KR20230116504A - Anti-aging composition containing soybean peptide - Google Patents

Abstract

Disclosed herein is an anti-aging composition comprising soy peptide. More specifically, disclosed herein are a cosmetic composition for moisturizing or strengthening the skin barrier containing soy peptide as an active ingredient and a food composition for moisturizing or strengthening the skin barrier containing soy peptide as an active ingredient. The soy peptide provides the effect of promoting the expression of aquaporin-3 and/or involucrin.

Description

Anti-aging composition containing soybean peptide {ANTI-AGING COMPOSITION CONTAINING SOYBEAN PEPTIDE}

The present disclosure discloses an antiaging composition comprising soybean peptides.

The skin protects internal organs from external environmental stimuli and plays an important role in maintaining body homeostasis such as regulating body temperature. Such skin aging occurs due to various internal/external factors, and aging is largely divided into endogenous aging due to genetic causes and extrinsic aging caused by environmental causes. In particular, ultraviolet rays reduce the amount of hyaluronic acid to reduce the water content in the skin and increase the amount of transepidermal water loss, causing damage to the skin barrier. As a result, the skin becomes rough and elasticity is reduced, resulting in wrinkles. In other words, the loss of moisturizing power of the skin is a major cause of skin aging.

Stratum corneum, which is the outermost layer of the epidermis, is formed from keratinocytes and is composed of fully differentiated keratinocytes and a lipid layer surrounding them. Keratinocytes are characteristic cells in which basal cells continuously proliferating in the lowermost layer of the epidermis go through morphological and functional changes step by step and rise to the skin surface. After a certain period of time, old keratinocytes are eliminated from the skin and new keratinocytes take their place, and this repetitive series of changes is called "differentiation of epidermal cells" or "keratinization". During the keratinization process, keratinocytes form the stratum corneum while producing natural moisturizing factor (NMF) and intercellular lipids (ceramide, cholesterol, fatty acids) to make the stratum corneum firm and flexible, thereby providing a skin barrier. to retain its function as When the stratum corneum becomes thin and weak, structures that are tightly coupled, such as bricks and cement, become loose and gaps are formed.

KR 10-1504908 B1

In one aspect, an object of the present disclosure is to provide a cosmetic composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

In another aspect, an object of the present disclosure is to provide a food composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

In another aspect, an object of the present disclosure is to provide a pharmaceutical composition for preventing or treating atopic dermatitis comprising soybean peptide as an active ingredient.

In one aspect, the present disclosure provides a cosmetic composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin.

In one exemplary embodiment, the cosmetic composition may contain soybean peptides at a concentration of 1 ppm or more.

In another aspect, the present disclosure provides a food composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin.

In an exemplary embodiment, the food composition may contain soybean peptides at a concentration of 1 ppm or more.

In another aspect, the present disclosure provides a pharmaceutical composition for preventing or treating atopic dermatitis comprising soybean peptide as an active ingredient.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin.

In an exemplary embodiment, the pharmaceutical composition may contain soybean peptide at a concentration of 1 ppm or more.

In one aspect, the technology disclosed in the present disclosure has the effect of providing a cosmetic composition for moisturizing or skin barrier enhancement containing soybean peptide as an active ingredient.

In another aspect, the technology disclosed in the present disclosure has the effect of providing a food composition for moisturizing or skin barrier strengthening containing soybean peptide as an active ingredient.

In another aspect, the technology disclosed in the present disclosure has an effect of providing a pharmaceutical composition for preventing or treating atopic dermatitis comprising soybean peptide as an active ingredient.

1 shows a soybean peptide manufacturing process diagram according to an embodiment.
Figure 2 shows the results of evaluating the moisturizing effect of soybean peptides according to an experimental example.
Figure 3 shows the results of evaluating the skin barrier strengthening efficacy of soybean peptides according to one experimental example.

Hereinafter, the present disclosure will be described in detail.

In one aspect, the present disclosure provides a cosmetic composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

The soybean peptide herein is a protein degradation product produced by hydrolysis from soybean protein, and can be obtained by hydrolyzing the protein contained in soybean using a protease, which is a hydrolase, and ultrafiltering it. For example, the soybean protein may have a protein content of 90% or more, 95% or more, or 99% or more. In addition, the ultrafiltration may be performed using a membrane having a molecular weight cutoff of 10,000 Daltons.

As used herein, the active ingredient refers to a component that can exhibit the desired activity alone or together with a carrier having no activity itself.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less. In another exemplary embodiment, the soybean peptide may have passed through an ultrafiltration membrane having a molecular weight cutoff of 10,000 Daltons.

In another exemplary embodiment, the soybean peptide is 100 daltons or more, 1,000 daltons or more, or 5,000 daltons or more, and 10,000 daltons or less, 9,000 daltons or less, 8,000 daltons or less, 7,000 daltons or less, 6,000 daltons or less, 5,000 daltons or less, 4,000 daltons or less. It may have a molecular weight that is less than daltons, less than 3,000 daltons, or less than 2,000 daltons. Preferably, the soybean peptide may have a molecular weight of 100 to 5,000 Daltons or 100 to 3,000 Daltons.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may be obtained by decomposing soybean protein with Alcalase.

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin in a subject in which the expression of aquaporin-3 and/or involucrin is inhibited.

In one exemplary embodiment, the cosmetic composition may contain soybean peptides at a concentration of 1 ppm or more.

In an exemplary embodiment, the cosmetic composition may further include functional additives and components included in general cosmetic compositions in addition to the active ingredient according to the present disclosure. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extracts. Ingredients other than those included include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation accelerators, cooling agents, antiperspirants, purified water and the like.

The formulation of the cosmetic composition is not particularly limited, and may be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, foundation, essence, nutrient essence, pack, soap, cleansing It may be prepared in any one or more formulations selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion and body cleanser, but is not limited thereto.

In an exemplary embodiment, when the formulation of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc as a carrier component Alternatively, zinc oxide or the like may be used.

In an exemplary embodiment, when the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additionally propellants such as chlorofluorohydrocarbons, propane/butane or dimethyl ether.

In an exemplary embodiment, when the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

In an exemplary embodiment, when the formulation of the present invention is a suspension, water, a liquid diluent such as ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester and The same suspending agent, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

In an exemplary embodiment, when the formulation of the present invention is a surfactant-containing cleansing agent, fatty alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, and methyl taurate as carrier components , sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters.

In another aspect, the present disclosure provides a food composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less. In another exemplary embodiment, the soybean peptide may have passed through an ultrafiltration membrane having a molecular weight cutoff of 10,000 Daltons.

In another exemplary embodiment, the soybean peptide is 100 daltons or more, 1,000 daltons or more, or 5,000 daltons or more, and 10,000 daltons or less, 9,000 daltons or less, 8,000 daltons or less, 7,000 daltons or less, 6,000 daltons or less, 5,000 daltons or less, 4,000 daltons or less. It may have a molecular weight that is less than daltons, less than 3,000 daltons, or less than 2,000 daltons. Preferably, the soybean peptide may have a molecular weight of 100 to 5,000 Daltons or 100 to 3,000 Daltons.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may be obtained by decomposing soybean protein with Alcalase.

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin in a subject in which the expression of aquaporin-3 and/or involucrin is inhibited.

In an exemplary embodiment, the food composition may contain soybean peptides at a concentration of 1 ppm or more.

In an exemplary embodiment, the food composition may be preferably administered at 0.001 g / kg / 1 day or more to a subject in need of moisturizing or strengthening the skin barrier of soybean peptide.

In an exemplary embodiment, the food composition may be a liquid or solid formulation, for example, various foods, beverages, gum, tea, vitamin complexes, health supplements, health functional foods, etc., powders, It can be prepared in the form of granules, tablets, capsules or beverages. The food composition of each formulation can be selected and blended without difficulty by a person skilled in the art according to the formulation or purpose of use other than the active ingredient, and synergistic effects can occur when applied simultaneously with other ingredients.

In an exemplary embodiment, the food composition may include various flavoring agents or natural carbohydrates as additional ingredients, as in conventional beverages, as liquid ingredients that may be contained in addition to active ingredients, but there are no particular restrictions on the liquid ingredients. There is not. Examples of the natural carbohydrate include monosaccharides, disaccharides such as glucose and fructose, polysaccharides such as maltose and sucrose, common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. etc. As the flavoring agent, natural flavoring agents (thaumatin, stevia extract (eg rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (eg saccharin, aspartame, etc.) can be advantageously used. The proportion of the natural carbohydrate may generally be about 1 to 20 g, and in one aspect about 5 to 12 g per 100 ml of the composition disclosed in the present disclosure.

In an exemplary embodiment, the food composition in one aspect includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, Organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, and the like may be included. In another aspect, it may further include fruit flesh for preparing natural fruit juice and vegetable beverages. These components may be used independently or in combination. The proportions of these additives may vary, but may be selected in the range of 0.001 to 20 parts by weight per 100 parts by weight of the composition disclosed in this disclosure.

In another aspect, the present disclosure provides a pharmaceutical composition for preventing or treating atopic dermatitis comprising soybean peptide as an active ingredient.

In an exemplary embodiment, the soybean peptide may have a molecular weight of 10,000 Daltons or less. In another exemplary embodiment, the soybean peptide may have passed through an ultrafiltration membrane having a molecular weight cutoff of 10,000 Daltons.

In another exemplary embodiment, the soybean peptide is 100 daltons or more, 1,000 daltons or more, or 5,000 daltons or more, and 10,000 daltons or less, 9,000 daltons or less, 8,000 daltons or less, 7,000 daltons or less, 6,000 daltons or less, 5,000 daltons or less, 4,000 daltons or less. It may have a molecular weight that is less than daltons, less than 3,000 daltons, or less than 2,000 daltons. Preferably, the soybean peptide may have a molecular weight of 100 to 5,000 Daltons or 100 to 3,000 Daltons.

In an exemplary embodiment, the soybean peptide is obtained by digesting soybean protein with one or more hydrolases of Alcalase, Flavorzyme, Neutrase and Protamax. it could be

In an exemplary embodiment, the soybean peptide may be obtained by decomposing soybean protein with Alcalase.

In an exemplary embodiment, the soybean peptide may promote the expression of aquaporin-3 and/or involucrin in a subject in which the expression of aquaporin-3 and/or involucrin is inhibited.

In an exemplary embodiment, the pharmaceutical composition may contain soybean peptide at a concentration of 1 ppm or more.

In an exemplary embodiment, the pharmaceutical composition may be preferably administered at 0.001 g/kg/day or more of soybean peptide to a subject in need of prevention or treatment of atopic dermatitis.

Hereinafter, the present disclosure will be described in more detail through examples. These examples are only for exemplifying the present disclosure, and it will be apparent to those skilled in the art that the scope of the present disclosure is not to be construed as being limited by these examples.

Example 1. Soybean Peptide Preparation

10 L of water was added to 2 kg of the isolated soybean protein dry matter, mixed well, and 20 mL of Alcalase was added as a hydrolase, followed by reaction at 60 °C for 12 hours. After the first sterilization and cooling process, the supernatant was obtained by centrifugation at 3,000 rpm for 30 minutes, and then, after the second sterilization and cooling process, the supernatant was filtered through a 0.45 μm filter to remove insoluble substances. As an ultrafiltration membrane, a MWCO (Molecular Weight Cut Off) 10,000 Dalton filtration membrane was installed, and the filtrate obtained by passing it was recovered, followed by tertiary sterilization and cooling. Then, the filtrate was spray-dried to obtain soybean peptide powder.

Experimental Example 1. Moisturizing efficacy evaluation

In order to confirm the effect of the soybean peptide prepared in the above example on the expression of Aquaporin-3 (AQP3), a moisturizing-related factor, HaCaT cells were dispensed in a 6-well plate at 1×10 ⁶ cells/well and after 24 hours, soybean Peptides were treated at concentrations of 0.01 to 1 μg/ml. After 24 hours, RNA was extracted from the cells using RNA iso plus, and cDNA was synthesized using SuperScript II Reverse transcription kit. PCR was performed using a Kapa Taq PCR kit according to the manufacturer's manual. PCR was carried out 35 cycles at a denaturation temperature of 95 °C, annealing temperature of 57.5 °C, and elongation temperature of 74 °C.

Aquaporin -3 primer sequences

Forward primer: 5'-GGTTGATGGTGAGGAAACCA-3'

Reverse primer: 5'-GGGACCCTCATCCTGGTG-3'

As a result, as shown in FIG. 2, the soybean peptide tended to increase the expression of aquaporin-3, a skin moisturizing-related factor, in a concentration-dependent manner. In particular, at a concentration of 1 μg/ml (ie, 1 ppm), the expression level of aquaporin-3 was significantly increased compared to the control group not treated with the soybean peptide. Accordingly, it was confirmed that the soybean peptide has an effect on skin moisturizing.

Experimental example 2. Evaluation of skin barrier strengthening efficacy

In order to confirm the effect of the soybean peptide prepared in the above example on the expression of Involucrin (INV), a skin barrier-related factor, HaCaT cells were dispensed in a 6-well plate at 1×10 ⁶ cells/well, and after 24 hours, soybean peptide was treated at a concentration of 0.01 to 1 μg/ml. After 24 hours, RNA was extracted from the cells using RNA iso plus, and cDNA was synthesized using SuperScript II Reverse transcription kit. PCR was performed using a Kapa Taq PCR kit according to the manufacturer's manual. PCR was carried out 40 cycles at a denaturation temperature of 95 °C, annealing temperature of 60 °C, and elongation temperature of 75 °C.

Involucrin primer sequences

Forward primer: 5'- TGCCTGAGCAAGAATGTGAG-3'

Reverse primer: 5'-AGCTGCTGATCCCTTTGTGT-3'

As a result, as shown in FIG. 3, the soybean peptide tended to increase the expression of involucrin, a skin barrier-related factor, in a concentration-dependent manner. In particular, at a concentration of 1 μg/ml (ie, 1 ppm), the amount of involucrin expression was significantly increased compared to the control group not treated with the soybean peptide. Accordingly, it was confirmed that the soybean peptide was effective in strengthening the skin barrier.

Formulation examples of the composition according to one aspect of the present disclosure will be described below, but can also be applied to various other formulations, which are only intended to be specifically described, not intended to limit the present disclosure.

Formulation example 1. Softening lotion

0.01% by weight of soybean peptide, 3% by weight of glycerin, 2% by weight of butylene glycol, 2% by weight of propylene glycol, 0.1% by weight of carboxyvinyl polymer, 1% by weight of ethanol, 0.1% by weight of triethanolamine and the remaining amount of purified water, trace amounts of preservatives, trace amounts It was prepared according to a conventional softening lotion manufacturing method by mixing a colorant and a small amount of perfume.

Formulation example 2. Nutrient lotion

Soybean peptide 0.01% by weight, beeswax 4% by weight, polysorbate 60 1.5% by weight, sorbitan sesquioleate 0.5% by weight, liquid paraffin 5% by weight, squalane 5% by weight, caprylic / capric triglyceride 5% by weight , 3% by weight of glycerin, 3% by weight of butylene glycol, 3% by weight of propylene glycol, 0.1% by weight of carboxyvinyl polymer, 0.2% by weight of triethanolamine, the remaining amount of purified water, trace amounts of preservatives, trace amounts of colorants, and trace amounts of flavorings were mixed to obtain normal nutrients. It was prepared according to the lotion manufacturing method.

Formulation example 3. Nutritional cream

Soybean peptide 0.01% by weight, beeswax 10% by weight, polysorbate 60 1.5% by weight, sorbitan sesquioleate 0.5% by weight, liquid paraffin 10% by weight, squalane 5% by weight, caprylic / capric triglyceride 5% by weight , 5% by weight of glycerin, 3% by weight of butylene glycol, 3% by weight of propylene glycol, 0.2% by weight of triethanolamine, and the remaining amount of purified water, trace amounts of preservatives, trace amounts of pigments, and trace amounts of spices were mixed and prepared according to a conventional nutritional cream manufacturing method. .

Formulation Example 4. Pack

Soybean peptide 0.01% by weight, polyvinyl alcohol 13% by weight, sodium carboxymethylcellulose 0.2% by weight, allantoin 0.1% by weight, ethanol 5% by weight, nonylphenyl ether 0.3% by weight and the remaining amount of purified water, trace preservatives, trace coloring matter, trace flavoring It was prepared according to a conventional pack manufacturing method by mixing.

formulation example 5. Drinks

150 mg of soybean peptide, 10 g of glucose, 50 mg of red ginseng extract, 2 g of citric acid, and 187.8 g of purified water were mixed and filled into a bottle. The final volume of the content was 200 ml.

Formulation Example 6. Manufacture of health food

Soybean Peptide ................................... 1000 mg

vitamin mixture

Vitamin A Acetate .................70 μg

Vitamin E ................................. 1.0 mg

Vitamin B1 ................................. 0.13 mg

Vitamin B2 ................................... 0.15 mg

Vitamin B6 ................................. 0.5 mg

Vitamin B12........................... 0.2 μg

Vitamin C ................................. 10 mg

Biotin ................................................ 10 μg

Nicotinamide ................................. 1.7 mg

Folic acid ................................. 50 μg

Calcium Pantothenate ................... 0.5 mg

mineral mixture

Ferrous Sulphate ................................. 1.75 mg

Zinc Oxide ................................. 0.82 mg

Magnesium Carbonate ........................... 25.3 mg

Potassium Phosphate Monobasic ................................. 15 mg

Dibasic Calcium Phosphate ................... 55 mg

Potassium Citrate ................................... 90 mg

Calcium Carbonate ................................. 100 mg

Magnesium Chloride ................... 24.8 mg

Although the composition ratio of the above vitamin and mineral mixture was prepared by mixing ingredients suitable for relatively healthy food in a preferred embodiment, the mixing ratio may be arbitrarily modified. Granules are prepared and can be used for preparing health food compositions according to conventional methods.

formulation example 7. Manufacture of health drinks

Soybean Peptides........... .. .. ............ 1000 mg

Citric acid ................................. 1000 mg

Oligosaccharides ................................ 100 g

Plum concentrate ................................. 2 g

Taurine ................................................ 1 g

Add purified water to make the total ............ 900 ml

After mixing the above ingredients according to the usual health drink manufacturing method, stirring and heating at 85 ° C. for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2-liter container, sealed and sterilized, and then refrigerated. It was used for preparing a health drink composition according to the method.

Although the composition ratio is a mixture of ingredients suitable for a relatively favorite beverage in a preferred embodiment, the mixing ratio may be arbitrarily modified according to regional and ethnic preferences such as the class of demand, the country of demand, and the purpose of use. Those skilled in the art to which the present invention pertains will be able to make various applications and modifications within the scope of the present invention based on the above information.

In the above, specific parts of the present disclosure have been described in detail, and for those skilled in the art, it is clear that these specific descriptions are only preferred embodiments, and the scope of the present disclosure is not limited thereby. something to do. Accordingly, the substantial scope of the disclosure will be defined by the appended claims and their equivalents.

Claims (15)

A cosmetic composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.
According to claim 1,
The soybean peptide has a molecular weight of 10,000 Daltons or less, a cosmetic composition for moisturizing or skin barrier enhancement.
According to claim 1,
The soybean peptide is obtained by decomposing soybean protein with at least one hydrolase of Alcalase, Flavourzyme, Neutrase and Protamax, moisturizing or skin barrier A cosmetic composition for strengthening.
According to claim 1,
The soybean peptide promotes the expression of aquaporin-3 and / or involucrin in a subject in which the expression of aquaporin-3 and / or involucrin is inhibited, a cosmetic composition for moisturizing or strengthening the skin barrier.
According to claim 1,
The cosmetic composition is a cosmetic composition for moisturizing or strengthening the skin barrier, comprising a soybean peptide at a concentration of 1 ppm or more.
A food composition for moisturizing or skin barrier enhancement comprising soybean peptide as an active ingredient.
According to claim 6,
The soybean peptide has a molecular weight of 10,000 Daltons or less, a food composition for moisturizing or skin barrier enhancement.
According to claim 6,
The soybean peptide is obtained by decomposing soybean protein with at least one hydrolase of Alcalase, Flavourzyme, Neutrase and Protamax, moisturizing or skin barrier Food composition for fortification.
According to claim 6,
The soybean peptide promotes the expression of aquaporin-3 and / or involucrin in a target in which the expression of aquaporin-3 and / or involucrin is inhibited, a food composition for moisturizing or strengthening the skin barrier.
According to claim 6,
The food composition is a food composition for moisturizing or strengthening the skin barrier, wherein the soybean peptide is administered at 0.001 g / kg / 1 day or more to a subject in need of moisturizing or skin barrier strengthening.
A pharmaceutical composition for preventing or treating atopic dermatitis comprising soybean peptide as an active ingredient.
According to claim 11,
The soybean peptide has a molecular weight of 10,000 Daltons or less, a pharmaceutical composition for preventing or treating atopic dermatitis.
According to claim 11,
The soybean peptide is obtained by decomposing soybean protein with at least one hydrolase of Alcalase, Flavourzyme, Neutrase and Protamax. Prevention of atopic dermatitis or a pharmaceutical composition for treatment.
According to claim 11,
The soybean peptide promotes the expression of aquaporin-3 and / or involucrin in a target in which the expression of aquaporin-3 and / or involucrin is inhibited, a pharmaceutical composition for preventing or treating atopic dermatitis.
According to claim 11,
The pharmaceutical composition is a pharmaceutical composition for the prevention or treatment of atopic dermatitis, wherein the soybean peptide is administered to a subject in need of prevention or treatment of atopic dermatitis at 0.001 g / kg / day or more.