insert the code chip.

In addition, the type of biosensor can be read based on the shape of the biosensor electrode without changing the PCB circuit or connector. Therefore, it is characterized by the ability to use multiple biosensors with one biosensor reading device.

A biosensor reading device according to an embodiment of the present invention is an integrated strip type and body composition device that senses the combination of a specific biosensor, determines the type of the biosensor, and obtains a detection signal from the biosensor based on the type of biosensor. Concentration reading unit; It may be a biosensor measurement system that includes a biosensor information reading device, including an output unit that outputs measurement information based on the detection signal, and a plurality of biosensors with different electrode configurations.

In addition, it further includes an electrode switch, wherein the strip type reading unit and the body composition concentration reading unit are composed of a plurality of electrodes, and the electrode switch can connect or disconnect at least some of the plurality of electrodes.

In addition, the electrode switch connects the plurality of electrodes when determining the type of the biosensor, and when obtaining a detection signal from the biosensor, two ground electrodes among the plurality of electrodes are switched off. off) to separate the electrodes, and the detection signal can be acquired using the remaining electrodes among the plurality of electrodes.

Additionally, the strip type reading unit may determine the type of the biosensor based on the connection relationship between the plurality of electrodes.

A method of reading biosensor information using a biosensor reading device according to another embodiment of the present invention includes the steps of sensing a combination of biosensors; determining the type of the biosensor; Obtaining a detection signal from the biosensor based on the type of the biosensor; and outputting measurement information based on the detection signal.

In addition, the biosensor reading device includes an electrode switch and a plurality of electrodes for performing the steps of determining the type of the biosensor and acquiring the detection signal, and controlling the electrode switch to determine the type of the biosensor. It may include connecting or disconnecting at least some of the electrodes.

In addition, when determining the type of the biosensor by controlling the electrode switch, connecting the plurality of electrodes, and when obtaining a detection signal from the biosensor, two ground electrodes among the plurality of electrodes are switched off ( It may include the step of separating the electrodes by switching off and acquiring the detection signal using the remaining electrodes among the plurality of electrodes.

Additionally, it may include determining the type of the biosensor based on the connection relationship between the plurality of electrodes.

According to the present invention, firstly, the type of biosensor, that is, the analyte of the biosensor, can be automatically recognized by the measuring instrument without any separate button operation, so it is convenient to use because the user does not have to perform a separate step.

Second, rather than adding a separate electrode or device to determine the type of biosensor, only the patterns of existing electrodes are changed and used, reducing the cost and time for manufacturing electrochemical biosensors. can do.

Thirdly, according to the prior art, technology has been developed to read measurement information by varying the design of the PCB's configuration lines, and a plurality of biosensors with different coupling lines for the measurement substance are used in a reading unit measuring device composed of the same PCB. Quantitative analysis can be performed by reading.

Figure 1 is a flowchart showing a biosensor reading method according to an embodiment of the present specification.
Figure 2 is a block diagram showing components of a biosensor reading device according to an embodiment of the present specification.
Figure 3 is a diagram illustrating an example of a biosensor according to an embodiment of the present specification.
Figure 4 shows the electrode configuration of various types of biosensors according to an embodiment of the present specification.
Figure 5 shows a circuit diagram for acquiring a detection signal from a biosensor according to an embodiment of the present specification.
Figures 6 and 7 show contact areas of a strip reading electrode and a detection signal electrode according to an embodiment of the present specification.
Figure 8 shows a circuit diagram of an electrode switch according to an embodiment of the present specification.

Definition of terms in this specification

All embodiments described below are shown as examples to aid understanding of the present invention, and may be modified differently from the embodiments described herein and implemented in various embodiments. Additionally, when describing the present invention, if it is determined that a detailed description of a related known function or known component may unnecessarily obscure the gist of the present invention, the detailed description will be omitted.

In order to facilitate understanding of the invention, the attached drawings are not drawn to scale, but the dimensions of some components may be exaggerated, and when reference numbers are given to each component, the same components are shown in different drawings. Even if it is indicated in , it is indicated with the same symbol as much as possible.

Additionally, when describing the components of an embodiment of the present invention, terms such as first, second, A, B, (a), and (b) may be used. These terms are only used to distinguish the component from other components, and the nature, sequence, or order of the component is not limited by the term. When a component is described as being 'connected', 'coupled' or 'connected' to another component, that component may be directly connected, coupled or connected to that other component, but that component and that other component It should be understood that another component may be 'connected', 'combined', or 'connected' between elements.

Therefore, the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention and do not represent the entire technical idea of the present invention, so there may be various modified embodiments of the present invention. .

In addition, the terms or words used in this specification and claims should not be limited to common or dictionary meanings, and the inventor may appropriately define the concept of terms to explain his or her invention in the best way. It must be interpreted as meaning and concept consistent with the technical idea of the present invention based on principles.

Additionally, as used in this application, singular expressions include plural expressions unless the context clearly dictates otherwise.

Main embodiments of the present specification

Figure 1 Description

Figure 1 is a flowchart showing a biosensor reading method according to an embodiment of the present specification.

As shown in FIG. 1, the biosensor reading method (S100) according to an embodiment of the present specification includes steps S110, S130, S150, and S170, and detailed descriptions are as follows.

First, the biosensor reading device senses the binding of the biosensor (S110).

For example, the strip type reading unit of the biosensor reading device can sense the combination of biosensors or biosensor strips coupled to the biosensor reading device.

Next, the biosensor reading device determines the type of biosensor (S130).

For example, the strip type reading unit may determine the type of the combined biosensor through the coupling relationship of the plurality of terminals constituting the strip type reading unit.

Next, the biosensor reading device acquires a detection signal from the biosensor based on the biosensor type (S150).

Next, the biosensor reading device outputs measurement information based on the detection signal (S170).

Figure 2 Description

Figure 2 is a block diagram showing components of a biosensor reading device according to an embodiment of the present specification.

As shown in FIG. 2, the biosensor reading device (measuring device) 200 includes a code pattern information reading unit 210, a code information storage unit 260, a control unit 230, an output unit 240, and an input unit ( 250), a strip type reading unit and a body composition concentration reading unit 220, and an electrode switch 270.

The code pattern information reading unit 210 is composed of a plurality of reading electrodes that are electrically connected by the sensor code pattern formed on the biosensor. For example, the code pattern information reading unit operates a plurality of switches connected between the reading electrode in contact with the sensor code pattern of the biosensor and the ground in a predetermined combination order to provide code pattern information corresponding to the sensor code pattern formed in the biosensor. Read . For example, the code pattern information reading unit can read the code pattern information corresponding to the strip code pattern, determine the body composition concentration information input according to the code information, and finally calculate it to minimize measurement error.

The biosensor reading device (measuring device) 200 senses the combination of the biosensor 100. Here, the electrodes 150 and 152 of the biosensor transmit strip type information and bioinformation (eg, body composition concentration information) detected by the biosensor to the biosensor reading device. That is, the strip type reading unit and the body composition concentration reading unit are electrically connected to the biosensor type electrode (150, 152) pattern of the biosensor, detect the pattern information of each sensor type, and transmit it to the biosensor measuring device (200) to determine the sensor type. Read information corresponding to the pattern. Hereinafter, body composition concentration information will be described as bio information as an example, but the present invention is not limited thereto.

In the case of an electrochemical system, the electrode switch 270 can connect and disconnect the biosensor 100, the strip type reading unit, and the body composition concentration reading unit.

The code information storage unit 260 may store preset information for reading code pattern information.

The control unit 230 can control the overall operation of the output unit, input unit, code information storage unit, code pattern information reading unit, strip type reading unit, and body composition concentration reading unit.

As described in FIG. 1, the output unit 240 may output measurement information under the control of the control unit based on the detection signal.

The input unit 250 may acquire an input signal input to the biosensor reading device and transmit the acquired input signal to the control unit.

Figure 3 Description

Figure 3 shows an example of a biosensor according to an embodiment of the present specification.

As shown in FIG. 3, the biosensor is composed of an upper insulating substrate 310 and a lower insulating substrate 320, and the strip reading electrode 313 printed on the front of the lower insulating substrate is the biosensor reading device of FIG. 2. The electrode switch 270 is connected to the ground terminal, and strip (biosensor) type information is read by the output signal output by the operation of each switch. In addition, the code electrode 321 of a certain shape printed on the back of the lower insulating substrate 320 reads the code pattern information of the biosensor.

The strip reading electrode 313 reads the strip type according to the shape of the pattern connected to the two virtual grounds (VG1, VG2) of the electrode switch 270 and then turns off the virtual ground to serve as a working electrode. , the body composition concentration signal of the strip is detected through a sensing unit consisting of a reference electrode, a counter electrode, and a trigger electrode.

Figure 4 Description

Figure 4 shows the electrode configuration of various types of biosensors according to an embodiment of the present specification.

As shown in FIG. 4, the biosensor can be coupled to a connector inside the biosensor reading device.

Here, the biosensor has a different shape depending on the type of biosensor, and the biosensor reading device can sense/recognize the type of biosensor at the connector (eg, strip type reading unit) of the biosensor reading device. Types of biosensors can be divided into blood sugar sensors, ketone sensors, hemoglobin sensors, lactic acid sensors, uric acid sensors, or cholesterol sensors.

The biosensor reading device can display the type of recognized biosensor on the output unit 240 (eg, a display).

Referring to FIG. 4, various types of biosensors 410, 420, 430, 440, 450, and 460 may include electrode configurations of different lengths/shapes for coupling to a biosensor reading device. For example, a biosensor may be composed of a plurality of electrodes (for example, 2 or more and 10 or less) in a zigzag shape. Accordingly, the connector of the biosensor reading device may include pins of different lengths/shapes that can contact the electrodes of the biosensor.

The terminal in contact with the biosensor consists of 6 measurement terminals and 4 code terminals. The number of terminals for measurement terminals and code terminals is not limited depending on the plurality of strip reading patterns.

Figure 5 Description

Figure 5 shows a circuit diagram for acquiring a detection signal from a biosensor according to an embodiment of the present specification.

Electrochemical analysis to obtain detection signals from biosensors can be classified as two-electrode or three-electrode depending on the electrode configuration. In the case of two electrodes, it consists of a working electrode and a counter electrode, and when voltage is applied between the working electrode and the counter electrode, current flows. As shown in Figure 5, the three electrodes consist of a working electrode, a counter electrode, and a reference electrode. In three electrodes, the difference in potential generated between the working electrode and the reference electrode is maintained at a constant voltage by the counter electrode.

Figures 6 and 7 Description

Figures 6 and 7 show contact areas of a strip reading electrode and a detection signal electrode according to an embodiment of the present specification.

As shown in FIG. 6, the strip reading electrode may include six or more measurement terminals. Here, the electrode for strip reading may include a working electrode, a reference electrode, a counter electrode, a trigger electrode, and two grounds (Ground1, Ground2).

Specifically, when performing strip reading (strip reading electrode), the VG1 (601) contact, VG2 (604) contact, P1 (603) contact, Q1 (602), and Q2 (605) contact can be used.

Additionally, when sensing a detection signal from a biosensor (sensing electrode), the detection signal can be sensed using only the P1 (603) contact, VG2 (604) contact, and Q2 (605) contact.

Here, the VG1 contact point can be defined as a virtual ground, the VG2 contact point (virtual ground) can be defined as a counter electrode, the P1 contact point can be defined as a working electrode, and the Q2 contact point can be defined as a trigger electrode.

As shown in FIG. 7 and Table 1 below, the biosensor reading device operates when the biosensor is coupled and the electrode switch operates so that each terminal of the strip reading electrode is connected as shown in 710 to 760 of FIG. 7. , the type of biosensor (biosensors 1 to 6) can be determined as shown in Table 1.

For example, as shown in Table 1 below, the VG1 (601) and P1 (603) terminals are connected (ON), the VG2 (604) terminal and the Q1 (602) terminal are disconnected (OFF), and the VG2 (604) terminal is connected (ON). When the and Q2 (605) terminals are connected, the biosensor reading device can determine that the type of biosensor connected is biosensor 1 (strip type 1).

As another example, among the strip reading electrodes, when the VG1 electrode and the P1 electrode are connected, the VG2 electrode and the Q1 electrode are connected, and the VG2 electrode and the Q2 electrode are connected, the biosensor reading device selects the type of biosensor as biosensor 2 (strip type). 2) can be judged.

As another example, when the VG1 electrode and the P1 electrode among the strip reading electrodes are connected, and the VG2 electrode and the Q1 electrode are connected, the biosensor reading device can determine the type of biosensor as biosensor 3 (strip type 3).

As another example, when the VG2 electrode and the Q2 electrode among the strip reading electrodes are connected, the biosensor reading device can determine the type of biosensor as biosensor 4 (strip type 4).

As another example, when the VG2 electrode and the Q1 electrode among the strip reading electrodes are connected, and the VG2 electrode and the Q2 electrode are connected, the biosensor reading device can determine the type of biosensor as biosensor 5 (strip type 5).

As another example, when the VG2 electrode and the Q1 electrode among the strip reading electrodes are connected, the biosensor reading device can determine the type of biosensor as biosensor 6 (strip type 6).

As shown in FIGS. 6 and 7 above, the control unit of the biosensor reading device controls the electrode switch to automatically recognize the type of biosensor according to the number of strip reading cases. The types of biosensors recognized in this way can be used as follows. First, it is possible to easily distinguish various types of biological substances such as blood sugar, ketones, hemoglobin, lactic acid, uric acid, cholesterol, creatine, hemoglobin, cancer, and DNA.

In this way, the strip information corresponding to the sensor configuration pattern formed in the biosensor is read by operating a plurality of switches connected between the reading electrode in contact with the sensor configuration pattern of the biosensor and the ground in a predetermined combination order. Sensor measuring devices can provide accurate strip measurement information.

In addition, since information on body fluid concentration can be simply provided using a biosensor with a sensor configuration pattern, the manufacturing cost of the biosensor can be reduced.

The terminal in contact with the biosensor consists of 6 measurement terminals and 4 code terminals. The number of measurement terminals and code terminals is not limited depending on the multiple strip reading pattern.

VG1-P1 VG2-Q1 VG2-Q2 Strip configuration information (One) ON OFF ON Biosensor 1 (2) ON ON ON biosensor 2 (3) ON ON OFF biosensor 3 (4) OFF OFF ON biosensor 4 (5) OFF ON ON biosensor 5 (6) OFF ON OFF Biosensor 6

If there is no output signal corresponding to the switch operation according to Table 1 above, the biosensor reading device outputs an error message through the output unit. In this way, the biosensor reading device operates a plurality of switches connected between the reading electrode in contact with the sensor configuration pattern of the biosensor and the ground in a predetermined combination order to create a strip corresponding to the sensor configuration pattern formed in the biosensor. By reading the information, the biosensor measuring device can provide accurate strip measurement information. Additionally, since information on body fluid concentration can be simply provided using a biosensor with a sensor configuration pattern, the manufacturing cost of the biosensor can be reduced.

Figure 8 Description

Figure 8 shows a circuit diagram of an electrode switch according to an embodiment of the present specification.

As shown in FIG. 8, after determining the type of strip, the control unit of the biosensor reading device controls the electrode switches 801 and 802 to measure body composition concentration, thereby separating VG1 and VG2 by switching off. And, the strip signal can be sensed using the electrodes of P1, VG2, and Q1 and Q2.

The biosensor reading device reads strip configuration information using the output signal output by the operation of each switch connected to the ground terminal.

How to interpret this specification

Although embodiments of the present invention have been described in more detail with reference to the accompanying drawings, the present invention is not necessarily limited to these embodiments, and may be modified and implemented in various ways without departing from the technical spirit of the present invention.

Accordingly, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but are for illustrative purposes, and the scope of the technical idea of the present invention is not limited by these embodiments. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive. The scope of protection of the present invention should be interpreted in accordance with the claims below, and all technical ideas within the equivalent scope should be construed as being included in the scope of rights of the present invention.

100: biosensor
200: Biosensor reading device

Claims (8)

An integrated strip type and c that senses the combination of biosensors, determines the type of the biosensor, and obtains a detection signal from the biosensor based on the type of the biosensor, and outputs measurement information based on the detection signal. A biosensor information reading device including an output unit and a plurality of biosensors with different electrode configurations.
Biosensor measurement system.
According to paragraph 1,
Further comprising an electrode switch,
The strip type reading unit and the body composition concentration reading unit are composed of an integrated connector with a plurality of recognition lines,
The electrode switch connects or disconnects at least some of the integrated connectors having a plurality of recognition lines,
Biosensor measurement system.
According to paragraph 2,
The electrode switch is,
When determining the type of biosensor,
Connecting the plurality of electrodes,
When obtaining a detection signal from the biosensor,
Two ground electrodes among the plurality of electrodes are switched off and separated, and the detection signal is acquired using the remaining electrode among the plurality of electrodes.
Biosensor measurement system.
According to paragraph 3,
The strip type reading unit,
Determining the type of the biosensor based on the connection relationship between the plurality of electrodes,
Biosensor measurement system.
In a method of reading biosensor information using a biosensor reading device,
Sensing the binding of the biosensor;
determining the type of the biosensor;
Obtaining a detection signal from the biosensor based on the type of the biosensor; and
Including outputting measurement information based on the detection signal,
method.
According to clause 5,
The biosensor reading device includes an electrode switch and a plurality of electrodes for determining the type of the biosensor and acquiring the detection signal,
Comprising the step of controlling the electrode switch to connect or disconnect at least some of the plurality of electrodes,
method.
According to clause 6,
Connecting the plurality of electrodes when determining the type of the biosensor by controlling the electrode switch, and
When acquiring a detection signal from the biosensor, switching off two ground electrodes of the plurality of electrodes to separate them, and using the remaining electrode of the plurality of electrodes to obtain the detection signal. ,
method.
In clause 7,
Comprising the step of determining the type of the biosensor based on the connection relationship between the plurality of electrodes,
method.

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