KR20200052157A - Digital microscope in which high-magnification image is guided by low-magnification image and digital microscope system - Google Patents

Abstract

By simultaneously disposing the low magnification imaging module and the high magnification imaging module, the entire area of the sample is roughly observed with a low magnification image, and the high magnification imaging module is moved to the characteristic area of the sample to solve the hassle of locating and focusing the feature area. A digital microscope and a digital microscope system are provided.
The digital microscope comprises a stage on which the sample is placed; A low magnification imaging module that captures the sample to generate a low magnification image; A high magnification imaging module that captures the sample to generate a high magnification image and is located on the opposite side of the low magnification imaging module based on the sample; And a driving module for moving at least one of the sample, the stage, and the high magnification imaging module, and an imaging area of the high magnification imaging module is changed by driving the driving module.

Description

DIGITAL MICROSCOPE IN WHICH HIGH-MAGNIFICATION IMAGE IS GUIDED BY LOW-MAGNIFICATION IMAGE AND DIGITAL MICROSCOPE SYSTEM

The present invention relates to a digital microscope and digital microscope system in which a high magnification image is guided by a low magnification image.

As shown in FIG. 1, a conventional microscope is equipped with a stage on which a sample is seated, an objective lens for determining the magnification of the imaged image, and imaging light of the sample with the user's eye. It consists of a guided eyepiece (Ocular lens) and a tube lens (Extention tube) that optically connects the objective lens and the eyepiece.

In addition, in the conventional microscope, a plurality of objective lenses having different magnifications are selected by rotation of a rotating plate, thereby generating a low magnification image and a high magnification image, respectively.

Therefore, in a conventional microscope, the user grasps the approximate location of the feature region in the entire image (low magnification image) with a low magnification objective lens in order to observe the feature region of the sample (the region where the feature point is found and requires precise observation), and then the high magnification The objective region was located again with an objective lens to perform precise observation (high magnification image).

As a result, in the conventional microscope, the low magnification objective lens needs to be switched to the high magnification objective lens for precise observation, and the feature region of the high magnification objective lens and the sample is optically aligned by moving the stage (x-axis, y-axis: position alignment; There was a hassle to do (z-axis: focus alignment).

Republic of Korea Utility Model Publication No. 20-2018-0000430, 2018.02.14. open

The problem to be solved by the present invention is to place the low magnification imaging module and the high magnification imaging module at the same time, roughly observing the entire area of the sample with the low magnification image, and at the same time moving the high magnification imaging module to the characteristic area of the sample, thereby grasping the position of the characteristic area And a digital microscope and a digital microscope system capable of solving the hassle of focusing.

The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

A digital microscope according to an aspect of the present invention for solving the above-described problem is a stage in which a sample is seated; A low magnification imaging module that captures the sample to generate a low magnification image; A high magnification imaging module imaging the sample to generate a high magnification image and positioned on the opposite side of the low magnification imaging module based on the sample; And a driving module for moving at least one of the sample, the stage, and the high magnification imaging module, and an imaging area of the high magnification imaging module may be changed by driving the driving module.

The driving module may move at least one of the sample, the stage, and the high magnification imaging module based on the x-axis and the y-axis.

The optical axis of the low magnification imaging module and the optical axis of the high magnification imaging module may be arranged based on the z axis.

The driving module moves at least one of the sample, the stage, and the high magnification imaging module based on the x-axis, y-axis, and z-axis, and the imaging area of the high-magnification imaging module drives the x-axis driving and the y-axis driving of the driving module. And the focal length of the high-magnification imaging module may be changed by driving the z-axis of the driving module.

Each of the low magnification imaging module and the high magnification imaging module may be a lens-free image sensor module equipped with an objective lens or a camera module.

The low magnification imaging module may be a lens-free image sensor module disposed between the sample and the stage.

A digital microscope system according to an aspect of the present invention for solving the above-described problems is a digital microscope; A user device in which a low magnification image and a high magnification image are reproduced; It includes an electronic control module for controlling the digital microscope, the digital microscope, the stage where the sample is seated; A low magnification imaging module that captures the sample to generate the low magnification image; A high magnification imaging module that generates the high magnification image by imaging the sample, and is located on the opposite side of the low magnification imaging module based on the sample; And a driving module for moving at least one of the sample, the stage, and the high-magnification imaging module, the imaging area of the high-magnification imaging module is changed by driving the driving module, and the electronic control module is configured to The driving module may be controlled such that the imaging area corresponds to the area selected from the low magnification image.

The electronic control module matches the image coordinate system formed on the basis of the low magnification image with a microscope coordinate system formed on the basis of the space in which the sample is present, and selects the imaging area of the high magnification imaging module and the area selected from the low magnification image in the sample. And matching parts.

The electronic control module moves at least one of the sample, the stage, and the high-magnification imaging module based on the x-axis and y-axis in the microscope coordinate system, thereby selecting an imaging area of the high-magnification imaging module and an area selected from the low-magnification image in the sample. And matching parts.

The electronic control module may analyze at least one of a low magnification image and a high magnification image by comparing it with standard data in a database.

Since the digital microscope and the digital microscope system of the present invention simultaneously generate a low magnification image and a high magnification image, the high magnification image is guided by the low magnification image, thereby reducing the time required to locate the feature region.

In addition, the digital microscope and the digital microscope system of the present invention has the advantage of reducing the time required to find the desired feature point in the database and perform analysis.

In addition, in the digital microscope and digital microscope system of the present invention, since the focal lengths of the low magnification imaging module and the high magnification imaging module are maintained at the initial setting, it is easy to focus.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a conceptual view showing a conventional microscope.
2 is a conceptual diagram showing the digital microscope system of the present invention.
3 is a conceptual diagram showing a digital microscope system of a modification of the present invention.
4 is a conceptual diagram showing a digital microscope system of another modification of the present invention.
5 is a conceptual diagram illustrating that light emitted from a light source is guided to a lens-free image sensor module after passing through a sample by a dichroic mirror.
6 and 7 are conceptual diagrams showing that a high magnification image is guided by a low magnification image in the digital microscope system of the present invention.
8 is a conceptual diagram showing that a high magnification image and a low magnification image are simultaneously reproduced in the user device of the present invention.

Advantages and features of the present invention, and methods for achieving them will be clarified with reference to embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, and only the present embodiments allow the disclosure of the present invention to be complete, and are common in the technical field to which the present invention pertains. It is provided to fully inform the skilled person of the scope of the present invention, and the present invention is only defined by the scope of the claims.

The terminology used herein is for describing the embodiments and is not intended to limit the present invention. In the present specification, the singular form also includes the plural form unless otherwise specified in the phrase. As used herein, “comprises” and / or “comprising” does not exclude the presence or addition of one or more other components other than the components mentioned. Throughout the specification, the same reference numerals refer to the same components, and “and / or” includes each and every combination of one or more of the components mentioned. Although "first", "second", etc. are used to describe various components, it goes without saying that these components are not limited by these terms. These terms are only used to distinguish one component from another component. Therefore, it goes without saying that the first component mentioned below may be the second component within the technical spirit of the present invention.

Unless otherwise defined, all terms (including technical and scientific terms) used in the present specification may be used as meanings commonly understood by those skilled in the art to which the present invention pertains. In addition, terms defined in the commonly used dictionary are not ideally or excessively interpreted unless explicitly defined.

The spatially relative terms "below", "beneath", "lower", "above", "upper", etc., are as shown in the figure. It can be used to easily describe a correlation between a component and other components. Spatially relative terms should be understood as terms including different directions of components in use or operation in addition to the directions shown in the drawings. For example, if a component shown in the drawing is turned over, a component described as "below" or "beneath" of another component will be placed "above" the other component. Can be. Accordingly, the exemplary term “below” can include both the directions below and above. The component can also be oriented in other directions, so that spatially relative terms can be interpreted according to the orientation.

Hereinafter, the digital microscope system 1000 of the present invention will be described with reference to the drawings. Figure 2 is a conceptual diagram showing a digital microscope system of the present invention, Figure 3 is a conceptual diagram showing a digital microscope system of a modification of the present invention, Figure 4 is a conceptual diagram showing a digital microscope system of another modification of the present invention, 5 is a conceptual diagram showing that light emitted from a light source is guided to a lens-free image sensor module after passing through a sample by a dichroic mirror, and FIGS. 6 and 7 show a high magnification image using the digital microscope system of the present invention. It is a conceptual diagram showing that being guided by a low magnification image, and FIG. 8 is a conceptual diagram showing that a high magnification image and a low magnification image are simultaneously reproduced in the user device of the present invention.

In the digital microscope system 1000 of the present invention, the low magnification image 1 and the high magnification image 2 are simultaneously generated from the sample s, and the high magnification image 2 is guided by the low magnification image 1 to accurately observe. It can be performed quickly and easily (that is, the user can be guided through a feature area to be observed from a low magnification image to a high magnification image).

The digital microscope system 1000 of the present invention may include a digital microscope 100, an electronic control module 200, and a user device 300.

The digital microscope 100 of the present invention may be a device that simultaneously generates a low magnification image 1 and a high magnification image 2 for a sample s (i.e., simultaneously captures a sample to generate a low magnification image and a high magnification image). . Meanwhile, the sample s may be covered with a slide glass and a cover glass and seated on the stage 130.

To this end, the digital microscope 100 of the present invention may include a low magnification imaging module 110, a high magnification imaging module 120, a stage 130, and a driving module (not shown). On the other hand, the digital microscope 100 of the present invention may further include a light source (not shown, light source) for irradiating light to the sample (s).

The light irradiated from the light source to the sample s is converted to imaging light, and may be obtained by the low magnification imaging module 110 and the high magnification imaging module 120. As an example, the light source may output laser light and a contrast agent may be injected into the sample s. The excitation light output from the light source is converted to emission light from the sample s treated with the contrast agent, thereby generating a fluorescence image in the low magnification imaging module 110 and the high magnification imaging module 120 ( Fluorescence microscopy implementation).

Particularly, when the low magnification imaging module 110 and the high magnification imaging module 120 are "the lens-free image sensor module on which the objective lens is mounted", the light source may be disposed in a ring type along the outer surface of the objective lens. In this case, the light source disposed in the low magnification imaging module 110 may output the imaging light of the high magnification imaging module 120 (high magnification light source), and the light source disposed in the high magnification imaging module 120 may have a low magnification imaging module 110. ) Can be output (light source for low magnification).

In addition, when the low magnification imaging module 110 and the high magnification imaging module 120 are "a lens-free image sensor module mounted with an objective lens," the objective lens and the lens-free image sensor module may be disposed adjacent to the objective. A dichroic mirror may be disposed between the lens and the lens-free image sensor module. In this case, the objective lens, the lens-free image sensor module, and the dichroic mirror may be packaged integrally.

The emitted light of the light source may be reflected (or transmitted) from the dichroic mirror and irradiated to the sample s via the objective lens, and the light passing through the sample s may pass through the objective lens and the dichroic mirror. It may be transmitted (or reflected) to be irradiated to the lens-free image sensor module (see FIG. 5). In this case, the light emitted from the light source may be excitation light (laser light), and the light obtained by tilting the sample s may be light emitted by the contrast-treated sample.

In addition, in order to remove noise, a filter (for example, an excitation light filter) for selectively transmitting the exit light of the light source may be disposed on a surface where the exit light of the light source is incident from the dichroic mirror, and the sample s A filter (for example, an emission light filter) for selectively transmitting light passing through the sample s may be disposed on a surface through which light passing through is transmitted. In this case, the filter may be a filter (BPF) that selectively transmits a specific wavelength band.

In addition, when the low magnification imaging module 110 is a "lens free image sensor module" disposed between the sample s and the stage 130, the high magnification light source is irradiated to the low magnification imaging module 110 to generate noise. In order to prevent the high-magnification light source, the lens-free image sensor module and the sample include a transparent surface light source (a transparent, light-emitting illumination film) disposed at a predetermined angle around the substrate of the lens-free image sensor module. (s).

The low magnification imaging module 110 may generate a low magnification image 1 by imaging the sample s, and the high magnification imaging module 120 may generate a high magnification image 2 by imaging the sample s.

The low magnification imaging module 110 has a wide imaging area (wide viewing angle) and can generate a low magnification image 1 for the entire area of the sample s, and the high magnification imaging module 120 has a narrow imaging area ( The field of view is narrow) A high magnification image 2 for the feature region among the regions of the sample s can be generated.

The imaging area of the low magnification imaging module 110 may include all areas of the sample s, and may mean an area reproduced by the low magnification image 1 in the user device 300. In addition, the imaging area of the high magnification imaging module 120 includes a feature area (a region in which a feature point is found) among the areas of the sample s, and refers to an area reproduced by the high magnification image 2 in the user device 300. Can be.

For example, when the sample s is human blood, the user can observe the blood in the low magnification image 1 as a whole, and in the high magnification image 2, the characteristic region of the blood (eg, a feature point is found, and is precisely The area requiring observation) can be observed in cell units (red blood cells, white blood cells, etc.).

That is, the imaging area of the low magnification imaging module 110 may include at least a part of the imaging area of the high magnification imaging module 120, and at least a part of the area of the high magnification image 2 may be a region of a part of the low magnification image 1 It may be an area enlarged with this high magnification.

Meanwhile, the low magnification image 1 and the high magnification image 2 may have various forms, such as an electronic signal, image information, and an image recognized by the naked eye, according to an image processing step.

For example, the low magnification image 1 and the high magnification image 2 may exist in the form of an electronic signal generated by converting the imaging light of the sample s in the low magnification imaging module 110 and the high magnification imaging module 120. Thereafter, the low magnification image 1 and the high magnification image 2 are image-processed to be reproduced by the user device 300 in the electronic control module 200, and may exist in the form of image information. Thereafter, the low magnification image 1 and the high magnification image 2 may be reproduced in the form of an image recognized by the user device 300 with the naked eye.

In the digital microscope 100 of the present invention, the low magnification imaging module 110 may be disposed on one side based on the sample s, and the high magnification imaging module 120 may be disposed on the other side. That is, the high magnification imaging module 120 may be located on the opposite side of the low magnification imaging module 110 based on the sample s.

Furthermore, the optical axis of the low magnification imaging module 110 and the optical axis of the high magnification imaging module 120 may be arranged based on the z axis. In this case, the low magnification imaging module 110 may be located on the lower side and the high magnification imaging module 120 may be located on the upper side. However, the present invention is not limited thereto, and the high magnification imaging module 120 may be located on the lower side and the low magnification imaging module 110 may be located on the upper side.

By the position and arrangement of the low magnification imaging module 110 and the high magnification imaging module 120 described above, in the digital microscope 100 of the present invention, the low magnification imaging module 110 and the high magnification imaging module 120 are the same sample (s) By simultaneously imaging, a low magnification image 1 and a high magnification image 2 can be generated simultaneously.

Meanwhile, various optical modules may be used for the low magnification imaging module 110 and the high magnification imaging module 120. Each of the low magnification imaging module 110 and the high magnification imaging module 120 may be a lens-free image sensor module mounted with an object lens or a camera module.

For example, as shown in FIG. 2, in the digital microscope 100 of the present invention, both the low magnification imaging module 110 and the high magnification imaging module 120 may be a “lens free image sensor module mounted with an objective lens”.

In addition, as shown in FIG. 3, in the digital microscope 100 of the modified example of the present invention, the low magnification imaging module 110 may be a “camera module” and the high magnification imaging module 120 may be a “lens free lens mounted with an objective lens. Image sensor ".

In this case, the objective lens and the lens-free image sensor module may be connected by connectors as separate optical components, or may be packaged integrally as a single optical component.

In addition, the "lens free image sensor module" may be composed of a substrate (PCB, Printed circuit board) and an image sensor mounted on the substrate (image sensor), an optical lens other than the objective lens to determine the magnification of the captured image is mounted Lenses (eg, eyepieces, tube lenses, etc.) may be omitted. As a result, the digital microscope 100 of the present invention has an advantage in that the length of the entire length (z-axis length) is minimized and can be manufactured in a compact manner.

In addition, the "camera module" may be formed of a lens holder, a lens array disposed on the lens holder, a substrate, and an image sensor mounted on the substrate while light transmitted through the lens array is irradiated. In the lens array of the camera module, other optical lenses may be omitted in addition to the objective lens that determines the magnification of the captured image. As a result, the camera module, like the lens-free image sensor module, can minimize the length of the digital microscope 100 of the present invention.

However, the embodiment of the digital microscope 100 of the present invention is not limited to the above-described embodiment.

For example, as shown in FIG. 4, in the digital microscope 100 of another modification of the present invention, the low magnification imaging module 110 may be a “lens free image sensor module” in which various optical lenses including an objective lens are omitted. .

In this case, the low magnification imaging module 110 may be disposed between the sample s and the stage 130. As a result, the low magnification imaging module 110 is close to the sample s (in contact with the slide glass or the cover glass), so that the sample s is affixed, so that the low magnification image 1 can be generated even though the objective lens is omitted. have.

The stage 130 may be a portion on which the sample s is seated. In more detail, a preparat in which the sample s is covered with a slide glass and a cover glass may be seated on the stage 130. A hole for providing an optical path of the imaging light of the sample s may be formed at a portion where the sample s is seated in the stage 130.

The driving module (not shown) may be a module that moves at least one of the sample s and the high magnification imaging module 120 and the stage 130 based on at least one of the x-axis, y-axis, and z-axis. In this case, the x-axis, y-axis, and z-axis may be axes constituting a microscope coordinate system formed based on a space in which the sample s is present.

The imaging area of the high magnification imaging module 120 may be changed by “driving the x-axis and y-axis of the driving module”. Therefore, it is possible to change the feature region to be precisely observed with the high magnification image 2 among the regions of the sample s by “driving the x-axis and y-axis of the driving module”. For example, the driving module may change the imaging area of the high magnification imaging module 120 by moving the high magnification imaging module 120 based on the x-axis and y-axis. However, the present invention is not limited thereto, and the driving module exhibits substantially the same effect as moving the stage 130 by moving the sample s (eg, implemented by moving the preparat) or moving the stage 130. Can be. On the other hand, when the driving module moves only the high-magnification imaging module 120 based on the x-axis and y-axis, the imaging area of the low-magnification imaging module 110 is fixed without being changed (ie, the effect that the low-magnification image is not changed) Can represent.

The focal length of the high-magnification imaging module 120 may be changed by “driving the z-axis of the driving module”. Accordingly, a focusing step of the high magnification imaging module 120 may be determined by “driving the z-axis of the driving module”.

On the other hand, the digital microscope 100 of the present invention has the advantage that the focal length of the high magnification imaging module 120 is maintained at the initial setting. That is, in the digital microscope 100 of the present invention, the focal length is not changed in the initial setting by switching of the objective lens having various magnifications like the conventional microscope. Therefore, the digital microscope 100 of the present invention has an advantage of being easy to focus.

Meanwhile, various types of driving devices may be used as the driving module. For example, the digital microscope 1000 of the present invention may be driven by a lead screw type or a ball screw type.

The electronic control module 200 transmits and receives the digital microscope 100, receives the low magnification image 1 and the high magnification image 2 from the digital microscope 100, performs analysis, and controls the digital microscope 100 Can be a module.

The user device 300 may be a device that transmits and receives the electronic control module 200 and reproduces the low magnification image 1 and the high magnification image 2.

The user device 300 may include one or more of a telecommunication device such as a smart phone, a tablet, a PDA, a laptop, and a remote controller, but is not limited thereto.

In the display panel of the user device 300, only one of the low magnification image 1 and the high magnification image 2 may be reproduced as shown in FIGS. 6 and 7 according to the user's selection, and the low magnification image as shown in FIG. (1) and the high magnification image (2) may be reproduced at the same time.

Furthermore, when the low magnification image 1 and the high magnification image 2 are simultaneously reproduced, as shown in FIG. 8 (1), the low magnification image 1 is reproduced as the main screen while the high magnification image 2 is reproduced as a sub screen. As shown in FIG. 8 (2), the high magnification image 2 may be reproduced on the main screen and the low magnification image 1 may be reproduced on the sub screen.

The digital microscope system 1000 of the present invention can analyze by comparing the low magnification image 1 and the high magnification image 2 with standard data stored in a database using artificial intelligence (AI). In this case, artificial intelligence for comparative analysis may be programmed in the electronic control module 200.

For example, the digital microscope system 1000 of the present invention may diagnose cancer cells by analyzing a low magnification image 1 and a high magnification image 2.

In this case, after comparing the low magnification image 1 with standard data to derive a feature point (a suspected area for cancer cells), the high magnification image 2 can be used to more accurately analyze the feature point (cancer cell) (high magnification image after low magnification image analysis) analysis).

In addition, after comparing the high magnification image (2) with the standard data to derive feature points (cancer cells), the low magnification image (1) analyzes the surrounding area of the feature points (cancer cells) derived from the high magnification image (2), thereby highlighting the feature points (cancer cells suspected). Area) can be further discovered (high magnification image analysis followed by low magnification image analysis).

Furthermore, the user may select an area to be observed from the low magnification image 1 to the high magnification image 2 through the user device 300. As an example, the user may observe the low magnification image 1 through the user device 300 and then, with a high magnification image 2, for a specific area where a feature point or a problem occurs.

That is, in the digital microscope system 1000 of the present invention, since the low magnification image 1 and the high magnification image 2 are simultaneously generated, the high magnification image 2 may be guided by the low magnification image 1.

Hereinafter, it will be described with reference to FIGS. 6 and 7 that the high magnification image 2 is guided by the low magnification image 1. 6 and 7 (1) is a conceptual diagram showing that a specific area is selected from the low magnification image 1 of the user device 300, and FIGS. 6 and 7 (2) are low magnification images from the user device 300. It is a conceptual diagram showing that the area selected in (1) is reproduced.

For example, the user may select a specific area from the low magnification image 1 using a touch screen method. The user device 300 may transmit a control signal according to the user's selection to the electronic control module 200, and the electronic control module 200 controls the digital microscope 100 according to the control signal of the user device 300. can do.

In this case, the electronic control module 200 may control the driving module of the digital microscope 100 so that the imaging area of the high magnification imaging module 110 corresponds to the area 10 selected from the low magnification image 1.

As an example for implementing this, the electronic control module 200 has a microscopic coordinate system formed based on a space in which the sample s actually exists, an image coordinate system formed based on the low magnification image 1. system), and match the portion 20 that matches the region 10 selected from the low magnification image 1 in the sample s and the high magnification image pickup filed of the high magnification imaging module 110. have.

The electronic control module 200 moves the sample s, at least one of the stage 130, and the high-magnification imaging module 120 based on the x-axis and y-axis in the microscope coordinate system, thereby imaging the imaging area of the high-magnification imaging module 110 ( High magnification image pickup filed) and the portion 20 matching the selected region 10 in the low magnification image 1 in the sample s may be matched.

That is, by matching the image coordinate system on the low magnification image 1 with the microscope coordinate system on the space where the sample s is present, the sample 10 s on the microscope coordinate system is matched with the region 10 selected from the low magnification image 1. The portion 20 can be derived.

Thereafter, at least one of the sample s, the stage 130, and the high-magnification imaging module 120 is moved to match the selected region 10 of the sample s with the high-magnification imaging region, so that the low-magnification image 1 is obtained. By this, a high magnification image 2 guided can be obtained. For example, as shown in FIG. 6, by moving at least one of the sample s and the stage 130 based on the x-axis and the y-axis in the microscope coordinate system, the selective region 10 of the sample s and the high magnification imaging module 120 ) Or by moving the high magnification imaging module 120 in the microscope coordinate system with reference to the x-axis and y-axis as shown in FIG. 7, the selected region 10 of the sample s and the high-magnification imaging module 120 ).

According to the above, in the digital microscope system 1000 of the present invention, the user can be guided by the low magnification image 1 to reproduce the high magnification image 2 for the characteristic region of the sample s.

The embodiments of the present invention have been described above with reference to the accompanying drawings, but a person skilled in the art to which the present invention pertains may implement the present invention in other specific forms without changing its technical spirit or essential features. You will understand. Therefore, it should be understood that the above-described embodiments are illustrative in all respects and not restrictive.

Claims (10)

A stage on which the sample is seated;
A low magnification imaging module that captures the sample to generate a low magnification image;
A high magnification imaging module that captures the sample to generate a high magnification image and is located on the opposite side of the low magnification imaging module based on the sample; And
And a driving module for moving at least one of the sample, the stage, and the high magnification imaging module,
A digital microscope in which the imaging area of the high-magnification imaging module is changed by driving the driving module.
According to claim 1,
The driving module is a digital microscope that moves at least one of the sample, the stage, and the high magnification imaging module based on the x-axis and y-axis.
According to claim 1,
A digital microscope in which the optical axis of the low magnification imaging module and the optical axis of the high magnification imaging module are arranged on the basis of the z axis.
According to claim 3,
The driving module moves at least one of the sample, the stage, and the high magnification imaging module based on the x-axis, y-axis, and z-axis,
The digital microscope in which the imaging area of the high magnification imaging module is changed by the x-axis driving and the y-axis driving of the driving module, and the focal length of the high-magnification imaging module is changed by the z-axis driving of the driving module.
According to claim 1,
Each of the low magnification imaging module and the high magnification imaging module is a digital microscope that is a lens-free image sensor module or a camera module equipped with an objective lens.
According to claim 1,
The low magnification imaging module is a digital microscope that is a lens-free image sensor module disposed between the sample and the stage.
Digital microscope;
A user device in which a low magnification image and a high magnification image are reproduced; And
It includes an electronic control module for controlling the digital microscope,
The digital microscope,
A stage on which the sample is seated;
A low magnification imaging module that captures the sample to generate the low magnification image;
A high magnification imaging module that captures the sample to generate the high magnification image, and is located on the opposite side of the low magnification imaging module based on the sample; And
And a driving module for moving at least one of the sample, the stage, and the high magnification imaging module,
The imaging area of the high-magnification imaging module is changed by driving the driving module,
The electronic control module,
A digital microscope system for controlling the driving module so that an imaging area of the high magnification imaging module corresponds to an area selected from the low magnification image.
The method of claim 7,
The electronic control module matches the image coordinate system formed on the basis of the low magnification image with a microscope coordinate system formed on the basis of the space in which the sample is present, and selects the imaging area of the high magnification imaging module and the area selected from the low magnification image in the sample. The digital microscope system that matches the part to be matched with.
The method of claim 8,
The electronic control module moves at least one of the sample, the stage, and the high-magnification imaging module based on the x-axis and y-axis in the microscope coordinate system, thereby selecting an imaging area of the high-magnification imaging module and an area selected from the low-magnification image in the sample. The digital microscope system that matches the part to be matched with.
The method of claim 7,
The electronic control module is a digital microscope system for analyzing by comparing at least one of the low magnification image and the high magnification image with standard data in the database.

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