KR20030072418A - Wound dressing on which an ointment type of dressing agent is applied - Google Patents

Abstract

The present invention provides a dressing for wound treatment to which a dressing agent in an ointment form is applied. The wound dressing according to the present invention comprises a wound dressing substrate used for protecting the wound and a dressing agent in the form of an ointment applied on the dressing substrate. The ointment dressing agent a) 50 to 95% by weight of a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or at a skin temperature (15 to 38 ° C.), b) capable of increasing the viscosity of the hydrophobic solvent. 0.5 to 20% by weight of a polymeric material serving as a viscosity increasing agent, and c) 0.5 to 40% by weight of polyolefins serving as a flow regulator of the dressing agent. The ointment dressing agent may further comprise d) a moisturizing agent of 20% by weight or less to keep the wound moisturized. The ointment dressing agent may further include at least one functional agent selected from the group consisting of antibiotics, desiccants, skin preparations, anesthetics, and analgesics.

Description

Wound dressing on which an ointment type of dressing agent is applied}

The present invention relates to a dressing for wound treatment to which an ointment dressing agent is applied, and in particular, may be used to treat a wound of a skin, which means the destruction of a structural layer of the skin due to pressure or physical stimulus such as a burn, a wound, or a trauma. The present invention relates to a wound dressing. The invention also relates to a dressing agent in the form of the ointment described above for use in the dressing.

Generally, wound dressing is used to effectively treat skin wounds such as wounds and traumas. Wound dressings include: 1) ability to maintain adequate moisture in contact with the wound, 2) ability to control wound discharge, 3) ease of attachment and removal of the dressing to the wound, 4) air and water vapor penetration between the exterior and the wound site It is required to have characteristics such as sex, 5) heat insulation of the wound site to the outside, 6) resistance to invasion of bacteria, 7) non-toxic to human body, and 8) excellent mechanical properties.

Conventionally, in order to protect the wound of the skin, the wound treatment was facilitated by simply covering the wound with a cover or an absorption band, and further, dressing was applied after applying an ointment containing an antiseptic or antibiotic to the wound. However, applying an ointment that can promote wound healing and dressing for wound protection has some effect in promoting wound healing. In addition to the accompanying, due to the high flow of the ointment applied to the wound site, the phenomenon that the ointment flows out of the dressing frequently after dressing. This ointment not only reduces the effect of healing the wound, but also causes visual and tactile discomfort.

Although it depends on the type of wound and the severity of the wound, in general, in order to make the wound heal faster and more effective, it is necessary to supply functional agents such as desiccants, antibiotics, and antimicrobial agents to help treat the wound. is average. Such functional agents have been conventionally contained in ointments and supplied to wounds. However, the method of applying the ointment containing the functional agent to the wound and dressing on the wound was accompanied by a reduction in the inconvenience of use and wound healing as mentioned above.

A method of using a film of polymer material or a hydrogel matrix as a wound dressing is disclosed. For example, Korean Patent Application Nos. 1997-62011 and 1998-52921 disclose that certain polyurethanes made in the form of films or hydrogels can be used as dressings for wound healing. The document does not describe that dressings in the form of films or hydrogels can be prepared, including functional agents such as antibiotics, antibacterial agents, analgesics, anesthetics and the like.

Until now, ointment drugs have been mainly used for wound healing, and consumers are accustomed to using such ointment drugs, and therefore, have a tendency to psychologically prefer ointment drugs.

Accordingly, it is an object of the present invention to provide a dressing for treating wounds applied with an ointment-type dressing agent, which can fix functional agents such as desiccants, antibiotics, antibacterial agents, skin preparations, anesthetics, analgesics, and the like to the wound site of the skin. will be. The dressing agent for wound treatment according to the present invention is fixed to the wound site while giving the user a feeling of ointment, thereby not only reducing the wound healing effect but also providing a good feeling of use.

It is also an object of the present invention to provide a dressing for wound treatment, to which an ointment-type dressing agent is applied, which is easy to apply to the wound of the skin and does not cause any damage even upon removal and does not leave much residue. .

It is also an object of the present invention to provide the above dressing agent for use in the above dressing.

Still other objects and advantages of the invention will be understood by the following detailed description of the invention.

1 is a cross-sectional view showing a specific embodiment of the wound dressing of the present invention applied to wounded skin to treat skin wounds.

The present invention provides a dressing for wound treatment to which a dressing agent in an ointment form is applied. The wound dressing according to the present invention comprises a wound dressing substrate used for protecting the wound and a dressing agent in the form of an ointment applied on the dressing substrate. The ointment dressing agent a) 50 to 95% by weight of a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or at a skin temperature (15 to 38 ° C.), b) capable of increasing the viscosity of the hydrophobic solvent. 0.5 to 20% by weight of a polymeric material serving as a viscosity increasing agent, and c) 0.5 to 40% by weight of polyolefins serving as a flow regulator of the dressing agent.

The ointment dressing agent may further include a softening agent having silicone wax or stearate as an end group in order to further impart ointment.

The ointment dressing agent may further comprise d) a moisturizing agent of 20% by weight or less to keep the wound moisturized.

The ointment dressing agent may further include at least one functional agent selected from the group consisting of antibiotics, desiccants, skin preparations, anesthetics, and analgesics.

The present invention also provides the above dressing agent for use in the wound dressing.

Hereinafter, the present invention will be described in more detail with reference to the drawings. 1 is a cross-sectional view showing a specific embodiment of the wound dressing of the present invention applied to wounded skin to treat skin wounds. Such an embodiment may be a band.

As shown in Figure 1, the wound dressing according to the present invention includes a base 11 in the form of a film of a polymer material used as a substrate of a conventional bands. An adhesive layer 13 is formed on the base 11 to adhere the dressing to the skin around the wound. The pressure-sensitive adhesive used for the pressure-sensitive adhesive layer 13 may be any one conventionally used as long as adhesion and detachment to the skin are easy.

The dressing base 15 is formed on a portion of the pressure-sensitive adhesive layer 13, preferably in the middle portion. The dressing base 15 is adhered to and fixed to a part of the pressure-sensitive adhesive layer 13, and both end portions of the pressure-sensitive adhesive layer 13 are parts to be attached to the skin when the dressing for wound treatment of the present invention is applied to the skin. The material that can be used as the dressing substrate 15 may be any material that can be applied to the ointment or gel material. For example, plastic films and foams such as PVC, urethane, and polyolefin resins, nonwoven surfaces, gauze, paper, and the like can be used. On the dressing base 15, the dressing agent 17 of the ointment form of this invention is apply | coated. The ointment-type dressing agent 17 may be attached to the surface of the dressing substrate 15, may be absorbed in the dressing substrate 15, or may be formed in and on the dressing substrate 15.

The exposed portions of the pressure sensitive adhesive layer 13 and the dressing agent 17 are protected by the release agent 19 formed on them until they are applied to the skin.

The ointment-type dressing agent 17 used in the present invention comprises a) 50 to 95% by weight of a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or skin temperature (15 to 38 ° C.), b) the hydrophobic solvent. 0.5 to 20% by weight of a polymeric material that acts as a viscosity increasing agent capable of increasing the viscosity of c), and 0.5 to 40% by weight of polyolefins that act as a flow control agent of the dressing agent. In addition, the ointment-type dressing agent may further include a softening agent having silicone wax or stearate as an end group in addition to the hydrophobic solvent (a) in order to further impart ointment. Furthermore, the ointment-type dressing agent may further comprise d) 20% by weight or less of a moisturizing agent to keep the wound moisturized.

The hydrophobic solvent (a) contained in the ointment-type dressing agent used in the wound dressing of the present invention gives the dressing agent used in the present invention an ointment-like feel, adjusts the delivery process of the drug and When removing the wound dressing from the skin, it acts to prevent foreign substances from adhering to the wound. In order to perform this function, the hydrophobic solvent should be a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or skin temperature (15 to 38 ° C.). Hydrophobic solvent may be in a liquid, semi-solid or solid state at room temperature, 50 to 95% by weight based on the total weight of the dressing agent in order to ensure that the dressing agent of the present invention has the characteristics of an ointment having an appropriate viscosity, more Preferably it is contained in 75 to 85% by weight. Examples of such hydrophobic solvents include petroleum-based saturated hydrocarbons, mineral oils, castor oils, paraffin waxes, bead waxes, and fatty acids having a similar structure. If the hydrophobic solvent used in the present invention deviates from the above viscosity range and ratio, the flowability of the dressing agent to be formed is not appropriate, and the delivery of the drug does not occur efficiently, which is not preferable. In addition, even if not specifically mentioned in the present specification, if the properties of the hydrophobic solvent as described above alone or in combination with other substances can have the appearance of the ointment at room temperature or skin temperature, these things are not excluded from the present invention Do not. In addition, the ointment-type dressing agent may further include a softening agent having silicone wax or stearate as an end group in addition to the hydrophobic solvent (a) in order to further impart ointment. The additionally added silicone wax or softening agent enhances or partially replaces the ointment properties of the hydrophobic solvent, thereby giving flexibility in controlling the properties of the dressing agent.

The polymeric material (b) contained in the ointment-type dressing agent used in the wound dressing of the present invention acts as a viscosity increasing agent to increase the viscosity of the hydrophobic solvent to control the flowability of the dressing agent of the present invention. Do it. In order for the polymer material, which is a viscosity increasing agent, to properly play this role, to properly flow the dressing agent of the present invention and to facilitate the drug delivery process, the ratio of 0.5 to 20% by weight based on the total weight of the dressing agent, in particular, 2 It is preferable to be contained in a dressing agent in the ratio of -8 weight%. Examples of such high molecular materials include synthetic synthetic rubbers, polyacrylic acid, polyethylene oxide cellulose, polysaccharides, and the like, formed from at least one selected from the group consisting of polystyrene copolymers, isoprene, ethylene-butadiene, and ethylene-propylene. Can be mentioned. In addition, other polymer materials may be used that increase the viscosity of the hydrophobic solvent and do not significantly impair the drug delivery ability of the hydrophobic solvent.

Polyolefins (c) contained in the ointment-type dressing agent used in the wound dressing of the present invention serves as a flow control agent of the dressing agent. In order to obtain the physical properties required by the present invention, the flow control agent used in the present invention is preferably used in a proportion of 0.5 to 40% by weight, particularly 5 to 10% by weight based on the total weight of the dressing agent. Specific examples of such flow control agents include ethylene vinyl acetate copolymer, polyisobutylene, ethylene-propylene copolymer, polyethylene, and the like. These flow control agents play the opposite role to the polymeric material (b), which is a viscosity increasing agent, but act as a component that makes the flow of the dressing agent appropriate as a whole. do.

Therefore, the dressing agent of the present invention basically dressing as the above three components, that is, hydrophobic solvent (a), viscosity increasing agent (b) and flow control agent (c) are properly combined to obtain appropriate flow and adhesion Even if applied to the substrate retains the properties of the ointment. As a result, the dressing agent of the present invention not only effectively performs the drug delivery process but also adheres to the wound site to maximize the wound healing effect. In addition, the dressing agent of the present invention, due to such properties, does not leave foreign matter on the wound when removing the dressing of the present invention from the wound, and provides a moisturizing environment favorable for wound healing.

The ointment dressing agent of the present invention may further include a moisturizing agent (d) for maintaining moisturizing property on the wound. Such a moisturizing agent is preferably used in a proportion of 20% by weight or less based on the total weight of the dressing agent. If it is more than its weight, it may interfere with the interaction of the basic ingredients (a, b and c) of the dressing agent and enhance the properties of the liquid so that it does not have flowability to achieve the object of the present invention. When such a moisturizing agent is contained in an appropriate amount, the dressing agent of the present invention can not only help to absorb some of the foreign matter in the liquid generated from the wound site, but can also create an environment that is helpful for wound healing. Examples of such moisturizing agents include castor oil, glycerin and polyethylene glycol.

The ointment-type dressing agent used in the present invention may further include an antibiotic, a desiccant, a skin treatment preparation, an anesthetic and an analgesic. In general, in order to prevent infection of the wound site or to prevent deterioration of the castle due to infection, it is possible to supply drugs such as antibiotics, antibacterial agents, etc., and to provide local anesthetics and analgesics to alleviate pain. Examples of antibiotics that can be commonly used include neomycin sulfate, benzalkonium chloride, silver sulfate diazine, and the like and the like. In addition, functional drugs such as desiccant and skin treatment preparation can be supplied as necessary. Such functional drugs have conventionally been supplied in ointments applied directly to the skin, but the present invention provides convenience for use by supplying them through a dressing agent which can be an appropriate drug delivery means and integrated into the dressing substrate. In addition, the wound healing effect can be improved by creating an environment conducive to efficient drug delivery and wound healing.

Hereinafter, examples of specific embodiments of the present invention are given. These examples are only intended to present specific embodiments of the present invention, and the scope of the present invention should not be construed as being limited to these examples.

Example 1

180 g of white petrolatum (highly purified petroleum jelly) and 180 g of Elvax 40W (EVA copolymer, supplied by DuPont) were added to the reaction vessel, and the temperature was raised to 125 ° C to dissolve. 15 g of mineral oil, 15 g of polystyrene and 15 g of Kraton G1702 (Shell, Inc.), which is an ethylene-propylene copolymer, were added thereto, and the temperature was lowered to about 80 ° C. while stirring for about 1 hour, followed by further stirring for about 30 minutes. The mixture was applied to the gauze while maintaining the temperature of 80 ℃ to prepare the wound dressing of the required form.

The dressing agent applied to the dressing thus produced was observed to easily flow down at a temperature of about 48 ℃. In other words, this was not suitable for the purpose of the present invention.

Example 2

In the same manner as in Example 1, a dressing was applied. However, a dressing agent consisting of 180 g of white petrolatum, 80 g of EVA, 180 g of Elvax 40W, and 15 g of Kraton G1702 was used. Addition of the emulsion in form of EVA did not improve the results in Example 1.

Example 3

In the same manner as in Example 1, a dressing was applied. However, a dressing agent consisting of 210 g of white petrolatum, 90 g of lanolin alcohol, 80 g of polyethylene wax L-C 104N (from Lion Chemtech, South Korea), 60 g of Elvax 40W, and 15 g of Kraton G1702 was used. The dressing agent thus prepared was judged to have ointment properties, that is, flowability, required by the present invention. However, as a result of dropping water droplets on the gauze to which the dressing agent was applied, it was judged that hydrophilicity was weak because water absorption occurred very slowly.

Examples 4-8

The same experiment was carried out using glycerin instead of the hydrophilic lanolin alcohol among the components of Example 3 and slightly changing the component ratio.

ingredient Example 4 Example 5 Example 6 Example 7 Example 8 Pedrolactum mineral oil G1702 Elvax 40W glycerin L-C 104N 62g-20g17g16g28g 73g38g22g18g36g30g 40g21g12g10g12g16g 51g10g12g5g10g16g 69g36g20g17g4g28g

As a result of applying the dressing agent formed according to Example 7 among the dressing agents formed according to Examples 4 to 8 to the gauze, it was determined that overall characteristics such as flowability, hydrophilicity, and feeling were better.

Example 9

As shown in the following table, based on the formulation of Example 7, and applied to the dressing agent to which the antibiotic was added to the gauze to prepare a dressing for wound treatment.

ingredient Amount Pedrolactum mineral oil G1702 Elvax 40W glycerin L-C 104N antibiotic 51g10g12g5g10g16g0.4g

The wound dressing prepared as described above was easily applied to the wound site, including an ointment-type dressing agent having proper flowability, and when removed from the wound site, the wound dressing was easily removed without leaving a foreign substance.

The present invention provides a dressing for wound treatment to which a dressing agent in an ointment form having appropriate flowability is applied. The dressing agent according to the present invention has an appropriate flow in the state applied on the dressing base to create an environment that helps to heal the wound without leaking to the outside of the dressing, and also the delivery of functional drugs such as antibiotics It creates the conditions that can be effectively achieved. Therefore, the dressing of the present invention can be used simply and conveniently for the treatment of wounds of the skin, shortens the duration of wound healing and improves the effect of wound healing. In addition, the dressing of the present invention can be easily removed without leaving any foreign matter or residue even when removed from the wound area of the skin by containing a dressing agent having suitable viscosity properties.

Claims (11)

Wound dressing base (wound dressing) substrate used for wound protection and ointment dressings located on the dressing substrate, The ointment dressing agent a) 50 to 95% by weight of a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or at a skin temperature (15 to 38 ° C.), b) capable of increasing the viscosity of the hydrophobic solvent. 0.5-20% by weight of a polymeric material that acts as a viscosity increasing agent, and c) 0.5-40% by weight of polyolefins that act as flow control agents of the dressing agent. The method of claim 1, The ointment dressing agent is wound dressing, characterized in that it further comprises a softening agent having a silicone wax or stearate as an end group in order to further impart ointment. The method of claim 1, The hydrophobic solvent is at least one selected from the group consisting of petroleum-based saturated hydrocarbon, mineral oil, castor oil, paraffin wax, bead wax and fatty acids having a similar structure. The method of claim 1, The polymeric material which is the viscosity increasing agent is a synthetic rubber, polyacrylic acid, polyethylene oxide cellulose, and polysaccharide of a network formed from at least one selected from the group consisting of polystyrene copolymer, isoprene, ethylene-butadiene, and ethylene-propylene. Wound dressing, characterized in that at least one selected from the group consisting of. The method of claim 1, The flow control agent is a wound dressing, characterized in that at least one selected from the group consisting of ethylene vinyl acetate copolymer, polyisobutylene, ethylene-propylene copolymer, and polyethylene. The method of claim 1, The ointment-type dressing agent d) dressing for wound treatment, characterized in that it further comprises a moisturizing agent of 20% by weight or less to maintain the moisturizing properties on the wound. The method of claim 6, The moisturizing agent is a wound dressing, characterized in that at least one selected from the group consisting of castor oil, glycerin and polyethylene glycol. The method according to claim 1 or 6, The ointment-type dressing agent further comprises at least one functional agent selected from the group consisting of antibiotics, desiccants, skin preparations, anesthetics and analgesics. The method according to claim 1 or 6, The dressing may be formed on the base, the pressure-sensitive adhesive layer formed on the base, the dressing substrate formed on the center portion of the pressure-sensitive adhesive layer so that both ends of the pressure-sensitive adhesive layer adhere to the skin when the dressing is applied to the skin. And a release agent layer covering the pressure-sensitive adhesive layer and the dressing agent layer exposed to the opposite side of the dressing agent layer and the base, and removed when the dressing is applied to the skin. a) 50 to 95% by weight of a saturated hydrocarbon-based hydrophobic solvent having a viscosity of 1 to 100,000 cps at room temperature or at a skin temperature (15 to 38 ° C), b) a polymer that acts as a viscosity increasing agent that can increase the viscosity of the hydrophobic solvent 0.5 to 20% by weight of the substance, and c) 0.5 to 40% by weight of the polyolefins acting as a flow control agent of the dressing agent in the form of ointment. The method of claim 10, d) ointment dressings, characterized in that it further comprises up to 20% by weight of a moisturizing agent to keep the wound moisturized.