KR20170017853A - Natural antibacterial composition and spray device including the same - Google Patents

Abstract

A natural antimicrobial composition and an injection device comprising the natural antimicrobial composition.

Description

TECHNICAL FIELD [0001] The present invention relates to a natural antimicrobial composition and an injection device including the natural antibacterial composition.

The present invention relates to a natural antimicrobial composition and an injection device comprising the natural antimicrobial composition.

Generally, when a microorganism or a bacterium absorbs contaminants such as sweat or sebum secreted from the human body, the skin is irritated by strong skin irritation, and bacteria such as Staphylococcus aureus, Escherichia coli, A bad odor may be generated.

In particular, in the case of the armpit, foot, head and genital area of the human body, it has a favorable humidity and temperature condition for propagation of bacteria and is rich in nutrients to be ingested by the bacteria. Therefore, bacteria, fungi, Various microorganisms such as fungi can propagate. As a result, various microorganisms are inhabited to produce skin irritation, itching, inflammation, blistering, rash, and odor.

In addition, when secretions such as sweat and sebum secreted from the human body are buried in clothes, bedding, shoes, etc., various microorganisms can reproduce vigorously and cause bad odor. Such clothes, bedclothes, It is difficult to remove the causative organisms harmful to human body. Therefore, in the environment of group life such as military unit, dormitory, training center, etc., exposure frequency to various kinds of microorganisms harmful to human body is increased, causing infection and odor.

In order to solve this problem, various antibacterial agents have recently been developed to inhibit the growth of various microorganisms and to remove odors caused by microorganisms. In particular, a fungicide for removing fungi, a chemical detergent for removing various bacteria in clothing and bedding, and a skin disease drug for eradicating bacteria that cause the inflammation in the human body have been developed .

However, these various antimicrobial agents require different antimicrobial agents depending on the type of microorganisms they are responsible for, and antimicrobial agents having different uses depending on places, objects, and the body where bacteria must be removed. Therefore, There is a problem in that the division is not easy and the cost of the user is increased.

Accordingly, development of a general-purpose antibacterial agent that can be widely used for various applications is urgently required.

Korean Patent No. 1380905 discloses silver (Ag) -based inorganic antimicrobial agents. As described above, most recently developed and used antimicrobial agents are composed of materials produced by chemical processing. Therefore, there is a concern that environmental pollution may be caused by a non-environmentally friendly substance or may cause harmful actions to the human body.

The present invention is intended to provide a natural antimicrobial composition capable of eliminating strong antibacterial activity, odor removal, various mycelium, and causative microorganisms, and an injection device comprising the natural antimicrobial composition.

However, the problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description.

The first aspect of the invention provides a natural antimicrobial composition comprising an extract of cinnamon tree extracted from cinnamon and a lip oil obtained from plants.

A second aspect of the present application provides a storage container for storing an aerosol-type natural antimicrobial composition comprising a natural antimicrobial composition and an aerosol propellant according to the first aspect of the present invention; And a spray nozzle for spraying the aerosol-type natural antimicrobial composition stored inside the storage container to the outside of the storage container.

According to one embodiment of the present invention, it is possible to suppress the proliferation of various bacteria, harmful pathogens, and bacteria by using the extracts extracted from natural plants, especially cinnamon trees, and to have a strong antibacterial activity of 99.9% A natural antimicrobial agent can be provided. In addition, since the natural antimicrobial composition uses a component extracted from a natural plant as a main ingredient, it can be widely used for various skin diseases which are harmless to humans and animals and can be caused by various bacteria, harmful pathogens, and bacteria.

In one embodiment of the invention, the natural antimicrobial composition can be used for the mite or mosquito repellent and may be helpful in treating atopy.

In addition, the injection device including the above-described natural antimicrobial composition can be used intermittently at regular times such as a school, a public office, a church, a resting place, a waiting room, a hall, a hospital, a restaurant, a bus, a train, a karaoke room, By spraying, it is possible to prevent the propagation and transmission of various bacteria, harmful pathogens, and bacteria.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a schematic diagram showing an injection device comprising an antimicrobial composition according to one embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. It should be understood, however, that the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In the drawings, the same reference numbers are used throughout the specification to refer to the same or like parts.

Throughout this specification, when a part is referred to as being "connected" to another part, it is not limited to a case where it is "directly connected" but also includes the case where it is "electrically connected" do.

Throughout this specification, when a member is " on " another member, it includes not only when the member is in contact with the other member, but also when there is another member between the two members.

Throughout this specification, when an element is referred to as " including " an element, it is understood that the element may include other elements as well, without departing from the other elements unless specifically stated otherwise. The terms " about ", " substantially ", etc. used to the extent that they are used throughout the specification are intended to be taken to mean the approximation of the manufacturing and material tolerances inherent in the stated sense, Accurate or absolute numbers are used to help prevent unauthorized exploitation by unauthorized intruders of the referenced disclosure. The word " step (or step) " or " step " used to the extent that it is used throughout the specification does not mean " step for.

Throughout this specification, the term " combination (s) thereof " included in the expression of the machine form means a mixture or combination of one or more elements selected from the group consisting of the constituents described in the expression of the form of a marker, Quot; means at least one selected from the group consisting of the above-mentioned elements.

Throughout this specification, the description of "A and / or B" means "A or B, or A and B".

The "cinnamon tree" according to the embodiment of the present application is an evergreen tree belonging to the camphoraceae and is a plant mainly cultivated in warm regions such as southern China (Guangdong, Guangxi, Fujian, Yunnan) and Vietnam. The extracts of Cinnamomum cassia L. can be obtained by mixing volatile substances such as cinnamaldehyde, eugenol and phellandrene with tannin, mucilage, gum, sugar, , Coumarin and the like.

The term " lip oil " according to the embodiment of the present application is an oil extracted from the leaf of a plant. It is an oil extracted from leaves of a plant, such as Cinnamomum cassia, Pinus densiflora, Pinus densiflora, Pinus densiflora, Eucalyptus, German chamomile, Cedarwood, But are not limited to, lip oils of plants selected from the group consisting of grass, juniper berry, tea tree, peppermint, rosemary, sandalwood, ginger, lavender, thyme, and combinations thereof, And preferably cinnamon leaf oil extracted from the leaves of cinnamon trees.

The term " phytoncide " according to the embodiment of the present application is a term created by the combination of 'phyton' meaning 'plant' and 'cide' meaning 'killing' The substance is collectively referred to herein as a natural substance which is capable of preventing the oxidation and proliferation of microorganisms by collecting and decomposing the source material of the odor and deodorizing, insecting, antibacterial, anti-inflammatory, Of the natural healing component. The phytoncide may be obtained from all the trees and preferably includes those obtained from the group consisting of a cedar tree, a perennial tree, a deciduous tree, a cedar, a cinnamon, a pine, a pine, and combinations thereof However, the present invention is not limited thereto. The phytoncide contains terpenes having high volatility as a main component, and is composed of other phenol compounds, alkaloid components, glycosides and the like.

Hereinafter, the term " microorganism " according to the embodiments of the present application will be understood to include Escherichia coli, Salmonella, Staphylococcus aureus, Bacillus, Staphylococcus or Vibrio , But may not be limited thereto.

Hereinafter, the " active ingredient " according to the embodiments of the present invention refers to a component that alone exhibits the desired activity or can exhibit activity together with a carrier that is not active per se.

Hereinafter, embodiments and examples of the present invention will be described in detail with reference to the accompanying drawings. However, the present invention is not limited to these embodiments and examples and drawings.

The first aspect of the invention provides a natural antimicrobial composition comprising an extract of cinnamon tree extracted from cinnamon and a lip oil obtained from plants.

In one embodiment of the present invention, the natural antimicrobial composition may include an extract of cinnamon tree and a natural lip oil obtained from the plant as an active ingredient.

In one embodiment of the present invention, the method for extracting the cinnamon tree from cinnamon can be used without any particular limitation as long as it is a method known in the art for extracting an extract from a plant. Examples of the method include a steam distillation method, A solvent extraction method, a carbon dioxide gas extraction method, or a low temperature extrusion method, but the present invention is not limited thereto.

In one embodiment of the invention, the extract of Cinnamomum cassia may include a purified form of the extract through filtration, a concentrated liquid extract from which the extraction solvent has been removed, and a solid extract from which the extraction solvent has been removed However, the present invention is not limited thereto.

In one embodiment of the invention, the cinnamon tree extract may be, but not limited to, cinnamaldehyde, eugenol, phellandlane, tannin, plant clot, gum, sugar, and coumarin. More preferably, the extract of Cinnamomum cassia may include but is not limited to eugenol. The yugenol is an essential oil extracted from cinnamon tree. It is excellent in activity as an antibacterial and anesthetic agent, has a transparent pale yellow color and has low solubility in water, but is easily dissolved in an organic solvent.

In one embodiment of the present application, the lip oil is an oil extracted from the leaf of a plant and is an oil extracted from the leaves of a plant, such as cinnamon, white pine, pine, spruce, eucalyptus, German chamomile, cedarwood, bergamot, lemon, cypress, But are not limited to, lip oils of plants selected from the group consisting of jellyfish, juniper berry, tea tree, peppermint, rosemary, sandalwood, ginger, lavender, thyme, and combinations thereof, May include cinnamon leaf oil extracted from the leaves of cinnamon trees. The method of extracting the lip oil may be any method known in the art for extracting plant oils such as steam distillation, solvent extraction, carbonic acid gas extraction, and low-temperature extrusion, and may be used without limitation, The leaves may be those that only utilize steam distillation to capture low molecular weight, highly volatile components.

In one embodiment of the present invention, the antimicrobial composition may further include a dispersant or a carrier in addition to the effective ingredient, so long as the antibacterial effect of the active ingredient is not impaired. For example, the dispersant may be water, an alcohol solvent (e.g., methyl alcohol, ethyl alcohol, ethylene glycol, isopropyl alcohol, propylene glycol, diethylene glycol, glycerin, etc.) , Alcohols such as benzene, toluene, xylene, naphthalene, methylnaphthalene, and the like may be used as the solvent (e.g., dioxane, tetrahydrofuran, cellosolve, and diethylene glycol dimethyl ether), aliphatic hydrocarbons Etc.), halogenated hydrocarbons (e.g. chloroform, carbon tetrachloride etc.), acid amides (e.g. dimethylformamide etc.), esters (e.g. methyl acetate ester, ethyl acetate ester, butyl acetate ester, fatty acid glycerin ester etc.) (Such as acetonitrile), surfactants (such as higher alcohol sulfate esters, alkyl sulfonic acids, alkyl allyl sulfonic acids, quaternary ammonium salts, When alkyl amines, fatty acid ester, polyalkylene oxide compounds, but may be, including those not selected from dihydro-sorbitol compounds), and the group consisting of the combinations thereof, may not be limited thereto. For example, the carrier may be selected from the group consisting of clay (e.g., kaolin, bentonite, acid clay), talc (e.g. talcum powder, tin powder), silica (e.g. diatomaceous earth, silicic anhydride, mica powder, , Activated charcoal, and combinations thereof. However, the present invention is not limited thereto.

In one embodiment of the present invention, the natural antimicrobial composition may further include, but is not limited to, an alcohol-based solvent and phytoncide. In one embodiment of the present invention, the alcohol-based solvent may be one contained in the natural antimicrobial composition as a dispersant, and examples thereof include methyl alcohol, ethyl alcohol, isopropyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, But are not limited to, those selected from the group consisting of glycerin, and combinations thereof. However, in order to produce an antimicrobial composition in which the toxicity of the present invention is minimized to human body, it may be preferable to use ethyl alcohol as a main component as the alcoholic solvent.

In one embodiment of the present invention, the phytoncide is a substance contained in all the trees, and may have effects of preventing microbial growth or growth, preventing oxidation and removing odor, but it is not limited thereto have. The phytoncide contains terpenes having high volatility as a main component, and contains other phenol compounds, alkaloid components, glycosides and the like. The terpenes function as a bactericide and an antiseptic agent because they act to kill bacteria, fungi, parasites, insects and the like and inhibit growth and proliferation. They can be liquefied and can inhale deep into the body, There is no side effect, and the value is excellent.

In one embodiment of the present invention, it is preferable that 1 to 5 parts by weight of the cinnamon extract and 0.1 to 1 part by weight of the lip oil are contained in 100 parts by weight of the natural antimicrobial composition. But may not be limited. If the content of cinnamon tree extract is less than 1 part by weight, the content of cinnamon tree extract is too low to exhibit the desired antibacterial performance and odor removing ability of the present invention. If the content of cinnamon tree extract is more than 5 parts by weight The improvement of the antibacterial performance and odor removal performance is insignificant, while the content of the expensive cinnamon tree extract is unnecessarily increased, which causes a problem of raising the product unit price too much. In the case of the lip oil, when the content is less than 0.1 part by weight, there is a problem that the fragrance unique to the lip oil is hardly noticeable. On the other hand, when the content is more than 1 part by weight, the fragrance of the lip oil becomes excessively strong. This is because there is a problem that can give a sense of rejection.

For example, the cinnamon bark extract may be present in an amount of from about 1 part to about 5 parts, from about 1 part to about 4 parts, from about 1 part to about 3 parts, from about 1 part to about 3 parts, But are not limited to, from 1 part by weight to about 2 parts by weight, from about 2 parts by weight to about 5 parts by weight, from about 3 parts by weight to about 5 parts by weight, or from about 4 parts by weight to about 5 parts by weight Preferably, about 2 parts by weight of the cinnamon bark extract may be contained in 100 parts by weight of the natural antimicrobial composition. For example, the lip oil may include, but is not limited to, about 0.1 part by weight to about 1 part by weight based on 100 parts by weight of the natural antimicrobial composition. For example, the lip oil may be present in an amount of from about 0.1 parts by weight to about 1 part by weight, from about 0.3 parts by weight to about 1 part by weight, from about 0.5 parts by weight to about 1 part by weight, from about 0.7 part by weight From about 0.1 part by weight to about 0.5 part by weight, or from about 0.1 part by weight to about 1 part by weight, from about 0.9 part by weight to about 1 part by weight, from about 0.1 part by weight to about 0.9 part by weight, To about 0.3 part by weight, but may not be limited thereto. Preferably, about 0.5 part by weight of the lip oil may be added to 100 parts by weight of the natural antimicrobial composition.

In one embodiment of the present invention, it is preferable that 80 to 98 parts by weight of the alcohol-based solvent and 1 to 5 parts by weight of the phytoncide are contained in 100 parts by weight of the natural antimicrobial composition, But may not be limited. Particularly, when the content of phytoncide is less than 1 part by weight, the content of phytoncide is too low to exhibit the desired antibacterial performance and odor removing ability of the present invention. When the content of phytoncide is more than 5 parts by weight, The improvement is insignificant, but the amount of expensive phytoncide is unnecessarily increased, which may cause a problem of excessively raising the product price.

More preferably, about 95 parts by weight of the alcoholic solvent may be included in 100 parts by weight of the natural antimicrobial composition, and about 2.5 parts by weight of the phytoncide may be included.

In one embodiment of the invention, the natural antimicrobial composition comprises an extract of Cinnamomum, preferably about 2 parts by weight of eugenol, about 0.5 parts by weight of lip oil, about 2.5 parts by weight of phytonchide, about 85 parts by weight of ethanol, And an alcoholic solvent containing about 10 parts by weight of isopropyl alcohol, thereby providing an excellent antimicrobial composition having a sterilizing power of about 99.9%. In addition, since the natural antimicrobial composition according to one embodiment of the present invention uses a component extracted from a plant as an active ingredient as a main ingredient, it is harmless to humans and animals and can be used for various skin diseases such as various bacteria, harmful pathogens, Can be widely used.

A second aspect of the present invention is a storage container for storing an aerosol-type natural antimicrobial composition comprising a natural antimicrobial composition according to the first aspect of the present invention and an aerosol propellant; And a spray nozzle for spraying the aerosol-type natural antimicrobial composition stored inside the storage container to the outside of the storage container.

The second aspect of the present invention relates to an injection device comprising a natural antimicrobial composition according to the first aspect of the present application, and a detailed description thereof is omitted for the parts overlapping with the first aspect of the present application. However, May be applied equally to the second aspect of the present invention even if the description thereof is omitted.

In this regard, Figure 1 is a schematic diagram illustrating an injection device comprising an antimicrobial composition according to one embodiment of the present invention. As shown in Figure 1, an injection device 100 comprising a natural antimicrobial composition according to one embodiment of the present invention includes a reservoir 110 for storing an aerosol-type natural antimicrobial composition comprising a natural antimicrobial composition and an aerosol propellant, And a spray nozzle 120 for spraying the aerosol-type natural antimicrobial composition to the outside of the storage container 110.

In one embodiment of the present invention, storing the aerosol-type natural antimicrobial composition in the storage container 110 may be accomplished by placing the natural antimicrobial composition into a storage container 110, ≪ / RTI > In addition, the storage container 110 may additionally include, but is not limited to, a surfactant or a UV stabilizer to prevent discoloration due to corrosion and / or antimicrobial composition of the storage container.

In one embodiment herein, the aerosol propellant is selected from the group consisting of nitrogen, air, carbon dioxide, carbon monoxide, dimethyl ether, difluoroethane, propane, butane, isobutane, liquefied petroleum gas (LPG) But are not limited thereto.

In one embodiment of the present invention, the spray controller determines the spray cycle for spraying the aerosol-type natural antimicrobial composition and controls the operation so that the spray nozzle 120 injects the aerosol- But may not be limited thereto. The injection period controlled by the injection controller can be easily adjusted according to the set value.

Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited thereto.

[Example]

1. Preparation of cinnamon tree extract

The leaves, stems, and roots of cinnamon trees were ground to a size of 0.5 cm to 1 cm. In order to remove impurities present in the crushed cinnamon tree, the crushed cinnamon tree was washed with water and dried. Then, the washed and dried cinnamon flakes were dried by blowing air at a temperature of 25 ° C to 30 ° C to remove residual water of water used in the washing. The moisture-removed cinnamon pulverization product was dried in a natural state for 7 to 8 days. The naturally dried cinnamon wood pulverized product was pulverized in the form of a powder having a particle size of 50 mesh to 300 mesh using a pulverizer. The pulverized cinnamon powder was mixed with ethanol at a weight ratio of 1: 100 (100 g of ethanol per gram of cinnamon powder) at a temperature of 35 캜 to 40 캜 at a low speed of 100 rpm to 300 rpm using a stirrer for 24 hours Lt; / RTI > Subsequently, the mixture of cinnamon powder and ethanol was filtered through a funnel and firstly filtered to separate only liquid components except for the solid content. The separated components were subjected to secondary filtration using a funnel containing a filter paper to remove residual residues. The filtrate, which had undergone the secondary filtration, was allowed to settle for 24 hours, after which only the supernatant was separated.

Subsequently, to remove impurities in the separated supernatant, the supernatant, methylene chloride, and purified water were mixed at a weight ratio of 1: 1: 1, respectively, and stirred for 1 hour to 2 hours. The mixture of the supernatant, methylene chloride and purified water was filtered three times to five times using a funnel containing filter paper, and then precipitated for 24 hours. After the precipitation, filtration was carried out in the same manner, and the solvent (ethanol, methylene chloride, and purified water) contained in the cinnamon tree extract was evaporated with a rotary evaporator and the impurities were removed.

Finally, the concentrated liquid concentrated by a rotary evaporator was placed in an oven at 50 DEG C to 100 DEG C and dried at 1 atm for 24 hours to obtain a cinnamon tree extract according to the present example. The cinnamon tree extract thus obtained contained eugenol as a main component.

2. Preparation of lip oil

The lip oil was prepared using steam distillation. Specifically, a small amount of distilled water and leaves of cinnamon were crushed finely with a mixer and placed in a 3 L concentrated flask. The temperature of the mantle of the flask containing the diethylether and hexane (40 mL, 1/1, v / v) in the flask was maintained at about 70 DEG C on a heating mentle at 30 to 40 DEG C And heated for 2 hours. After heating, sodium sulfate (Na ₂ SO ₄ ) was added to remove moisture in the collected oil, and then concentrated using a filter paper to obtain a cinnamon lip oil.

3. Preparation of natural antimicrobial composition

2% by weight of the eugenol obtained from the cinnamon extract obtained in this Example, 0.5% by weight of lip oil and 2.5% by weight of phytoncide were added to a mixed solution of 10% by weight of isopropyl alcohol (IPA) and 85% by weight of ethanol To prepare a natural antimicrobial composition according to this Example.

Experimental Example 1: Sterility Test of Natural Antimicrobial Composition

The antimicrobial activity of the natural antimicrobial composition according to this example was tested. At this time, Escherichia coli, Staphylococcus aureus, Escherichia coli 0157, Salmonella, Bacillus, Pseudomonas, Vibrio, and Streptococcus were used as experimental strains.

Each strain was cultured in a liquid medium, and the cultured bacteria were diluted and adjusted so that the initial inoculum number was 1 × 10 ⁵ CFU / mL to 9 × 10 ⁵ CFU / mL.

20 mL of the natural antimicrobial composition according to the present example was added to the sterilized cap tube, the number of bacteria inoculated after the inoculation was measured 15 minutes after the inoculation of the bacteria was adjusted by diluting the cultured bacteria, Respectively. However, in the initial dilution stage, the experiment was performed by neutralizing with D / E Neutralizing Broth (DIFCO).

When bacteria were grown in the medium, the number of bacteria on the medium was multiplied by the dilution factor, and the value was calculated. When the bacteria did not proliferate in the medium (when the bactericidal power was 99.9% or more) ".

The results according to Experimental Example 1 are shown in Table 1 below.

At this time, the reduction rate (more than 99.9%) of the number of bacteria measured after 15 minutes was calculated from the formula of {(A-B) / A} x 100. Where A is the initial inoculum number and B is the number of bacteria measured after 15 minutes.

As shown in Table 1, when the natural antimicrobial composition according to the present invention was exposed for 15 minutes, all of the strains to be tested were not proliferated, and thus the natural antimicrobial composition according to the present example was found to be effective against bacteria and pathogenic harmful bacteria It was confirmed that it had an excellent sterilizing power of 99.9% or more.

Experimental Example 2: Deodorization test of natural antimicrobial composition

The deodorizing ability of the natural antimicrobial composition according to this example against ammonia (NH ₃ ) was examined.

Specifically, the natural antimicrobial composition according to the present example was mixed with ammonia having strong odor components, and ammonia concentrations were measured at 0 minute, 30 minutes, 60 minutes, 90 minutes, and 120 minutes, respectively. At this time, sterilized physiological saline was used as a control.

The results of Experimental Example 2 are shown in Table 2 below.

As shown in Table 2, in the case of the natural antimicrobial composition according to the present invention, the deodorization ratio of about 95% after 30 minutes of mixing with the ammonia of the experiment was observed. After about 60 minutes, (not detected).

It will be understood by those of ordinary skill in the art that the foregoing description of the embodiments is for illustrative purposes and that those skilled in the art can easily modify the invention without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.

100: Injection device
110: Storage container
120: injection nozzle
130:

Claims (4)

2% by weight of the extract, 0.5% by weight of cinnamon oil, 2.5% by weight of phytonchid, 10% by weight of isopropyl alcohol (IPA) and 10% by weight of ethanol 85% < / RTI > by weight of the composition.
A storage container for storing an aerosol-type natural antimicrobial composition comprising a natural antimicrobial composition according to claim 1 and an aerosol propellant; And
A spray nozzle for spraying the aerosol-type natural antimicrobial composition stored inside the storage container to the outside;
≪ / RTI > comprising a natural antimicrobial composition.
3. The method of claim 2,
Wherein the aerosol propellant is selected from the group consisting of nitrogen, air, carbon dioxide, carbon monoxide, dimethyl ether, difluoroethane, propane, butane, isobutane, liquefied petroleum gas, and combinations thereof. Lt; / RTI >
3. The method of claim 2,
Further comprising a spray controller for determining an spray cycle for spraying the aerosol-type natural antimicrobial composition and controlling operation to spray the aerosol-type natural antimicrobial composition at each spray cycle with the spray nozzle Jetting device.

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