KR20130060682A - Cosmetic composition of oil in water type containing fructose 1,6-diphosphate - Google Patents

Abstract

The present invention relates to an oil-in-water cosmetic composition comprising fructose 1,6-diphosphate, and more particularly, to an oil-in-water composition containing fructose 1,6-diphosphate and having excellent emulsion stability and usability.

Description

Cosmetic composition of oil-in-water cosmetics containing fructose 1,6-diphosphate

The present invention relates to an oil-in-water cosmetic composition comprising fructose 1,6-diphosphate, and more particularly, to an oil-in-water composition containing fructose 1,6-diphosphate and having excellent emulsion stability and usability.

Fructose 1,6-Diphosphate (FDP) protects tissues from oxidative damage, such as ischemia / reperfusion, or prevents damage from ATP depletion of isolated organs It has been used to Whether fructose 1,6-diphosphate can protect skin cells in an environment that causes oxidative damage such as ultraviolet rays, such as effectively protecting tissues such as the heart in a rapid environment such as surgery. Whether these effects can directly alleviate or delay skin aging can be achieved by multi-faceted experiments on animals and humans as well as skin cells.Fructose 1,6-diphosphate can be used to protect skin cells from UV damage. In addition to suppressing, it was possible to significantly reduce or improve skin aging.

However, fructose 1,6-diphosphate is a substance having a strong salt property with a phosphate salt in its molecular structure, which greatly reduces the thickening ability of the ionic polymer thickener and the stability of the oil-in-water formulation. This has been greatly limited.

Recently, as a method for increasing the stability of the oil-in-water formulation containing fructose 1,6-diphosphate, a method of thickening cosmetics and stabilizing emulsification by adding a wax of high content, xanthan gum, cellulose A method of thickening cosmetics and stabilizing emulsification using cellulose thickeners such as gum and hydroxyethyl cellulose has been proposed.

However, all of the above-mentioned methods have the following problems. That is, the method of adding a high content of wax is known to have a certain amount of emulsification and stabilizing effect as a wax as a wax, but the appearance of unevenness of the cosmetics due to the high content of wax, separation of the water phase may be caused. There is a disadvantage in that the feeling of use of cosmetics is greatly reduced, and if the wax is oxidized, it may also cause problems of discoloration and discoloration, and thus it is not recognized as a stabilization method of oil-in-water formulation containing fructose 1,6-diphosphate.

In addition, the use of cellulose-based thickeners such as xanthan gum, cellulose gum, and hydroxyethyl cellulose helps to stabilize the emulsification because it can realize relatively stable thickening ability even with salts of fructose 1,6-diphosphate. However, due to the sticky feeling and gelling phenomenon peculiar to the cellulose thickener, the feeling of the cosmetics is greatly reduced, and the cellulose-based thickener also significantly reduces the antiseptic power of the cosmetics.

Republic of Korea Patent Application No. 2006-0008134 Republic of Korea Patent Application No. 2002-0028646

Accordingly, the present inventors have conducted a study on an oil-in-water emulsion formulation capable of stably supporting fructose 1,6-diphosphate, and as a result, the stability of the cosmetic composition including fructose 1,6-diphosphate is maintained. Optimal formulation conditions have been found and the present invention has been completed.

Accordingly, an object of the present invention is to provide an oil-in-water composition which contains fructose 1,6-diphosphate and is excellent in emulsion stability and usability.

In order to achieve the above object, the present invention provides a topical skin composition, further comprising a surfactant and a thickener as a topical skin composition containing a fructose 1,6-diphosphate compound as an active ingredient.

Furthermore, the present invention is a composition for external application for skin containing fructose 1,6-diphosphate compound as cetearylglucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate surfactant It provides a skin external composition, comprising a combination, further comprising polyacrylate crosspolymer-6 as a thickener.

The present invention can provide a topical skin composition stabilized in an oil-in-water formulation containing a fructose 1,6-diphosphate compound by setting an optimum combination of surfactants and thickeners in which the stability of the cosmetic composition can be maintained. .

In addition, the stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound as an active ingredient in the composition can increase the stability of the interface to the salt along with a surfactant having a strong surfactant activity. It is possible to provide an anti-aging skin external composition for improving the stability of the oil-in-water type by improving the stability of the oil-in-water type by including a thickening agent that can improve the stability by including a surfactant that is not inhibited by the salt thickening power. Can be.

The present invention provides an external preparation composition for skin, further comprising a surfactant and a thickener as an external preparation composition containing a fructose 1,6-diphosphate compound as an active ingredient.

Hereinafter, the present invention will be described more specifically.

Fructose 1,6-Diphosphate (FDP), an active ingredient of the present invention, can protect skin cells in an environment causing oxidative damage such as ultraviolet rays, and further directly May alleviate or delay aging.

In other words, fructose 1,6-diphosphate has a strong antioxidant effect, through which it has the effect of preventing the aging progress by offsetting free radicals that cause oxidation, and also improve wrinkles as a functional material to improve wrinkles It helps relieve skin aging.

More specifically, fructose 1,6-diphosphate exhibits anti-inflammatory effect by attenuating prostaglandin E2 synthesis and COX-2 expression, and inhibiting MMP expression to increase wrinkle suppression and collagen synthesis to enhance skin elasticity and release histamine It exhibits complex skin aging improvement through stimulating mitigation through inhibition, skin moisturizing through regulating keratinocyte differentiation, and skin vitality through increasing ATP synthesis.

Fructose 1,6-diphosphate as an active ingredient of the present invention is preferably contained in 0.001 to 7.0% by weight based on the total weight of the composition. This is because less than 0.001% by weight of the anti-aging, antioxidant effects are insignificant, and more than 7.0% by weight of the large amount of phosphate salts cause instability of the cosmetic formulation.

The stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound as an active ingredient in the external preparation composition for skin of the present invention is generally used in all types of oil-in-water surfactants and thickeners used in cosmetics. By this, stability can be improved. Surfactants usable in the present invention include: Fiji-100 Stearate, Sorbitan Stearate, Sorbitan Sesquioleate, Fiji-40 Stearate, Polysorbate 60, Sucrose Stearate, Polyglyceryl- 3-methylglucose distearate, cetearyl glucoside, arachidyl glucoside, C12-20 alkyl glucoside, inulin lauryl carbame and the like. In addition, thickeners usable in the present invention include cellulose gum, carbomer, hydroxyethyl cellulose, polyvinyl alcohol, FV, xanthan gum, acrylate / C10-30 alkyl acrylate crosspolymer, sodium polyacrylate, Ammonium Acryloyl Dimethyl Taurate / V-Picopolymer, Hydroxypropyl Starch Phosphate, Polyacrylate-13, Hydroxyethylacrylate / Sodium Acryloyl Dimethyl Taurate Copolymer, Fiji-240 / H-Diacico Polymer bisdecyltesraceses-2 ethyl, polyacrylic acid and the like.

In particular, the stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound as an active ingredient in the external preparation composition for skin of the present invention, along with the surfactant having a strong surfactant activity, the stability of the interface to the salt It is a combination of surfactants that can increase the content of cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate to maximize the stability, salt It is preferable to further contain polyacrylate crosspolymer-6, an ionic thickener that is not inhibited, to increase the viscosity of the composition and to assist in maximizing the stability of the oil-in-water emulsion formulation.

Among the surfactant combinations used in the present invention, cetearylglucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate surfactant combination, the cetearyl glucoside or sodium stearoyl glutamate composition 0.1-10.0 wt% with respect to the total weight, inulin lauryl carbamate or glyceryl stearate citrate is preferably contained 0.1-10.0 wt% with respect to the total weight of the composition. This is because less than 0.1% by weight of each of the surface active ability does not appear, and more than 10.0% by weight inhibits the feeling of use and formulation stability of the cosmetic formulation.

The thickener of the present invention is preferably contained in 0.1 to 5.0% by weight relative to the total weight of the composition. This is because if less than 0.1% by weight, the thickening effect and the emulsion stability effect does not appear, and if it is more than 5.0% by weight, it greatly inhibits the production productivity of the cosmetic formulation due to the high viscosity.

The topical skin composition according to the present invention may comprise one or more non-toxic, pharmaceutically acceptable carriers, adjuvants, diluents or other active ingredients conventionally used in the art. The external preparation composition for skin according to the present invention may be formulated by a known method using a pharmaceutically acceptable carrier and excipient.

Specific examples may be formulated and used in any form suitable for pharmaceutical preparations, including external preparations such as ointments, gels, creams, patches or sprays, and each of these formulations may be formulated with various bases necessary and appropriate for the formulation thereof. It may contain additives, and the kind and amount of these components can be easily selected by the inventor.

In addition, when the external composition for skin preparations according to the present invention is formulated as a cosmetic, it is not particularly limited in the formulation, softening longevity, astringent longevity, nourishing longevity, eye cream, nourishing cream, massage cream, cleansing cream, cleansing foam, It may have a formulation such as cleansing water, powder, essence or pack.

Hereinafter, the present invention will be described in detail with reference to Examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

[Examples 1-6 and Comparative Examples 1-12]

In Tables 1 to 3, cosmetic compositions (Comparative Examples 1 to 12) for comparison with the cosmetic compositions according to the present invention (Examples 1 to 6) were prepared.

Examples 1 to 6 are external skin composition containing fructose 1,6-diphosphate compound prepared according to the present invention as an active ingredient cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glycerol A cosmetic composition comprising a reel stearate citrate surfactant combination and comprising a polyacrylate crosspolymer-6 as a thickener, and Comparative Examples 1 to 4 are cosmetics prepared using only one component other than the above-described surfactant combination. Composition. Comparative Examples 5 to 6 are cosmetic compositions prepared using a combination of surfactants other than the above-described surfactant combinations, and Comparative Examples 7 to 12 are not polyacrylate crosspolymer-6, which is a thickener of the present invention. It is a cosmetic composition using another kind of polymeric thickener.

Category (% by weight) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Paid Cetearylglucoside 1.50 0.50 0.30 0.00 0.00 0.00 Sodium Stearoyl Glutamate 0.00 0.00 0.00 2.00 2.00 1.00 Glyceryl Stearate Citrate 0.00 0.00 0.00 0.30 1.50 1.50 Cetearyl Alcohol 0.50 0.50 0.50 0.50 0.50 0.50 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 Olefin Polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin Lauryl Carbamate 0.30 0.50 1.50 0.00 0.00 0.00 Polyacrylate Crosspolymer-6 1.00 0.50 0.20 1.00 0.50 0.20 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene Glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

Category (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Paid Cetearylglucoside 1.50 0.00 0.00 0.00 0.00 0.00 Sodium Stearoyl Glutamate 0.00 0.00 2.00 0.00 0.00 0.00 Glyceryl Stearate Citrate 0.00 0.00 0.00 1.50 0.00 0.00 Cetearyl Alcohol 0.50 0.50 0.50 0.50 0.50 0.50 FAGE -100 stearate 0.00 0.00 0.00 0.00 1.00 1.00 C12-20 alkylglucoside 0.00 0.00 0.00 0.00 1.00 0.00 Polyglyceryl-3methylglucose distearate 0.00 0.00 0.00 0.00 0.00 1.00 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 Olefin Polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin Lauryl Carbamate 0.00 0.50 0.00 0.00 0.00 0.00 Polyacrylate Crosspolymer-6 0.50 0.50 0.50 0.50 0.50 0.50 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene Glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

Category (% by weight) Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Paid Cetearylglucoside 1.50 0.00 1.50 0.00 1.50 0.00 Sodium Stearoyl Glutamate 0.00 2.00 0.00 2.00 0.00 2.00 Glyceryl Stearate Citrate 0.00 1.50 0.00 1.50 0.00 1.50 Cetearyl Alcohol 0.50 0.50 0.50 0.50 0.50 0.50 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 Olefin Polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin Lauryl Carbamate 1.50 0.00 1.50 0.00 1.50 0.00 Carbomer 0.50 0.00 0.00 0.00 0.00 0.00 Tromethamine 0.35 0.00 0.00 0.00 0.00 0.35 Ammonium Acryloyl Dimethyl Taurate / V-Picopolymer 0.00 0.50 0.00 0.00 0.00 0.00 Hydroxyethylacrylate / Sodium Acryloyl Dimethyl Taurate Copolymer 0.00 0.00 0.50 0.00 0.00 0.00 Sodium polyacrylate 0.00 0.00 0.00 0.50 0.00 0.00 Polyacrylate-13 0.00 0.00 0.00 0.00 0.35 0.00 Acrylate / C10-30 alkyl acrylate crosspolymer 0.00 0.00 0.00 0.00 0.00 0.50 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene Glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

<Manufacturing Method>

1) The oily ingredients were weighed in a beaker and warmed to 75 ° C to completely dissolve.

2) The aqueous phase components were completely dissolved by heating to 70 ° C. in a separate vessel.

3) The mixture of the aqueous phase components of 2) was transferred to a homogenizer and added to the mixture of oily components of 1) while slowly increasing the rpm.

4) After mixing the mixture of 3) at 7,200rpm for about 5 minutes, when the temperature of the mixed phase is about 50 ℃, fructose 1,6-diphosphate was added to prepare a cosmetic.

Test Example 1 Viscosity Evaluation

The viscosity of the cosmetic compositions of Examples 1 to 6 and Comparative Examples 1 to 12 was measured and the results are shown in Table 4 below. At this time, the viscosity was measured in 2 minutes at 12rpm with a spindle 3 using a Brookfield viscometer after all samples were left for about 2 hours at 30 ℃.

Viscosity (cps) Example 1 9,300 Example 2 7,200 Example 3 5,200 Example 4 8,200 Example 5 15,100 Example 6 9,200 Comparative Example 1 5,100 Comparative Example 2 3,700 Comparative Example 3 6,100 Comparative Example 4 5,300 Comparative Example 5 5,300 Comparative Example 6 6,500 Comparative Example 7 620 Comparative Example 8 1,300 Comparative Example 9 1,200 Comparative Example 10 4,500 Comparative Example 11 2,100 Comparative Example 12 650

 Test Example 2 Emulsion Stability Measurement

In order to determine the emulsion stability of the compositions of Examples 1 to 6 and Comparative Examples 1 to 12, each composition sample was placed in a 45 ° C. high temperature thermostat and the time taken for the aqueous phase and the oil phase of the emulsion formulation to be separated was measured.

Emulsion Formulation Example 1 More than 2 months Example 2 More than 2 months Example 3 More than 2 months Example 4 More than 2 months Example 5 More than 2 months Example 6 More than 2 months Comparative Example 1 Within 15 days Comparative Example 2 Within 5 days Comparative Example 3 Within 15 days Comparative Example 4 Within 12 days Comparative Example 5 Within 12 days Comparative Example 6 Within 15 days Comparative Example 7 Within 1 day Comparative Example 8 within 3 days Comparative Example 9 Within 2 days Comparative Example 10 Within 5 days Comparative Example 11 Within 2 days Comparative Example 12 Within 1 day

As can be seen in Table 4 and Table 5, cetearyl glucoside / inulin lauryl carbamate or sodium stea as a composition for external application containing a fructose 1,6-diphosphate compound prepared according to the present invention as an active ingredient In the case of Examples 1 to 6, which is a cosmetic composition containing a combination of a royl glutamate / glyceryl stearate citrate surfactant and comprising polyacrylate crosspolymer-6 as a thickener, at least two months at high temperature with excellent thickening power. Compared to Examples 1 to 6, the incremental strength was significantly lower than that of Examples 1 to 6, and the labile formulations in which the emulsion formulations were separated within 15 days were observed. It was confirmed that the formation.

Claims (8)

Fructose 1,6-diphosphate;
Cetearylglucoside / inulinlaurylcarbamate or sodium stearoylglutamate / glycerylstearate citrate; And
A composition for external application of skin, comprising polyacrylate crosspolymer-6 The composition for external application for skin according to claim 1, wherein the fructose 1,6-diphosphate is contained in an amount of 0.001 to 7.0% by weight based on the total weight of the composition. The method of claim 1, wherein the cetearyl glucoside or sodium stearoyl glutamate is 0.1 to 10.0% by weight based on the total weight of the composition, inulin lauryl carbamate or glyceryl stearate citrate is 0.1 to 10.0% by weight of the total weight of the composition An external preparation composition for skin, which is contained in%. The composition for external application for skin according to claim 1, wherein the composition contains 0.1% to 5.0% by weight of polyacrylate crosspolymer-6. The external preparation composition for skin according to any one of claims 1 to 4, wherein the composition is for anti-aging. The composition for external application for skin according to any one of claims 1 to 4, wherein the composition is for skin wrinkle improvement. The composition for applying the external of the skin according to any one of claims 1 to 4, wherein the composition is for promoting skin elasticity. The external preparation composition for skin according to any one of claims 1 to 4, wherein the composition is for moisturizing the skin.