KR20220066595A - Cosmetic composition for preventing hair loss containing riboflavin and angelica archangelica leaf extract as active ingredients - Google Patents

Abstract

The present invention is a cosmetic composition for preventing hair loss comprising RIBOFLAVIN and ANGELICA ARCHANGELICA LEAF EXTRACT as active ingredients. It relates to a cosmetic composition for preventing hair loss that can promote hair growth by stimulating blood circulation of

Description

Cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract as active ingredients

The present invention relates to a cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract as active ingredients.

Due to various causal factors such as environmental and social factors according to the development of society, symptoms of hair loss are increasing in various age groups and women as well. This hair loss phenomenon is caused by environmental and social factors. In particular, due to frequent perming, dyeing, stress, and severe diet, the incidence rate of the symptoms is increasing not only in men but also in women in recent years, and the age of occurrence is also gradually decreasing. have. The scalp basically protects all organs in the body from external environments such as mechanical external forces, chemical poisons, invasion of microorganisms, sunlight, etc., and has functions of absorption, respiration and excretion, and sensory functions. The scalp also excretes harmful substances and wastes from the body. When dead skin cells and waste products are mixed with sebum on the scalp and accumulate on the surface, they block the scalp pores, prevent skin respiration, cause inflammation in the scalp, and cause hair thinning. do. If the skin does not breathe smoothly, it accumulates in the body and eventually disturbs the body's balance, which has a huge effect on other functions, leading to abnormal scalp phenomenon.

In general, soap or shampoo is used a lot for washing hair, and in particular, in recent years, as general consumers' interest in hair health has increased, functional shampoo for preventing hair loss through not only simple washing but also scalp and hair health. development is being actively pursued. In addition, in real life, more than 70% of hair cosmetics such as shampoo are used, and when external pharmaceuticals are included, it accounts for more than 80%, so it is important to develop a healthy shampoo useful for life.

Korean Patent No. 10-1310970 discloses a hair product composition comprising a first anti-hair loss oriental herbal extract containing yellow lily, yellow white, golden, and the like, and a second anti-hair loss, oriental herbal extract, including woobangja, windbreak, and the like.

An object of the present invention is to exert a synergistic effect when using a mixture of riboflavin and angelica leaf extract without reducing the original function of hair products such as shampoo, hair conditioner or hair essence, and prevent hair loss and at the same time stimulate blood circulation of the scalp. To provide a cosmetic composition that promotes hair growth

In order to achieve the above object, the present invention provides a cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract as active ingredients.

Preferably, the riboflavin may be included in an amount of 0.00001 to 0.006% by weight based on the total weight of the cosmetic composition.

Also preferably, the angelica leaf extract may be included in an amount of 0.1 to 60.0% by weight based on the total weight of the cosmetic composition.

Also preferably, the cosmetic composition has the effect of promoting hair growth and preventing hair loss.

Also preferably, the riboflavin and angelica leaf extract may be mixed and included in a weight ratio of 1: 10,000 to 40,000.

The cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract according to the present invention can prevent hair loss by improving blood circulation around the scalp and hair root, and at the same time keep the scalp healthy, and provides nutrients to the hair to promote hair growth It has an excellent effect. In addition, the cosmetic composition for preventing hair loss according to the present invention has the effect of preventing hair loss by alleviating stimulation of the scalp compared to conventional hair products, and contains riboflavin and angelica leaf extract for preventing hair loss that exhibits excellent efficacy in scalp healing and hair growth promotion. As it is added, blood circulation around the scalp and hair roots is improved, hair loss is prevented, the scalp can be kept healthy, and nutrients are provided to the hair to promote hair growth.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and have the meanings as commonly understood by one of ordinary skill in the art of the present invention. In addition, although preferred methods and samples are described herein, similar or equivalent ones are also included in the scope of the present invention. The contents of all publications herein incorporated by reference are incorporated herein by reference. The term about means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, 4, means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length varying by 3, 2 or 1%.

Throughout this specification, unless the context requires otherwise, the terms "comprises" and "comprising" include, but are not limited to, a given step or element, or group of steps or elements, but any other step or element, or It is to be understood that a step or group of elements is not excluded.

As a result of research on various components to search for substances that prevent skin aging, the present inventors have found that the combination of riboflavin and angelica leaf extract, which plays an important role in body metabolism, is effective in preventing hair loss. was completed.

The present invention relates to a cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract as active ingredients.

Riboflavin (7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine; 7,8-dimethyl-10-ribitylisoalloxazine) is a type of water-soluble vitamin known as vitamin B2. Also called lactoflavin. The molecular formula is C17H20N4O6, the molecular weight is 376.36, and it has the property of being decomposed at 278-282 °C and has the structure of Formula 1 below. Flavin means yellow in Latin, and the aqueous solution is actually yellow, and the anhydrous riboflavin powder has an orange color. Riboflavin is known to be involved in metabolism related to oxidation of carbohydrates and amino acids. It is abundantly present in milk, eggs, and liver of animals. Adults require 1.2 to 1.7 mg of vitamin B2 daily. A significant amount of vitamin B2 is also synthesized by bacteria in the large intestine. Therefore, the hair composition for preventing hair loss of the present invention containing riboflavin having such various functions not only increases the activation of dermal papilla cells but also increases blood circulation, thereby providing an excellent effect in preventing hair loss.

In the present invention, riboflavin was used by SIGMA's RIBOFLAVIN (EC No. 201-507-1). Riboflavin has the structure of Formula 1 below.

The riboflavin is characterized in that it is contained in an amount of 0.00001 to 0.006% by weight based on the total weight of the cosmetic composition. If the content of the extract is less than 0.0001% by weight, the effect of preventing hair loss does not appear, and when it exceeds 0.006% by weight, the degree of increase in the effect of preventing hair loss with respect to the increase in the content is insignificant, and there is a problem in safety and stability in the formulation and economy. not even an enemy

Angelica (Angelica archangelica) is a plant of the umbel family, native to Europe, and is derived from the word 'angelus' meaning 'angel'. became The aromatic bitter taste of angelica is very good for the stomach and is known to relieve indigestion, abdominal pain, colic, flatulence, and has a stimulating and warming effect on the digestive system. In addition, angelica promotes blood circulation and is effective in anemia, and has been confirmed to have antibacterial and antifungal actions.

The angelica extract of the present invention can be prepared according to a conventional method of cooling extraction using liquid nitrogen known in the art, that is, under conditions of conventional temperature and pressure, using a conventional solvent. Preferably water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms (e.g., methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate , butyl acetate, dichloromethane, chloroform, hexane, and can be obtained using one or more extraction solvents selected from the group consisting of mixtures thereof. More preferably, it is obtained by using ethanol, 70% (v/v) ethanol or water, and most preferably, it can be obtained by using 70% (v/v) ethanol.

The angelica leaf extract may be included in an amount of 0.1 to 60.0 weight based on the total weight of the cosmetic composition. More preferably, it may be included in an amount of 1.0 to 40.0% by weight based on the total weight of the cosmetic composition.

The cosmetic composition of the present invention may include riboflavin and angelica leaf extract in a weight ratio of 1: 10,000 to 40,000, more preferably, by mixing it in a weight ratio of 1: 30,000.

The components contained in the cosmetic composition of the present invention include components commonly used in cosmetic compositions in addition to the angelica extract, for example, conventional auxiliary agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers. include

The ingredients included in the cosmetic composition of the present invention may include ingredients commonly used in hair cosmetic compositions in addition to the active ingredients as active ingredients, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments, and fragrances. phosphorus adjuvant, and a carrier. The hair cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, a solution, suspension, emulsion, paste, gel, cream, lotion, surfactant-containing cleansing, pack, It may be formulated as a hair massage cream and spray, but is not limited thereto. More specifically, it may be applied to a hair tonic, hair nourishing water, hair massage cream, hair, hair cleansing water, pack, spray or hair shampoo.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, and microcrystals Adult cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a cleansing agent containing surfactant, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide ether as carrier components Sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester may be used.

When the cosmetic composition of the present invention is a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, it may be applied to the hair and then wiped off, removed, or washed off with water.

When a cosmetic method using the cosmetic composition comprising riboflavin and a fraction of the present invention is performed, it helps blood circulation and thus prevents hair loss.

Hereinafter, the present invention will be specifically described with reference to Examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples according to the gist of the present invention.

[Experimental Example 1]

Human-derived dermal papilla cells are cultured using DMEM medium containing 10% FBS and 1% antibiotics (100 units/ml penicillin and 100 ug/ml streptomycin). The effect of growth and proliferation of dermal papilla cells was confirmed by MTT assay using 3rd and 4th generation dermal papilla cells. In a 96-well microplate, dermal papilla cells (1×104 cells/ml) were put in DMEM medium containing 1% FBS, and pre-cultured for 24 hours, and the samples obtained from Preparation Example were treated with various concentrations, and then cultured for 4 days. 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) ) was added and incubated for another 4 hours, and then centrifuged to remove the supernatant. After dissolving the precipitate by adding dimethyl sulfoxide to it, the proliferation effect of human-derived dermal papilla cells was confirmed to the extent of the formation of the formazan precipitate according to the reduction of MTT, and the results are shown in Table 1.

Sample name density Cell proliferation effect (%)
(vs control) Riboflavin 30 ppm 101.60% ± 0.61 10 ppm 99.53% ± 0.71 1 ppm 98.04% ± 0.65 Angelica Herb Extract
30 wt% 99.50% ± 0.51 10 wt% 99.43% ± 0.61 1 wt% 98.34% ± 0.43 Angelica Root Extract 30 wt% 99.70% ± 0.51 10 wt% 99.68% ± 0.61 1 wt% 98.61% ± 0.43 Angelica Leaf Extract 30 wt% 99.70% ± 0.78 10 wt% 98.98% ± 0.63 1 wt% 98.21% ± 0.57 Angelica Herbal Extract
+
Riboflavin Angelica Extract
(outpost) 30 wt% +
Riboflavin 30ppm 101.04% ± 0.65 Angelica Root Extract
+
Riboflavin Angelica Root Extract
30 wt% +
Riboflavin 30ppm 101.53% ± 0.21 Angelica Leaf Extract
+
Riboflavin Angelica Leaf Extract
30 wt% +
Riboflavin 30ppm 112.60% ± 0.81

[Experimental Example 2]

After each hair ampoule was prepared according to the composition in Table 2 below, 25 people, including 10 people with dandruff and itchy scalp, were divided into the first and second groups, respectively, and then riboflavin for 25 people belonging to group A. The hair ampoule containing this (Example 1) was used for 7 weeks (45 days), and the hair ampoule without riboflavin and LED light irradiation were not performed (Comparative Example 1) for 25 people belonging to group B. They were allowed to use for 7 weeks (45 days). The results are shown in Table 3.

Ingredients (wt%) Comparative Example 1 Example 1 Purified water remaining amount remaining amount ethanol 13.00 13.00 glycerin 4.00 4.00 dimethicone 2.60 2.60 panthenol 0.10 0.10 Salicylic Acid 0.10 0.10 cetyl alcohol 0.60 0.60 sodium chloride 0.55 0.55 Polyquaternium-10 0.31 0.31 Hydrogenated Polydecene 0.20 0.20 Panthenyl ethyl ether 0.20 0.20 p-anisic acid 0.10 0.10 glycerin 0.03 0.03 Cocamidopropyl Betaine 0.03 0.03 C12-15 Pares-3 0.03 0.03 Spices appropriate amount appropriate amount Disodium EDIT 0.10 0.10 Riboflavin - 0.0030 Angelica Leaf Extract - 30.00 total amount 100.00 100.00

division state change 1st group 2nd group hair growth very good 17 - good 5 6 no change 3 19 hair nutrition very good 18 - good 5 5 no change 2 20 scalp condition very good 17 One good 6 3 no change 2 21

In the case of hair growth, if there is hair growth on the entire head and there is an increase in the number of hairs, it is 'Very good', if there is hair growth on a part of the head and there is an increase in the number of hair in a part of the head, it is 'good', if there is no symptom of hair growth In the case of hair nutritional status, it was set as 'Very good' if there was little damage to the hair and if the hair was in a smooth and abundant condition, 'Good' if the hair damage was limited to a part and the hair was smooth. If there was no improvement in hair condition, it was set as 'no change'. In the case of scalp condition, if the scalp is completely free of sebum and there is no itching, if the scalp is clean, it is 'Very good', if the sebum or itching is partially improved and the cleanliness is improved. 'Good', and 'No change' if there was no change in scalp condition before use.

As can be seen in Table 3 above, when the composition for preventing hair loss containing riboflavin was continuously used, the effect of reducing the hair loss rate was shown to 55% or more of users, and the effect of preventing hair loss was shown to all users as well. , had the effect of thickening fine hair or fine hair. In addition, it was confirmed that most of the hair nutritional status had a good change, and the effect was excellent by more than 65%, and the condition of the scalp was mostly improved.

As described above in detail a specific part of the present invention, for those of ordinary skill in the art, this specific description is only a preferred embodiment, and it is clear that the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (5)

Cosmetic composition for preventing hair loss comprising riboflavin and angelica leaf extract as active ingredients The cosmetic composition for preventing hair loss according to claim 1, wherein the riboflavin is included in an amount of 0.00001 to 0.006% by weight based on the total weight of the cosmetic composition. The cosmetic composition for preventing hair loss according to claim 1, wherein the angelica leaf extract is contained in an amount of 0.1 to 60.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition for preventing hair loss according to claim 1, wherein the cosmetic composition contains riboflavin and angelica leaf extract mixed in a weight ratio of 1: 10,000 to 40,000. The cosmetic composition for preventing hair loss according to claim 1, wherein the cosmetic composition promotes hair growth and has an effect of preventing hair loss.