KR20190112515A - Urine analyzing method and apparatus using nano spectrometer sensor - Google Patents

Abstract

The present invention relates to a urine test method using a nano-spectrometry sensor and a urine test paper reading device using a nano-spectrometry sensor, it is possible to improve the reading performance in more detail than the conventional method, and portable at home without the general individual to go to the hospital Urine test method using the nanospectral sensor that can be used to test the urine by using the device, and can be connected to a personal smart device such as a smart phone to read and measure the response color change measured using a test paper for urine test And a urine test paper reading device using a nanospectral sensor.

Description

Urine test method using nano spectroscopy sensor and urine test test paper reading device using nano spectroscopy sensor {Urine analyzing method and apparatus using nano spectrometer sensor}

The present invention relates to a urine test method using a nano-spectrometry sensor and a urine test paper reading device using a nano-spectrometry sensor, it is possible to improve the reading performance in more detail than the conventional method, and portable at home without the general individual to go to the hospital Urine test method using the nanospectral sensor that can be used to test the urine by using the device, and can be connected to a personal smart device such as a smart phone to read and measure the response color change measured using a test paper for urine test And a urine test paper reading device using a nanospectral sensor.

If abnormal components increase in blood due to metabolic diseases, heart, liver, endocrine diseases, etc., urine released through the kidneys contains inorganic salts, hormones, detoxifiers, protein breakdown products, nucleic acid breakdown products, sugars, proteins, ketone bodies , Bilirubin, eurobiliin, pathological crystals, etc. increases in the urine appearing in the analysis can be detected, and the results of urine analysis can reflect the health or pathological condition of the human body in medical institutions or patients Urine analysis is performed using urine.

The general method of urinalysis is to wet the urine using a urine test strip (Reagent strip) to discolor the micropad in response to urine, and to compare the color of the micropad with the colorimetric table and the naked eye to determine the disease. That's the way it is. Since this method compares the response color of the micropad with the colorimetric eye, a technique using a urine analyzer using a conventional color sensor is used.

Conventional urine analyzer using color sensor is arranged on urine test paper and irradiates light to micropad reacted by urine (generally using white light source), and reflects RGB value of reflected color of response sensor such as photodiode Photometric method for extracting color and reading color change, and Contact Image Sensor method for obtaining color average of a subject through image processing using CMOS-based camera lens.

Among the above methods, in the photometric method, the reading is easy in a section in which the color difference of the colorimetric is clear, but there is a problem in that the reading is wrong in a section in which the color difference of the colorimetric table is small.

Korean Patent Registration No. 10-1548302 ("Urinary Chemical Analysis Device", 2015.08.24.)

The present invention has been made to solve the problems described above, the purpose of the urine test method using the nanospectral sensor and the urine test paper reading device using the nanospectral sensor according to the present invention is the reaction color and colorimetric of the micropad Urine test method and nanospectral sensor using nanospectral sensor can improve the measurement accuracy even if the color difference in the table is not clear and insignificant, and make it easy to analyze the reaction color of urine test paper and manage the analysis result. The present invention provides a urine test paper reading device.

Urine test method using a nanospectral sensor according to the present invention for solving the above problems, a) irradiating light to the micropad in response to urine, b) is reflected from the micropad in the nanospectral sensor Acquiring spectral data of light; c) measuring and analyzing the spectral data obtained in step b) at predetermined wavelength intervals to determine the color of the micropad in response to urine; and d) determined in step c). And comparing the color and colorimetric table of the micropad to determine whether the test item is negative or positive.

In addition, in step b), the nanospectral sensor may obtain spectral data of light reflected from the micropad in the form of a plurality of frames for a predetermined time.

In addition, the step c) is characterized in that the spectral data obtained in the step b) by a predetermined amount of wavelength, and then measured and analyzed at a predetermined wavelength interval to determine the color of the micropad responding to the urine.

Urine test paper reading device using a nanospectral sensor according to the present invention is a body to which the urine test paper attached with a micro pad is transferred, the light source for irradiating light to the micro pad, the spectral data by detecting the light reflected from the micro pad A nano spectroscopy sensor for acquiring a control unit, installed in the body to control the light source and the nano spectroscopy sensor, and connected to the control unit and the control unit for transmitting the spectral data obtained from the nanospectroscopic sensor, and receiving the spectral data, And a readout unit configured to measure and analyze the received spectral data at predetermined wavelength intervals to determine the color of the micropad.

The body may include a housing configured to be opened and closed with an inner space, an inner body in which the light source and the nanospectral sensor are installed, and a transfer part for transferring a urine test paper located in the inner space.

In addition, the reading unit is installed on the body, or characterized in that it is installed in a terminal separate from the body.

In addition, the light irradiated from the light source is reflected on the surface of the micro pad, the process of detecting the light reflected by the nanospectral sensor is characterized in that the inside of the sealed structure.

In addition, a partition wall is formed between the light source and the nanospectral sensor in the hermetic structure to prevent the light emitted from the light source from directly entering the nanospectral sensor.

The nanospectral sensor may include a shutter function that adjusts a time for sensing light, and the controller controls a time for sensing light in the nanospectral sensor through the shutter function.

The reader may amplify the received spectral data by a predetermined wavelength, and then measure and analyze the amplified spectral data at predetermined wavelength intervals to determine the color of the micropad.

According to the urine test method using the nanospectral sensor and the urine test test strip reading device using the nanospectral sensor according to the present invention as described above, the light reflected from the discolored micropad in response to urine is detected by the nanospectral sensor Since acquiring the data and measuring and analyzing the acquired spectral data at a predetermined wavelength interval to determine the response color of the micropad, there is an effect that can improve the reading performance than the conventional method.

In addition, according to the present invention, by using a urine test paper test device using a nano-spectral sensor, a general user can easily test the urine, the measurement and analysis of the test results can be stored / managed in a terminal such as a smartphone It works.

1 is a schematic diagram of the urine test paper to be tested in the present invention.
Figure 2 is the colorimetric table for each item measured in the urine test paper.
Figure 3 is a block diagram of the urine test paper reading apparatus according to an embodiment of the present invention.
Figure 4 is a perspective view of the inside of the urine test paper reading apparatus according to an embodiment of the present invention.
5 is a wavelength characteristic graph of a conventional general white LED.
Figure 6 is a graph of the wavelength characteristics of the LED used in the urine test paper reading apparatus according to an embodiment of the present invention.
Figure 7 is a schematic cross-sectional view of the urine test paper reading apparatus according to an embodiment of the present invention.
Figure 8 is a screen showing the measurement results in the terminal of the urine test paper reading apparatus according to an embodiment of the present invention.
Figure 9 is a flow chart of the urine test method using a nanospectral sensor according to an embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings will be described in detail with respect to a preferred embodiment of the urine test method using the nanospectral sensor and the urine test paper reading device using the nanospectral sensor according to the present invention.

In one embodiment of the present invention to be described below, the urine test method using the nanospectral sensor may be performed by the urine test paper reading device using the nanospectral sensor, for convenience, the urine test paper reading device using the nanospectral sensor first It will be described later in detail with respect to the urine test method using a nanospectral sensor performed using this.

Figure 1 shows a urine test strip (Reagent strip) 10 to be tested in the present invention.

Generally, as shown in FIG. 1, the urine test paper 10 has a plurality of micro pads 11 to 20 formed on a surface thereof, and each micro pad is discolored in different colors by reacting with urine. You can check As shown in FIG. 1, items that can be tested for each micro pad formed on the surface of the urine test paper 10 are marked on each.

In FIG. 2, colors of each of the micropads 11 to 20 illustrated in FIG. 1 react with urine, and colors required for normal / photographic photography according to the degree of discoloration are displayed. In the present invention, the color of the micropads is changed. I want to measure the color more accurately.

Figure 3 shows a block diagram of the urine test paper reading apparatus using a nanospectral sensor according to an embodiment of the present invention.

As shown in FIG. 3, the urine test paper reading apparatus using the nanospectral sensor according to an embodiment of the present invention includes a body 100, a light source 200, a nanospectral sensor 300, a controller 400, and a readout. It may include a portion (not shown).

Body 100 is a portion to which the urine test paper 10, the micro pad is formed on the surface is transported, as shown in Figure 3 may include an inner body 120 and the transfer unit 130, in addition to the inside The body 120 and the transfer unit 130 may further include a housing accommodated therein.

4 illustrates the components installed in the body, including the inner body 120 and the transfer unit 130 forming the body.

As shown in FIGS. 3 and 4, the inner body 120 is a portion in which the light source 200 and the nanospectral sensor 300 are installed, and the lower inner body 121 and the light source in which the sealing structure 123 is formed. The upper inner body 122 coupled to the lower inner body 121 so that the 200 and the nanospectral sensor 300 is installed on the lower surface, and the light source 200 and the nanospectral sensor 300 are inserted into the hermetic structure 123. It can be made of).

The inner body 120 may be fixed to the housing described above, even if the urine test paper 10 inserted into the housing is moved within the housing.

As shown in FIG. 4, the transfer unit 130 is configured to transfer the urine test paper 10 placed on the upper portion, and moves the tray 131 and the tray 131 on which the urine test paper 10 is placed. The motor 132 may be included, and as shown in FIG. 3, the motor 132 may be connected to a motor driver 133 that controls the motor.

As shown in FIG. 4, the tray 131 and the motor 132 are connected in a rack and pinion structure, and the tray 131 is operated as the motor 132 fixed inside the housing 110 operates. 131 may be moved to one side. However, the connection relationship between the tray 131 and the motor 132 is not limited to the rack and pinion structure, and the tray 131 and the motor 132 may have various structures if the tray 131 can be transferred to one side or the other side. Can be connected to each other.

The tray 131 may be provided with a magnet 134 for detecting whether the tray 131 is opened or closed, and the hall sensor 410 may be formed in the inner body 120. The hall sensor 410 has a characteristic that the reference voltage decreases when the magnetic force of the magnet 133 is applied and the reference voltage rises when the magnetic force is not applied, and the tray 131 and the hall sensor are provided through the characteristics of the hall sensor 410. The operation of the transfer unit 130 may be controlled by determining a relative position between the inner body 120 in which the 410 is installed.

Since the micropad of the urine test test paper 10 to be tested in the present invention needs to accurately measure each reaction color, it is necessary to precisely position the micropad to be tested. To this end, the type of the motor 132 used in the present invention may be a step motor. The step motor does not have a phenomenon in which the rotating shaft continuously rotates due to inertia when a stop signal is applied to the motor, and is input to the step motor as a drive signal. Since the rotation angle per pulse is predetermined, it may be suitable for one embodiment of the present invention for the above purpose.

The user button 140 shown in FIG. 3 is a button for controlling opening and closing of the tray 131.

The light source 200 is a part for irradiating light with a micro pad, and a general LED may be used. However, the LED used in the present embodiment may use an excellent wavelength characteristic for the entire visible light region.

5 and 6 show the wavelength characteristics of the conventional white LED and the wavelength characteristics of the LED used in the present invention, respectively, to explain the characteristics of the light source used in this embodiment.

As shown in FIG. 5, a general white LED has the strongest intensity in the 480 nm band of the visible light wavelength band (380 to 770 nm), and weakly in the other wavelength bands. In the case of a conventional white LED having a wavelength characteristic as shown in Figure 5, in the reading unit to be described later to determine the RGB color by amplifying a predetermined value for the wavelength region of the remaining region except for the region having a strong intensity, The weaker the wavelength band, the greater the amplification and the larger the error. Therefore, there is a problem that the color determined when reading the RGB color is not accurate.

In this embodiment, to overcome this problem, the light source 200 uses LEDs having improved wavelength characteristics for the entire visible light region as shown in FIG. 6, so that the amount of amplification does not have to be greater than that of a general white LED. The error that occurs during amplification can be reduced, so that the accuracy of reading can be improved.

The nanospectral sensor 300 is a part for obtaining spectral data by sensing light reflected from the micropad, and may be a nanofilter array type spectroscopic sensor having an N × M (N and M are natural numbers) form. Light emitted through the light source 200 is incident and reflected on the surface of one of the micro pads in the sealed space 123 as shown in FIG. 7, and detects the reflected light in the nanospectral sensor 300. The nanospectral sensor 300 acquires a plurality of frame data during light sensing time.

Figure 7 shows a schematic cross-sectional view of the urine test paper reading apparatus using a nanospectral sensor according to an embodiment of the present invention.

As shown in FIG. 7, in one embodiment of the present invention, the light source 200 and the nanospectral sensor 300 are blocked by the partition wall 124. This is to prevent the light emitted from the light source 200 is directly incident to the nanospectral sensor 300.

The controller controls the light source 200, the nanospectral sensor 300, and the transfer unit 130, and transmits the frame data obtained by the nanospectral sensor 300 to a reading unit to be described later.

As shown in FIG. 3, the controller 400 may be connected to each of the components and wired / wireless to control the light source 200, the nanospectral sensor 300, and the transfer unit 130. Can be implemented.

The reading unit is connected to the control unit 400 to receive the spectrum data obtained from the nanospectral sensor 300, and to measure and analyze the received spectrum data at predetermined wavelength intervals to determine the color of the micropad.

The reading unit may be a smart device in which an application or program for the above operation is installed, and the reading unit may be the smart device 500 or the PC illustrated in FIG. 3. The reading unit and the control unit 400 may be connected by wire / wireless, and when the reading unit and the control unit 400 are connected wirelessly, a method such as Bluetooth or wireless Internet (Wi-fi) may be used. It may include a wireless communication module for.

In the present exemplary embodiment illustrated in FIG. 3, the control unit 400 may be connected to the smart device 500 as a reading unit through the USB interface 420. That is, the controller 400 and the smart device 500 may be connected to each other via a USB cable to transmit and receive data.

Since the reading unit needs to receive the spectrum data and analyzes it, it may include an arithmetic unit. The reading unit receives the spectrum data from the controller and measures and analyzes the spectrum data at a predetermined wavelength interval. In this case, the predetermined wavelength interval measured by the analyzer may be 1 nm in this embodiment, but the present invention is not limited thereto and may be added or subtracted within a predetermined range based on 1 nm.

The reading unit may be connected to the light source 200 and the nanospectral sensor 300 to read and control information of each device. For example, the nanospectral sensor 300 may have a built-in shutter function for sensing light and measuring spectral data, and the shutter function embedded in the nanospectral sensor 300 may be implemented using a semiconductor device. have. Since the intensity of the light emitted from the light source 200 depends on the light emitting device used in the light source 200, the readout part is applied to the nanospectral sensor 300 through a register setting for optimal measurement in the nanospectral sensor 300. By controlling the built-in shutter speed, you can adjust the light detection time.

For the above process, the reading unit needs to check the type of the nanospectral sensor 300. When the user executes reading through the reading unit (terminal such as a smartphone), the type of the nanospectral sensor 300 is firstly determined. After confirming and setting the shutter speed or other factors, the reading of the urine test paper may be performed.

When the reading unit determines the color of the micro pad, the result data of comparing the color and colorimetric table of the determined micro pad may be stored or output. FIG. 8 is a screen of outputting the result data to the smart device 500 by the reading unit. It is shown.

Hereinafter, the urine test method using the nanospectral sensor according to the present invention will be described in detail.

The urine test method using the nanospectral sensor according to the present invention may be made of steps a) to d), and other steps may be further included in addition to the steps a) to d).

9 is a view briefly illustrating a process in which the urine test method using the nanospectral sensor according to the present invention is performed while the smart device 500 is connected to the urine test paper test apparatus according to the present invention.

First, when the user requests the analysis of the urine test paper through the smart device 500, the smart device 500 transmits a message requesting confirmation of the ID to the nanospectral sensor 300 and the light source to the control unit 400. (Spectral sensor ID read message) This is to check the type of the nano-spectral sensor 300 currently connected, and to check the various parameters required to correct the spectrum data received after the measurement, transmitted to the controller 400 The ID confirmation message is transmitted back to the nanospectral sensor 300, the nanospectral sensor 300 transmits an ID response message to the smart device 500 through the control unit 400. One of various parameters required for correcting the spectral data may be amplification for each wavelength band according to the wavelength-specific characteristics of the light source used in the present invention described above.

The smart device 500 checks the type of the nanospectral sensor 300 through the received ID response message, and then transmits a shutter speed setting message to the nanospectral sensor 300 through the control unit 400. ) Sets the time to detect light, that is, the time when frame data is accumulated.

Thereafter, the smart device 500 may operate the nanospectral sensor 300 through the control unit 400 to transmit a message requesting spectrum data, and the nanospectral sensor 300 may open and close the shutter for a predetermined time. Generates and transmits a plurality of frame data for a time. (Corresponding to steps (a) and b)) The plurality of frame data transmitted from the nanospectral sensor 300 is transmitted to the smart device 500 through the control unit 400. The smart device 500 obtains an average of the received plurality of frame data, converts the spectrum data into spectral data, and then measures and analyzes the converted spectral data at predetermined wavelength intervals to determine the color of the micropad to be read. This can be compared with the colorimetric table to determine the voice / positiveness or the degree of the item to be examined in the corresponding micropad (corresponding to step (d)).

However, as described in the above-described urine test reading apparatus using the nanospectral sensor of the present invention, before measuring the spectral data in step c), amplify the frame data for each wavelength to a predetermined degree, and light the entire visible wavelength band. The step of uniformly matching the intensity of may be performed.

In general, since a plurality of micro pads are formed on the surface of the urine test paper 10, when the reading of one micro pad is completed, the smart device 500 moves the tray 131 to move the tray 131 to the controller 400. The control unit 400 transmits a control command to the motor driver 133 to drive the motor 132 to read the next micropad.

The above process may be repeated until all the micropads are read, and the number of the micropads to be read may be preset by the user.

In the above-described embodiment of the present invention, the control unit 400 and the reading unit have been described as being configured as separate devices, but the present invention is not limited thereto, and the control unit 400 and the reading unit may be installed in the same device. In this case, a separate display may be installed outside the body 100 of the present invention, and a read result may be output to the display.

The present invention is not limited to the above-described embodiments, and the scope of application is not limited, and various modifications can be made without departing from the gist of the present invention as claimed in the claims.

10: urine test paper 11 ~ 20: micro pad
100: body 120: internal body
121: lower inner body 122: upper inner body
123: sealed structure 124: partition wall
130: transfer unit 131: tray
132: motor 133: motor driver
134: magnet 140: button switch
200: light source
300: Nano Spectroscopy Sensor
400: control unit
410: Hall sensor 420: USB interface
500: smart device

Claims (10)

a) irradiating light on the micropad in response to urine;
b) acquiring spectral data of light reflected from the micropad in a nanospectral sensor;
c) measuring and analyzing the spectral data obtained in step b) at predetermined wavelength intervals to determine the color of the micropad in response to urine; And
d) comparing the color and colorimetric table of the micropad determined in step c) to determine whether the test item is negative or positive;
Urine test method using a nano-spectral sensor comprising a.
The method of claim 1,
In step b), the nanospectral sensor is a urine test method using a nanospectral sensor, characterized in that for obtaining a spectral data of the light reflected from the micropad in the form of a plurality of frames for a predetermined time.
The method of claim 1,
C) amplifying the spectral data obtained in step b) by a predetermined wavelength, and measuring and analyzing the wavelength at a predetermined wavelength interval to determine the color of the micropad responding to urine. Urine test method.
Body to which urine test paper with micro pad is attached is transferred;
A light source for irradiating light with the micropad;
A nanospectral sensor that detects light reflected from the micropad to obtain spectral data;
A control unit installed in the body to control the light source and the nanospectral sensor and to transmit spectral data obtained from the nanospectral sensor; And
A reading unit connected to the control unit to receive the spectral data, and to measure and analyze the received spectral data at predetermined wavelength intervals to determine the color of the micropad;
Urine test paper reading device using a nano-spectral sensor comprising a.
The method of claim 4, wherein
The body has an inner space housing configured to be opened and closed,
An inner body in which the light source and the nanospectral sensor are installed;
Urine test paper reading device using a nano-spectral sensor, characterized in that it comprises a transfer unit for transferring the urine test paper located in the inner space.
The method of claim 4, wherein
The reading unit is installed on the body, or the urine test test paper reading device using a nano-spectral sensor, characterized in that installed on a separate terminal from the body.
The method of claim 4, wherein
The light irradiated from the light source is reflected on the surface of the micropad, the process of detecting the light reflected by the nanospectral sensor is a urine test paper reading device using a nanospectral sensor, characterized in that the inside of the closed structure.
The method of claim 4, wherein
A barrier rib is formed between the light source and the nanospectral sensor to prevent the light emitted from the light source from directly entering the nanospectral sensor. .
The method of claim 4, wherein
The nano-spectral sensor includes a shutter function that can adjust the time to detect the light,
The control unit is a device for reading urine test paper using a nano-spectral sensor, characterized in that for controlling the time to detect the light in the nano-spectral sensor through the shutter function.
The method of claim 4, wherein
The reading unit amplifies the received spectral data for each wavelength to a predetermined wavelength, and then measures and analyzes the amplified spectral data at predetermined wavelength intervals to determine the color of the micropad. Device.

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