KR20150050234A - Composition containing octyl gallate - Google Patents

Abstract

The present invention relates to cosmetic compositions, quasi-drug compositions, preservative compositions, antimicrobial compositions and pharmaceutical compositions comprising octyl gallate. Since the octyl gallate according to the present invention can be used for the purpose of enhancing the antimicrobial activity, it can exhibit a broad spectrum of antimicrobial activity against various fungi. Therefore, the composition containing the same can be used as a sterilizing, antibacterial and antifungal agent in various fields such as cosmetics, medicines, It is useful for preservation purposes.

Description

COMPOSITION CONTAINING OCTYL GALLATE [0002]

The present invention relates to cosmetic compositions, quasi-drug compositions, preservative compositions, antimicrobial compositions and pharmaceutical compositions comprising octyl gallate.

Due to the development of traffic these days, global movement is active, and various infectious diseases and new diseases are rapidly spreading along with human movement. In the meantime, the use of indiscriminate antimicrobial agents has threatened mankind because many microorganisms are resistant. In particular, there continues to be a need for a direct cosmetic improvement to microorganisms that may adversely affect the body for the preservation of perishable products (such as cosmetics, medicines or foods) or for materials with antimicrobial properties for therapeutic treatment.

Pesticides can be broadly divided into bactericides, insecticides, herbicides, and growth regulators. In the case of damage to crops caused by viruses or microorganisms, the use of fungicides is used. In the field of agriculture, cheap and powerful synthetic synthetic antimicrobials have become overuse, threatening our table. Various antimicrobial substances are also used in household products that are directly used in the human body, and most cheap chemical substances are used. Unfortunately, it has been scientifically proven that most of the antimicrobials used in this way can be harmful to humans for long periods of use.

Many products such as foods, medicines, daily necessities and cosmetics widely used in our daily lives are added with preservatives, which are antimicrobial substances approved for human use, to prevent changes in internal properties and to preserve them for a certain period of time. In particular, cosmetics can be used by hand, or due to the nature of products that are frequently in contact with human body, microorganisms can flow in from the outside and the quality of products can be changed by these microorganisms. In particular, there is a risk that contamination of products used in the eye can cause eye diseases. In the 1920s, there was a case where consumers using mascara contaminated by microorganisms were blinded. Accordingly, techniques for securing the safety of consumers and preserving the quality of products have been continuously developed by preventing contamination of the products by microorganisms.

On the other hand, as a substance used as the preservative, there are some materials derived from natural materials, but most of them are chemically synthesized artificial materials. Even preservatives of parabens, which are most safe as conventional preservatives and commonly used in household products, cosmetics, and medicines, have been shown to be effective against skin allergies (Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36) Edwin et al., Toxicology and applied pharmacology, 1998, 153, 12-19) and resistance to inducing resistant bacteria.

Most of the natural active substances used as preservatives are not commercialized because of color, stability, narrow antibacterial spectrum, shape problems, etc., and the hinokitiol, hinokitiol, Magnolol extract, grapefruit extract Such as DF-100, are commercially available. Therefore, the need for a naturally occurring antimicrobial substance capable of replacing the existing synthetic chemical antimicrobial substance is maximized. In particular, it is necessary to develop a natural antimicrobial substance having a wide range of antimicrobial spectrum and shape stability while reducing side effects, which are the biggest disadvantages of the antimicrobial agent.

Under these circumstances, the present inventors have made intensive efforts to reduce the absolute amount of components that can induce overall skin irritation by mixing with antimicrobial substances that are currently in use, and as a result, they have found that a combination of using octyl gallate .

One object of the present invention is to provide a cosmetic composition comprising octyl gallate.

It is another object of the present invention to provide a quasi-drug composition comprising octyl gallate.

It is another object of the present invention to provide a pharmaceutical composition comprising octyl gallate.

It is another object of the present invention to provide an antimicrobial composition comprising octyl gallate.

It is another object of the present invention to provide a preservative composition comprising octyl gallate.

In one aspect, the present invention provides a composition comprising a synergistic target mixture of octyl gallate. In particular, the composition of the present invention is a composition comprising octyl gallate and a preservative mixture as an active ingredient, wherein the preservative may be a 1,2-alkane diol. That is, it may be a composition comprising a mixture of octyl gallate and a 1,2-alkanediol as an active ingredient.

The octyl gallate of the present invention may be a substance having an IUPAC name of Octyl 3, 4, 5-trihydroxybenzoate, a chemical formula of C ₁₅ H ₂₂ O ₅ and a molecular weight of 282.33, and may be produced by a chemical synthesis method or an enzyme But is not limited thereto.

The octyl gallate of the present invention is contained in an amount of 0.001 to 50% (w / v), preferably 0.01 to 50% (w / v), more preferably 0.1 to 30% (w / v) . The octyl gallate of the present invention may be synergistic when used with a preservative.

The term " synergistic target mixture " of the present invention refers to all materials which contain octyl gallate and which, when used in admixture with octyl gallate, have a synergic effect than when each is used alone in terms of antimicrobial activity.

In the present invention, the preservative contained in the octyl gallate and the preservative mixture may include, without limitation, preservatives having synergistic effect when mixed with octyl gallate, but 1,2-alkanediol may be particularly used. For example, the 1,2-alkanediols can be selected from 1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2- But are not limited thereto.

When the mixture of octyl gallate and preservative according to the present invention is used as an active ingredient for the preservation of organic substances, it is possible to have a more excellent preservative (antibacterial activity) by adding one or more additional preservatives. Preferably, the additional preservative is a synergistically increased composition, wherein the preservative further comprises an additional preservative, wherein the additional preservative is selected from the group consisting of benzoic acid, its esters and salts, propionic acid and salts thereof, salicylic acid and salts thereof , 2,4-hexanoic acid (sorbic acid) and salts thereof, formaldehyde and paraformaldehyde, 2-hydroxybiphenyl ether and salts thereof, 2-zinc sulfide pyridine-N-oxide, (II) 5-amino-1,3-bis (2-hydroxy) benzoic acid, salts and esters thereof, dehydratcetic acid, formic acid, Hexahydrophthalic acid, 1,6-bis (4-amidino-2-bromophenoxy) -n-hexane and its salts, sodium salt of ethyl mercury- (II) thiosalicylic acid, phenyl mercury and salts thereof, Amino-1,3-bis (2-ethylhexyl) -5-methyl-hexahydropyrimidine, 5-bromo-5- 2-nitro-1,3-propanediol, 2,4-dichlorobenzyl alcohol, N- (4-chlorophenyl) -N '- (3,4- Chloro-m-cresol, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1'-methylene -Bis (3- (1-hydroxymethyl-2,4-dioxiimidazolidin-5-yl) urea) Poly- (hexamethylene ziguanide) hydrochloric acid, 2-phenoxyethanol, hexamethylenetetramine , 1- (3-chloroallyl) -3,5,7-triaza-1-azonia-adamantane-chloride, l- (4-chlorophenoxy) ) -3,3-dimethyl-2-butanone, 1,3-bis- (hydroxy-methyl) -5,5-dimethyl-2,4-imidazolidinedione, benzyl alcohol, , 2-dibromo 2,4-dicyanobutane, 2,2'-methylene-bis (6-bromo-4-chloro-phenol), bromo-chlorophen, magnesium chloride, Chloro-2-methyl-3 (2 H) -isothiazolinone and 2-methyl-3 (2 H) 2-chloro-4-chlorophenol, 2-chloroacetamide, chlorohexidine, chlorohexidineacetate, chlorohexidine gluconate, chlorohexidine hydrochloride, 1-phenoxy- (C12-C22) trimethyl-ammonium bromide and chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl- Hydroxymethyl) -2,5-dioxoimidazolidin-4-yl) -N'-hydroxy-methyl urea, 1,6-bis (4-amidinophenoxy) , Glutaraldehyde 5-ethyl-1-aza 3,7-dioxabicyclo (3.3.0) octane, 3- (4-chlorophenoxy) -1,2-propanediol, hyamine, Alkyl- (C8-C18) -dimethyl-benzyl-ammonium chloride, alkyl- (C8-C18) -dimethyl- benzylammonium bromide, alkyl- , 3-yordo-2-propynyl-butyl carbamate, and sodium hydroxymethyl aminoacetate It may be one or more selected from the group consisting of, and may be especially 1,2-dibromo-2,4-dicyano-butane.

In a specific example of the present invention, it was confirmed that the mixture of octyl gallate and preservative (1,2-hexanediol) had an antimicrobial activity increase index (SI) of 0.11, Was synergistically increased (Example 1, Table 2 and Table 7).

In a specific embodiment of the present invention, an additional preservative (Euxyl K400; 1,2-dibromo 2,4-dicyanobutane) is added to the octyl gallate and the preservative (1,2-hexanediol) It was confirmed that the antimicrobial activity of the combination mixture of the present invention was increased synergistically (Example 3, Table 9, and Table 10 ).

That is, the advantages of the mixture (a) of octyl gallate and preservative according to the invention and the combined mixture with at least one additional preservative (b) added are the same as those of Example 1 (synergistic effect of octyl gallate and preservative) And Example 3 (synergistic effect of octyl gallate / preservative mixture and additional preservative).

The composition of the present invention can be widely used in various fields such as a cosmetic composition, a quasi-drug composition, a pharmaceutical composition, an antimicrobial composition or an antiseptic composition since it has an effect of increasing preservability by containing octyl gallate and a preservative.

The composition of the present invention may preferably have an antibacterial activity against a bacterium, fungus or yeast. More preferably, the composition of the present invention may further comprise an antibacterial agent selected from the group consisting of Brevibacterium epidermis, Corynebacterium kiocellis, Spaulicococus epidermis, It may be a composition having increased antimicrobial activity compared to octyl gallate or preservative alone when used against bacterium acnes, tricophyton mentagrophytes and epidermophyton frondosa. Even more preferably, Brevibacterium epidermis ATCC 35514, Corynebacterium kirilicis ACCC 771, Spiropylococus epidermis ATCC 12228, Propionibacterium acnes ATCC 11829, Tricophyton mentagrophytes CBS 26379 and It may be a composition having an antimicrobial activity that is increased than when octyl gallate or preservative alone is used in Epidermophyton fulocochle CBS 55384.

In the present invention, the term "antibacterial" means the ability to resist bacteria and means all mechanisms that are carried out to defend against the action of microorganisms such as bacteria, fungi,

In the present invention, the term "bacterium" is a bacterium belonging to bacteria. It is the most prolific species among living organisms, and most of them are pathogenic bacteria, but they do not have nucleus, mitochondria and chloroplast. Sizes range from 0.5 μm to 0.5 mm. The bacteria include, for example, Brevibacterium epidermis, Corynebacterium kerchisis, Spa pilococce epidermis, Propionibacterium acnes, Tricophyton mentagrophytes and Epidermophyton furocostae Such as Brevibacterium epidermis ATCC 35514, Corynebacterium kioclissis ACCC 771, Spiropylococus epidermis ATCC 12228, Propionibacterium acnes ATCC 11829, Tricophyton mentagrophytes CBS 26379 And Epidermophytone fulocom CBS 55384 may be included.

The term "fungus" in the present invention refers to a group of microorganisms consisting of more than 72,000 species including fungi, yeast and mushroom. It belongs to a nuclear eukaryote, and mitochondria and endoplasmic reticulum And there are cell walls composed of chitin, glucan, and the like. Most of them are characterized by the formation of cell-grown mycelium to elongate, develop, sexual reproduction and asexual reproduction. Spores are formed in the form of reproductive sperm but some of the species are unicellular. It is mainly a negative bacterium, but it is involved in the organic decomposition of nature, but some parasitism or symbiosis with plants and animals. Such fungi include, for example, Candida albicans and Aspergillus niger .

The term "yeast" in the present invention refers to a single-celled organism that is a fungus or mushroom herb but has no mycelium, no photosynthetic ability or motility, and has the simplest form of eukaryotes having a cell cycle similar to a human cell cycle It is known. The yeast includes, for example, Saccharomyces spp., Pichia spp., Candida spp.

According to a preferred embodiment of the present invention, the composition comprising the octyl gallate and the preservative mixture according to the present invention as an active ingredient is selected from the group consisting of Brevibacterium epidermis ATCC 35514, Corynebacterium kirilicis ACCC 771, Dermis ATCC 12228, Propionibacterium acnes ATCC 11829, Tricophyton mentagrophytes CBS 26379 and Epidermophyton furochom CBS 55384.

Synergistic action of the 1,2-alkanediol according to the present invention When the target mixture is mainly used for inhibiting the growth of animal organisms or undesirable microorganisms therein, Combinations can also be advantageous depending on the case. Suitable active compounds for this are large groups of conventional antibiotics, which can be used, for example, for axillas, jaws or dandruff. Especially products related to cosmetics such as triclosan, cribasol, ocotoxyglycerol, orcpypox (1 -hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) 1 H) -pyridone, 2-aminoethanol), chitosan, parnesol, glycerol monolaurate or a combination of the above materials.

In addition, the synergistic target mixture of 1,2-alkanediols can be used in combination with an anti-perspirant compound (inhibitor) to suppress body odor. The antiperspirant active compounds used are in particular aluminum salts, such as aluminum chloride, aluminum chlorohydrate, nitrate, sulfate, acetate and the like. However, the use of further zinc, magnesium and zirconium compounds is also advantageous. Although somewhat less effective than aluminum salts in essence, alumina / zirconium salt combinations have proven effective in cosmetic and dermatological limitations. Thus, some neutralized aluminum hydroxy chlorides that are better and acceptable for the skin, but not as effective, are also suitable. In addition to aluminum salts, for example: a) protein-coagulating substances such as formaldehyde, glutaraldehyde, natural and synthetic tanning agents and trichloroacetic acid which cause surface insult of the glands, b) (For example, lidocaine, prilocaine or a diluted solution of a mixture of these substances), which interrupts the supply of sympathetic nerves of the sweat glands by cessation of sweat secretion, X, A, or Y zeolites, and d) Botulinum toxin, which is also used in cases of pathologically increased sweat secretion and whose action is based on the irreversible blockade of the release of acetylcholine from the transmitter that is involved in sweat secretion Of Clostridium botulinum) can also be used.

Synergistic action of octyl gallate according to the present invention. When the target mixture is used for the antimicrobial treatment of the surface (for example of a human or animal body), the combination with (metal) chelate may be advantageous in some cases. Particularly preferred (metal) chelates that can be used include, but are not limited to,? -Hydroxy fatty acids, phytinic acid, lactoterein,? -Hydroxy acids such as citric acid, lactic acid and malic acid, Biliary extract, bilirubin, biliveridine or EDTA, EGTA and derivatives thereof.

Various compositions having an antimicrobial activity effect containing octyl gallate and a preservative (1,2-alkanediol) as an active ingredient of the present invention can be applied to any formulations such as liquid, cream, paste, And its use can be applied to various fields. And can be applied to various cosmetic compositions such as a body-related cleanser for body, skin, mouth, hair and the like.

In addition to the octyl gallate and / or preservative as the active ingredient, the composition according to the present invention may further include a substance having antibacterial activity known in the art.

In another aspect, the present invention provides a cosmetic composition comprising octyl gallate and a preservative (1,2-alkanediol) as an active ingredient. In particular, a cosmetic composition comprising octyl gallate and a preservative (1,2-alkanediol) as an antibacterial component is provided as an active ingredient.

The cosmetic composition contains, in addition to the octyl gallate and the preservative mixture as an active ingredient, the components conventionally used in cosmetic compositions, and may contain conventional additives such as, for example, antioxidants, stabilizers, solubilizers, vitamins, Carrier.

When the octyl gallate and preservative mixture of the present invention is used as a cosmetic additive, the mixture may be added as it is or may be used together with other cosmetic ingredients, and may be suitably used according to conventional methods. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment).

The cosmetic composition of the present invention can be prepared into any of the formulations conventionally produced in the art and can be used as a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, , Oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a cream, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 1, 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid esters of sorbitan.

In addition, when the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interface-active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, Fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.

In the cosmetic composition of the present invention, the amount of the octyl gallate and the preservative mixture is 0.001 to 50% (w / v), preferably 0.01 to 50% (w / v), more preferably 0.1 to 30% (w / v).

Synergistic action of octyl gallate according to the present invention When the target mixture is used as a cosmetic and / or cosmetic composition, it may be contained in cosmetics and dermatological products and applied in an appropriate amount to skin and / or hair in a usual manner. In this respect, the cosmetic and cosmetic compositions having the use of the ultraviolet screening agent containing the mixture according to the present invention have specific advantages. Specifically, the composition contains at least one UVB filter and / or at least one inorganic dye. For example, it can be of various forms commonly used in sunscreen compositions. They can therefore be used, for example, as emulsions in the form of solutions, water-in-oil (W / O) or oil-in-water (O / W) O / W) multiple emulsions, gels, hydrodispersions, solid sticks or aerosols.

As described above, a composition containing octyl gallate and a synergistic target mixture can be advantageously combined with a material that absorbs UV light to increase the function of protecting hair and / or skin against ultraviolet light. The composition of octyl gallate and the synergistic target mixture in the cosmetic composition may be from 0.01% (w / w) to 40% (w / w), preferably from 0.1% (w / w) to 10% (w / w), in particular 1.0 to 5.0% (w / w).

   When the composition according to the invention contains UVB filter material it may be useful or water-soluble. Advantageous utility UVB filters are, for example, 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) cordierite, 3- benzylidene camphor, 4-aminobenzenic acid derivatives, 2-ethylhexyl benzoate, amyl 4- (dimethylamino) benzoate, ester of cinnamic acid, preferably 2-ethylhexyl 4-methoxy cinnamate, isopentyl 4-methoxy cinnamate, esters of salicylic acid, 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate, benzophenone derivatives, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy- -Methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, esters of benzalmalonic acid, preferably 4-methoxybenzalmaronic acid (2-ethylhexyl), 2,4,6 -

Tri-anilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine. Advantageous water-soluble UVB filters are, for example, salts of 2-phenylbenzimidazole-5-sulfonic acid, salts of sodium, potassium or triethanolammonium salts and sulfone, benzophenone sulfonic acid derivatives, preferably 2-hydroxy- Methoxybenzophenone-5-sulfonic acid and salts thereof, sulfonic acid derivatives of 3-benzylidene camphor, for example 4- (2-oxo-3-boronidene methyl) benzenesulfonic acid, (2-oxo-10-sulfo-3-boronylidenemethyl) -benzene and salts thereof (10-sulfato Compounds such as sodium, potassium or triethanol ammonium salts) or benzene-1,4-di (2-oxo-3-boronidene methyl 10-sulfonic acid.

   The synergistic target mixture of octyl gallate according to the present invention is a cosmetic adjuvant commonly used in such a composition, and therefore, for example, antioxidants, perfume oils, foaming inhibitors, colorants, coloring pigments, thickeners, (For example, an alcohol, a polyol, a polymer, a foam stabilizer, an electrolyte, an organic solvent, or a silicone derivative) of an emulsifier, a plasticizer, a humidifying and / or moisturizing substance, a fat, Can be used.

Synergistic action of octyl gallate for the prevention of topical or cosmetic treatment of the skin. A composition containing a high activity of the composition containing the target active mixture may be advantageous. In a preferred embodiment, the composition comprises one or more animal and / or plant treatment fats and oils such as olive oil, sunflower oil, refined soybean oil, palm oil, sesame oil, rapeseed oil, almond oil, Coconut oil, shea butter, jojoba oil, diesel oil, tallow, milk and fat and optionally further processing components, for example fatty alcohols having 8 to 30 carbon atoms. Here, fatty alcohols may be saturated or unsaturated, linear or branched. For example, decanol, decenol, oak tenor, dodecanol, dodecenor, otazienor, decazenor.

In addition, the combination of the octyl gallate according to the present invention with the synergistic target mixture is preferred, and the combination material is ceramide, wherein the ceramide is an N-acylsuphinosine Amides) or synthetic analogues of these fats (so-called pseudo-ceramides); Phospholipids such as soybean lecithin, alesitin and cephalin; Petrolatum, paraffin and silicone oil, the latter in particular dialkyl- and alkylaryl-siloxanes such as dimethicone and methylphenylpolysiloxane and such alkoxylated and quarternized derivatives.

Hydrolyzed proteins of animals and / or plants may also be advantageously added to the synergistic target mixture of octyl gallate according to the invention. In this regard, it is also possible to use in particular, elastin, collagen, keratin, milk protein, soy protein, auto protein, pea protein, almond protein and wheat protein flower or corresponding hydrolyzed protein but with condensation products with fatty acids, Hydrolyzed proteins are advantageous, wherein the use of plant hydrolyzed proteins is preferred.

Synergistic action of octyl gallate according to the present invention When the cosmetic or cosmetic composition containing the target mixture is a potion or lotion, the solvent used is water or an aqueous solution; Fatty alcohols such as fatty acids, fatty acids, fatty acids, fats, waxes and other natural and synthetic fatty substances, preferably alcohols having a low carbon number, such as isopropanol, propyleneglycol or glycerol, or alkanoic acids having low carbon numbers Ester; Alcohols, diols or polyols having a low carbon number and such ethers and preferably ethers such as ethanol, isopropanol, propyleneglycol, glycerol, ethylene glycol, ethylene glycol ethyl or monobutyl ether, propyleneglycol monomethyl, ethyl or monobutyl Ether, diethylene glycol monomethyl or ethyl ether, and the like. In particular, mixtures of the above solvents may be used.

The cosmetic composition containing the synergistic target mixture of octyl gallate according to the present invention may contain an antioxidant so that it can be used for cosmetic and / or dermatological applications as well as any conventional antioxidant. Antioxidants advantageously include amino acids (such as glycine, histidine, tyrosine) and derivatives thereof, imidazoles (such as uronic acid) and derivatives thereof, D, L-carnosine , Carotenoids (e.g., alpha -carotene, beta -carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (for example, peptides such as D-carnosine, L-carnosine and such derivatives Acetyl, methyl, ethyl, isopropyl, n-butyl, isobutyl, isopropyl, n-butyl, isobutyl, isobutyl, Amyl, butyl and lauryl, palmitoyl, gamma -linoleyl, cholesteryl and glyceryl esters) and their salts, thiadiopropionic acid dilauryl, thiodipropionic acid distearyl, thiodipropyl Acid and its derivatives (esters, ethers, peptides, fats, nucleotides, nucleosides and salts), and sulfoximine compounds (such as bithionine sulfoximine, homocysteine, sulfoximine, Hydroxycarboxylic acids (for example, urea, urea, urea, urea, urea, urea, urea, Such as citric acid, lactic acid, malic acid, fumaric acid, bile acids, bile extracts, bilirubin, viliverdine, EDTA, EGTA and such derivatives, unsaturated fatty acids and derivatives thereof (for example,? -Linolenic acid, linoleic acid, oleic acid) Folic acid and derivatives thereof, ubiquinone and ubiquinone and derivatives thereof, vitamin C and derivatives (for example, ascorbyl palmitate, ascorbyl phosphate Mg, ascorbyl acetate), tocopherol and derivatives thereof Acetic acid (Vitamin E), vitamin A and its derivatives (palmitic acid vitamin A), and furthermore benzoic acid coniferyl benzoate, rutinic acid and its derivatives, pelacic acid and its derivatives, butylhydroxytoluene, butylhydroxyanisole, (For example, ZnO, ZnSO ₄ ), selenium and derivatives thereof (for example, sodium dodecylbenzenesulfonate, sodium dihydrogenphosphate, Ester, ether, sugar, nucleotide, nucleoside, peptide (for example, selenium-methionine), stilbene and such derivatives (for example stilbene oxide, trans-stilbene oxide) And fat).

The cosmetic composition containing the synergistic target mixture of octyl gallate according to the present invention can contain vitamins and vitamin precursors and can be used suitably for cosmetic and / or dermatological applications and contains all the usual vitamins and vitamin precursors Can be used. Especially vitamins of tocopherol, vitamin A, nicotinic acid and niacinamide, B complex, especially biotin, and vitamin C, pantothenic alcohol and its derivatives, especially the esters and ethers of pantothenic alcohol, and derivatives of pantothenic alcohol of cations , Vitamin and vitamin precursors such as, for example, pantothenic alcohol triacetate, pantothenic alcohol monoethyl acetal and acetate, and pantothenic alcohol derivatives of cations.

The cosmetic composition containing octyl gallate and the synergistic target mixture according to the present invention may contain anti-inflammatory compounds and / or activating compounds which alleviate redness and / or itching. There may be suitable, cosmetic and / or dermatological applications thereof, for which all the usual anti-inflammatory compounds and active compounds that alleviate redness and / or itch may be used. The anti-inflammatory compound used and the active compound that alleviates redness and / or itching are advantageously steroidal anti-inflammatory agents in the form of a corticosteroid, for example hydrocortisone, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone, You can expand your list by adding more steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory agents may also be used. (For example, aspirin, disalcid, sorpurin or fendoster), an acetic acid derivative (for example, diclofenac, phenoscopican, , Indomethacin, sulindadac, tolmetin or crydavik), phenamates (e.g., mefenamic, macropenamic, furfenamic or nifurmic), propionic acid derivatives such as ibuprofen, naproxen , Belloxaprofen), or a pyrazole (e.g., phenylbutazone, oxyphenylbutazone, pebra steel or azapropazone) can be exemplified. Or natural anti-inflammatory substances and substances that reduce redness and / or itching. Highly pure active substances isolated from plant extracts, particularly notably active plant extracts and plant extracts, can be used. Extracts from pollen, camomile, aloe, Commiphora species, Rubia species, willow, willow herb and carob bore, pollen and active substances and pure substances (for example, especially bisabolol, apigenin-7- Particular preference is given to seeds, boswellic acid, phytosterol, glycyrrhizin, glabridin or licochalkon A. Synergistic action of octyl gallate A preparation containing a target mixture may contain two or more May contain a mixture of anti-inflammatory compounds.

The cosmetic composition containing the synergistic target mixture of octyl gallate according to the present invention may contain an active compound having a skin tone improving action. Any of the cosmetic and / or dermatological applications of this, and any of the usual skin tone improving active compounds, may be used in accordance with the present invention. Advantageous skin tone improving active compounds include active ingredients such as kojic acid, hydroquinone, arbutin, ascorbic acid, magnesium ascorbyl phosphate, licorice root extract and glabridin or licochalkon A components, Rumex and laminarum Extracts from Ramulus species, Extracts from Pinus and Extracts from Vitis species containing especially skin tone improving stilbene derivatives.

The cosmetic composition containing the octyl gallate and the synergistic target mixture according to the present invention may contain an active compound having skin tanning action. As regards this, there are also those which are suitable for cosmetic and / or dermatological applications and in which all usual skin tanning active compounds can be used. Here, dihydroxyacetone (DHA; 1,3-dihydroxy-2-propanone) is exemplified. DHA can exist in either monomeric or dimeric form, with dimer proportions predominating in crystalline form.

The cosmetic composition containing the synergistic target mixture of octyl gallate according to the present invention may also contain mono-, di and oligosaccharides such as glucose, galactose, fructose, mannose, fructose and lactose.

Synergistic action of octyl gallate according to the invention The cosmetic composition containing the target mixture is usually prepared by extraction of a complete plant, but in individual cases it may be further blended with flowers and / or leaves, wood, ≪ / RTI >

The available plant extracts include aloe, hammamelis, algae, oak bark, willow-herb, nettles, dead nettles, hops, chamomile, milfoil such as milfoil, arnica, marigold, burdock root, burdock root, hawthorn, linden blossom, almond, pine needles, horsechestnut, , Sandalwood, juniper, coconut, mango, apricot, orange, lemon, lime, grapefruit, apple, green tea, grapefruit seeds, wheat, oats, barley, barley, sage leaf, time, basil Rosemary, birch, mallow, bitter-crass, willow bark, restharrow, coltsfoot, althaea, Korean ginseng and ginger Is particularly advantageous. Among these, extracts from aloe, chamomile, algae, rosemary, marigold, Korean ginseng, cucumber, sage leaf, nettle, linden blossom, arnica and hanamelis are particularly preferred . Mixtures of two or more plant extracts may also be used. Extractants which can be used for the preparation of the above plant extracts may in particular be water, alcohols and mixtures thereof. Among alcohols, lower alcohols (e.g., ethanol and isopropanol) but polyhydric alcohols (e.g., ethylene glycol, propylene glycol and butylene glycol) are used in this regard and specifically as a sole extractant and more Use of solutions is preferred. Plant extracts can be used in pure form or in diluted form.

The cosmetic composition containing the synergistic target mixture of octyl gallate according to the present invention is particularly suitable for the preparation of cosmetic compositions containing anionic, cationic, non-ionic and / or non-ionic cosmetic compositions, especially when crystalline or microcrystalline solids, And may contain cationic surfactants. Surfactants are amphipathic substances that can dissolve organic nonpolar materials in water. The hydrophilic portions of the surfactant molecules hereof is normal, for a polar functional group, for _{^{example, -COO -, -OSO 3 2 -}} , -SO 3 - , but, on the other hand, the hydrophobic part is generally a non-polar hydrocarbon group. Surfactants are broadly classified according to the properties of the hydrophilic part of the molecule and the type of the consumer, and can be classified into four groups: anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants.

The anionic surfactant usually contains a carboxylic acid, a sulfuric acid or a sulfonic acid group as a functional group. In aqueous solutions, they form negative organic ions in acidic or neutral solvents. Cationic surfactants are substantially exclusively characterized by the presence of quaternary ammonium groups. In aqueous solutions, they form positive organic ions in acidic or neutral solvents. Amphoteric surfactants, including both anionic and cationic groups, act like anionic or cationic surfactants depending on the pH value in aqueous solution. In strong acid solvents, they have a positive charge, and in an alkaline solvent they have a negative charge. In contrast, in the neutral pH range they are cationic. Polyether chains are typical of non-ionic surfactants. Nonionic surfactants do not form ions in aqueous solvents.

Anionic surfactants which may be advantageously used are acyl amino acids and salts thereof, and specifically include, for example, acyl glutamates, such as sodium acyl glutamate, di-TEA palmitoyl aspartate and sodium capryl / caprylate; For example, palmitoyl hydrolyzed milk protein, sodium cocoyl hydrolyzed soy protein and sodium / potassium cocoyl hydrolyzed collagen acyl peptide; For example, salicylate, salicyl sarcosine, TEA-lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate; Taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate; Acyl lactylate, lauroyl lactylate, caprolactylate or arraninate.

In addition, the anionic surfactants that can be advantageously used may be carboxylic acids and derivatives, and specifically include, for example, lauric acid, aluminum stearate, magnesium arcanolato and undecylenic acid zinc; For example, ester carboxylic acids such as calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 laura mid carboxylate; For example, ether-carboxylic acid which is sodium laisse-13 carboxylate and sodium PEG-6 cocoamidocarboxylate; Or phosphate esters and salts which are, for example, DEA-ores 10 phosphate and zeolite 4 phosphate.

In addition, the anionic surfactants that may be advantageously used may be sulfonic acids and salts, and specifically include, for example, acyl isethionates such as sodium / ammonium cocoyl isethionate; Alkyl aryl sulfonates; For example, sodium coconut monoglyceride sulfate, alkylsulfonates such as sodium C12-14 olefin-sulfonate; Sodium lauryl sulfoacetate and magnesium PEG-3 cocoamide sulfate; Or diols such as, for example, dioctyl sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium lauryl sulfosuccinate, and disodium silicate amide sulfosuccinate, have.

In addition, the anionic surfactants that can be used advantageously can be sulfuric acid esters, and specifically include, for example, sodium, ammonium, magnesium, MIRA, TIPA laisse sulfate, sodium myrus sulfate, and sodium C12-13 palm sulphate Alkyl ether sulfates; Or an alkyl sulphate such as, for example, sodium, ammonium and TEA lauryl sulphate.

Advantageously, the cationic surfactants include alkylamines, alkylimidazoles, ethoxylated amines, quaternary surfactants (RNH ₂ CH ₂ CH ₂ COO- (for pH = 7), RNHCH ₂ CH ₂ COO-B ⁺ (for pH = 12) B ⁺ = any cation such as Na ⁺ ) and a quaternary ester.

The quaternary surfactant comprises at least one N atom covalently bonded to four alkyl or aryl groups. This leads to a positive charge regardless of the pH value. Alkyl betaines, alkyl amide propyl betaines, and alkyl amide propyl hydroxysulfates are advantageous. The cationic surfactants used are also preferably quaternary ammonium compounds, in particular benzyltrialkylammonium chlorides or bromides, such as benzyldimethylstearylammonium chloride, and furthermore alkyltrialkylammonium salts, such as, for example, , Cetyltrimethylammonium chloride or bromide, alkyldimethylhydroxyethylammonium bromide or bromide, dialkyldimethylammonium chloride or bromide, alkylamidoethyl-trimethylammonium ether sulfate, alkylpyridinium salts such as, for example, lauryl chloride or Cetyl-pyridinium, imidazoline derivatives, and oxides such as alkyldimethylamine oxides or alkylaminoethyldimethylamine oxides. Cetyltrimethylammonium salts can be used particularly advantageously.

Amphoteric surfactants that can be used advantageously include, for example, sodium acyl amphoacetate, disodium acyl anodipropionate, disodium alkyl anojia cetethoate, sodium acyl anhydroxy-propyl group sulfonate, disodium acyl Acyl / dialkylethylenediamine, anhydrodiacetate and sodium acylamphopropionate; Or N-alkyl amino acids which are, for example, aminopropyl alkyl glutamides, alkyl aminopropionic acids, sodium alkyl imide dipropionates and lauroanocarboxyl glycinates.

Nonionic surfactants that can be advantageously used include alcohols; For example, alkanolamides such as cocoamide MEA / DEA / MIPA; For example, oxidized amines such as cocoamidopropylamine oxide; Esters formed by the esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols; Propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated cholesterol, ethoxylated / propoxylated triglyceride esters, ethoxylated / propoxylated glycerol esters, Propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers, and alkylpolyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside; Sucrose esters and ethers; Polyglycerol ester, diglycerol ester, glycerol ester; Or an ester of a methyl ester, a hydroxy acid.

Use of anionic and / or amphoteric surfactants with one or more nonionic surfactants is also advantageous. The detergent substance may be present in the preparation according to the invention containing the synergistic target mixture of the 1,2-alkanediol at a concentration of between 1 and 98% (w / w), based on the total weight of the preparation .

The cosmetic or cosmetic composition containing octyl gallate and the synergistic target mixture according to the present invention may also be present in the form of an emulsion.

The oil phase is advantageously mineral oil, mineral wax; Esters of fatty acids with alcohols (e. G. Isopropanol, propylene glycol or glycerol), or alkanoic acids or fatty acids having low carbon numbers, with fatty acids, fats, oils, waxes and other natural and synthetic fatty substances, Esters of fatty alcohols; Alkyl benzoate; Or silicone oils (e.g., dimethicone, diethylpolysiloxane, diphenylpolysiloxane) and mixtures thereof; .

(a) Saturated and / or unsaturated branched and / or straight chain alkanecarboxylic acids having a length of 3 to 30 C atoms and saturated and / or unsaturated branched and / or straight chain alcohol esters having a length of from 3 to 30 carbon atoms , (b) Branched carboxylic acid esters of saturated and / or unsaturated branched and / or straight chain alcohols having a length of from 3 to 30 carbon atoms can be advantageously used. Preferred ester oils are isopropyl Ntetradecanoate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, iso-stearate Nonyl, isonononanoic acid isononyl, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, nail oleic acid, erucic acid nail, oleic acid Erucyl, erucic acid, and the synthesis of these esters, semisynthetic and natural mixtures, such as Jovovaya.

The oil phase is advantageously selected from the group consisting of branched and straight chain hydrocarbons and waxes, silicone oils, groups completed with dialkyl ethers, saturated or unsaturated branched or straight chain alcohols, and also fatty acid triglycerides, specifically from 8 to 24, And a triglycerol ester of saturated and / or unsaturated branched and / or straight chain alkanecarboxylic acids having a length of 12 to 18 carbon atoms. Fatty acid triglycerides are advantageously included in the composition of the present invention including synthetic, semisynthetic and natural oils (such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, You can choose from the complete group. Any mixture of such oil and wax ingredients may also be used to advantage. In some cases, it is also advantageous to use wax (for example, cetyl palmitate) as the oil component of the oil phase. The oil phase is advantageously selected from 2-ethylhexyl isostearate, octyldodecanol, iso Iso-octanoic acid, 2-ethylhexyl cocoate, C12-C15-alkyl benzoic acid, caprylic acid / capric acid triglyceride and gicaprylyl acetate. A mixture of benzoic acid C12-C15-alkyl and 2-ethylhexyl isostearate, a mixture of benzoic acid C12-C15-alkyl and isononanate isotridecyl and a mixture of benzoic acid C12-C15-alkyl, 2-ethylhexyl isononanoate and isononane Mixtures of acid isotridecyl are particularly advantageous. The liquid paraffin, squalane and squalene of hydrocarbons can also be used advantageously. The oil phase advantageously may further comprise a cyclic or linear silicone oil and may be completed solely with such oil, but it is preferred that it further contains other oil components in addition to the one or more silicone oils. Cyclomethicone (for example, decamethylcyclopentasiloxane) can be advantageously used as a silicone oil. However, other silicone oils such as undecamethylcyclosiloxane, polydimethylsiloxane and poly (methyl-phenylsiloxane) can also be used to advantage. Mixtures of cyclomethicone and isononanate isotridecyl and mixtures of cyclomethicone and 2-ethylhexyl isostearate are also particularly advantageous.

The aqueous phase of the preparation in the form of an emulsion, containing the aimed mixture of octyl gallate in accordance with the invention, can be obtained by reacting an alcohol, a diol or a polyol having a low carbon number and furthermore such an ether (preferably ethanol, isopropanol, Propylene glycol monomethyl, ethyl or monobutyl ether, diethylene glycol monomethyl or ethyl ether) and similar products and alcohols having a lower carbon number (e.g., propylene glycol monomethyl ether, propylene glycol monomethyl ether, ethylene glycol monomethyl ether, ethylene glycol monomethyl ether, (For example, ethanol, isopropanol, 1,2-propanediol glycerol) and more particularly, silicon dioxide, aluminum silicate, polysaccharides and derivatives thereof such as hyaluronic acid, xanthan gum, hydroxypropyl methylcellulose, , And particularly advantageously from the group consisting of polyacrylates, Preferably from the group consisting of the polyacrylates from the group completed, including the combinations themselves, the so-called carbophores (for example, carbopols of type 980, 981, 1382, 2984, 5984) It can be completed by including one or more thickeners that can be selected.

According to the invention, the preparations containing the synergistic target mixture of octyl gallate in the form of emulsions on the one hand advantageously contain one or more emulsifiers. O / W emulsifiers are, for example, advantageously, for example, polyethoxylated or polypropoxylated or polyethoxylated, while polypropoxylated products such as fatty alcohol ethoxylates; Ethoxylated wool wax alcohols; The general formula _{RO - (- CH 2 -CH 2} -O-) nR ' of polyethylene glycol ethers; The general formula _{R-COO - (- CH 2} -CH 2 -O-) fatty acid ethoxylates of nH; The general formula _{R-COO - (- CH 2} -CH 2 -O-) 2 -R ' of the etherified fatty acid ethoxylates; The general formula _{R-COO - (- CH 2} -CH 2 -O-) n -C (O) -R esterified fatty acid ethoxylates of the "; Polyethylene glycol glycerol fatty acid esters; Ethoxylated sorbitan esters; Cholesterol ethoxylate; Ethoxylated triglyceride; The general formula _{R-COO - (- CH 2} -CH 2 -O-) n -OOH (n is the number of 5 to 30) alkyl ether carboxylic acid; Polyoxyethylene sorbitol fatty acid esters; The general formula _{RO - (- CH 2 -CH 2} -O-) in the alkyl ether sulfate n-SO ₃ -H; The general formula _{RO - (- CH 2 -CH (} CH 3) -O-) nH of fatty alcohols propoxy Montserrat; The general formula _{RO - (- CH 2 -CH (} CH 3) -O-) nR ' of the polypropylene glycol ethers; Propoxylated wool wax alcohol; The general formula _{R-COO - (- CH 2} -CH (CH 3) -O-) nR ' of the esterified fatty acids propoxy Montserrat; The general formula _{R-COO - (- CH 2} -CH (CH 3) -O-) nC (O) -R ' of the esterified fatty acids propoxy Montserrat; The general formula _{R-COO - (- CH 2} -CH (CH 3) -O-) nH of fatty propoxy Montserrat; Propyleneglycol glycerol fatty acid ester; Propoxylated sorbitan esters; Cholesterol propoxylate; Propoxylated triglyceride; Alkyl ether carboxylic acids of the general formula RO - (- CH ₂ - CH (CH ₃ ) - O--) n - CH ₂ -COOH; Alkyl ether sulfates of the formula RO - (- CH ₂ --CH (CH ₃ ) - O--) n --SO ₃ --H and acids based on such sulfates; Fatty alcohol ethoxylate / propoxylate of formula RO-Xn-Ym-H; Polypropylene glycol ethers of the general formula RO-Xn-Ym-R '; Esterified fatty acid propoxylates of the general formula R-COO-Xn-Ym-R '; And fatty acid ethoxylates / propoxylates of the general formula R-COO-Xn-Ym-H; ≪ / RTI >

Polypropoxylated or polyethoxylated polyethoxylated or polyethoxylates used according to the invention. On the other hand, the polypropoxylated O / W emulsifiers are particularly advantageously characterized in that the O / W emulsifiers contain saturated radicals R and R ' , An HLB value of 11 to 18, and very particularly advantageously a material having an HLB value of 14.5 to 15.5. If the O / W emulsifier contains an unsaturated group R and / or R ', or if an isoalkyl derivative is present, the preferred HLB level of such an emulsifier may be lower or higher than that

It is advantageous to select the fatty alcohol ethoxylate from the group comprising ethoxylated stearyl alcohol, cetyl alcohol, cetylstearyl alcohol (cetearyl alcohol). The following is particularly preferable.

Polyethylene glycol (13) stearyl ether (Stearase 13),

Polyethylene glycol (14) stearyl ether (Stearath 14),

Polyethylene glycol (15) stearyl ether (Stearase 15),

Polyethylene glycol (16) stearyl ether (Stearos 16),

Polyethylene glycol (17) stearyl ether (Stearath 17),

Polyethylene glycol (18) stearyl ether (Stearos 18),

Polyethylene glycol (19) stearyl ether (Stearath 19),

Polyethylene glycol (20) stearyl ether (Stear 20),

Polyethylene glycol (12) Isostearyl ether (Isostearase 12),

Polyethylene glycol (13) isostearyl ether (Isostearase 13),

Polyethylene glycol (14) isostearyl ether (Isostearase 14),

Polyethylene glycol (15) Isostearyl ether (Isostearase 15),

Polyethylene glycol (16) isostearyl ether (Isostearase 16),

Polyethylene glycol (17) isostearyl ether (Isostear 17),

Polyethylene glycol (18) isostearyl ether (Isostearase 18),

Polyethylene glycol (19) isostearyl ether (Isostearase 19),

Polyethylene glycol (20) isostearyl ether (Isostearase 20),

Polyethylene glycol (13) Cetyl ether (Ceteth 13),

Polyethylene glycol (14) Cetyl ether (Ceteth 14),

Polyethylene glycol (15) Cetyl ether (Ceteth 15)

Polyethylene glycol (16) Cetyl ether (Ceteth 16),

Polyethylene glycol (17) Cetyl ether (Ceteth 17),

Polyethylene glycol (18) Cetyl ether (Ceteth 18),

Polyethylene glycol (19) Cetyl ether (Ceteth 19),

Polyethylene glycol (20) cetyl ether (Ceteth 20),

Polyethylene glycol (13) isocetyl ether (isoceteth 13),

Polyethylene glycol (14) Isocetyl ether (Isocetes 14),

Polyethylene glycol (15) isocetyl ether (isoceteth 15),

Polyethylene glycol (16) Isocetyl ether (Isocetes 16),

Polyethylene glycol (17) Isocetyl ether (Isocetes 17),

Polyethylene glycol (18) Isocetyl ether (Isocetes 18),

Polyethylene glycol (19) Isocetyl ether (Isocetes 19),

Polyethylene glycol (20) isocetyl ether (isoceteth 20),

Polyethylene glycol (12) oleyl ether (Ores 12),

Polyethylene glycol (13) oleyl ether (Ores 13),

Polyethylene glycol (14) oleyl ether (Ores 14),

Polyethylene glycol (15) oleyl ether (Ores 15),

Polyethylene glycol (12) lauryl ether (lauryl-12),

Polyethylene glycol (12) isoleyl ether (iso-lauryl-12),

Polyethylene glycol (13) cetyl stearyl ether (Cetearyl 13),

Polyethylene glycol (14) cetyl stearyl ether (Cetearyl 14),

Polyethylene glycol (15) Cetyl stearyl ether (Cetearyl 15),

Polyethylene glycol (16) cetyl stearyl ether (Cetearyl 16),

Polyethylene glycol (17) cetyl stearyl ether (Cetearyl 17),

Polyethylene glycol (18) cetyl stearyl ether (Cetearyl 18),

Polyethylene glycol (19) cetyl stearyl ether (Cetearyl 19),

Polyethylene glycol (20) Cetyl stearyl ether (Cetearyl 20).

The fatty acid ethoxylate may be selected from the following group.

Polyethylene Glycol (20) Stearate, Polyethylene Glycol (21) Stearate, Polyethylene Glycol 22 Stearate, Polyethylene Glycol 23 Stearate, Polyethylene Glycol 24 Stearate, Polyethylene Glycol 25, Stearate, polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol Stearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (20) isostearate, polyethylene glycol Stearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene Recolour (24) Isostearate Polyethylene glycol (25) isostearate, polyethylene glycol (12) oleate, polyethylene glycol (13) oleate, polyethylene glycol (14) oleate, polyethylene glycol Polyethylene glycol (16) oleate, polyethylene glycol (17) oleate, polyethylene glycol (18) oleate, polyethylene glycol (19) oleate, polyethylene glycol (20) oleate.

Sodium lauryl-11 carboxylate can be advantageously used as an ethoxylated alkyl ether carboxylic acid or salt thereof. Sodium lauryl 1-4 sulfate can be used advantageously as an alkyl ether sulfate. Polyethylene glycol (30) Cholesteryl ether can be advantageously used as an ethoxylated cholesterol derivative. Polyethylene glycol (25) soya sterols have also proven to be useful. Polyethylene glycol (60) evening primrose glycerides can be used advantageously as ethoxylated triglycerides.

The polyethylene glycol glycerol fatty acid ester may also be used in combination with polyethylene glycols such as polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, Glycol (6) glyceryl caprate / caprinate, polyethylene glycol (20) glyceryl oleate, polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoate ≪ / RTI >

Sorbitan esters include polyethylene glycol (20) sorbitan monolaurate; Polyethylene glycol (20) sorbitan stuff stearate; Polyethylene glycol (20) sorbitan isostearate; Polyethylene glycol (20) sorbitan monopalmitate; Polyethylene glycol (20) sorbitan monooleate; And the like.

As preferred W / O emulsifiers, the following can be used: fatty alcohols having 8 to 30 carbon atoms, saturated and / or unsaturated branched and / or straight chain alkanecarboxylic acids having a length of 8 to 24, in particular 12 to 18 carbon atoms Glycerol esters of acids, diglycerol esters of saturated and / or unsaturated branched and / or straight chain alkanecarboxylic acids having a length of from 8 to 24, in particular 12 to 18 carbon atoms, 8 to 24, in particular 12 to 18 carbon Glycerol ethers of saturated and / or unsaturated branches and / or straight chain alcohols having a length of atoms of from 8 to 24, in particular saturated and / or unsaturated branched and / or straight chain alcohols having a length of from 12 to 18 carbon atoms, diglycerol Propyleneglycol esters of saturated and / or unsaturated branched and / or straight chain alkanecarboxylic acids having a length of from 8 to 24, in particular 12 to 18, carbon atoms and from 8 to 24, in particular from 12 to 18 carbon atoms in length The saturation and / or fire Sorbitan esters of Chemistry branched and / or straight-chain alkane carboxylic acids.

Particularly advantageous W / O emulsifiers are glyceryl monostearate, glyceryl isostearate, glyceryl myristate, glyceryl monooleate, diglyceryl stearate, diglyceryl isostearate, propyleneglycol stearate, Propyleneglycol monolaurate, sorbitan isostearate, sorbitan monolaurate, sorbitan caprylate, sorbitan isoleate, sucrose fatty acid esters, (2) stearyl ether (stearyl-2), glyceryl monolaurate (stearyl alcohol), stearyl alcohol, stearyl alcohol, arachidic alcohol, behenyl alcohol, isobenyl alcohol, , Glyceryl monocaprate, and glyceryl monocaprylate.

As another embodiment, the present invention can provide a quasi-product composition containing octyl gallate and a preservative (1,2-alkanediol) as an active ingredient. That is, the composition of the present invention may be a quasi-drug composition requiring antibacterial activity.

When the composition of the present invention is used as an additive, the composition may be added as it is or may be used together with other quasi-drugs or quasi-drugs, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient can be appropriately determined depending on the purpose of use.

Preferably, the quasi-drug composition may be a disinfectant cleaner, shower foam, gagrin, a wet tissue, a detergent soap, a hand wash, a humidifier filler, a mask, an ointment agent, a coating agent or a filter filler.

In another embodiment, the present invention can provide a pharmaceutical composition containing octyl gallate and a preservative (1,2-alkanediol) as an active ingredient. The composition of the present invention may be a pharmaceutical composition having antimicrobial activity and may be used as an adjuvant of an active ingredient having medicinal use. The pharmaceutical compositions of the present invention may be prepared according to methods well known to those skilled in the art.

The pharmaceutical composition of the present invention may be formulated in the form of tablets, pills, powders, capsules, suspensions, oral solutions, emulsions or syrups, oral preparations, suppositories or injection solutions according to a conventional method have. In detail, when formulated, it can be prepared by using diluents or excipients such as fillers, weighing agents, binders, wetting agents, disintegrants, surfactants and the like which are generally used. Solid formulations for oral administration include, but are not limited to, tablets, pills, powders, granules, capsules, and the like. Such a solid preparation may be prepared by mixing at least one excipient such as starch, calcium carbonate, sucrose, lactose, gelatin and the like in addition to the composition comprising the octyl gallate and the synergistic target mixture.

In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral administration, liquid paraffin, and various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate, and the like. Examples of the suppository base include withexol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.

The composition of the present invention may be administered orally or parenterally (for example, intravenously, subcutaneously, intraperitoneally or topically) depending on the desired method, and the dose may be determined depending on the condition and weight of the patient, The mode of administration, the route of administration, and the time, but may be suitably selected by those skilled in the art.

In another aspect, the present invention can provide an antimicrobial composition containing octyl gallate and a preservative (1,2-alkanediol) as an active ingredient. The composition of the present invention may be an antimicrobial composition, and the antimicrobial composition may be prepared by a method well known to those skilled in the art.

In another aspect, the present invention can provide a preservative composition containing octyl gallate and a preservative (1,2-alkanediol) as an active ingredient. The composition of the present invention may be an antiseptic composition comprising as an active ingredient, and the preservative composition may be prepared according to a method well known to those skilled in the art.

The preservative composition according to the present invention may be used in combination with an appropriate amount of commonly used components depending on the kind of the product containing the preservative composition and the intended use. For example, it is possible to add acetic acid, sodium acetate, sorbic acid, benzoic acid and propionic acid. It is emulsified with natural emulsifier such as natural linseed oil soap, propolis soap and acacia sap, Powder, etc. can be freely manufactured and supplied.

Since the octyl gallate according to the present invention can be used for the purpose of enhancing the antimicrobial activity, it can exhibit a broad spectrum of antimicrobial activity against various fungi. Therefore, the composition containing the same can be used as a sterilizing, antibacterial and antifungal agent in various fields such as cosmetics, medicines, It is useful for preservation purposes.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not construed as being limited by these embodiments.

Example  One. Octyl Go Rate And preservation of existing preservative mixtures

Octyl gallate was mixed with conventional preservatives to confirm the synergistic effect of preservability. Conservative testing was performed according to the European Pharmacopoeia. Briefly, the contamination degree (final ratio) of the preparation after the normal inoculation of the microorganisms, the preservation of the inoculated preparation at a specific temperature, and the number of microorganisms were measured in the sample collected from the container at specific time intervals. The storage stability was considered adequate when the microbial count of the inoculum was significantly reduced or maintained under normal temperature conditions under the operating conditions. The details of the method of measurement were the same as in the European Pharmacopoeia (ISBN 3-7692-2768-9; 3rd ed. 2001, Chapter 5.1.3, pages 421-422).

1-1. Use microorganism and initial concentration

The following microorganisms were used for storage stability.

A: E. coli ATCC 8739

B: Pseudomonas aeruginosa ATCC 9027

C: Staphylococcus aureus ATCC 6538

D: white Candida ATCC 10231

E: Black Aspergillus ATCC 16404

For various experiments, the microorganisms were treated with an initial number of microorganisms (CFU / g; "0" value) within the range of 240, 000-300,000.

1-2. Preparation  Produce

For the preservability measurement, (a) an antimicrobial active mixture to measure synergism and (b) a corresponding unmixed 1,2-AlkaneDiol as a control group were prepared.

The combinations of the preparations thus prepared had the composition shown in Table 1 below.

Composition of an emulsion preparation containing a mixture of octyl gallate and hexanediol Cosmetic raw materials (including trade name) manufacturer % (w / w) water - 77.6 Citric acid - 0.4 Dragopho S DRAGOCO 2 PCL solution DRAGOCO 3 Isodragol DRAGOCO 7 Lanette 18 Cognis 4.5 Dracoin GMS DRAGOCO 2 Dow Corning 200 fluid Dow coring 2 Octyl gallate - One 1,2-hexanediol - 0.5 gun - 100

1-3. Conservation experiment

In order to measure the preservability of the prepared emulsion, Aspergillus was inoculated in the emulsion, and the microorganisms were counted by culturing for 14 days. As the control group, emulsions of the same composition containing octyl gallate and 1,2-hexanediol were separately prepared without mixing them, and the same experiment was carried out. The synergistic coefficient (SI) of octyl gallate and 1,2-hexanediol according to the above test was measured. The results are shown in Table 2 below.

Calculation of synergistic levels (SI) for aspergillus microorganisms in a 1: 2 mixed emulsion of octyl gallate and 1,2-hexanediol Emulsion 1
(Including octyl gallate) Emulsion 2
(Including 1,2-hexanediol) Emulsion 3
(Including 1: 2 mixture of octyl gallate and 1,2-hexanediol) Aspergillus Day 14
(CFU / g) 28, 000 10, 000 2, 000 A: Number of microorganisms of emulsion 1 28, 000 B: Number of microorganisms of emulsion 2 10, 000 C: Number of microorganisms of emulsion 3 2, 000 D: the ratio of emulsion 1 in emulsion 3 0.66 (2/3) E: Percentage of emulsion 2 in emulsion 3 0.33 (1/3) SI: Elevation value 0.11

The Kull equation for ascertaining numerical values is as follows.

SI = C x D / A + C x E / B

The synergistic target enhancement of the activity of the diol mixture according to the present invention is described in the Kull equation (FCKull et al., Applied Microbiology Vol. 9, p. 538-541 (1961); David C. Steinberg; Cosmetics & Toiletries Vol.115 (No.11), p. 59-62; November 2000). The Kull's equation makes it possible to compare pure materials and mixtures of active compounds prepared therefrom against such antimicrobial activity. This equation determines the synergistic target activity of a mixture having an antibacterial action, but also the so-called synergistic coefficient SI, which is an index of possible antagonistic action. The synergistic effect is clear when the determined SI value is less than 1. On the other hand, when an SI of exactly one is calculated, there exists a pure addition effect of two kinds of substances having antibacterial action. On the other hand, in the case of an SI value exceeding 1, an antagonistic effect exists.

1-4. Conservation test result

As a result of the preservation experiment, it was found that the mixture of octyl gallate with the normal mass ratio had much greater activity than the individual substances measured at the same concentration. This was especially noted for residual microbial counts remaining after 14 and 28 days.

The results in Table 2 above show the calculation of the SI value for the treatment of aspergillus with a mixture of octyl gallate and 1,2-hexanediol (ratio 1: 2) after 14 days of culture. The calculated SI of 0.11 clearly shows that a 1: 2 mixture of octyl gallate and 1,2-hexanediol is a prominent synergistic combination of active compounds.

A mixture of two and three octyl gallates with 1,2-pentanediol, 1,2-hexanediol and / or 1,2-octanediol has proven to be particularly effective here. For all of the 5 tested microorganisms (E. coli, P. aeruginosa, S. staphylococci, Candida and Aspergillus), after 28 days, the concentration of the colony forming units (CFU) could be reduced to zero of the desired target. That is, when the mixture was used, the number of microorganisms after the incubation phase was 0, so the SI value of 28-days could not be determined (see Table 3). Therefore, although the Kull equation can not be used in this specific example, synergism is apparent based on the number of microorganisms of zero.

(3% in an O / W emulsion), 1,2-hexanediol (3% in an O / W emulsion), and a mixture of octyl gallate As can be seen in the logarithm of the decrease in the number of microorganisms for the octyl galalte / 1,2-hexanediol mixture (mass ratio 2: 1, volume is 3%), In the case of the parasites, the number of microorganisms (number of colony forming unit, CFU) could be reduced to 0 within 28 days when the mixture according to the present invention was used. On the other hand, the same 3% capacity of each substance (octyl gallate, 1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol, 2-octanediol and 1, 2-decane diol) could not be reduced to zero, the microbial reduction of the mixture. Thus, according to the test series and Table 3, it was confirmed that octyl gallate was composed of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and 1,2- The octyl gallate and the 1,2-alkanediol mixture, which are composed of at least two different constituents, have synergistically increased activity.

Buoyancy for 28 days of Aspergillus microorganisms 0 day Day 1 Day 2 Day 7 Day 14 Day 28 Hexanediol 3% 541, 000 510, 000 510, 000 480, 000 445, 000 2, 900 Octylgalate 3% 541, 000 47, 000 3, 800 3, 000 3, 000 2, 000 2% octylgallate, 1% hexanediol, 541, 000 40, 700 40, 000 280 240 0

Example  2. Determination of the minimum inhibitory concentration for various microorganisms and MIC  Chi-based Calculation of ascendant values

It was confirmed that the mixture of octyl gallate and hexane diol according to the present invention had an effect on the inhibition of various microorganisms causing body odor. Particularly, the minimum inhibitory concentration was measured for Staphylococcus epidermidis, Corynebacterium crispycis, and Epidermis Brevibacterium in relation to body odor and the ascendant value by the mixture was measured using the above formula.

Specifically, the antimicrobial activity of a mixture of octyl gallate and 1,2-hexanediol according to the present invention was measured by an agar dilution method based on DIN 58 940 / ICS and DIN 58 944 / ICS. 13.5 ml of the prepared Mueller-Hinton agar (Merck, Ref. 1. 054437 or Wilkins-Chalgren agar juice, Oxoid, Ref. CM 643, supplemented with 10 g of agar / 1 liter), diluted samples of various concentrations were added at 10% (V / V) = 1.5 ml. For the test microbial Malassezia furfur, a Mueller-Hinton agar containing 3% Tween 80 (Merck, Ref.8.22 187) was used.

For each example, 5 ml of sample was diluted with distilled water to prepare 10 ml. A specific dilution series of the upper test concentration prepared in the form of a geometric target sequence was prepared by gradual 1: 1 dilution of this batch with distilled water.

A final concentration of 10-fold diluted for each sample was achieved by dilution with the test agar (1.5 ml of sample or corresponding dilution + 13.5 ml of agar) (each concentration reaching 50,000 ppm for the first time). Two agar plates per one test concentration and nutrient medium were injected. The following control tests were carried out on two agar plates for each example, and the experimental conditions are shown in Table 3 below.

Sample name Condition Whether K1 15.0 ml Mueller-Hinton agar Non-vaccination K2 13.5 ml Mueller-Hinton agar + 1.5 ml distilled water inoculation K3 13.5 ml Mueller-Hinton agar + 1.5 ml distilled water inoculation K4 15.0 ml Mueller-Hinton agar inoculation K5 15.0 ml Mueller-Hinton agar + 3% Tween 80 Non-vaccination K6 13.5 ml Mueller-Hinton agar + 3% Tween 80 + 1.5 ml distilled water Non-vaccination K7 13.5 ml Mueller-Hinton agar + 3% Tween 80 + 1.5 ml distilled water inoculation K8 15.0 ml Mueller-Hinton agar + 3% Tween 80 inoculation K9 15.0 ml Wilkins-Chalgren agar Non-vaccination K10 13.5 ml Wilkins-Chalgren agar + 1.5 ml distilled water Non-vaccination K11 13.5 ml Wilkins-Chalgren agar + 1.5 ml distilled water inoculation K12 15.0 ml Wilkins-Chalgren agar + 1.5 ml distilled water inoculation

After solidification and drying (about 1 hour at 37 占 폚), the test plates were inoculated in dotted form with 1 占 of the test microbial suspension in the table below for each sample. Bacteria (Brevibacterium epidermis, Corynebacterium kiocellisis, Spilophyllococus epidermis) growing on aerials to calibrate and classify purity were cultured on Columbia blood agar medium (BioMerieux, Ref. 430049) did. Fungal black aspergillus, yeast white candida, and two types of skin fungus, tricophyton menthylphosphate and epidermophytonthrophococcus, were cultured on Sabouraud agar (BioMerieux, Ref. 43555). Marassezia fructus was cultured on a Sabourad HLT agar containing a depressor inhibitor (3% Tween 80: 1%; lecithin: 0.3%; histidine: 0.1%; Merck, Ref.1.18368 supplemented). Propionibacterium acnes were cultured on Schaedler agar (BioMerieux, Ref.43273). Further details of the test microorganisms are summarized in Table 5 below.

Black fungus and fungus Black fungus Strain number CFU / mL Brevibacterium epidermis ATCC 35514 28, 000, 000 Corynebacterium kiocarpisis ACCC 7711 21, 000, 000 Propionibacterium acnes ATCC 11829 200, 000, 000 Spa Filoxucci Epidemis ATCC 12228 22, 000, 000 Marasa Jiaulpullo DSM 6171 30, 000, 000 Epidermophyton fullo CBS 55384 21, 000, 000 Tricot Python menta Gropitess CBS 26379 33, 000, 000

Test of bacterial microorganisms growing on aerials The preparation of bacterial suspensions was carried out by incubating several individual colonies of the relevant test organisms at 36 ° C with an inoculated Mueller-Hinton broth (Merck, Ref. 1.10293) . After obtaining clear turbidity, the sterile nutrient broth was added to the suspension in an amount corresponding to the turbidity of McFarland standard 0.5 (about 1.5 x 108 CFU / ml).

For the preparation of other test strain suspensions, the test strains were cultivated on the above-mentioned solid nutrient medium and harvested using a sterile swab, the turbidity of the suspension was measured using a Mueller-Hinton equivalent to McFarland standard 0.5, borth diluted.

All suspensions of the test bacteria except Propionibacterium acnes were diluted 1:10 with sterile broth again and the number of bacteria was measured by a surface method using a spiral meter.

The inoculated plates were cultured under the conditions shown in Table 6 below and evaluated. The MIC (minimum inhibitory concentration) was considered to be the lowest concentration of active compound that could not be observed microscopically. It was evaluated as inhibitory concentration when growth was small or small individual colonies were seen because they were small in size.

Inoculation and culture Black fungus Strain Growth condition Nutrient badge Culture conditions Brevibacterium epidermis ATCC 35514 Expiration Mueller-Hinton agar 18h, 36 < Corynebacterium kiocarpisis ACCC 7711 Expiration Mueller-Hinton agar 18h, 36 < Propionibacterium acnes ATCC 11829 anaerobe Wilkins-Chalgren agar 72 h, 30 캜 Spa Filoxucci Epidemis ATCC 12228 Expiration Mueller-Hinton agar 18h, 36 < Marasa Jiaulpullo DSM 6171 Expiration Mueller-Hinton agar +
3% twin 80 72 h, 30 캜 Epidermophyton fullo CBS 55384 Expiration Mueller-Hinton agar 18h, 36 < Tricot Python menta Gropitess CBS 26379 Expiration Mueller-Hinton agar 72 h, 30 캜

The MIC values of the mixture of octyl gallate, 1,2-hexanediol, and octyl gallate / 1,2-hexanediol = 2: 1 were determined according to the general method, Respectively. The results are shown in Table 7 below.

The MIC for a mixture of octyl gallate (OTG) and 1,2-hexanediol (HD) Black fungus Strain MIC in OTG processing HD processing MIC MIC for OTG-HD (2: 1) mixture treatment OTG-HD (2: 1) mixture treatment SI Spa Filoxucci Epidemis ATCC 12228 25000 12500 6250 0.55 Corynebacterium kiocarpisis ACCC 771 12500 6250 6250 0.66 Brevibacterium epidermis ATCC 35514 25000 3125 6250 0.83 Propionibacterium acnes ATCC 11829 25000 6250 3125 0.25 Marasa Jiaulpullo DSM 6171 12500 50000 50000 2.97 Tricot Python menta Gropitess CBS 26379 6300 1562 1562 0.49 Epidermophyton fullo CBS 55384 6250 3125 1562 0.32

According to the results shown in Table 7, two kinds of 2: 1 mixture of octyl gallate and 1,2-hexanediol exhibit a synergistic effect of antimicrobial activity. Therefore, microorganisms such as Staphylococcus epidermis, Brevibacterium epidermis, Corynebacterium kyciatus, Propionibacterium acnes, Tricophyton mentagrophytes, and Epidermophyton furocotes correspond. The activity is clearly inhibited by a mixture of octyl gallate and 1,2-hexanediol.

The synergistic coefficients calculated through the Kull equation based on the MIC values are also shown in Table 7 above. The SI value has a synergistically enhanced action of a mixture of octyl gallate / 1,2-hexanediol and added to its excellent activity as a preservative (see Example 1). More preferably, SI propionibacterium epidermis: 0.55; SI cornea bacterium keratosis: 0.66; SI bributibacterium epidermis: 0.83), inhibition of acne (SI propionibacterium acnes: 0.25) and tricophytonthin (SI tricophyton mentagrophytes: 0.49; SI epidermophytone furocotes: 0.32) can be used to inhibit skin and mycosis caused by epidermidis and epidermophyton. However, for Marasegia frumula, it did not show the synergistic target effect on the mixture of octyl gallate / 1,2-hexanediol (SI Marasegia frumula: 2.97, that is, antagonistic effect).

Example  3. Octyl Go Rate  Conservation test by mixture and additional preservative mixture

Synergism of octyl gallate The preservability of the mixture of the target mixture (a) and the additional preservative (b) was measured in the same manner as in Example 1 according to European Pharmacopoeia.

3-1. Use microorganism and initial concentration

The following microorganisms were used for storage stability.

A: E. coli ATCC 8739

B: Pseudomonas aeruginosa ATCC 9027

C: Staphylococcus aureus ATCC 6538

D: white Candida ATCC 10231

E: Black Aspergillus ATCC 16404

For various experiments, the microorganisms were treated with a range of initial microorganisms (CFU / g; "0" value) in the range of 280, 000 to 320, 000.

3-2. Preparation  Produce

For the preservability measurement, an emulsion containing the synergistic candidate combination mixture comprising the octyl gallate mixture (a) according to the invention and the additional preservative (b) was prepared. For comparison, an emulsion comprising the octyl gallate mixture (a) and the additional preservative (b) alone as a control group was prepared.

The combinations of the preparations prepared above had the composition shown in Table 8 below.

Composition of an emulsion preparation containing an octyl gallate mixture and an additional preservative Cosmetic raw materials (including trade name) manufacturer Emulsion A
0.1% Euxyl K400 Emulsion B
0.5% octyl gallate, 0.5% 1,2-hexanediol Emulsion C
0.05% Euxyl K400, 0.25% octyl gallate, 0.25% hexane diol Octyl gallate - 0 0.5 0.25 Hexanediol DRAGOCO 0 0.5 0.25 Euxyl K 400 Schulke / Mayr 0.1 0 0.05 K sorbate Ringe + Kuhlmann 0 0 0 Pehenoxyethanol 0 0 0 Paraben mixture - 0 0 0 Water - 79.25 78.35 78.75 Citric acid, 10% - 0.15 0.15 0.2 Dragophos S DRAGOCO 2 2 2 PCL liquid DRAGOCO 3 3 3 Isodragol DRAGOCO 7 7 7 Lanette 18 COGNIS 4.5 4.5 4.5 Dracorin GMS 2/008474 2 2 2 Dow Corning 200 fl Dow Corning 2 2 2 Total - 100 100 100

In Table 8 above, a mixture of 0.05% Euxyl K400 (mixture of 1,2-dibromo 2,4-dicyanobutane (20%) and 2-phenoxyethanol (80%)), 0.25% An emulsion preparation for a mixture according to the invention consisting of 0.25% of 1,2-hexanediol is given as an example. The change in the total concentration of the octyl gallate mixture in the emulsion and the additional preservative Euxyl K400 was corrected by increasing or decreasing the moisture content so that the same preparation always contained 100 parts by weight in total

3-3. Conservation experiment

In order to measure the preservability of the prepared emulsion, Aspergillus was inoculated into the emulsion and cultured for 28 days to determine the number of remaining black aspergillus microorganisms. That is, in order to confirm the synergistic action of the octyl gallate / 1,2-hexanediol mixture and the additional preservative according to the present invention, emulsions of the same composition containing each alone and octyl gallte / 1,2- / EuxylK400 (Table 9). ≪ tb > < TABLE >

Evaluation results of the antimicrobial-synergistic effect of the three combinations of emulsion emulsion Date Escherichia coli P. aeruginosa Staphylococcus aureus Candida Aspergillus Emulsion A 0 300, 000 320, 000 310, 000 310, 000 280, 000 One 200 0 0 <100 220, 000 2 <100 0 0 <100 140, 000 7 0 0 0 0 200, 000 14 0 0 0 0 160, 000 28 0 0 0 0 32, 000 Emulsion B 0 300, 000 320, 000 310, 000 310, 000 280, 000 One 0 0 0 3, 200 180, 000 2 0 0 0 200 160, 000 7 0 0 0 0 180, 000 14 0 0 0 0 120, 000 28 0 0 0 0 60, 000 Emulsion C 0 300, 000 320, 000 310, 000 310, 000 280, 000 One <100 <100 <100 <100 20, 000 2 0 0 0 0 12, 000 7 0 0 0 0 8, 000 14 0 0 0 0 8, 000 28 0 0 0 0 2, 800

The synergistic coefficient (SI) of the octyl gallate / 1,2-hexanediol mixture and Euxyl K400 according to the above experiment was measured. The results are shown in Table 10 below.

The synergistic coefficient (SI) of the octyl gallate / 1,2-hexanediol mixture and EuxylK400 Emulsion 1
- octyl gallate 0.5% + 1,2 hexanediol 0.5% Emulsion 2
-Euxyl K400 0.1% Emulsion 3
- octyl gallate 0.25% + 1,2hexanediol 0.25% + Euxyl K400 0.05% Aspergillus 28th day
(CFU / g) 60, 000 32, 000 2, 800 A: Number of microorganisms of emulsion 1 60, 000 B: Number of microorganisms of emulsion 2 32, 000 C: Number of microorganisms of emulsion 3 2, 800 D: the ratio of emulsion 1 in emulsion 3 0.5 E: Percentage of B component in C 0.5 SI: Synergy Index 0.066

The formula for obtaining the ascendant value (SI = C x D / A + C x E / B) is as described in the first embodiment.

3-4. Conservation test result

As a result of the preservation test to measure the residual microorganisms remaining after 28 days from the inoculation of the black aspergillus, a mixture of octyl gallate and the 1,2-hexanediol mixture itself as well as the additional preservative was also added to each individual substance Lt; RTI ID = 0.0 &gt; synergistic &lt; / RTI &gt; activity.

As can be seen in Table 8, the use of Emulsion C for micro-aspergillus microorganisms, which is particularly problematic for the preservation of industrial products, could reduce microbial counts to 2,800 CFU / g over 28 days. On the other hand, emulsion A, which was tested at 1% capacity, and emulsion B, which was tested at a dose of 0.1%, showed no significant decrease compared to emulsion C for Aspergillus.

The results show that (a) octyl gallate can be treated with 1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol or 1,2- , And (b) a mixture containing an additional preservative may be even more superior in terms of antimicrobial activity.

The results in Table 10 show that the number of microorganisms in the emulsion containing the mixture containing octyl gallate, 1,2-hexanediol and Euxyl K400 inoculated with Aspergillus and incubated for 28 days or for 28 days, The results of SI calculation are shown in Fig. The SI value 0.066 clearly indicates the synergistic action of the octyl gallate / 1,2-hexanediol mixture and EuxylK400.

The above results indicate that octyl gallate according to the present invention can be used for the purpose of enhancing the antibacterial activity to exhibit a broad spectrum of antimicrobial activity against various fungi. Therefore, sterilization, antibacterial and antimicrobial activities in various fields such as cosmetics, medicines, , And it can be useful for preservation purposes.

From the above description, it will be understood by those skilled in the art to which the present invention pertains that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. In this regard, it should be understood that the above-described embodiments are illustrative in all aspects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, as well as all changes or modifications derived from the meaning and scope of the appended claims and their equivalents.

Claims (5)

An antimicrobial composition comprising a mixture of octyl gallate and a 1,2-alkanediol as an active ingredient.
The antimicrobial composition according to claim 1, wherein the octyl gallate is contained in an amount of 0.01 to 50% (w / v) based on the total weight of the composition.
The method of claim 1, wherein the 1,2-alkanediol is selected from the group consisting of 1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol, - decane diol. &Lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt;
The antimicrobial composition according to claim 1, wherein the preservative is further synergistically increased, wherein the preservative further comprises an additional preservative, wherein the additional preservative is selected from the group consisting of benzoic acid, its esters and salts, propionic acid and salts thereof, Salts thereof, 2,4-hexanoic acid (sorbic acid) and salts thereof, formaldehyde and paraformaldehyde, 2-hydroxybiphenyl ether and salts thereof, 2-zinc sulfide pyridine-N-oxide, (II) 5-amino-1,3-bis (2-hydroxy) benzoic acid, salts and esters thereof, dehydratcetic acid, formic acid , N-hexane and its salts, 1,6-bis (4-amidino-2-bromophenoxy) -n-hexane and its salts, sodium salt of ethyl mercury- (II) thiosalicylic acid, phenyl mercury and salts thereof, Amino-1,3-bis (2-ethylhexyl) -5-methyl-hexahydropyrimidine, 5-bromo-5-nitroso 1,3- 2-nitro-1,3-propanediol, 2,4-dichlorobenzyl alcohol, N- (4-chlorophenyl) -N '- (3,4-dichlorophenyl) Chloro-m-cresol, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1'- (1-hydroxymethyl-2,4-deoxyimidazolidin-5-yl) urea) poly- (hexamethylene zigand) hydrochloric acid, 2-phenoxyethanol, hexamethylenetetramine, 1- -Chloroallyl) -3,5,7-triaza-1-azonia-adamantane-chloride, l- (4-chlorophenoxy) Dimethyl-2-butanone, 1,3-bis- (hydroxy-methyl) -5,5-dimethyl-2,4-imidazolidinedione, benzyl alcohol, Chloro-2-methylpyridine with 2,2'-methylene-bis (6-bromo-4-chloro-phenol), bromo-chlorophene, magnesium chloride and magnesium nitrate. -3 (2 H) -isothiazolinone and 2-methyl-3 (2 H) isothiazolinone , 2-benzyl-4-chlorophenol, 2-chloroacetamide, chlorohexidine, chlorohexidineacetate, chlorohexidine gluconate, chlorohexidine hydrochloride, 1-phenoxy- (C12-C22) trimethylammonium bromide and chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl-N- (1,3- ) -2,5-dioxoimidazolidin-4-yl) -N'-hydroxy-methyl urea, 1,6-bis (4-amidinophenoxy) Aldehyde 5-ethyl-1-aza 3,7-dioxabicyclo (3.3.0) octane, 3- (4-croophenoxy) -1,2-propanediol, hyamine, C8-C18) -dimethyl-benzyl-ammonium chloride, alkyl- (C8-C18) -dimethyl- benzylammonium bromide, alkyl- Propyl-butylcarbamate, and sodium hydroxymethylaminoacetate. &Lt; RTI ID = 0.0 &gt; The stand will be selected at least one cosmetic composition.
The composition according to any one of claims 1 to 4, wherein the composition is used as a cosmetic composition, a pharmaceutical composition, a quasi-drug composition or an antiseptic composition.