KR20120079706A - An insecticidal composition for disinfecting stable and poultry farm - Google Patents

Abstract

The present invention relates to a pesticide composition for barn and poultry disinfection and a method for preparing the same, and more specifically, 0.1 to 30 parts by weight of formic acid, 0.1 to 20 parts by weight of the active ingredient (acaricide) for tick repellent and 50 to 99.8 parts by weight of excipients It relates to an insecticide composition. Insecticide composition according to the present invention has a fast-acting astringent effect within 24 hours to chicken mites (mite, chicken wagu) and shows a sustained fertilizing effect for more than one month, if used periodically, reduce the distribution of chicken mites to stress the livestock It can reduce and block infection of other pathogens mediated by chicken ticks.

Description

Insecticide composition for barn and poultry disinfection and its manufacturing method {AN INSECTICIDAL COMPOSITION FOR DISINFECTING STABLE AND POULTRY FARM}

The present invention relates to a pesticide composition for barn and poultry disinfection and a method of manufacturing the same.

Chicken mite (mite, wagumo) corresponds to the arachnid mite, and due to its ecological characteristics, the blood of the livestock is required for the eggs, and it has a habit of migrating to the livestock. In general, it is known to live on a livestock barn or utensil, and to move mainly at night for vampires, causing blood wounds on the skins of livestock. This behavior is associated with the spread of livestock disease agents, especially in laying hens, the spawning rate is known to decrease due to vampire stress. It can also be shifted to the worker, causing a sense of literacy for the worker. In order to remedy this, farmers and workers purchase and use commercial products such as carpomate, organophosphorus, and organic chlorine pesticides, such as propoxur and dimethylester phosphonic acid. Mite and wagumo) are not effectively controlled.

As mentioned above, no effective product is registered as an animal drug or quasi-drug for controlling ticks, mites and wagumo, which are parasitic in chickens, and some livestock farms use pesticides. However, it is very toxic, causing severe irritation and stress in animals, leading to problems such as weight gain and lower egg production. Products registered as pesticides have some limitations for use in animals. In general, there are some substances used in the pesticide field that are not applicable to animal medicines or quasi-drugs for veterinary medicine. This is equivalent to class 2 of substances classified by the EPA and is not applicable to veterinary medicines. In the case of veterinary drugs and quasi-drugs, the present invention was implemented because only the substances listed in the EPA level 4 material and the veterinary drug process and human drug process are easy to use. As a result, a suitable composition was developed.

The object of the present invention is safe even when sprayed directly on animals while at the same time inhabiting barns and poultry and exhibiting a rapid control effect against ticks, mites, beetles and arachnids causing problems such as weight loss, low egg production and increased stress in animals. To develop a composition excellent in the persistence of pesticides.

In one embodiment, to achieve the above object, it provides an insecticide composition comprising formic acid, mite repellent active ingredient (acaricide) and excipients. In another embodiment, the composition of the pesticide composition provides a pesticide composition, characterized in that it comprises 0.1 to 30 parts by weight of formic acid, 0.1 to 20 parts by weight of the active ingredient (acaricide) for tick repellent and 50 to 99.8 parts by weight of excipients. In another embodiment, the acaricide active against the tick is metomyl, pyrimiphos-methyl, endosulfan, bifenthrin, Halfenprox, Halfenprox, Abamectin, Milbemectin, Amitraz, Benzoximate, Bifenazate, Chinomethionat, Cyflumetofen, Dicopol, Diafenthiuron, Azocyclotin, Fenbutatin oxide, Propargite, Chlorfenapyr, Acequinocyl, Acequinocyl, Fluacrypyrim, Fenazaquin, Pyridaben, Tebufenpyrad, Cyenopyrafen, Clofentezine, Hexythiazox, Etoxazole, bistrifluron, Flucycloxon oxuron), Flufenoxuron and Spirodiclofen are provided at least one mixture selected from the group consisting of pesticide compositions. In another embodiment, the active ingredient provides a pesticide composition, characterized in that (Pyridaben). In another embodiment, the excipient provides an insecticide composition which is one or more mixtures selected from the group consisting of surfactants, stabilizers, preservatives and solvents. In another embodiment, the surfactant is a polyoxyethylene-polyoxypropylene polymer, glyceryl monooleate, lauryl sulfate, sorbitan ester, polyoxyethylene sorbitan fatty acid ester, hydrogenated ethoxylated castor oil, It provides a pesticide composition characterized in that at least one mixture selected from the group consisting of hydrogen bonded ethoxylated triethanolamine, polyoxyethylene sorbitan monooleate, propylene glycol and polyethylene glycol. In another embodiment, the stabilizer is at least one selected from the group consisting of zinc phosphate, magnesium aluminum silicate, potassium sorbate, potassium bicarbonate, sodium polymer acrylate, carboxymethyl cellulose sodium, simethicone, dimethicone and xanthan gum It provides a pesticide composition characterized in that the mixture. In another embodiment, the preservative provides an insecticide composition, characterized in that at least one mixture selected from the group consisting of methylparaben, propylparaben and benzyl alcohol. In another embodiment, the solvent is at least one mixture selected from the group consisting of water, ethanol, methanol, ethyl acetate, acetone, N-methylpyrrolidone, dimethylsulfoxide and dimethylformamide. To provide. In another embodiment, the pesticide composition is a pesticide composition, characterized in that any one form selected from the group consisting of solutions, emulsions, suspensions, dispersible powders, water-soluble powders, granules, pellets, pastes and concentrates. do.

In one embodiment, it provides a method for producing a pesticide composition, characterized in that the formic acid, mite repellent active ingredient (acaricide) and excipients are mixed and prepared. In another embodiment, the composition of the pesticide composition is prepared by mixing 0.1 to 30 parts by weight of formic acid, 0.1 to 20 parts by weight of acaricide active ingredient and 50 to 99.8 parts by weight of an excipient. Provide a method.

In the present invention, the "excipient" is a substance added to make the medicament easy to eat or to form a certain form, but may be one or more mixtures selected from the group consisting of surfactants, stabilizers, preservatives and solvents.

In the present invention, "organic acid" shows an antiseptic power, and also shows an excellent role in increasing the insecticidal effect of an acaricide.

In the present invention, the "surfactant" is an environment-friendly material that serves to diffuse the pesticide component on the treated surface, but is not limited thereto, and may be used that does not pollute the environment even by mass use.

In the present invention, the "stabilizer" can be used to contribute to increase the long-term storage by stabilizing the state in which the organic acid and the active ingredient is dissolved or dispersed in a solvent.

In the present invention, the "preservative" may be used to increase the preservation of the solvent described below including the organic acid and the active ingredient.

In the present invention, the "solvent" occupies most of the formulation of the present invention and may include a pesticidal component and a function of dispersing them smoothly in water.

Insecticides according to the present invention has a fast-acting astringent effect within 24 hours to chicken mites (mite, chicken wagu) and has a sustained abolition effect for more than one month, so when used periodically, it reduces the stress of livestock by reducing the distribution of chicken mites And can prevent infection of other pathogens mediated by chicken ticks.

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the contents of the present invention are not limited by the following examples.

Example

Example  1. Confirm the efficacy of organic acids

"Organic acid" exhibits antiseptic power and synergistic effect in increasing the insecticidal effect of acaricide. In the efficacy test, concentration and time control were evaluated using chicken mites (wagumo) collected outdoors (Table 1).

Treatment concentration Control price (%) 0.5h 1h 2h 3h 4h 24h 10.0% formic acid 11.67 55.00 61.67 61.67 61.67 63.14 2.0% formic acid 3.33 11.67 15.00 15.00 15.00 20.00 10.0% acetic acid 0.00 5.00 5.00 5.00 5.00 5.00 2.0% acetic acid 0.00 0.00 5.00 5.00 5.00 5.00 10.0% citric acid 0.00 0.00 0.00 0.00 0.00 5.00 2.0% citric acid 0.00 0.00 0.00 0.00 0.00 0.00 10.0% tartaric acid 0.00 0.00 0.00 0.00 0.00 0.00 2.0% tartaric acid 0.00 0.00 0.00 0.00 0.00 0.00 10.0% succinic acid 0.00 0.00 0.00 0.00 0.00 0.00 2.0% Succinic Acid 0.00 0.00 0.00 0.00 0.00 0.00

In the above examples, it was confirmed that formic acid was a preferred component as the organic acid.

In addition, it was confirmed through the test that the organic acid acts to increase the insecticidal effect of the active ingredient (acaricide) for tick repellent (Table 2).

Treatment concentration Control price (%) 0.5h 1h 2h 3h 4h 24h 1.0% pyridaben + 0.5% formic acid 31.67 48.33 53.33 61.67 63.33 96.08 1.0% Pyridabene + 1.0% Formic Acid 50.00 61.67 61.67 65.00 68.33 94.71 1.0% Pyridabene + 2.0% Formic Acid 68.33 71.67 76.67 81.67 83.33 96.08 1.0% pyridaben 10.21 14.59 25.23 32.88 45.64 67.21

The effective concentration of pyridaben, one of the active ingredient for tick repellent, was fixed and treated with formic acid at 0.5, 1.0, and 2.0 times levels. At this time, the group tested by mixing formic acid, compared with the other group, due to the synergistic effect of the formic acid was confirmed fast fast action and high insecticidal effect at all concentrations.

Example  2. Chicken mite ( Wagumo ) Preparation of Control Composition

Formic acid, active ingredients (acaricide), surfactants, stabilizers, preservatives and solvents were prepared in the same ingredients and ratios as in Preparation Examples 1 to 3 in order to prepare a chicken tick control composition. At this time, the solid or liquid components, such as the active ingredient and stabilizer, respectively, were also subdivided and mixed to prepare a primary mixture. Then, this was pulverized with a conventional pulverizer (particle size 0.1 ~ 20㎛), and then added a surfactant and a preservative using a conventional mixer, etc. to complete the secondary mixing process.

Manufacturing example Item ingredient Weight ratio One Insecticide Formic acid 25.0 Pyridaben 10.0 Surfactants Polyoxyethylene-Polyoxypropylene Polymer 5.0 Propylene glycol Triethanolamine menstruum water 55.0 Stabilizer Xanthan gum 0.3 Magnesium Aluminum Silicate 0.5 Preservative Benzyl alcohol 0.2 Stabilizer Shimechikon 1.0 2 Insecticide
Formic acid 15.0 Etofenprox 10.0 Surfactants
Polyoxyethylene 20 sorbitan monooleate 20.0 Ethoxylated Castor Oil Combined with Hydrogen menstruum

Ethyl acetate 10.0 Propylene glycol 22.5 water 30.0 Stabilizer Zinc phosphate 0.5 3 Insecticide
Formic acid 5.0 Bystrifluron 10.0 Surfactants

Polyoxyethylene Sorbitan Fatty Acid Ester 5.0 Propylene glycol Hydrogen-bonded ethoxylated triethanolamine menstruum water 55.0 Stabilizer
Xanthan gum 0.3 Magnesium Aluminum Silicate 0.5 Preservative
Methylparaben 0.5 Propylparaben 0.5

Example  3. Confirmation of the efficacy of the composition

3-1. Content test for long term storage

The composition was stored for 3 months at 25 ° C. and 40 ° C. in order to check the stability of the prepared compositions (Preparation Examples 1 to 3), and the content of formic acid and pyridaben over time was determined by high performance liquid chromatography (HPLC). : Agilent 1100 series HPLC system, Agilent, column: Capcell pak MG-II, 4.6 × 250 mm, 5.0 um (SHISEIDO), solvent: 80% acetonitrile / 20% ultrapure water, flow rate: 1.0 ml / min, detector: UV 225 (λ max), temperature: room temperature)). Changes in the amounts of formic acid and pyridaben over time are shown in Table 4 below.

Manufacturing example long time
(25 ℃, RH 60% ± 5), Acceleration
(40 ℃, RH 75% ± 5) Remarks One 0 (initial) Formic acid Pyridaben Formic acid Pyridaben Standard: formic acid 25% /
10% pyribenane 0 (initial) 25.37 10.50 25.37 10.50 1 month 25.46 10.45 25.05 10.20 2 months 25.33 10.38 25.43 10.04 3 months 25.14 10.56 25.22 10.03 2 0 (initial) Formic acid Etofenprox Formic acid Etofenprox Standard: formic acid 15% /
Etopen Prox 10% 0 (initial) 15.55 10.67 15.55 10.67 1 month 15.32 10.70 15.46 10.22 2 months 15.21 10.39 15.10 10.48 3 months 15.07 10.32 15.01 10.17 3 0 (initial) Formic acid Bystrifluron Formic acid Bystrifluron Standard: formic acid 5% /
Bistrifluron 10% 0 (initial) 5.41 10.29 5.41 10.29 1 month 5.29 10.30 5.66 10.17 2 months 5.17 10.28 5.42 10.11 3 months 5.22 10.48 5.35 10.05

3-2. On chicken ticks  Drug efficacy test

To confirm the target animal safety of the prepared composition (Preparation Example 1) was applied as the excess composition to the target animal was prepared as shown in Table 5.

Individual number Dilute composition five times in purified water Dilute composition 10-fold in purified water Purified Water Treatment Day 1 Day 14 Day 1 Day 14 Day 1 Day 14 One clear clear clear clear clear clear 2 clear clear clear clear clear clear 3 clear clear clear clear clear clear 4 clear clear clear clear clear clear 5 clear clear clear clear clear clear

In order to confirm the efficacy and safety of the target animal at the effective concentration of the prepared composition (Preparation Example 1), it is applied to a general barn (conventional A type / fluent cage, modern type H / changsa) and the target animal as shown in Table 6 below. Created. Optionally, 1 cm ³ volumes of 1 cm in length, 1 cm in height, and 1 cm in depth were collected at 15 locations, and the number of chicken mites (mites, chicken wagu) distributed in the sample was counted. The composition was treated with a 50-fold dilution of the recommended dilution concentration and the average number of individuals before and after treatment was calculated.

Before treatment Day 1 Day 7 Day 14 Day 28 Day 56 Gyeonggi Pocheon Material Breeder, Conventional Type A fluent chicken 54.6 0 0 0 0 0 Gyeonggi Pocheon Material
Laying hens, modern H-type poultry 89.4 0 0 0 0 0 Gyeonggi Yangjae
Laying hens, conventional type A fluent poultry 43.2 0 0 0 0 0 Namyang-si, Gyeonggi-do spawning station, conventional type A fluent chicken 117.4 0 0 0 0 0 Yanggyejang, Gyeonggi Yangji-jae, Conventional Type A fluent chicken 102.4 0 0 0 0 0 Gyeonggi Cheorwon Material
Laying hens, modern H-type poultry 72.7 0 0 0 0 0

As shown in the tables, it was confirmed that the composition according to the present invention is a composition safe for the target animal and effective for chicken mites (mite, wagumo).

While the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. You will know. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Accordingly, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention be construed as including all embodiments falling within the scope of the appended claims.

Claims (12)

A pesticide composition comprising formic acid, acaricide active ingredient (acaricide) and excipients. The method of claim 1,
The insecticide composition is a pesticide composition comprising 0.1 to 30 parts by weight of formic acid, 0.1 to 20 parts by weight of the active ingredient (acaricide) for tick repellent and 50 to 99.8 parts by weight of excipients. The method of claim 1,
The active ingredient (acaricide) for tick repellent is methomyl, pyrimiphos-methyl, endosulfan, bifenthrin, Halfenprox, hafenfenx, abamectin, Milbemectin, Amitraz, Benzoximate, Bifenazate, Chinomethionat, Cyflumetofen, Dicopol, Diafenthiuron, Azocyclotin, Fenbutatin oxide, Propargite, Chlorfenapyr, Acequinocyl, Fluacrypyrim ), Fenazaquin, Pyridaben, Tebufenpyrad, Cyenopyrafen, Clofentezine, Hexythiazox, Etoxazole, Bistrifluron, Flucycloxuron, flufenoxuron ( Insecticide composition characterized in that at least one mixture selected from the group consisting of Flufenoxuron) and Spirodiclofen. The method of claim 3, wherein
The active ingredient is a pesticide composition, characterized in that pyridaben (Pyridaben). The method of claim 1,
Wherein said excipient is one or more mixtures selected from the group consisting of surfactants, stabilizers, preservatives and solvents. 6. The method of claim 5,
The surfactants include polyoxyethylene-polyoxypropylene polymers, glyceryl monooleate, lauryl sulfate, sorbitan esters, polyoxyethylene sorbitan fatty acid esters, hydrogen bonded ethoxylated castor oil, hydrogen bonded ethoxylated triethanol Insecticide composition, characterized in that at least one mixture selected from the group consisting of amines, polyoxyethylene sorbitan monooleate, propylene glycol and polyethylene glycol. 6. The method of claim 5,
The stabilizer is an insecticide characterized in that at least one mixture selected from the group consisting of zinc phosphate, magnesium aluminum silicate, potassium sorbate, potassium bicarbonate, polymer sodium acrylate, sodium carboxymethyl cellulose, simethicone, dimethicone and xanthan gum. Composition. 6. The method of claim 5,
The preservative is a pesticide composition, characterized in that at least one mixture selected from the group consisting of methyl paraben, propyl paraben and benzyl alcohol. 6. The method of claim 5,
Wherein said solvent is at least one mixture selected from the group consisting of water, ethanol, methanol, ethyl acetate, acetone, N-methylpyrrolidone, dimethyl sulfoxide and dimethylformamide. The method of claim 1,
The insecticide composition is a pesticide composition, characterized in that any one selected from the group consisting of solutions, emulsions, suspensions, dispersible powders, water-soluble powders, granules, pellets, pastes and concentrates. A method for producing an insecticide composition, characterized by mixing formic acid, acaricide active ingredient (acaricide) and excipients. 12. The method of claim 11,
0.1 to 30 parts by weight of formic acid, 0.1 to 20 parts by weight of an active ingredient (acaricide) for mite repellent and 50 to 99.8 parts by weight of an excipient, a method for producing a pesticide composition.