KR20110118439A - Wound dressing with UV blocking film and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a wound coating material having a UV blocking film and a method for manufacturing the same, and more particularly, to form a porous adhesive plastic, acrylic adhesive layer, porous plastic mesh layer, acrylic adhesive layer on top of the urethane film used as a support The present invention relates to a wound coating material having a UV blocking film formed by fixing a mesh layer to a urethane film, and forming an ultraviolet blocking film and a silicone gel layer on an acrylic adhesive layer, and a method of manufacturing the same.
According to the present invention, it is possible to improve the deformation and curling properties of the support, and to protect the wound from ultraviolet rays due to the excellent UV protection effect, can induce normal wound healing, prevent the pigmentation of the scar to prevent scarring It is possible to provide a wound dressing which can improve the appearance.

Description

Wound dressing with Ultraviolet Barrier Layer and Producing Method for the Same

The present invention is a manufacturing method for forming a composite film to remove the deformation and curling phenomenon by inserting a porous plastic mesh into a flexible support film having excellent moisture permeability and breathability, and coating a film with a sunscreen that can effectively block ultraviolet rays, and the outside, The present invention relates to a wound dressing including a blocking film for protecting a wound from ultraviolet rays, inducing normal wound healing, and preventing pigmentation of the scar to improve the appearance of the scar.

Skin is an important organ that occupies the largest surface area of our body, and if skin is damaged extensively, it may lose its life due to dehydration, and not only protects the human body from various harmful environments such as microorganisms, ultraviolet rays, and chemicals. It inhibits water evaporation and prevents dehydration and regulates body temperature. It must be resistant to physical stimuli and have elasticity.

However, skin damage due to various causes such as severe burns, trauma, wounds, pressure sores and skin diseases is common, for example, wounds that are not primary sutures may leave severe defects inevitable. Therefore, the repair of damaged skin tissue is a very important problem, and in order to speed up the healing of wounds and to minimize the secondary side effects, it is necessary to treat wounds using appropriate wound dressings.

In other words, the skin of the human body has a property to protect the wound and to naturally heal when wounds, burns, etc., in this case, wound dressing is used as a method to effectively protect the wound and increase the speed of healing.

Such wound dressings should be equipped with excellent biocompatibility and should not have a rejection reaction to the wounded area, should be able to sufficiently absorb the fluids exuded from the wounded area, and normal skin swelling around the wound. In order to prevent the high moisture permeability to maintain the moisture permeability and the like.

Among the wound dressings, silicone wound dressings (silicone gel films) are wound coatings in which the wound contact layer is coated with a tacky silicone gel, which is a non-traumatic wound contact layer and gel that has the basic characteristics of not causing inflammation of the wound or normal skin. Refers to dressings used for the treatment of scars of thickening scars and keloids composed of thin films for protection.

In particular, silicone has a very stable property because of the high bond strength of silicon and oxygen, and thus has a very wide range of application in medicines and medical devices. It has been proven.

Such a silicone dressing is composed of a silicone gel layer having a tacky adhesive and a silicone elastomer having no adhesiveness, using a cotton cloth instead of a silicone elastomer, a mixture thereof, a urethane instead of a silicone elastomer, and a mixture of a urethane and a nonwoven fabric. And the like have been developed. Products commercialized for this purpose include Cica-Care (Smith & Nephew), Oleeva (Bio Med Science), Epi-Derm (Biodermis), Scar Clinic (Hans Biomed), Nagosil (Nagor), and Mepiform (Integra).

Ultraviolet rays, on the other hand, have longer wavelengths than visible light and are shorter than X-rays. Ultraviolet rays consist of UV-A (long wavelength 320-400 nm), UV-B (medium wavelength 280-320 nm), and UV-C (short wavelength 100-280 nm). Among them, UV-C radiation is absorbed by the ozone layer before reaching the ground, and UV-A and UV-B radiation cause skin inflammation and melanogenesis in the epidermal and dermal layers.

UV-A mainly affects the dermis, causing wrinkles and skin aging. UV-B affects the dermis, causing erythema and burns, and its ability to absorb chromosomes due to its strong absorption by DNA is known to cause skin cancer. It has been mentioned as a major factor in melanoma. The UV-A bandwidth (80 nm) is twice the UV-B bandwidth (40 nm) and accounts for 90-95% of the solar ultraviolet radiation (W / m 2) reaching the ground. Only 5-10% of them are UV-B. Because UV-A has a longer wavelength than UV-B, it can penetrate deep into the skin, so that 19-50% of UV-A reaches the depth where melanocytes are present. UV-B, on the other hand, only 9-14% reaches melanocytes. The effect of causing burns is that UV-B is 1000 times higher than UV-A.

The most widely used among the various methods for blocking the ultraviolet rays are sunscreens, and the sunscreens can be largely divided into inorganic sunscreens and organic sunscreens.

Inorganic sunscreens include titanium dioxide (TiO ₂ ), zinc oxide, magnesium oxide, iron black oxide, kaolin (kaolin), talc and the like. Among inorganic sunscreens, especially titanium dioxide is excellent for blocking UV-B, and zinc oxide is excellent for blocking UV-A. Organic blockers include PABA derivatives, cinnamate derivatives, benzophenones, debenzole methane and the like. Organic blockers block UV through chemical absorption.

Sunscreens scatter or absorb ultraviolet light, which prevents it from directly affecting cells or tissues. However, the problem is the safety of the sunscreen itself.

In the case of organic sunscreens, the molecular weight is low and the fat-soluble properties are many that can penetrate into the skin. In addition, even if it is not toxic itself, it may be toxic when absorbed ultraviolet rays and chemically activated, thereby causing contact dermatitis. On the other hand, inorganic sunscreens are generally used because they do not penetrate into the skin because they do not dissolve in sebum, unlike chemical absorbers (organic sunscreens).

On the other hand, when looking at the effect of ultraviolet light on the skin, first deplete the moisture of the skin to cause the skin dry, thereby forming fine wrinkles, the elasticity is reduced and the stratum corneum is thickened to promote the skin aging phenomenon. Ultraviolet rays also increase melanin pigment, forming spots and freckles, making the skin black. If the condition worsens, the capillaries expand, and rapid exposure in a short time can cause erythema, which can cause sunburn. Increasing the amount of UV light on the surface of the ozone layer can cause corneal burns, cataracts and skin cancer.

UV-A penetrates the dermis and causes photoaging. In natural aging, skin becomes thinner, whereas photo aging causes skin elasticity to drop rapidly, causing wrinkles and thickening of the epidermis, making the skin stiff. UV-A is constantly surveyed from sunrise to sunset throughout the four seasons, even on cloudy or rainy days. The glass penetrates the glass and can be exposed indoors or inside a vehicle. UV-B penetrates only to the epidermis, but can redden the skin, form blisters, tan the skin, and cause spots and freckles. UV-B has a lot of irradiation during summer season, especially during the daytime (12-4 hours), but has no property of penetrating glass, so it is not exposed indoors.

Due to the effect of ultraviolet light on the wound, UV-A deforms the collagen and elastin of the dermis, delaying normal skin regeneration, causing capillary disorders, impeding oxygen and nutrient supply, and creating a moist environment due to dehydration of the skin. It causes pigmentation by oxidizing existing melanin pigment. UV-B increases the production of melanin in the basal layer of the epidermis, causing hyperpigmentation, altering DNA in the cell, making it difficult for normal wound healing, and inducing skin cancer.

Wound healing mechanisms are multifaceted and affected by ultraviolet radiation. Pigmentation is increased, for example, by UV-induced inflammation (erythema). Collagen Type-I is also a rich extracellular matrix protein present in scar tissue that determines skin elasticity and the appearance of scars. However, the metabolism of collagen type-I is affected by UV exposure time. In addition, E. due suggests that human scars may not be exposed to sunlight during the healing period after treatment. .

The present invention is to insert a porous plastic mesh into a flexible support film having excellent moisture permeability and breathability to form a composite film to remove the deformation and curling phenomenon while maintaining the function of the film, and to form a UV blocking film that can effectively block ultraviolet rays thereon Accordingly, an object of the present invention is to provide a wound coating material and a method of manufacturing the same that can protect the wound from ultraviolet rays.

As an example for achieving the above object, the wound coating material having the ultraviolet blocking film of the present invention includes a urethane film 10, a first acrylic adhesive layer 11 coated on the urethane film 10, and the agent. 1 second acrylic plastic layer 12 formed on the acrylic adhesive layer 11 and second acrylic formed on the porous plastic mesh layer 12 to fix the porous plastic mesh layer 12 to the urethane film 10. The adhesive layer 13, the ultraviolet blocking film 14 formed on the second acrylic adhesive layer 13, the silicone gel layer 15 formed on the ultraviolet blocking film 140 and in contact with the wound site, and the silicone gel layer. It characterized by including a release paper layer 16 formed on (15).

As another example for achieving the above object, the wound coating material manufacturing method having the UV blocking film of the present invention, after forming the first acrylic pressure-sensitive adhesive layer 11 by applying an acrylic pressure-sensitive adhesive on the upper portion of the urethane film (10) porous plastic Installing a mesh layer 12 and applying an acrylic adhesive again to form a second acrylic adhesive layer 13, applying a titanium dioxide solution dispersed in an organic solvent on the second acrylic adhesive layer 13 To form the UV blocking film 14, and to form a silicone gel layer 15 by applying and curing a silicone gel on the UV blocking film 14, and then bonding the release paper. .

According to the present invention described above, it is possible to provide a wound coating material having improved deformation and curling properties while maintaining the function of moisture permeability and breathability of the urethane film.

In addition, according to the present invention, it is possible to provide a wound coating material in which an ultraviolet blocking film is formed to effectively protect a wound from ultraviolet rays.

In addition, according to the present invention, it is possible to provide a wound dressing that can protect the wound from ultraviolet rays to induce normal wound healing, and prevent the pigmentation of the scar to improve the appearance of the scar.

1 is a schematic diagram of a cross section of a wound coating according to the present invention.
Figure 2 is a schematic diagram of a cross section of a porous plastic mesh fixed to the urethane film of the wound coating according to the present invention.
Figure 3 is a photograph at a magnification of 50 times the porous plastic mesh used in the present invention.

Hereinafter, the present invention will be described in detail with reference to examples and drawings, but the present invention is not limited to the following examples and drawings.

The wound dressing of the present invention comprises the following configuration.

First, it is a urethane film 10. The urethane film 10 has a fine pore structure, prevents the invasion of bacteria from the outside, and is a semi-occlusive urethane film 10 having moisture permeability and breathability and having a thickness in the range of 15 to 100 μm. It is possible to use, preferably in the range of 25 to 70 ㎛.

A first acrylic adhesive layer 11 is formed on the urethane film 10, a porous plastic mesh layer 12 is formed on the first acrylic adhesive layer 11, and the porous plastic mesh layer 12 is formed. The second acrylic pressure-sensitive adhesive layer 13 is again formed on the) to fix the porous plastic mesh layer 12 to the urethane film 10.

That is, the porous plastic mesh layer 12 is formed in a sandwich structure between the first acrylic adhesive layer 11 and the second acrylic adhesive layer 13 applied on the urethane film 10, and thus the porous plastic mesh layer 12 is firmly fixed on the urethane film 10.

Since the porous plastic mesh layer 12 forms a net structure as shown in FIG. 3, while maintaining the function of moisture permeability and breathability of the urethane film 10, the deformation and curling of the wound coating material are improved. Can play a role. 3 illustrates a net structure of a triangular structure, the shape of the net structure may be made more variously. The porous plastic mesh layer 12 may be made of any one selected from polyethylene, polypropylene, polyester, nylon, and the like. If the chemically stable, light, flexible, and economical material for the acrylic adhesive is applied, it may be applied in addition to the above. It will be possible.

The thickness of the porous plastic mesh layer 12 is in the range of 50 to 200 μm, preferably 100 to 150 μm, which is suitable for the purpose of suppressing deformation of the wound coating material and improving curlability. In addition, the weight of the porous plastic mesh layer 12 is 7 to 30g / ㎡, preferably 13 to 20g / ㎡.

The pressure-sensitive adhesive constituting the first and second acrylic pressure-sensitive adhesive layer may be used an acrylic pressure-sensitive adhesive commonly used in the art, the total thickness of the first and second acrylic pressure-sensitive adhesive layer is a porous plastic mesh layer 12 It should be configured to a level that can be fixed sufficiently.

An ultraviolet blocking film 14 is formed on the second acrylic adhesive layer 13. The acrylic adhesive layer may have an adhesive property to induce the formation of the UV blocking film 14 having a thin film, and the UV blocking film 14 thus formed effectively blocks ultraviolet rays, thereby preventing pigmentation of wounds and scars. Play a role.

As the UV blocking material constituting the UV blocking film 14, it is preferable to use a commonly known inorganic UV blocking agent. Specifically, for example, titanium dioxide (TiO ₂ ), zinc oxide, magnesium oxide, black iron oxide, kaolin (kaolin) ), Talc and the like can be used, and preferably titanium dioxide is used.

In order to maximize UV protection, stable dispersion in the form of ultrafine particles having a very small average particle diameter is required. From this point of view, titanium dioxide is excellent in UV blocking effect and is very consistent with the above conditions because it is ultrafine particles.

In addition, when the particle size of titanium dioxide decreases, the ultraviolet scattering effect decreases, but similar to the ultraviolet absorber, it absorbs ultraviolet rays. In the ultrafine state, low energy titanium dioxide absorbs ultraviolet rays and changes to a high energy state. Because. The particle size of titanium dioxide is preferably used in the range of 5 to 20 nm.

The UV blocking material is coated on the second acrylic adhesive layer 13. In order to impart UV-blocking performance to the wound coating material, it is effective to form a thin film on the film rather than the form incorporated in the support film. In order to realize ultra-fine particles, it is highly desirable to disperse and coat titanium dioxide in an organic solvent.

When titanium dioxide ultrafine particles are stably dispersed in an organic solvent and exposed to the film surface under a certain temperature condition, a homogeneous titanium dioxide thin film (Homogenous TiO ₂ microthin-layer) is formed. Such a barrier film plays a very effective role in blocking ultraviolet rays by simultaneously accompanied by physical scattering and absorption of ultraviolet rays.

Suitable materials for dispersion in organic solvents are organic alkoxy titanate in combination with organic alkoxy, preferably tetra-n-Butyl titanate. Is recommended. The organic solvent for dispersing titanium dioxide is preferably selected from butanol, ethylacetate, acetone, hexane (n-hexane), heptane and isopropanol. .

The UV blocking film 14 may be formed uniformly in a thickness of 1 to 30㎛, preferably 5 to 15㎛ range.

The silicon gel layer 15 is formed on the UV blocking layer 14 to contact the wound portion. The silicone gel layer 15 is formed by applying a silicone gel on the UV blocking film 14 and curing it. The silicon gel layer 15 thus formed serves to fix the UV blocking film 14 together with the second acrylic adhesive layer 13. In particular, when titanium dioxide is used, the surface cohesion force of the silicone gel present on the interface of the titanium dioxide layer is improved, and the bonding force between the silicon gel layer 15 and the second acrylic adhesive layer 13 is improved.

The silicon gel layer 15 may be in a thickness of 0.2 to 1mm range, preferably 0.2 to 0.4mm range.

When the silicone gel layer 15 is formed, a release paper layer 16 is formed to attach the release paper to the surface to protect the gel surface.

It is preferable that the wound coating material of the present invention comprising the above-described configuration has a thickness in the range of 0.3 to 1.5 mm, preferably 0.4 to 0.6 mm.

On the other hand, the wound dressing of the present invention can be produced by the following process.

First, an acrylic pressure sensitive adhesive is applied to the upper portion of the urethane film to form a first acrylic pressure sensitive adhesive layer 11, a porous plastic mesh layer 12 is installed, and an acrylic pressure sensitive adhesive is applied to the second acrylic pressure sensitive adhesive layer 13. Forming process.

Application of the acrylic pressure-sensitive adhesive may be made by various coating methods, and in particular, it is preferable that the acrylic pressure-sensitive adhesive is made in terms of minimizing changes in physical properties of the urethane film. In addition, for smooth application of the acrylic pressure-sensitive adhesive, the viscosity of the acrylic pressure-sensitive adhesive is preferably made under conditions maintained in the range of 1,000 to 3,000 cPs.

After the application of the acrylic adhesive for forming the first acrylic adhesive layer is made, the porous plastic mesh layer 12 is installed, and the acrylic adhesive for forming the second acrylic adhesive layer 13 is applied. After all the application of the acrylic adhesive is made, the acrylic adhesive layer is cured at a temperature of 90 to 130 ° C. to harden to some extent, and then aged at 45 to 80 ° C. for 24 to 48 hours.

Next, the UV barrier film 14 is formed by applying a titanium dioxide solution dispersed in an organic solvent on the second acrylic adhesive layer 13.

Titanium dioxide is preferably used in the form of an organic alkoxy compound, which is dispersed in an organic solvent in an amount ranging from 1 to 5 wt% to prepare a titanium dioxide solution. The titanium dioxide solution is applied onto the second acrylic adhesive layer 13 to form a titanium dioxide film (ultraviolet ray blocking film 14).

Next, a silicone gel is applied and cured on the UV blocking film 14 to form a silicone gel layer 15 and then bonded to release paper to prepare a wound coating material having an UV blocking film.

The silicone gel forming the silicone gel layer 15 may use an additional polydimethylsilicone gel that cures vinyl organosiloxane and hydride organosiloxane using a platinum catalyst, which is applied onto the UV blocking film 14. Curing at 100 to 120 ℃ to form a silicone gel layer (15). Thereafter, a release paper for protecting the silicone gel layer 15 is bonded to produce a wound coating material of the present invention.

The present invention can effectively improve the appearance of scars by protecting the wound from harmful ultraviolet rays by forming an ultraviolet blocking film on the urethane film used as a support for such various products.

Experimental results based on ASTM D6603-07 are shown in Table 1 below. In the case of the wound coating material (urethane film + UV blocking film) of the present invention, the UPF value was 5 times higher than the reference UPF value, and 'very good' You can see that it falls under the category of 'protection' category [Table 2].

division Urethane Film + Sunscreen Urethane film UV-A Block Rate 85.3% 79.3% UV-B Block Rate 98.9% 90.7% UPF 36% 7%

UPF 15-24 25-39 40 or more classification category good protection very good protection excellent protection

ASTM D6603-07: standard guide for labeling of UV-protective textiles

According to the above results, the wound coating material of the present invention can be expected to have an excellent effect of protecting the wound from ultraviolet rays.

The present invention described above is not limited to the above-described embodiment and the accompanying drawings, and various substitutions, modifications, and changes are possible within the scope without departing from the technical spirit of the present invention. It will be evident to those who have knowledge of.

10 urethane film 11: first acrylic adhesive layer
12 porous plastic mesh layer 13 second acrylic adhesive layer
14: UV protection film 15: silicon gel layer
16: release strata

Claims (7)

Urethane film 10,
A first acrylic adhesive layer 11 applied on top of the urethane film 10,
The porous plastic mesh layer 12 formed on the first acrylic adhesive layer 11,
A second acrylic adhesive layer 13 formed on the porous plastic mesh layer 12 to fix the porous plastic mesh layer 12 to the urethane film 10;
UV blocking film 14 formed on the second acrylic adhesive layer 13,
A silicon gel layer 15 formed on the UV blocking film 14 and in contact with the wound portion;
Release paper layer 16 formed on the silicon gel layer 15
A wound dressing having an ultraviolet blocking film, characterized in that it comprises a.
The method according to claim 1,
The porous plastic mesh layer 12 has a wound coating having a UV blocking film, characterized in that the thickness range from 50 to 200 ㎛.
The method according to claim 1,
The porous plastic mesh layer 12 has a wound coating having a sunscreen, characterized in that the weight ranges from 7 to 30g / ㎡.
The method according to claim 1,
The porous plastic mesh layer 12 is a wound coating material having a sunscreen, characterized in that made of any one selected from polyethylene, polypropylene, polyester, and nylon.
The method according to claim 1,
The UV blocking film 14 has a wound coating having a UV blocking film, characterized in that the thickness of 1 to 30 ㎛ range.
The method according to claim 1,
The UV blocking film 14 is a wound coating having a UV blocking film, characterized in that using a titanium dioxide as a UV blocking material.
After the acrylic adhesive is applied on the urethane film 10 to form the first acrylic adhesive layer 11, the porous plastic mesh layer 12 is installed, and the acrylic adhesive is applied to the second acrylic adhesive layer 13. Forming process,
Forming a UV blocking film 14 by applying a titanium dioxide solution dispersed in an organic solvent on the second acrylic adhesive layer 13 and
The method of manufacturing a wound coating material having a UV blocking film, comprising the step of forming a silicone gel layer (15) by applying a silicone gel on the UV blocking film (14) and curing, and then bonding the release paper.

Images