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KR20220160733A - Hydrogel contact lenses with excellent durability, humidity and improved commerciality - Google Patents

Hydrogel contact lenses with excellent durability, humidity and improved commerciality Download PDF

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KR20220160733A
KR20220160733A KR1020210068742A KR20210068742A KR20220160733A KR 20220160733 A KR20220160733 A KR 20220160733A KR 1020210068742 A KR1020210068742 A KR 1020210068742A KR 20210068742 A KR20210068742 A KR 20210068742A KR 20220160733 A KR20220160733 A KR 20220160733A
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contact lens
hydrogel contact
wettability
isocyanate
durability
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김영일
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    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • C08F218/08—Vinyl acetate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F226/10—N-Vinyl-pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • C08F230/08—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Eyeglasses (AREA)

Abstract

The present invention relates to a high-quality contact lens molded from a hydrogel contact lens material having excellent durability and hydrophilic properties and increased compatibility, and more specifically, a hydrogel contact lens with excellent durability and hydrophilic properties and increased compatibility, wherein a functional monomer selected from an isocyanate group is mixed with a material based on a hydrophilic contact lens material such as 2-hydroxyethyl methacrylate (HEMA) and 2-hydroxy propyl methacrylate (HPMA) used as polymers to increase durability and a hydrophilic monomer selected from a VP group is used to complete the composition, such that a hydrogel contact lens material with high strength and hydrophilic properties and increasing compatibility with other monomers and is molded by being injected into a casting mold, thereby manufacturing high-quality contact lenses.

Description

내구성과 습윤성이 양호하고 상용성이 향상되는 하이드로겔 콘택트렌즈{Hydrogel contact lenses with excellent durability, humidity and improved commerciality}Hydrogel contact lenses with excellent durability, humidity and improved commerciality {Hydrogel contact lenses with excellent durability, humidity and improved commerciality}

본 발명은 내구성과 습윤성이 양호하고 상용성이 향상되는 하이드로겔 콘택트렌즈 재료로 성형되는 고품질 콘택트렌즈에 관한 것으로 보다 구체적인 것은, 고분자로 사용되는 HEMA(2-Hydroxyethyl methacrylate), HPMA(2-hydroxy Popyl methacrylate)와 같은 친수성 콘택트렌즈 재료를 기본물질로 하는 재료에 이소시아네이트(isocyanate) group에서 선택된 기능성 모노머를 혼합하여 내구성을 향상시키고, VP group에서 선택한 습윤성 모노머를 사용하여 조성물을 완성함으로써, 다른 모노머와 상용성이 향상되는 고강도 및 고습윤성의 하이드로겔 콘택트렌즈 재료를 조성하고, 이를 주형 몰드에 주입하여 성형함으로써, 고품질의 콘택트렌즈를 만들 수 있게 한 것이다.The present invention relates to a high-quality contact lens molded from a hydrogel contact lens material having good durability and wettability and improved compatibility, and more specifically, HEMA (2-Hydroxyethyl methacrylate) and HPMA (2-hydroxy Popyl methacrylate) by mixing a functional monomer selected from the isocyanate group with a material based on a hydrophilic contact lens material such as methacrylate) to improve durability, and by using a wettable monomer selected from the VP group to complete the composition, it is compatible with other monomers. It is possible to make a high-quality contact lens by composing a high-strength and high-wetting hydrogel contact lens material with improved properties, and injecting and molding it into a casting mold.

또한, 본 발명은 상용성이 좋은 소재를 사용하여 얇은 두께를 유지하면서 동시에 내구성과 습윤성이 향상되어 다른 제품과의 차별성이 확립되는 콘택트렌즈에 관한 것이다.In addition, the present invention relates to a contact lens that is differentiated from other products by maintaining a thin thickness by using a material with good compatibility and improving durability and wettability at the same time.

일반적으로 콘택트렌즈는 크게 메틸메타크릴레이트를 기본 물질로 하는 하드렌즈와, 2-하이드록시 에틸메타크릴레이트(HEMA)를 기본 물질로 하는 소프트렌즈로 구분되는데, 산소투과도와 함수율이 상대적으로 우수한 소프트렌즈의 사용이 확대되고 있으며, 이에 HEMA가 선택되고 있다.In general, contact lenses are largely divided into hard lenses based on methyl methacrylate and soft lenses based on 2-hydroxyethyl methacrylate (HEMA). The use of lenses is expanding, and HEMA is being chosen.

이는 HEMA에는 MMA와 달리 단량체내에 대표적인 친수성 분자구조인 히드록시기가 있어 함수율이 높기 때문이다.This is because HEMA, unlike MMA, has a hydroxyl group, which is a representative hydrophilic molecular structure, in the monomer and has a high water content.

따라서 콘택트렌즈에 사용하는 하이드로겔은 대부분 2-아이드록시 에틸메타 크릴레이트(2-Hydroxyethyl methacrylate)(HEMA) 를 단량체로 하고, 소량의 가교제와 혼용하여 제조되는 것이 현실이다.Therefore, it is a reality that most hydrogels used in contact lenses are prepared by using 2-hydroxyethyl methacrylate (HEMA) as a monomer and mixing it with a small amount of a crosslinking agent.

이와 같은 기술은 HEMA를 기반으로 하는 재료가 친수성이 높고 표면이 부드러워 각막에 부착되어 착용시에 이물감이 작고 각막에 대한 압박이 적어 편안한 감이 있기 때문이며, 어느정도 산소투과성도 있기 때문이다.This technology is because the HEMA-based material has a high hydrophilicity and a soft surface, so it is attached to the cornea, so there is little foreign body feeling when worn, and there is little pressure on the cornea, so it feels comfortable and has some oxygen permeability.

그러나 HEMA를 기반으로 하는 중합물은 내구성이 약한 문제가 있고, 또한 실리콘 하이드로겔 재료는 이질적인 특성을 갖는 실리콘과 하이드로겔 단량체의 조합으로 이루어지므로 적절한 배합기술이 요구되는 문제가 있다.However, polymers based on HEMA have a problem of poor durability, and since silicone hydrogel materials are made of a combination of silicone and hydrogel monomers having heterogeneous properties, there is a problem in that proper mixing technology is required.

또 다른 종래의 기술로서 특허 제10-1817883호로 등록된 상온 중합법에 의한 하이드로겔 콘택트렌즈 제조방법이 개시되어 있다.As another conventional technique, a method for manufacturing a hydrogel contact lens by room temperature polymerization method registered as Patent No. 10-1817883 is disclosed.

상기 방법은 2-Hydroxyethyl methacrylate(HEMA), 계면활성제, 교차결합제, 개시제, 초순수를 용기에 넣고 혼합하는 1단계; 질소버블링하고, 균질기를 이용하여 용액을 균질화하여 단량체 혼합물을 제조하는 2단계; 상기 단량체 혼합물에 개시제의 촉매제를 넣고 캐스트몰드에 주입하여 상온에서 방치하여 콘택트렌즈를 제조하는 3단계; 상기 콘택트렌즈를 캐스트몰드에서 꺼내어 초순수로 미반응된 물질을 제거하며, 수화과정을 거치는 4단계; 로 이루어지는 하이드로겔 콘택트렌즈를 제조하여 자외선이나 열처리과정 없이 중합을 가능하게 하여 생산공정을 단축시키고, 하이드로겔 콘택트렌즈의 습윤성 산소투과 및 투광도를 향상시키고, 단백질 흡착이 감소하는 효과를 도모 하고 있다.The method includes a first step of mixing 2-Hydroxyethyl methacrylate (HEMA), a surfactant, a crosslinking agent, an initiator, and ultrapure water in a container; A second step of preparing a monomer mixture by bubbling with nitrogen and homogenizing the solution using a homogenizer; Step 3 of preparing a contact lens by adding an initiator catalyst to the monomer mixture and injecting it into a cast mold and leaving it at room temperature; Step 4 of taking the contact lens out of the cast mold, removing unreacted substances with ultrapure water, and undergoing a hydration process; By manufacturing a hydrogel contact lens composed of, it is possible to polymerize without ultraviolet rays or heat treatment, thereby shortening the production process, improving wet oxygen transmission and light transmittance of the hydrogel contact lens, and reducing protein adsorption.

그럼에도 불구하고 HEMA를 기반으로 하는 하이드로겔 렌즈는 내구성이 약하므로 착용감을 개선시키고, 산소투과율을 높이기 위해 렌즈의 두께를 얇게 할 경우 내구성이 취약해 지는 문제가 있다.Nevertheless, HEMA-based hydrogel lenses have poor durability, so when the thickness of the lens is thinned to improve wearing comfort and increase oxygen permeability, there is a problem in that durability becomes weak.

(1) 선행기술 특허등록 제 10-1231181호(1) Prior art patent registration No. 10-1231181 (2) 선행기술 특허등록 제 10-1817883호(2) Prior art patent registration No. 10-1817883

본 발명은 상기 불편을 개선하기 위해 개발된 것이다.The present invention was developed to improve the above inconvenience.

본 발명은 고분자로 사용되는 HEMA, HPMA에 계면활성제, 결합제, 개시제를 혼합하는 하이드로겔 콘택트렌즈 제조용 재료에 이소시아네이트계 기능성 모노머를 사용하여 내구성을 높이고 VP group에서 선택되는 습윤성 모노머를 사용하여 습윤성을 향상시켜 다른 모노머와 상용성이 향상되고 고강도 및 고습윤성을 가지는 하이드로겔 콘택트렌즈 재료를 조성하여 콘택트렌즈를 제조한다.The present invention increases durability by using an isocyanate-based functional monomer for a material for manufacturing a hydrogel contact lens in which a surfactant, binder, and initiator are mixed with HEMA and HPMA used as polymers, and wettability is improved by using a wettable monomer selected from the VP group to prepare a contact lens by forming a hydrogel contact lens material having improved compatibility with other monomers and high strength and high wettability.

구체적으로 본 발명은 고분자로 사용되는 HEMA, HPMA에 MMA EDGMA TEGDMA를 일정비율로 혼합하고, 상기 혼합물에 Specifically, the present invention mixes MMA EDGMA TEGDMA with HEMA and HPMA used as polymers in a certain ratio, and in the mixture

2-I socyanato ethyl methacrylate,2-I socyanato ethyl methacrylate,

3-(TriethoxySilyl) propyl isocyanate3-(TriethoxySilyl)propyl isocyanate

Hexamethylene diisocyanateHexamethylene diisocyanate

isocyanate 중에서 선택한 이소시아네이트계 기능성 모노머를 일정비율로 혼합하고, PVP, PVA, PEGMEMA 와 같은 VP group 중에서 선택한 습윤성 모노머를 일정비율로 혼합함으로써, 다른 모노머와 상용성이 향상되고, 고강도 및 고습성을 가지는 하이드로겔 콘택트렌즈 재료를 조정하고, 이를 콘택트렌즈 제조용 몰드에 주입하여 렌즈를 제조함으로써, 얇은 두께를 유지하면서 내구성과 습윤성이 향상된 고품질의 콘택트렌즈를 제조하게 된다.By mixing isocyanate-based functional monomers selected from isocyanate at a certain ratio and mixing wettable monomers selected from the VP group such as PVP, PVA, and PEGMEMA at a certain ratio, compatibility with other monomers is improved, and hydro with high strength and high moisture By adjusting the gel contact lens material and injecting it into a mold for manufacturing a contact lens to manufacture a lens, a high-quality contact lens with improved durability and wettability while maintaining a thin thickness is manufactured.

상기에서 이소시아네이트계 기능성 모노머와 VP계 습윤성 모노머는 총량에 대하여 1∼15중량%를 사용할수 있으나, 1∼5중량%로 사용하는 것이 바람직하고 EDGMA첨가제는 0.1∼0.3중량%로 사용하는 것이 바람직하다.In the above, the isocyanate-based functional monomer and the VP-based wettable monomer may be used in an amount of 1 to 15% by weight based on the total amount, but it is preferable to use 1 to 5% by weight, and the EDGMA additive is preferably used in an amount of 0.1 to 0.3% by weight. .

이와 같이 된 본 발명은 하이드로겔 콘택트렌즈 재료에 이소시아네이트계 모노머를 혼합함으로써, 하이드로겔 재료인 HEMA, 또는 HPMA에 굴절율과 인장강도 향상으로 내구성을 개선할 수 있고, VP계 모노머를 혼합함으로써, 고강도와 고습윤성을 높힐 수 있어 고품질의 콘택트렌즈 제조용 재료를 제조할 수 있게 된다.Thus, the present invention can improve the durability by improving the refractive index and tensile strength of the hydrogel material HEMA or HPMA by mixing the isocyanate-based monomer with the hydrogel contact lens material, and by mixing the VP-based monomer, the high strength and High wettability can be increased, making it possible to manufacture a high-quality contact lens manufacturing material.

한편, 본 발명은 콘택트렌즈 제조용 재료는 기능성에 최적화됨에 따라 이에 상응하는 몰드를 사용함으로써, 보다 기능이 향상되면서 두께가 얇은 제품을 만들 수 있고, 얇으면서 내구성이 있고, 습윤성이 양호하여 산소투과 기능이 높은 콘택트렌즈 생산이 가능케 되는 이점을 얻을 수 있다.On the other hand, according to the present invention, as the material for manufacturing contact lenses is optimized for functionality, by using a corresponding mold, a product with improved functionality and a thin thickness can be made, and it is thin, durable, and has good wettability, so it has an oxygen transmission function. The advantage of enabling the production of this high quality contact lens can be obtained.

도 1은 본 발명의 콘택트렌즈 주형몰드 단면도
도 2는 도 1의 분리상태 단면도이다.1 is a cross-sectional view of the contact lens casting mold of the present invention
Figure 2 is a cross-sectional view of the separated state of Figure 1;

본 발명은 고분자로 사용되는 HEMA, HPMA와 같은 친수성콘택트렌즈 재료에 MMA, TEGDMA, EGDMA를 혼합하고, 상기 혼합물에 내구성 향상을 위해 선택된 이소시아네이트계 기능성 모노머를 혼합하고, 습윤성 향상과 상용성 향상을 위해 선택된 VP group계의 습윤성 모노머를 혼합함으로써, 다른 모노머와 상용성이 향상되고 고강도 및 고습윤성을 가지는 하이드로겔 콘택트렌즈 재료를 조성하고, 이를 콘택트렌즈 제조용 몰드에 주입하여 콘택트렌즈를 제조한다.In the present invention, MMA, TEGDMA, and EGDMA are mixed with hydrophilic contact lens materials such as HEMA and HPMA used as polymers, and isocyanate-based functional monomers selected to improve durability are mixed with the mixture, and to improve wettability and compatibility. By mixing the selected VP group-based wettable monomer, a hydrogel contact lens material having improved compatibility with other monomers and high strength and high wettability is formed, and the contact lens is manufactured by injecting it into a contact lens manufacturing mold.

구체적으로 본 발명은 고분자로 사용되는 HEMA, HPMA에 MMA EDGMA TEGDMA를 일정비율로 혼합하고, 상기 혼합물에Specifically, the present invention mixes MMA EDGMA TEGDMA with HEMA and HPMA used as polymers in a certain ratio, and in the mixture

2-I socyanato ethyl methacrylate,2-I socyanato ethyl methacrylate,

3-(TriethoxySilyl) propyl isocyanate3-(TriethoxySilyl)propyl isocyanate

Hexamethylene diisocyanateHexamethylene diisocyanate

isocyanate와 같은 내구성 향상 모노머인 이소시아네이트계 기능성 모노머를 일정비율로 사용하고, PVP, PVA, PEGMEMA 와 같은 VP group 에서 선택한 습윤성 향상용 모노머를 일정비율 사용하여 혼합물을 조정함으로써, 다른 모노머와 상용성이 향상되고, 고강도 및 고습성을 가지는 하이드로겔 콘택트렌즈 제조용 재료를 조정하고, 이를 도 1에 예시한 콘택트렌즈 제조용 몰드에 주입함으로써, 얇은 두께를 유지하면서 내구성과 습윤성이 향상되고, 산소투과 기능이 좋은 고품질의 콘택트렌즈를 제조하게 된다.Compatibility with other monomers is improved by using isocyanate-based functional monomers, which are durability-enhancing monomers such as isocyanate, in a certain ratio, and by adjusting the mixture by using a wettability-enhancing monomer selected from the VP group, such as PVP, PVA, and PEGMEMA, in a certain ratio. and, by adjusting the material for manufacturing a hydrogel contact lens having high strength and high moisture content, and injecting it into the mold for manufacturing a contact lens illustrated in FIG. 1, durability and wettability are improved while maintaining a thin thickness, and high quality with good oxygen permeability of contact lenses are manufactured.

상기에서 이소시아네이트계 내구성 향상용 기능성 모노머와 습윤성 향상용 기능성 모노머는 총량에 대하여 1∼15중량%를 사용 할수 있으나, 1∼5중량%로 사용하는 것이 바람직하고, EGDMA와 같은 첨가제는 0.1∼0.3중량%로 사용하는 것이 바람직하다.In the above, the isocyanate-based functional monomer for improving durability and the functional monomer for improving wettability may be used in an amount of 1 to 15% by weight based on the total amount, but it is preferable to use 1 to 5% by weight, and additives such as EGDMA are used in an amount of 0.1 to 0.3% by weight It is preferable to use %.

한편, 콘택트렌즈 제조용 몰드는 도 1에 그 구성이 예시되어 있고, 이를 사용함으로써, 두께가 얇고 곡률이 안정된 콘택트렌즈를 제조할 수 있다.On the other hand, the structure of the mold for manufacturing a contact lens is exemplified in FIG. 1, and by using this mold, a contact lens having a thin thickness and a stable curvature can be manufactured.

1 : 암몰드 2 : 숫몰드
3 : 콘택트렌즈1: female mold 2: male mold
3 : contact lens

Claims (3)

고분자로 사용되는 HEMA, HPMA와 같은 친수성 콘택트렌즈 재료에 MMA, TEGDMA, EGDMA를 혼한합하고, 상기 혼합물에 내구성 향상을 위해 선택된 이소시아네이트계 기능성 모노머와 습윤성향상을 위해 선택된 VP계 습윤성 모노머를 혼합하여 다른 모노머와 상용성이 향상되고 고강도 및 고습윤성을 가지는 하이드로겔 콘택트렌즈 재료를 조성하고, 이를 콘택트렌즈 제조용 몰드에 주입하여서 되는 내구성과 습윤성이 양호하고 상용성이 향상되는 하이드로겔 콘택트렌즈.
Hydrophilic contact lens materials such as HEMA and HPMA used as polymers are mixed with MMA, TEGDMA, and EGDMA, and the mixture is mixed with an isocyanate-based functional monomer selected for durability improvement and a VP-based wettable monomer selected for wettability improvement to obtain other monomers. A hydrogel contact lens having good durability and wettability and improved compatibility by forming a hydrogel contact lens material having improved compatibility with and having high strength and high wettability, and injecting it into a mold for manufacturing a contact lens.
 청구항 1에서 이소시아네이트계 모노머는
2-I socyanato ethyl methacrylate,
3-(TriethoxySilyl) propyl isocyanate
Hexamethylene diisocyanate
isocyanate 중에서 선택되고, VP계 습윤성 모노머는 PVP, PVA, PEGMEMA중에서 선택되는 내구성과 습윤성이 양호하고 상용성이 향상되는 하이드로겔 콘택트렌즈.
In claim 1, the isocyanate-based monomer
2-I socyanato ethyl methacrylate,
3-(TriethoxySilyl)propyl isocyanate
Hexamethylene diisocyanate
It is selected from isocyanate, and the VP-based wettable monomer is selected from PVP, PVA, and PEGMEMA. Hydrogel contact lens with good durability and wettability and improved compatibility.
 청구항 1에서
이소시아네이트계 모노머와 VP계 습윤성 모노머는 총량에 대하여 1∼15중량% 범위에서 조정이 되고, EGDMA 첨가제는 0.1∼0.3중량%로 조성되는 내구성과 습윤성이 양호하고 상용성이 향상되는 하이드로겔 콘택트렌즈.in claim 1
Isocyanate-based monomers and VP-based wettable monomers are adjusted in the range of 1 to 15% by weight with respect to the total amount, and the EGDMA additive is composed of 0.1 to 0.3% by weight. Hydrogel contact lenses with good durability and wettability and improved compatibility.
KR1020210068742A 2021-05-28 2021-05-28 Hydrogel contact lenses with excellent durability, humidity and improved commerciality Ceased KR20220160733A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101231181B1 (en) 2007-06-25 2013-02-07 남택인 Silicone-hydrogel compound for soft contact lens and soft contact lens produced using the compound
KR101817883B1 (en) 2016-12-20 2018-01-11 대구가톨릭대학교산학협력단 Manufacturing method for contact lens using polymerization method at room temperature

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101231181B1 (en) 2007-06-25 2013-02-07 남택인 Silicone-hydrogel compound for soft contact lens and soft contact lens produced using the compound
KR101817883B1 (en) 2016-12-20 2018-01-11 대구가톨릭대학교산학협력단 Manufacturing method for contact lens using polymerization method at room temperature

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