KR20190046365A - Method for preparing excipient for tableting comprising green tea residue and method for preparing green tea tablet using the same - Google Patents

Abstract

(A) extracting a green tea leaf with an extraction solvent to obtain a green tea extract, and separating the residue to prepare a first residue; (b) re-extracting the primary residue with an extraction solvent to produce a re-extract and a secondary residue; And (c) powdering the re-extract and the secondary residue to prepare a tableting excipient powder. The present invention also relates to a method for preparing a tableting excipient comprising a green tea residue. Thus, it is possible to prevent the generation of waste during the production of the tablets, thereby avoiding the process and cost associated with the disposal of the waste, and the catechin contained in the residue is contained in the green tea tablet, thereby increasing the catechin content.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a method for manufacturing a tableting excipient containing a green tea residue and a method for producing the same,

The present invention relates to a method for producing a tableting excipient containing green tea residue and a method for preparing a green tea tablet using the same, and more particularly, to a method for preparing a green tea tablet comprising a green tea residue which can be used as an excipient And a method for producing a green tea tablet using the same.

Green tea contains catechins, caffeine, amino acids, fibrin, pectin, vitamins, and inorganic salts. These ingredients contain various physiologically active substances that have antioxidant, antimutagenic and antitumor actions and inhibitory effects on cholesterol elevation.

Catechin belongs to flavon-3-ols (flavan-3-ols) of the flavonoid group and is a flavor component of green tea as a polyphenol. Derived from tea (Camellia sinensis), contained in white tea, green tea, black tea and oolong tea. However, in the case of tea or oolong tea, catechin is reduced by more than half in the fermentation process. The polyphenols in tea leaves have a mild bitter taste, a catechin with a bitter flavor, an ester catechin with a bitter taste, and a catechin with a strong bitter taste and a weak bitter taste, unlike the tannins of persimmon. The main catechins are epigallocatechualate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC).

Catechin has various effects such as inhibition of carcinogenesis, arteriosclerosis, inhibition of blood pressure increase, prevention of thrombosis, antiviral, anti-obesity, antidiabetic, antibacterial, detoxifying action, anti-inflammatory action, prevention of tooth decay, prevention of browning, normalization of intestinal flora. Catechin's antioxidant and antioxidant activity, which is a fundamental element of aging, has a stronger effect on the removal of free radicals than vitamin C and vitamin E, and its antioxidant activity has the effect of protecting against cardiovascular diseases such as low density lipoprotein oxidation Was reported. Catechins have been shown to stop or slow the production and initiation of undesirable cell populations, and to inhibit those that empirically cause DNA damage.

For easy ingestion of such catechins, there is a method of tabletting green tea extract to prepare tablets. However, the residues after green tea extraction in the tableting process are all discarded and waste disposal is further required. In addition, excipients such as dextrin and lactose are additionally used to further increase the processing cost and utilize the catechin components contained in the residue There was no problem.

Korean Patent Registration No. 10-1630853 Korean Patent Registration No. 10-0673605

The object of the present invention is to solve the above-mentioned problems, and it is an object of the present invention to provide a green tea extract which is prepared by using the remaining residues to prepare tableting excipients and using the same for tableting green tea tablets, The present invention also provides a method for manufacturing a tableting excipient for increasing the content of catechin because the catechin contained in the residue is contained in the green tea tablet, and a method for producing the green tea tablet containing the same.

According to an aspect of the present invention,

(a) extracting a dried green tea leaf with an extraction solvent to obtain a green tea extract, and separating the residue to prepare a first residue; (b) re-extracting the primary residue with an extraction solvent to produce a re-extract and a secondary residue; And (c) powdering the re-extract and the secondary residue to prepare a tableting excipient powder. The method for manufacturing a tableting excipient including a green tea residue is provided.

The extraction solvent in step (a) may be at least one selected from water, lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane, and diethyl ether .

The extraction solvent may be an ethanol aqueous solution having a concentration of 30 to 75%.

The extraction solvent used in the re-extraction of step (b) is selected from water, lower alcohols having 1-4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane, It may be more than one kind.

The extraction solvent used for the re-extraction may be hot water at 60-100 ° C.

The re-extraction of step (b) can be carried out by reflux extraction.

The sugar contained in the primary residue can be extracted by re-extraction of step (b).

The pulverization of step (c) may be carried out according to any one of the methods selected from spray drying, vacuum distillation and freeze drying.

According to another aspect of the present invention,

There is provided a tableting excipient comprising green tea residue prepared according to the above method.

According to another aspect of the present invention,

(1) extracting a dried green tea leaf with an extraction solvent to obtain a green tea extract, and separating the residue to prepare a primary residue; (2) removing the caffeine component from the green tea extract to prepare a decaffeinated green tea extract; (3) concentrating the decaffeinated green tea extract to prepare a green tea concentrated extract; (4) preparing green tea extract powder by pulverizing the green tea concentrated extract; And (5) preparing a green tea tablet by tableting the tableting excipient comprising the green tea residue prepared according to any one of claims 1 to 7 and the green tea extract powder with a material, Is provided.

The catechin content of the dried green tea leaves of step (1) may be 8 to 13 wt%.

In step (2), when the green tea extract is mixed with the extraction solvent, caffeine may be removed by ion-exchange resin treatment or ultrasonic treatment.

The ultrasonic treatment may be performed for 10 to 20 minutes.

In step (2), caffeine may be removed by adding ethyl acetate or methylene chloride while the green tea extract is mixed with the extraction solvent.

Concentration of step (3) can be carried out according to reduced pressure or centrifugal concentration.

The green tea extract powder of step (4) may have an average particle size of 20 to 23 탆.

The pulverization of step (4) can be carried out according to any one of the methods selected from spray drying, vacuum distillation and freeze drying.

In step (5), the tableting excipient and the green tea extract powder may be mixed and kneaded at a weight ratio of 3: 7 to 7: 3.

In step (5), a lubricant may be further included to be tableted.

The catechin content of the green tea tablet of step (5) may be 30 to 35 wt%.

According to another aspect of the present invention,

A green tea tablet prepared according to the above method is provided.

The method for manufacturing a tableting excipient containing the green tea residue of the present invention and the method for manufacturing a green tea tablet using the green tea extract according to the present invention can be used for preparing a tableting excipient using a remaining green tea extract, It is possible to prevent the generation of the process and cost due to waste treatment, and the catechin contained in the residue is contained in the green tea tablet, so that the catechin content can be increased.

1 is a flowchart illustrating a method for manufacturing a green tea tablet and a method for manufacturing a tableting excipient according to the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the detailed description. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flowchart illustrating a method for manufacturing a tableting excipient including green tea residue according to the present invention and a process for producing a green tea tablet using the method. Hereinafter, a method for producing a tableting excipient containing green tea residue according to the present invention will be described with reference to FIG.

First, Green tea leaves  Extracted with an extraction solvent to obtain a green tea extract, and the residue ( residue ) Were separated to obtain primary The residue  (Step a).

The extraction solvent may be water, lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane or diethyl ether.

Preferably, the extraction solvent may be an ethanol aqueous solution having a concentration of 30 to 75%, more preferably a concentration of 50 to 75%, and still more preferably a concentration of 60 to 75%.

As used herein, the term 'extract' has the meaning of being used as a crude extract in the art, but broadly it can also include fractions in which the extract is further fractionated.

Next, The residue  Re-extracted with an extraction solvent Re-extract and  Secondary The residue  (Step b).

Water, a lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane, diethyl ether and the like can be used as the extraction solvent used for re-extraction.

Preferably, the extraction solvent used for re-extraction may be hot water at 60-100 ° C, more preferably 70-95 ° C, even more preferably 80-90 ° C.

The re-extraction is preferably carried out by reflux extraction.

The sugar contained in the primary residue may be extracted by the re-extraction to further improve the function of the binder. In some cases, this step may be omitted and the primary residue may be directly pulverized to produce an excipient. In this case, however, the binder component may be insufficient to achieve proper tableting.

Finally, Re-extract and  Secondary The residue Powdered Other  The excipient powder is prepared (step c).

The pulverization may be carried out by spray drying, vacuum distillation, freeze-drying, etc., preferably spray drying.

The present invention provides a tableting excipient manufactured according to the above-described method for producing a tableting excipient containing a green tea residue.

Hereinafter, a method for manufacturing a green tea tablet of the present invention will be described with reference to FIG.

First, Green tea leaves  Extracted with an extraction solvent to obtain a green tea extract, and the residue ( residue ) Were separated to obtain primary The residue  (Step 1).

Step 1 is carried out in the same manner as step a in the above-mentioned method for manufacturing a tableting vehicle, and therefore, the details will be referred to.

The catechin content of the green tea extract may be 8 to 13 wt%.

Next, the caffeine component was removed from the green tea extract Decaffein  Green tea extract is prepared (Step 2).

The caffeine may be removed by treating the green tea extract with an ion exchange resin or an ultrasonic treatment in a state where the green tea extract is mixed with the extraction solvent, and the ultrasound treatment is preferably performed for 10 to 20 minutes.

Alternatively, the green tea extract may be mixed with an extraction solvent to remove caffeine by adding ethyl acetate or methylene chloride. However, the scope of the present invention is not limited thereto, and other known decaffeine methods may be used.

Then, Decaffein  Green tea extract is concentrated to prepare green tea concentrated extract (step 3).

Concentration can be performed according to reduced pressure concentration or centrifugal concentration.

Next, the green tea concentrated extract Powdered  Green tea extract powder is prepared (step 4).

The green tea extract powder may have an average particle size of 20 to 23 탆.

The pulverization may be carried out by spray drying, vacuum distillation, freeze-drying, etc., preferably spray drying.

Finally, the above-described green tea of the present invention The residue  Included Other  The excipient and the green tea extract powder By typing  green tea Tablet  (Step 5).

The catechin content of the green tea tablet may be 30 to 35 wt%. This is because catechin contained in green tea extract contains catechin contained in excipient and catechin content is greatly increased.

The present invention also provides a green tea tablet produced according to the above-described method for manufacturing a green tea tablet.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.

Example  One

(1) Extraction of green tea and obtaining residue

Green tea leaves (Jeju Special Self-Governing Province, Oedulok Farm) were used at room temperature on shade. 680 kg of the prepared green tea leaves were prepared and 10,200 L of 70% ethanol aqueous solution was added and heated. After reaching 70 캜, the mixture was extracted for 1 hour and filtered to separate the green tea extract and the residue.

(2) Production of green tea extract

The green tea extract was decaffeinated, and the concentrated extract obtained by removing the solvent by a vacuum concentrator was obtained, followed by spray drying and pulverization.

(3) Extraction of residues and preparation of excipient powder

3400 kg of hot water was added to the residue, and the mixture was refluxed at 86 ° C to extract the residue sugar to obtain a re-extract and a residue mixture. The re-extract and the residue mixture were spray-dried and powdered to prepare an excipient powder.

(4) Manufacture of green tea tablets

The green tea extract powder obtained in the step (2), the excipient powder obtained in the step (3), anhydrous silicic acid and magnesium stearate were mixed at a weight ratio of 55: 44: 0.5: 0.5, To prepare a green tea tablet. The total weight of the prepared green tea was 198.6 kg and the yield was 29.2%.

Comparative Example  One

A green tea tablet was prepared in the same manner as in Example 1, except that the residue re-extraction step was omitted and the residue was directly pulverized as an excipient. The total weight of the prepared green tea tablet was 202.4 kg, and the yield was 29.8%.

Comparative Example  2

A green tea tablet was prepared in the same manner as in Example 1 except that dextrin was used as an excipient instead of the excipient powder obtained in the step (3). The total weight of the prepared green tea tablet was 180 kg, and the yield was 26.5%. In addition, about 500 kg of residue generated after green tea extraction was disposed of, and the disposal cost was normally 75,000 won per ton.

[Test Example]

Test Example  1: Analysis of catechin content

100 ml of a 50% methanol aqueous solution was added to 0.5 g of each sample obtained by crushing the tablets prepared in Example 1, Comparative Example 1 and Comparative Example 2, and the resulting sample was subjected to ultrasonic treatment for 20 to 30 minutes, filtered through a 0.45 탆 membrane filter HPLC (High Performance Liquid Chromatography), and the amount of injected sample was 10 μl each, and gradient method was used.

As a result, the catechin content of the sample of Example 1 was 24.3%, that of Comparative Example 1 was 24.1%, and that of Comparative Example 2 was 19.6%. Thus, the green tea tablet using the residue as an excipient showed a relatively high catechin content.

Test Example  2: Tablet  Property evaluation

The tablets prepared according to Example 1, Comparative Example 1 and Comparative Example 2 were evaluated for hardness, disintegration time, and degree of abrasion. Hardness was measured according to United States Pharmacopoeia (USP) 1217 (tablet breaking force) and the disintegration time was measured according to USP 701 (Disinteration), and the degree of malondialdehyde was determined according to USP 1216 (tablet friability) , And the results are shown in Table 1 below. ≪ tb > < TABLE >

[expression]

(%) = (Initial tablet 20 defined weight (mg) - refined tablet 20 after weight loss test (mg)) / initial tablet 20 defined weight x 100 (%)

Evaluation items Hardness (kp) Marson (%) Disintegration time (minutes) Example 1 9.7 0.5 4.6 Comparative Example 1 6.5 1.8 3.2 Comparative Example 2 10.2 0.4 4.9

According to Table 1, the tablet of Example 1 showed no significant difference in evaluation of hardness, degree of shrinkage and disintegration time with the tablet of Comparative Example 2, which used conventional dextrin as an excipient while using green tea residue as an excipient. However, the tablet of Comparative Example 1 using the residue as the excipient without re-extraction showed a relatively low hardness and a high degree of scratching. These results indicate that the sugar contained in the residue is extracted during the re-extraction of the residue, and the re-extract containing the extracted sugar is included in the excipient, thereby acting as a binder, and thus the hardness of the tablet of Example 1 is increased.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, many modifications and changes may be made by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims. The present invention can be variously modified and changed by those skilled in the art, and it is also within the scope of the present invention.

Claims (11)

(a) extracting a dried green tea leaf with an extraction solvent to obtain a green tea extract, and separating the residue to prepare a first residue;
(b) re-extracting the primary residue with an extraction solvent to produce a re-extract and a secondary residue; And
(c) powdering the re-extract and the second residue to prepare a tableting excipient powder. The method of manufacturing a tableting excipient comprising green tea residue. The method according to claim 1,
The extraction solvent of step (a) or (b) is selected from the group consisting of water, lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane, Of the total amount of the green tea residue. The method according to claim 1,
Wherein the pulverization of step (c) is carried out according to any one of spray drying, vacuum distillation and freeze drying. A tableting excipient comprising a green tea residue prepared according to any one of claims 1 to 3. (1) extracting a dried green tea leaf with an extraction solvent to obtain a green tea extract, and separating the residue to prepare a primary residue;
(2) removing the caffeine component from the green tea extract to prepare a decaffeinated green tea extract;
(3) concentrating the decaffeinated green tea extract to prepare a green tea concentrated extract;
(4) preparing green tea extract powder by pulverizing the green tea concentrated extract; And
(5) A method for manufacturing a green tea tablet, comprising the steps of: (1) preparing a green tea tablet by tableting the green tea extract powder with a tableting excipient comprising a green tea residue prepared according to any one of claims 1 to 3; Gt; 6. The method of claim 5,
Wherein the caffeine is removed by adding ethyl acetate or methylene chloride while the green tea extract is mixed with the extraction solvent in step (2). 6. The method of claim 5,
Wherein the green tea extract powder of step (4) has an average particle size of 20 to 23 占 퐉. 6. The method of claim 5,
Wherein the pulverization of step (4) is performed according to any one of spray drying, vacuum distillation and freeze drying. 6. The method of claim 5,
Wherein in step (5), the tableting excipient and the green tea extract powder are mixed and weighed at a weight ratio of 3: 7 to 7: 3. 6. The method of claim 5,
Wherein the catechin content of the green tea tablet of step (5) is 30 to 35 wt%. A green tea tablet produced according to any one of claims 5 to 10.

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