KR20100010462A - Composition for improving constipation and skin-tone having good taste and the method for preparing thereof - Google Patents

Abstract

The present invention relates to a composition for improving constipation or skin tone with excellent palatability and a method for producing the same, and more particularly, surrounding the surface of the sugar core with at least one active ingredient selected from the group consisting of a deflector powder, an aloe powder and a chaff powder. By containing granules or granules added with a coating layer made of sugar, flavor, powdered tea or mixture thereof in the outermost layer of the granules, to improve the constipation in the mouth caused by residues such as bitterness and debris to improve constipation or skin tone It relates to a composition and a method for preparing the same. In addition, the composition according to the present invention to alleviate the symptoms of constipation and promote bowel function of the large intestine exhibits an excellent constipation or skin tone improvement effect.

Description

Composition for improving constipation or skin tone with excellent palatability and its preparation method {Composition for improving constipation and skin-tone having good taste and the method for preparing honey}

The present invention relates to a composition for improving constipation or skin tone with excellent palatability and a method for producing the same, and more particularly, surrounding the surface of the sugar core with at least one active ingredient selected from the group consisting of a deflector powder, an aloe powder and a chaff powder. By containing granules or granules added with a coating layer made of sugar, flavor, powdered tea or mixture thereof in the outermost layer of the granules, to improve the constipation in the mouth caused by residues such as bitterness and debris to improve constipation or skin tone It relates to a composition and a method for preparing the same. In addition, the composition according to the present invention to alleviate the symptoms of constipation and promote bowel function of the large intestine exhibits an excellent constipation or skin tone improvement effect.

Modern man is increasing in various adult diseases due to the intake of instant foods, high-fat foods and lack of exercise. Among them, obesity and constipation are mild and early symptoms of adult disease, but are causing a number of other complications. Recently, as a preventive measure against such diseases, interest in prevention and treatment using natural food as well as simple exercise is increasing.

Constipation refers to a case in which the stool is harder and drier than healthy, and the number of bowel movements and the amount of stool is significantly reduced, resulting in discomfort or physiological disorders. In order to improve and treat these constipation symptoms, it is recommended to eat foods high in fiber, such as sweet potatoes, greenish green vegetables, konjac, fruits, and meats. It is very difficult for young women who have fewer occasions to eat these foods. Thus, the use of herbal and herbal medicines excellent in the treatment of constipation has increased the need for a product that can be easily consumed without side effects.

Cassia Tora L. has long been known to be effective in treating constipation as well as ocular diseases such as decreased vision and night blindness when the eyes are red, swollen and sore by eliminating the heat in the liver and activating the peristalsis of the large intestine. . However, if you take the powder as a defect, the bitter taste in the mouth is severe, and when the throat overflow, due to the aggregation of the powder will cause severe rejection. In addition, when prepared by taking a granule formulation, the rejection is improved compared to the powder, but residues such as debris have a problem of deterioration in palatability.

Accordingly, the present inventors have studied to find a composition for improving constipation or skin tone having no side effects and excellent palatability, and as a result, by applying at least one active ingredient selected from the group consisting of a deficiency powder, aloe powder and chaff skin powder on the surface of the sugar core granules The present invention has been found to improve palatability by preparing or coating a raw material having excellent palatability on the outermost layer of the granules.

Accordingly, an object of the present invention is a sugar core; It is to provide a composition for improving constipation or skin tone comprising a granule consisting of; and an active ingredient-containing layer is applied to the surface of the sugar core, at least one selected from the group consisting of a powder, aloe powder, and chaff blood powder.

In addition, it is an object of the present invention to provide a composition for improving constipation or skin tone by improving the palatability by containing granules further added to the outermost layer of the granules, at least one coating layer selected from the group consisting of sugars, flavors and powdered tea.

Another object of the present invention to provide a method for producing a composition for improving constipation or skin tone excellent palatability.

In order to achieve the above object, the present invention provides a sugar core; It provides a composition for improving constipation or skin tone comprising a granule consisting of; and an active ingredient-containing layer is applied to the surface of the sugar core, at least one selected from the group consisting of a powder, aloe powder, and chaff blood powder.

In addition, the present invention comprises the steps of 1) preparing a powder by grinding each of the deflector, aloe and the chaff blood; It provides a method for producing a composition for improving constipation or skin tone, comprising; and 2) to the sugar core alone, mixing or sequentially applying the powders prepared in step 1) to granules.

The composition according to the present invention reduces the rejection by applying the powders of the lesser palatability, aloe and chaff blood to the sugar core to make the granules, and by coating the outermost layer of the granules with sugar, flavor, powdered tea or a mixture thereof, bitter taste And by improving the residual feeling in the mouth by the residue such as debris is very excellent palatability. In addition, by using natural herbal medicines, such as the deficiency, aloe and chaff as an active ingredient, there is no side effect and promotes bowel function of the large intestine, showing excellent skin tone improvement effect with excellent constipation relief and prevention effect.

Therefore, the composition of the present invention can be usefully used for foods and food manufacturing industry for constipation or skin tone improvement, synergistic effect by mixing with raw materials excellent in palatability and bowel efficacy, in addition to the active ingredient, skin tone improvement effect and A preference and an improvement effect can also be expected.

The present invention is a sugar core; And an active ingredient-containing layer coated on at least one selected from the group consisting of a clarifier powder, an aloe powder, and a chaff blood powder on the surface of the sugar core. It provides a composition for improving constipation or skin tone containing granules.

In another aspect, the present invention provides a composition for improving constipation or skin tone containing granules further added to the outermost layer of the granules, one or more coating layers selected from the group consisting of sugars, flavors and powdered tea.

The present invention comprises the steps of 1) preparing a powder by pulverizing the deflector, aloe and the chaff blood; It provides a method for producing a composition for improving constipation or skin tone, comprising; and 2) to the sugar core alone, mixing or sequentially applying the powders prepared in step 1) to granules.

In another aspect, the present invention provides a method for producing a composition for improving constipation or skin tone further comprising the step of coating the outermost layer of the granules of step 2) with one or more selected from the group consisting of sugar, flavor and powdered tea.

Hereinafter, the present invention will be described in more detail.

Cassia Tora L., also called super- or horse-seated, has been used mainly in habitual constipation in oriental medicine and in the private sector, and its seeds and leaves are constipated, indigestion, and intestinal tract. It is used for the purpose of strengthening eyesight, suit, diuresis, laxative, blue nominal, limbal stool, target carcinoma and thermal constipation.

Aloe arborescens mill is a perennial herb belonging to the genus Aloe of the Botanical Liliaceae family, and its origin is a global medicinal plant that grows widely throughout the continent of Africa and today in the tropics and temperate regions. Aloe is a bactericidal bactericidal and fungal neutralizing toxin, aloeursine effective against ulcers, and anti-cancer allomitin, including steroids, amino acids, saponins, antibiotics, wound healing hormones and minerals. Contains ingredients It is also known that the bitter yellow substance of aloe leaves is particularly effective in constipation.

Plantaginis Semen is a shell of the plantain (Plantago asiatica L.) family and contains a lot of dietary fiber, and when it is put in water, it forms a mucus layer and absorbs a lot of moisture like a sponge. In oriental medicine and in the private sector, his seeds were used for urinary tract diseases, cough, anti-inflammatory, diuresis, and laxative.

Hereinafter, the manufacturing method of the constipation or skin tone improvement composition of the present invention will be described in detail for each step.

1) preparing a powder by pulverizing the deflector, aloe and the chaff blood respectively

Clarifier, aloe and chaff powder can be prepared by known methods. For example, aloe is cut and then hot-air dried or the leaves of the green leaves are extracted, and only the gel component is extracted and freeze-dried. Subsequently, the dried crystallizer, the aloe and the chaff blood are finely ground with a grinder to prepare a powder.

The active ingredients are preferably ground to a size of 0.001 to 2.0mm. This is because the powder is too fine at less than 0.001 mm to be suitable for the formulation, and when it is more than 2.0 mm, the powder is too large to be suitable for the formulation.

2) to the granules by applying the powders prepared in step 1) alone, mixed or in turn to the sugar core

Dispersing the powders prepared in step 1) in an aqueous solution, and applying the particles to the sugar cores alone, mixed or in turn using a fluid bed coater to prepare granules comprising the sugar cores and the active ingredient-containing layer. do.

It is preferable that the notifier powder, aloe powder and chaff powder are contained in amounts of 0.01 to 60% by weight, respectively, based on the total weight of the composition. This is because if the content is less than 0.01% by weight, the expected efficacy of the raw material is lowered, so that it is difficult to obtain the effect, and when the content exceeds 60% by weight, the expected efficiency is lowered because it does not constitute an optimal ratio.

The sugar core of the present invention may be used maltodestrin, cyclodextrin, sugar, isosaccharide, glucose, fructose, lactose, xylose, maltose, fructooligosaccharide, maltooligosaccharide, isomaltooligosaccharide, galactooligosaccharide, soy oligosaccharide, etc. have. The sugar core is preferably included in an amount of 5 to 20% by weight based on the total weight of the composition.

Granules in which the sugar core, the aloe powder and the chaff powder are coated on the sugar core are in the form of beads and preferably have a size of 1 to 5 mm. This is because when the particle size is less than 1 mm, the palatability is reduced, and when the particle size is larger than 5 mm, the particle is too large and the neck is bad.

3) coating the outermost layer of the granules of step 2) with one or more selected from the group consisting of sugar, flavor and powdered tea

In a stainless container designed to rotate the granules prepared in step 2) to produce granules in which the granules of the sugar core and the active ingredient-containing layer are added to at least one coating layer selected from the group consisting of sugars, flavors and powdered tea. It is placed, and sprayed evenly to coat sugar, flavor, powdered tea or a mixture thereof through a fine spraying device designed to be sprayed into the interior space of the container.

Sugars usable in the present invention include sucrose, xylitol, oligosaccharides, dietary fiber, erythritol, glucose, fructose, stevioside and the like.

Flavors usable in the present invention include apple flavor, grape flavor, peach flavor, apricot flavor, orange flavor, guava flavor, mango flavor, lemon flavor, lime flavor, green grape flavor, raspberry flavor, cranberry flavor and the like.

Powdered teas usable in the present invention include green tea, black tea, herbal tea and the like.

At least one selected from the group consisting of sugars, flavors and powdered tea is preferably included in an amount of 0.01 to 30% by weight based on the total weight of the composition. This is because when the content is less than 0.01% by weight, the effect of each raw material does not appear, and the palatability enhancing effect is insignificant.

The composition for improving constipation or skin tone of the present invention may further include a pharmaceutically acceptable excipient, for example, a plasticizer, a flavoring agent, a colorant, a preservative, and the like, in addition to the active ingredient, mixed with other raw materials having excellent palatability and bowel efficacy. May be

In addition, the composition for improving constipation or skin tone of the present invention is administered orally, the dosage of the active ingredient depends on the subject to be treated, the specific disease or pathological condition to be treated, the severity of the disease or pathological condition, the route of administration, and the judgment of the prescriber. Different. Dosage determination based on these factors is within the level of skill in the art.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited only to these examples.

Preparation Example 1 Preparation of Clarifier Powder, Aloe Powder and Cha-Phi Powder

After cutting the green leaves, the aloe was hot-air-dried at a temperature of 60 ℃, and the tuber and the chaff blood was washed and dried. The dried crystallizer, aloe and chaff blood were finely ground with a grinder to prepare a powder having a size of 0.05 mm.

[Comparative Example 1] Mixture of Clarifier Powder, Aloe Powder and Charcoal Blood Powder

The mixture of the clarifier powder, aloe powder and chaff blood powder obtained in Preparation Example 1 were mixed in the composition and content of the following Table 1, and packaged by 3.0 g.

[Comparative Example 2] A composition prepared by mixing granule powder, aloe powder and chaff powder in granule formulation

The composition of the granule formulations containing a mixture of the clarifier powder, aloe powder and chaff blood powder obtained in Preparation Example 1 was prepared in the composition and content of Table 1 below. HPMC (hydroxypropyl methylcellulose) as a binder and water / EtOH as a solvent were used to form spherical granules of aloe powder, dendritic powder and chaff powder. Granules of 1-2 mm size were prepared and packaged in 3.0 g increments.

Comparative Example 3 Composition of granule formulation prepared by surrounding sugar core with excipient and coating the outermost layer with sugar, flavor and powdered tea

After adding the excipient powder, the aloe powder and the chaff blood powder to the sugar core only with excipients, the outermost layer of the granules coated with sugar, fragrance and powdered tea was prepared in the composition and content of Table 1 below. HPMC (hydroxypropyl methylcellulose) was used as the binder, water / EtOH was used as the solvent, and sugar sphere (KPT) was used as the sugar core. Spherical granules having a size of 1 to 5 mm were prepared by mixing so that dextrin was applied as an excipient to sugar spheres using HPMC and water / EtOH. Add Stevioside (BS Corporation) and powdered green tea (Manufacturer: AMOREPACIFIC), and coat the outermost layer of the spherical granules with sugar and powdered tea using HPMC and water / EtOH. Fragrance) was added. Then, 3.0 g each was packed.

Example 1 Composition of Granule Formulation Prepared by Surrounding Sugar Core, Aloe Powder and Cha-Phi Powder in a Sugar Core

The composition of the granule formulations containing a mixture of the clarifier powder, aloe powder and chaff blood powder obtained in Preparation Example 1 was prepared in the composition and content of Table 1 below. HPMC (hydroxypropyl methylcellulose) was used as the binder, water / EtOH was used as the solvent, and sugar sphere (KPT) was used as the sugar core. Spherical granules having a size of 1 to 5 mm were prepared by mixing the sugar spheres with HPMC and water / EtOH so as to apply a mixture of aloe powder, defector powder, and chaff powder. Then, 3.0 g each was packed.

Example 2 Composition of Granule Formulation in which Cascade Powder, Aloe Powder and Chaff Powder were sequentially surrounded by Sugar Core and the outermost layer was coated with Sugar.

Stevioside (manufacturer: BS Corporation) was added to the spherical granules of 1 to 5 mm size prepared in the same manner as in Example 1 to prepare granules coated with the sugar of the outermost layer of the spherical granules using HPMC and water / EtOH. . Then, 3.0 g each was packed.

Example 3 Composition of a Granule Formulation in which Cascade Powder, Aloe Powder, and Chaff Powder were Surrounded with Sugar Cores in Order and the Outer Layers Coated with Sugar and Scent

Stevioside (manufacturer: BC Corporation) was added to 1 ~ 5mm spherical granules prepared in the same manner as in Example 1, the outermost layer of the spherical granules was coated with sugar using HPMC and water / EtOH, and then jasmine flavor (Manufacturer: Seoul flavor) was added and mixed to prepare granules coated with sugar and flavor. Then, 3.0 g each was packed.

Example 4 Composition of Granule Formulation in which Cascade Powder, Aloe Powder and Chaff Powder were sequentially surrounded by Sugar Core and the outermost layer was coated with Sugar and Powdered Tea

Stevioside (manufacturer: BC Corporation) and powdered sulphon tea (manufacturer: AMOREPACIFIC) were prepared in spherical granules of 1 to 5 mm size prepared in the same manner as in Example 1, and spherical granules were prepared using HPMC and water / EtOH. Granules with outermost layers coated with sugar and powdered tea were prepared. Then, 3.0 g each was packed.

[Example 5] Composition of granule formulation in which Cassiae powder, Aloe powder and chaff powder were surrounded by sugar cores in turn and the outermost layer was coated with sugar, flavor and powdered tea

Stevioside (manufacturer: BC Corporation) and powdered green tea (manufacturer: AMOREPACIFIC) were added to the spherical granules of 1 to 5 mm size prepared in the same manner as in Example 1, and the outermost of the spherical granules was prepared using HPMC and water / EtOH. Each layer was coated with sugar and powdered tea, and then Jasmine flavor (manufactured by Seoul Flavor) was added to prepare granules coated with sugar, flavor, and powdered tea. Then, 3.0 g each was packed.

ingredient Comparative Example 1 (% by weight) Comparative Example 2 (wt%) Comparative Example 3 (wt%) Example 1 (% by weight) Example 2 (% by weight) Example 3 (% by weight) Example 4 (% by weight) Example 5 (% by weight) Sugar ball - - 5 15 10 10 10 5 Aloe Powder (Manufacturing Example 1) 28 28 - 28 28 28 28 28 Cascade Powder (Manufacturing Example 1) 30 30 - 30 30 30 30 30 Cha-Pi Powder (Manufacturing Example 1) 20 20 - 20 20 20 20 20 Stevioside - - 6 - 6 One One 6 Jasmine flavor - - 5 - - 5 - 5 Powdered green tea - - 5 - - - 5 5 Excipient 22 22 79 6 6 6 6 One

Test Example 1 Constipation Improvement Effect Experiment

Example 1 to 5 and Comparative Examples 1 to 2 were used to each of 20 subjects with constipation symptoms (evening once a day / day, a total of 1 week), and then improved constipation according to the criteria described in Table 2 below. Was compared. The results are shown in Table 3 below.

Item example Determination of improvement effect before and after use Defecation effect 0 points: less than 10% of respondents felt improvement 1 point: 10% to 25% of respondents felt improvement 2 points: 25% to 40% of respondents felt improvement 3 points: improvement 40% ~ 60% of respondents who felt the effect 4 points: 60% ~ 80% of respondents who felt improvement 5 points: 80% ~ 100% of respondents who felt improvement Among the respondents, the percentage of respondents who felt constipation improvement was judged from 0 (small) to 5 (large).

Production Example Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Example 5 Defecation effect 4 5 5 5 5 5 5

As can be seen in Table 3, Comparative Examples 1 and 2 and Examples 1 to 5 exhibited a similar bowel effect by the deflector powder, aloe powder and chaff blood powder, it was very excellent in the constipation improvement effect.

Test Example 2 Palatability Experiment

The palatability of Examples 1 to 5 and Comparative Examples 1 and 2 was evaluated for 10 sensory test personnel, and the results are shown in Table 4 below.

Sensory tester One 2 3 4 5 6 7 8 9 10 Average incense Comparative Example 1 One One One One One One One One One One 1.0 Comparative Example 2 One One One One One One One One One One 1.0 Example 1 One 3 2 2 One 3 One 2 2 One 1.8 Example 2 3 2 2 3 3 3 3 2 3 3 2.7 Example 3 4 4 4 4 5 4 3 5 3 4 4.0 Example 4 3 3 3 4 3 3 3 4 3 4 3.3 Example 5 5 5 4 4 4 3 5 4 5 4 4.0 flavor Comparative Example 1 One One One One One One One One One One 1.0 Comparative Example 2 One 2 2 One One One 2 One 2 2 1.5 Example 1 2 2 3 2 2 2 3 2 One 3 2.2 Example 2 5 5 4 4 4 5 5 4 4 4 4.4 Example 3 4 2 3 4 3 3 3 4 3 3 3.2 Example 4 4 4 3 4 3 4 3 4 3 3 3.5 Example 5 5 5 5 4 4 5 4 5 4 4 4.5 Overall preference Comparative Example 1 One One One One One One One One One One 1.0 Comparative Example 2 One 2 2 One One 2 2 One 2 One 1.5 Example 1 2 3 2 2 One 3 One 2 2 2 2.0 Example 2 3 3 4 3 3 3 4 3 3 3 3.2 Example 3 2 4 3 3 4 4 3 4 3 3 3.3 Example 4 4 4 3 4 3 4 4 3 4 4 3.7 Example 5 5 5 5 4 4 5 4 4 5 4 4.5 [Evaluation Criteria] 5: Very Good, 4: Good, 3: Normal, 2: Poor, 1: Very Poor

As can be seen in Table 4, compared to the powder formulation of Comparative Example 1, the granule formulation has improved taste and overall acceptability. In addition, in Examples 2 to 5 in which the outermost layer of the active ingredient-containing layer was coated with sugar, flavor, powdered tea, or a mixture thereof, all of flavor, taste, and overall acceptability increased significantly. In particular, in Example 5 coated with a mixture of sugar, fragrance and powdered tea, the highest palatability and satisfaction could be confirmed.

Test Example 3 Skin Tone Improvement Experiment

Ten subjects were selected as a negative control group of Comparative Example 3 and Example 5 was selected as an experimental group to be used by each of the 10 subjects with constipation symptoms (evening once a day / day, a total of one week), Facial Stage DM-3 (Moritex, Japan) was used to evaluate skin tone improvement. The skin tone improvement rate was determined by measuring the brightness and color of the skin.

Negative Control (Comparative Example 3) Experimental group (Example 5) Skin tone improvement rate (%) Brightness (mean ± standard deviation) Brightness (mean ± standard deviation) -0.4 ± 1.0 5.9 ± 1.0 Color (mean ± standard deviation) Color (mean ± standard deviation) 0.2 ± 1.1 10.9 ± 1.0

As can be seen in Table 5 and FIG. 1, Comparative Example 3, which is a negative control group, did not show significant skin tone improvement effect, but Example 5 of the present invention improved skin tone after use more than before use. Therefore, it was found that the composition of the present invention is excellent in improving skin tone by effectively inducing bowel movement.

1 is a photograph showing the skin tone improvement effect of the composition according to the present invention.

Claims (12)

Sugar cores; And An active ingredient-containing layer coated on at least one selected from the group consisting of a deflector powder, an aloe powder, and a chaff blood powder on a surface of the sugar core; Constipation or skin tone improvement composition containing the granules consisting of. The composition for improving constipation or skin tone according to claim 1, wherein the composition contains granules further comprising at least one coating layer selected from the group consisting of sugars, flavors and powdered tea. The composition for improving constipation or skin tone according to claim 1, wherein the deflector powder, the aloe powder and the chaff blood powder each have a size of 0.001 to 2.0 mm. The composition for improving constipation or skin tone according to claim 1, wherein the clarifier powder, the aloe powder and the chaff blood powder are contained in an amount of 0.01 to 60% by weight based on the total weight of the composition. The composition for improving constipation or skin tone according to claim 1, wherein the granule composed of the sugar core and the active ingredient-containing layer has a size of 1 to 5 mm. The composition for improving constipation or skin tone according to claim 2, wherein at least one selected from the group consisting of sugars, flavors and powdered tea is contained in an amount of 0.01 to 30% by weight based on the total weight of the composition. 1) pulverizing the deflector, aloe and chajapi each to prepare a powder; And 2) preparing the granules by applying the powders prepared in step 1) alone, mixed or in turn to the sugar cores; Method of producing a composition for improving constipation or skin tone comprising a. The method of claim 7, further comprising coating the outermost layer of the granules of step 2) with at least one selected from the group consisting of sugar, flavor, and powdered tea. . [9] The method of claim 7, wherein the clarifier, aloe and chaser blood of step 1) are pulverized to a size of 0.001 to 2.0 mm, respectively. The method of claim 7, wherein the clarifier powder, the aloe powder and the chaff blood powder of step 2) are contained in an amount of 0.01 to 60% by weight, respectively, based on the total weight of the composition. . [9] The method of claim 7, wherein the granules to which the clarifier powder, the aloe powder and the chaff powder of step 2) are applied have a size of 1 to 5 mm. The method of claim 8, wherein at least one selected from the group consisting of sugar, aroma and powdered tea is contained in an amount of 0.01 to 30% by weight based on the total weight of the composition.

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