KR20040054875A - Composition for cleaning to toothbrush - Google Patents

Abstract

The present invention relates to a toothbrush cleaning composition, at least one compound selected from the group consisting of benzalconium chloride (Benzalconium chloride), benzotonium chloride (Benzotonium Chloride), Cetyl Pyridinium Chloride cleaning agent active ingredient It provides a toothbrush cleaner composition comprising. Toothbrush cleaning composition of the present invention is characterized in that it contains 0.01 to 30% by weight of the cleaning agent active ingredient. The toothbrush cleaner composition of the present invention has an excellent bactericidal action against oral bacteria that may be attached to the toothbrush used for brushing teeth and harmful microorganisms present in the air, so that the toothbrush may be hygienically used and managed.

Description

Toothbrush Cleaner Composition {COMPOSITION FOR CLEANING TO TOOTHBRUSH}

The present invention relates to a toothbrush cleaner composition, and more particularly selected from the group consisting of bactericidal benzalconium chloride (Benzalconium chloride), benzotonium chloride (Benzotonium Chloride), Cetyl Pyridinium Chloride (Cetyl Pyridinium Chloride) A toothbrush cleaner composition comprising one compound or a mixture of two or more compounds as an active ingredient of a toothbrush cleaner.

The purpose of brushing is to remove food debris and plaque in the oral cavity. During this process, the oral harmful bacteria are attached to the toothbrush after brushing, and the toothbrush is not hygienicly stored due to the attachment of harmful bacteria in the air during storage.

Oral bacteria that reside in the mouth and cause oral diseases include Streptococcus, Neisseria, Veillonella, Fusobacterium, Actinomyces, and Nocadia. Nocardia, Leptotrichia, Cactobacillus, Capnocytophaga, etc. are mentioned.

In particular, the streptococcus mutans, a group of streptococcus, attracts attention as an important bacterium that causes dental caries. Streptococcus mutans breaks down sugar in food to produce acid and produces large amounts of glucan. Therefore, it is assumed that the plaque is attached to the surface of the teeth and stagnates. Glucan also collects Streptococcus mutans and forms agglomerates, which can be a cause of plaque formation. Plaque is most common in poor oral cleanliness and causes bad breath, caries and periodontal disease.

In addition, infectious bacteria in the air include Staphylococcus aureus, Escherichia coli, Pseudomonas, and yeast (Candida) and fungi (Aspergillus). Attached to a toothbrush in the middle of the mouth can be infected through the mouth through the mouth.

Many toothbrush users who believe that the above-mentioned bacteria remain in the teeth and are harmful to the human body may be boiled in boiling water or dried in the sun by sterilization and disinfection methods. Some consumers use UV germicidal sterilizers, but they are not popular because of the cost burden.

The present invention is to provide a toothbrush cleaning composition for sanitizing care by sterilizing, disinfecting the toothbrush after brushing.

The above object of the present invention is a toothbrush cleaning composition benzalconium chloride (benzalconium chloride), benztonium chloride (Benzotonium Chloride) and one or more compounds selected from the group of compounds consisting of Cetyl Pyridinium Chloride (Cetyl Pyridinium Chloride) It can achieve by making it contain 0.01-30 weight% of a mixture of compounds.

In the present invention, one or more compounds selected from the group consisting of benzalconium chloride (Benzalconium chloride), benzogenium (Benzotonium Chloride), cetylpyridinium chloride (Cetyl Pyridinium Chloride) is a detergent active ingredient Toothbrush cleaning composition is characterized in that it is contained.

Toothbrush cleaning composition of the present invention is a benzalconium chloride (Benzalconium chloride), Benzotonium Chloride (Benzotonium Chloride), Cetyl Pyridinium Chloride (Cetyl Pyridinium Chloride) A compound selected from the group consisting of a compound or a mixture of two or more compounds 0.01 wt% to 30 wt% of the active ingredient is included. Benzalconium chloride, Benztonium Chloride, and Cetyl Pyridinium Chloride are the detergent active ingredients of the present invention. In the present invention, when the content of the disinfectant is less than 0.01% by weight, it is difficult to expect the disinfecting effect and disinfection effect by the disinfectant, and when it exceeds 30% by weight, the synergistic effect of the disinfectant is weak and the use of the disinfectant price ratio increases. There is little advantage. Therefore, the toothbrush cleaning composition of the present invention preferably contains 0.5 to 5% by weight, most preferably 1% by weight of the fungicide.

Toothbrush cleaner according to the present invention may be provided in a variety of formulations, such as liquid form, tablet form, powder form. The most common form of the toothbrush cleaner according to the present invention will be referred to as a liquid formulation, but in terms of convenience and portability of the consumer, a tablet type that can be dissolved in drinking water at a desired place is preferable. In the present invention, the tablet-type toothbrush cleaner composition includes 35 to 65 parts by weight of a blowing agent, 5 to 15 parts by weight of a dehumidifying agent, 1.5 to 3 parts by weight of a hydrogen ion concentration (pH = pH) modifier, 1 to 5 parts by weight of a binder, and 5 to 10 parts by weight. It can be prepared by composition with a negative solvent and 0.01 to 30 parts by weight of a detergent active ingredient. The blowing agent may be one compound selected from the group consisting of sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate and iron carbonate or a mixture of two or more compounds, and the moisture removing agent is preferably sodium carbonate, and the pH adjusting agent is citric acid. Or sodium citrate. The solvent used for dissolving the binder is preferably polypropylene glycol, glycerin or ethanol. The binder is preferably a water-soluble polymer, more preferably carboxymethyl cellulose or polyvinylpyrrolidone.

The tablet-type toothbrush cleaner of the present invention may be carried out by a conventional method for preparing a regular formulation formulation, and preferably, the blowing agent, the moisture remover, and the pH adjuster are mixed, mixed with a binder solution dissolved in a solvent, and then granulated. After preparing, drying and sizing, the mixture is mixed with a lubricant and a medicament to prepare a tablet. Tablet-type toothbrush cleaner of the present invention can be prepared in the form of tablets, tablets or various release tablets having a surface shape such as ordinary R surface, sugar R surface, Smeker plane, smear plane, two-stage R surface, It is preferable that 1 tablet is 0.1-5 g, Most preferably, it is 1.0 +/- 0.1 g. The toothbrush can be sterilized and cleaned by dissolving 1 tablet in 1 milliliter (ml) -500 milliliter (ml) of drinking water and soaking the toothbrush for 1 minute. The most preferred method of use is to disinfect and sterilize a used toothbrush for 1 minute by dissolving 1.0 g tablets in 100 milliliters (ml) of drinking water.

The tablet formulation toothbrush cleaner composition of the present invention is composed of anhydrides to increase the stability of the disinfectant used to maintain the original function, and users can use dissolved in water immediately before use, regardless of the place to use the advantages of easy portability Have.

Hereinafter, preferred embodiments of the present invention are provided to aid in understanding the present invention. The embodiment used in the present invention is made of a tablet formulation in consideration of the consumer's convenience, which is provided only for the purpose of improving consumer convenience and understanding of the present invention. It is not limited.

EXAMPLE

Toothbrush cleaners of Examples 1 to 5 were prepared according to the composition components and the composition ratios shown in Table 1. Toothbrush cleaner firstly, uniformly mixed sodium hydrogen carbonate as a blowing agent, sodium carbonate as a dehumidifying agent, sodium citrate as a pH adjuster, dissolve the binder in a solvent and put it into the mixture and stirred, and then granulate the granules to a certain size using a granulator After drying, the granulated granules were prepared, mixed, mixed with a foaming agent, a lubricant, a fungicide, and stirred with the dried granules to prepare 1.0 ± 0.1 g of a tablet.

Raw material classification Raw material name Comparative example Example 1 Example 2 Example 3 Example 4 Example 5 disinfectant Benzalkonium chloride - 20.0 - - 10.0 - Benzetonium Chloride - - 25.0 - - 10.0 Cetylpyridinium Chloride - - - 25.0 20.0 20.0 blowing agent Sodium bicarbonate 65.0 50.0 50.0 50.0 45.0 45.0 Dehumidifier Sodium carbonate 15.0 15.0 15.0 15.0 15.0 15.0 PH adjuster Sodium citrate 2.0 1.5 1.0 1.5 2.0 1.5 Binder Carboxymethyl Cellulose 3.0 3.0 - - - - Polyvinylpyrrolidone - - 1.5 1.5 1.5 1.5 menstruum Polypropylene glycol 10.0 - - 7.0 6.5 - glycerin 5.0 10.5 7.0 - - 7.0 Sum 100.0 100.0 100.0 100.0 100.0 100.0

[Comparative Example]

According to the same production method as in Example 1 to the composition components and the composition ratios shown in Table 1, a tablet-type cleaner was prepared.

<Microbial bactericidal evaluation>

In order to verify the bactericidal effect on the oral microorganism of the composition (Experimental group 1 to 13) according to the present invention was evaluated by performing the experiment by the following experimental method.

(Use strain)

Actinomyces viscosus ATCC 15987, Streptococcus mutans ATCC 10449, Actinobacillus (Actinobacillus actinomycetumcomitans ATCC 33384), Porphyromonas gingivalis ATCC 381, Staphylococcus aureus KCTC 1916, Escherichia coli KCTC 25TC, 25 Candida, 25 Candida TC 10 25C al. 9 strains were used.

Among these strains, Streptococcus mutans ATCC 10449 and Porphyromonas gingivalis ATCC 381 exist in the oral cavity and cause tooth decay and gum disease.

Staphylococcus aureus is Staphylococcus aureus, Escherichia coli is Escherichia coli, Pseudomonas is Pseudomonas aeruginosa, Candida albicans is Candida, and Aspergillus niger is Black fungus. These bacteria are known to exist in the air and cause disease in the human body.

(Cultivation method)

The culture method of these strains is as follows.

Actinomyces viscosus ATCC 15987, Candida albicans ATCC 10231, Staphylococcus aureus KCTC 1916, Escherichia coli KCTC 2571, Pseudomonas KCTC 2513 are YM medium (glucose 10g / L, yeast extract 3g / L, malt extract 3g / L, bactopeptone 5 g / L) Streptococcus mutans ATCC 10449 was incubated in TH medium (Todd Hewitt broth 30g / L, sucrose 50g / L), and Actinobacillus actinomycetumcomitans ATCC 33384 and Porphyromonas gingivalis ATCC 381 were incubated in Thioglycollate Medium. Aspergillus niger KCTC 6960 was incubated in Agar solid medium, spores were separated and placed in sterile distilled water and incubated for 24 hours.

Actinomyces viscosus ATCC 15987 was incubated in an anaerobic incubator at 26 °, Candida albicans ATCC 10231, Staphylococcus aureus KCTC 1916, Escherichia coli KCTC 2571, Pseudomonas KCTC 2513, Aspergillus niger KCTC 6960, 37 ° and Actinobacillus 84 actins Porphyromonas gingivalis ATCC 381 was cultured in an anaerobic incubator at 37 °.

(Sterilization test)

The bactericidal test was carried out after passage of these strains and pre-cultivation for three times for 24 hours, and 0.1 g of a regular-form toothbrush cleaner prepared by experimental groups 1, 2, 3, 4, and 5dp in 9.9 g of each appropriate experimental group medium. 1 x 10 ⁶ strains were inoculated after addition. After incubation for 18 hours, the bacterial count was measured by colony count using agar dilution method and the results are shown in Table 2. In the present invention, the bactericidal power was evaluated in the tablet form of the embodiment prepared in the tablet form in consideration of the portability and ease of use of the consumer in the toothbrush cleaner.

Experimental results showed that the experimental group 1 (comparative example) had little inhibitory effect on the growth of microorganisms against the 9 strains used.

Experimental group Comparative example Example 1 Example 2 Example 3 Example 4 Example 5 A.viscosus 4 x 10 ⁵ 0 0 0 0 0 S.mutans 4 x 10 ⁶ 0 0 0 0 0 A.actinomycetum comitans 5 x 10 ⁶ 0 0 0 0 0 P.gingivalis 6 x 10 ⁵ 0 0 0 0 0 S.aureus 5 x 10 ⁶ 0 0 0 0 0 E.coli 7 x 10 ⁷ 0 0 0 0 0 Pseudomonsa 2 x 10 ⁷ 0 0 0 0 0 C.albicans 6 x 10 ⁵ 0 0 0 0 0 A.niger 6 x 10 ⁵ 0 0 0 0 0

Toothbrush cleaner composition of the present invention has an excellent sterilization action against oral bacteria and human harmful microorganisms that may be attached to the toothbrush used for brushing the hygiene has an effect that can be stored hygienically.

Claims (4)

In the toothbrush cleaning composition containing a bactericide, one or more compounds selected from the group consisting of benzalconium chloride, benzotonium chloride, cetylpyridinium chloride Toothbrush cleaner composition characterized in that the mixture of the compound is contained as an active fungicide. The toothbrush cleaner composition of claim 1, wherein the disinfectant active ingredient is contained in an amount of 0.01 to 30% by weight. The toothbrush cleaner composition of claim 1, wherein the formulation of the toothbrush cleaner is a regular formulation. The toothbrush cleaner of claim 3, wherein the toothbrush cleaner of the formulation is 0.01 to 30 parts by weight of the fungicide active ingredient, 5 to 65 parts by weight of blowing agent, 1 to 15 parts by weight of moisture scavenger, and 0.5 to 3 parts by weight of hydrogen ion concentration (pH) regulator. Toothbrush cleaning composition, characterized in that composed of 0.1 to 5 parts by weight of the binder, 0.1 to 10 parts by weight of the solvent.