KR20020046418A - Tonic compositions and tonic agents comprising the same - Google Patents

Abstract

The present invention relates to a tonic composition, comprising a grape extract and / or a buckwheat extract and a ginseng extract in a weight ratio of 1: 0.01 to 10 (dry weight basis), the total of the grape extract and / or the buckwheat extract and a ginseng extract It provides a tonic composition further comprising 0.01 to 10 times by weight (based on dry weight) of herbal extracts or natural fruit extracts by weight.

Description

Tonic compositions and tonic agents comprising the same

The present invention relates to a tonic composition and a tonic agent comprising the same, and more particularly, a tonic composition comprising ginseng as a main component, a tonic composition having less bitter taste of ginseng, a unique flavor of fruit, and suppressing side effects of ginseng, and It relates to a tonic containing the same.

Ginseng is generally classified into ginseng, white ginseng and red ginseng according to its condition. Fresh ginseng is ginseng that has not yet been dried and dried. White ginseng is sun-dried ginseng after removing the roots of the ginseng and peeling it. Red ginseng is traditionally the most important position among ginseng products, and is generally produced by steaming and drying ginseng. The red ginseng, ie, red ginseng, is formed by the non-enzymatic browning reaction, especially the amino-carbonyl reaction and the automatic oxidation of polyphenol, which occur during the red ginseng process, and is known to have excellent characteristics by the browning as described above. have.

In fact, as reported by the World Health Organization, the common active ingredients in red ginseng, fresh ginseng and white ginseng include ginsenoside, Ro, Ra ₁ , Ra ₂ , Ra ₃ , Rb ₂ , Rb ₃ , 18 kinds of Rc, Rd, Re, Rf, Rg ₁ , Rg ₂ , Rg ₃ , Rh ₁ , 20glc-Rf, QR ₁ and NR ₁ are known, and the active ingredient contained only in fresh ginseng and white ginseng is malonyl Four kinds of) -Rb ₁ , malonyl-Rb ₂ , malonyl-Rc and malonyl-Rd include the active ingredients contained only in red ginseng as Rs ₁ , Rs ₂ , Rg ₃ (S), Rh ₂ , NR ₄ 8 kinds of Rg ₂ (R), Rh ₁ (R) and Rh ₄ are known. Therefore, when the red ginseng is produced from the components present only in fresh ginseng and white ginseng, the eight new components are formed, and thus the unique efficacy of red ginseng appears.

Ginseng has been used as the best bosin material for a long time in the East, and there are more than 500 prescriptions that use ginseng among the 2000 prescriptions, which are the basic prescriptions of oriental medicine that have developed over the years. In addition, more than 100 years ago, many studies have been conducted on the pharmacological action of the mysterious plants in the West. As a result of these studies, the important pharmacological effects of ginseng have been derived from the saponin component.

Saponins generally form bubbles continuously when shaken with an aqueous solution, and have hemolytic action and non-saccharide saponogenin (sapogenin). In addition, the mucous membrane may be irritated in some cases and may bind to cholesterol in the blood to form a complex, thereby exhibiting harmful effects on blood vessels.

Unlike the general characteristics of saponins, ginseng saponins are known to have very beneficial pharmacological effects, rather than toxic effects, but also have side effects. In other words, oriental medicine classifies a person's constitution into several and prescribed a specific constitution to avoid the use of ginseng, and even in Western medicine, ginseng has been reported to show side effects depending on the person. For example, ginseng may contain ephedrine depending on the variety, and long-term use of ginseng may cause an increase in blood pressure, uterine bleeding, and ventricular arrhythmias, and these symptoms disappear completely when the ginseng is stopped. Clinical cases have been reported, and it is generally recognized that ginseng is not appropriate for people whose blood pressure is higher than normal.

Side effects of ginseng are usually caused by bad stools, fever, swelling, headache or excitement. It is known that the specific effects of ginseng components are considerably reduced by ingesting them by processing such as heat treatment rather than ingesting them directly without processing them. This is thought to be because the specific side effects of various components of ginseng are slightly neutralized by heat, including the change of high density components such as saponin to low density components by heat treatment.

Therefore, by using ginseng in a processed state, for example, water and boiled state, while maintaining the pharmacological efficacy of the ginseng to overcome some of the above digestive and metabolic problems. However, this method did not fundamentally solve the side effects of ginseng. Therefore, even in oriental medicine, ginseng prescription has been contraindicated to people with heart disease or kidney disease, hypertension patients or allergy patients, and there is no known substance that can suppress side effects of ginseng.

In addition, ginseng is mostly used as the ginseng itself, and the fragrance is very strong, depending on the race, has a strong objection to ginseng. The inventors examined the response to ginseng tea to people from all over the world twice. In other words, we participated in the Geneva Invention Competition in 1986 and the Tokyo Invention Competition in 1988 and examined the taste and aroma of ginseng tea for people from all over the world. As a result, most of the white people showed a strong rejection of the taste and aroma of ginseng tea. Among the Asians, Japanese showed a slight rejection and Chinese did not. As such, it was difficult to commercialize ginseng itself as a health food or a favorite product consumed worldwide.

The inventors have been continuously inventing the medicine for over 30 years and have been convinced that the ginseng processing method can exhibit excellent efficacy regardless of the constitution and can be used worldwide in terms of taste and flavor. We have continued our research for over a decade. In other words, research has been conducted to find a substance that can suppress the side effects of ginseng and cancel the strong fragrance of ginseng without affecting various effective effects of ginseng. At first, research was conducted to find a substance that can offset the strong fragrance of ginseng when processed with ginseng.These materials are selected by various plants and mixed with ginseng to those who show side effects on ginseng. As a result of continuing the experiments, the results were surprisingly brought to the present application.

Therefore, the technical problem to be achieved in the present invention is to provide a tonic composition containing ginseng as a main raw material to the side effect of the ginseng is suppressed.

Another technical problem of the present invention is to provide a tonic agent having the tonic composition as an active ingredient.

In order to achieve the object of the present invention, the present invention comprises a grape extract and / or Murume extract and ginseng extract in a weight ratio (based on dry weight) of 1: 0.01 to 10,

It provides a tonic composition further comprising 0.01 to 10 times by weight (based on dry weight) of the herbal extract and / or natural fruit extract with respect to the total weight of the grape extract and / or Murume extract and ginseng extract.

In the tonic composition according to the present invention, the ginseng extract is preferably prepared from at least one of ginseng, white ginseng and red ginseng, and is preferably a ginseng powder or ginseng stock solution.

In the tonic composition according to the present invention, it is preferable that the grape extract is a vinegar or grape powder, and the roe extract is a stock extract or buckwheat powder.

In the tonic composition according to the present invention, the herbal extract is preferably any one or more powders or undiluted solutions selected from the group consisting of licorice, chajeonja, deficiency, gojija, ganoderma lucidum, yin and yang, white light sleep, cheonma and donkey.

In the tonic composition according to the present invention, the natural fruit extract is pear, apple, watermelon, melon, pineapple, tangerine, grapefruit, peach, guava, apricot, strawberry, plum, tomato, lemon, plum, melon and lime It is preferably at least one powder or stock solution selected from the group consisting of.

In the tonic composition according to the present invention, the tonic composition preferably further includes any one or more selected from the group consisting of inorganic sources, organonutrient sources, dietary fibers and caffeine.

In addition, in order to achieve the above another technical problem, the present invention provides a tonic agent having any of the tonic compositions as described above having an active ingredient.

The form of the tonic is not particularly limited and is in various forms including liquids, powders, granules, tablets, gels, sol, capsules and pills.

Preferably, the tonic is used as a soft drink, tea, fatigue recovery, and the like, which may be formulated in admixture with a pharmaceutically acceptable excipient in some cases.

In the tonic composition of the present invention, the content ratio of the ginseng extract, grape and / or meru extract, and its extract ratio and / or natural vegetable extracts other than ginseng to them are in the above ranges. Although limited, the modification is possible depending on the intended use, of course, modifications that can be easily made by those skilled in the art without departing from the spirit of the invention defined by the appended claims are within the scope of the present invention. It should be understood to belong.

In the present invention, as a substance to suppress the side effects of ginseng and increase the tonic function of ginseng, grapes are reduced sugars such as glucose, fructose, pectin, malic acid, tartaric acid, tannin, nitrogen-containing compounds, citric acid, ash, amino acids, iron, magnesium, inositol , Carbohydrates, proteins, and leucoanthocyanidine and pycnogenol. Among these components, tannin, malic acid, and citric acid promote digestion, and pycnogenol and leucoanthocyanidin are anti-aging and detoxifying agents. It is known to do. Mixing grapes with these characteristics to ginseng eliminates the side effects of ginseng, such as digestive problems and fever, which can be caused by ingesting ginseng alone, and sugars, amino acids, and inorganic nitrogen compounds promote the browning of ginseng. It acts as a substance, and the browning phenomenon of ginseng is very beneficial for digestion of ginseng. Grapes belonging to the grape family also have the same effect as grapes.

In addition, the present invention further includes other herbal extracts and / or other natural vegetable extracts suitable for use purposes such as enhancing the tonic effect, enhancing the taste, or the like, in addition to the ginseng extract and grape and / or melon extract as described above. .

Such herbal extracts and / or other natural vegetable extracts are not particularly limited as long as they are suitable for the intended purpose, but for example, herbal extracts include licorice, tea, defector, wolfberry, ganoderma, yin and yang, white light, cheonma and At least one powder or undiluted solution selected from the group consisting of Angelica is preferred, and natural vegetable extracts include pear, apple, watermelon, melon, pineapple, tangerine, grapefruit, peach, guava, apricot, strawberry, plum, tomato, lemon It is preferably at least one powder or stock solution selected from the group consisting of, plum, melon and lime.

Hereinafter, the present invention will be described in more detail with reference to some examples of a method for producing a tonic composition according to the present invention.

First, ginseng is dried and powdered. Crush grapes and / or beets and compress the resulting filtrate to obtain a concentrate. The ginseng flour and grape and / or meringue concentrate are mixed at a ratio of 1: 0.1-10 weight ratio. In this case, the mixture may be mixed and then dried, or the grape concentrate may be dried and powdered prior to mixing.

Ginseng powder prepared by the same method. In addition to ginseng, grapes and beets, a mixture of grape (or mulberry) concentrates or concentrate powders is dried by appropriate herbal medicines according to the required purpose, and the concentrates crushed and compressed by crushing powdered powders and / or natural fruits are 0.01% by weight of the mixture. To 10 to 10 times by weight. In this case, the mixture may be dried and then dried, or the natural fruit concentrate may be dried and powdered before mixing.

In addition, the effect of the present invention can also be achieved by aging the final product prepared in the above ratio for a long time,

The composition may also be prepared by heating ginseng, grapes and / or muru, and other herbs other than ginseng and / or natural fruits other than grape muru with water. The composition thus prepared is in liquid or powder form.

In addition, the inorganic source in the liquid or powdery composition prepared by such a method. At least one selected from the group consisting of an organonutrient source, dietary fibers, and caffeine may be further added to match the shape of the composition to prepare a composition according to the present invention. Mineral source as described above. Organotrophic sources, dietary fibers and caffeine can be used without particular limitation as long as they are well known in the art.

In addition, the tonic agent, which is another object of the present invention, is prepared by including the composition prepared as described above as an active ingredient, and is formulated in various forms, for example, sol, gel, tablet, pill, capsule, etc. according to its end use. It may also be prepared in the form of tonic beverage or ginseng tea.

When formulating the tonic agent, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants are usually used. Pharmaceutically suitable excipients which are nontoxic and inert are solid, semisolid or liquid diluents, fillers and all types of formulation aids.

Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and liquid preparations for oral use include suspensions, solvents, emulsions, and syrups. In addition to liquid paraffin, various excipients may be included, such as wetting agents, sweetening agents, fragrances, preservatives and the like. Parenteral administration solutions and emulsions may be prepared in sterile form that is isotonic with blood.

Tablets, coated tablets, capsules, pills, and granules are conventional excipients such as (a) fillers and extenders (e.g. starch, lactose, sucrose, glucose, mannitol, and silicic acid), (b) binders (e.g. carboxy) Methylcellulose, alginate, gelatin, and polyvinylpyrrolidone), (c) hygroscopic agents (e.g. glycerol), (d) disintegrants (e.g. agar, calcium carbonate and sodium carbonate), (e) dissolution retardants (e.g. , Paraffin), (f) absorption accelerators (e.g. quaternary ammonium compounds), (g) wetting agents (e.g. cetyl alcohol and glycerol monostearate), (h) adsorbents (e.g. kaolin, and bentonite), (i) Active ingredients may be included in addition to lubricants (eg, talc, calcium stearate, magnesium stearate, magnesium styrate talc and solid polyethylene glycol), or mixtures of the materials described in (a) to (i) above. Tablets, coated tablets, capsules, pills and granules may optionally be provided with conventional coatings and sheaths containing milk whites, and may also consist of compositions which preferentially release only the active ingredient in certain areas of the intestine, If necessary, it may be formulated to be sustained-release using a polymerizing material or a scouring agent composition such as a wax.

Liquid and emulsifying agents, in addition to the active ingredients, include conventional excipients, for example solvent solubilizers and emulsifiers, for example water, ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol, dimethylformamide, oils, in particular cottonseed oil, peanut oil, corn seed oil, olive oil, castor oil and sesame oil, glycerol, glycerol form alcohol, tetrahydrofurfuryl alcohol, polyethylene glycol and sorb Non-fatty acid esters, or mixtures of these materials, and suspending agents may include liquid diluents (e.g. water, ethyl alcohol and propylene glycol, polyethylene glycol), suspending agents (e.g., ethoxylated isostearyl alcohol, polyoxy Conventional excipients such as ethylene sorbitol and sorbitan esters).

The formulations may also contain colorants, preservatives and additives and sweeteners that improve odor or taste.

The formulations are prepared in a known manner, for example in a conventional manner in which the active ingredient is mixed with excipients.

Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not necessarily limited thereto.

30 g of white ginseng and 90 g of grapes were placed in a container, 500 ml of water was poured, and then heated at 90 ° C. for 5 hours. The mixture thus obtained was filtered to prepare a tonic composition in liquid form.

Example 1

Ginseng solution was prepared by pouring 300 ml of water into a vessel containing 20 g of fresh ginseng. Subsequently, 180 g of grapes were crushed and filtered, and the obtained grape concentrate was mixed with the prepared ginseng solution to prepare a liquid mixture. Next, 300 ml of water was poured into a container containing 30 g of yin and yang, and boiled to prepare yin and yang, which was added to the mixture to prepare a tonic composition according to the present invention in liquid form.

Example 2

10 g of white ginseng powder and 50 g of the powder obtained by drying the grape concentrate prepared in Example 1 were uniformly mixed to prepare a mixture in the form of powder, and then 30 g of the separately prepared Yin-Yang dry powder was further added and uniformly mixed to obtain the steel according to the present invention. Qualitative compositions were prepared in powder form.

Example 3

20 g of red ginseng powder and 80 g of the powder obtained by drying the grape concentrate prepared in Example 1 were uniformly mixed to prepare a mixture in the form of powder, and then 70 g of the separately prepared Yin-Yang-Kak dry powder was further added and uniformly mixed to obtain the steel according to the present invention. Qualitative compositions were prepared in powder form.

Example 4

30 g of white ginseng, 90 g of grapes, and 100 g of yin and yang were placed in a container, poured 700 ml of water, and heated at 90 ° C. for 5 hours. The mixed extract thus obtained was filtered to prepare a tonic composition according to the invention in liquid form.

Example 5-8

Except for using licorice instead of yin and yang in the above Examples 1 to 4 to prepare a tonic composition according to the present invention.

Example 9

Ginseng solution was prepared by pouring 300 ml of water into a vessel containing 20 g of fresh ginseng. Subsequently, 180 g of grapes were crushed and filtered, and the obtained grape concentrate was mixed with the prepared ginseng solution to prepare a liquid mixture. Next, 180 g of strawberries were crushed and filtered to prepare a strawberry concentrate, which was obtained and added to the mixture to prepare a tonic composition according to the present invention in a liquid phase.

Example 10

10 g of white ginseng powder and 50 g of each powder obtained by drying the grape concentrate and the strawberry concentrate prepared in Example 1 were uniformly mixed to prepare a rigid composition according to the present invention in powder form.

Example 11

20 g of red ginseng powder and 50 g of each powder obtained by drying the grape concentrate and the strawberry concentrate prepared in Example 1 were uniformly mixed to prepare a rigid composition according to the present invention in powder form.

Example 12

30 g of white ginseng, 90 g of grapes and 100 g of strawberries were placed in a container, 700 ml of water was poured, and then heated at 90 ° C. for 5 hours. The mixed extract thus obtained was filtered to prepare a tonic composition according to the invention in liquid form.

Example 13-16

The tonic compositions according to the present invention were prepared in the same manner, except that in Example 9-12, instead of strawberries, plum was used.

Example 17

The tonic composition prepared in Example 1 was concentrated to a sol state, and an excipient was added thereto to prepare a tonic form in the form of a soft capsule.

Example 18-34

Except for using grapefruit instead of grapes in Example 1-17 was repeated Example 1-17 to obtain a tonic composition and tonic corresponding to each.

Example 35

The tonic composition was obtained according to the method described in Example 3, except that the amount of grape powder used in Example 3 was reduced to 1/2 and instead of using the flour powder.

Evaluation test 1

In this evaluation test, a test was conducted to see if the tonic composition of the present invention can be used in the form of ginseng drink.

First, the ginseng solution obtained by heating only ginseng in water and the tonic composition prepared according to Example 1 (30 males and females, age range 12-65 years old) Functionality test and palatability test for color were also conducted. As a result, in the sensory test, 25 out of 30 people who tested the color test and 27 out of 30 people showed that the tonic composition of the present invention was better.

Evaluation test 2

The capsule tonic prepared in Example 17 was administered to 35 male and female adults aged 20 to 65 as a group showing severe rejection (phenomena such as digestive disorder, fever, edema, etc.) against ginseng. As a dosage method, one or two at a time, one to three times daily, was continued for 10 days. As a result, among the 35, the severe rejection was gradually decreased as the number of doses increased, and after 3 days, only 3 were left. The rejection was weak in 8, and the rest was rejected. This was not found.

The same experiment was carried out on the tonic composition and tonic agent prepared in the examples. In these experiments, a random group of 5 to 10 people was selected, although not as many of these numbers were selected. As a result, similar results to the above were obtained, and in the case of using the tonic composition prepared according to Examples 4 to 8, better results were obtained. This means that the mechanism of action and enzymes present in grapes suppress the side effects of ginseng while increasing the pharmacological efficacy, but this effect is more pronounced in the case of the composition prepared by the heating method.

Evaluation test 3

Animal experiments were conducted using mice as experimental animals. That is, 30 mice, 40 days old, were divided into three groups (experimental group, control group 1 and control group 2). For the experimental group, the tonic composition prepared in Example 33 was administered once daily for one week in an amount of 20 mg / kg body weight based on dry weight. Ginseng powder was administered to the control group 1 in the same manner, and none was administered to the control group 2. One hour after the last administration was performed swimming experiments in a water bath at room temperature. The swimming time until the death of the mouse was examined with a metal ring weighing one third of the average weight of the mouse inserted in the tail of the mouse so that swimming continued. As a result, the average swim time was 45 minutes in the control group 2, the average swim time was 55 minutes in the control group 1, and the average swim time was 63 minutes in the experimental group.

In the same manner, animal experiments as described above (five animals for each group) were conducted using the tonic compositions prepared according to Examples 1 and 5. As a result, the result was similar to the above.

As described above, the ginseng composition of the present invention prepared by mixing grapes and / or muru with ginseng is suppressed side effects of ginseng such as digestive disorders, fever, and edema caused by ingestion of ginseng alone, It shows the effect of tonic increase, and it is better in terms of taste, aroma and color because it is mixed with other herbal medicines or natural fruits and vegetables as needed, so it can not only appeal to many people but also strengthen the tonic effect or other pharmacological effects. It can be used even.

In addition, it may be used in the form of a herbal tea or herbal drink is prepared in a powder or liquid, and can be easily taken anywhere anytime because it is manufactured in various forms.

Claims (13)

Grape extract and / or meringue extract and ginseng extract in a weight ratio of 1: 0.01 to 10 (dry weight basis), Tonic composition, characterized in that it further comprises from 0.01 to 10 times the weight (based on dry weight) of the herbal extract or natural fruit extract with respect to the total weight of the grape extract and / or Murume extract and ginseng extract. The tonic composition of claim 1, wherein the ginseng extract is prepared from at least one of ginseng, white ginseng, and red ginseng. The tonic composition of claim 1, wherein the ginseng extract is ginseng powder or ginseng stock solution. The tonic composition of claim 1, wherein the grape extract is a vinegar or grape powder. The tonic composition of claim 1, wherein the extract is a stock extract or a powder. The tonic composition of claim 1, wherein the medicinal herb extract is any one or more powder or undiluted solution selected from the group consisting of licorice, chajeon, gyeongja, gojija, ganoderma lucidum, yin and yang gwak, white light sleep, cheonma, and donkey. According to claim 1, wherein the natural fruit extract is selected from the group consisting of pear, apple, watermelon, melon, pineapple, tangerine, grapefruit, peach, guava, apricot, strawberry, plum, tomato, lemon, plum, melon and lime Tonic composition, characterized in that any one or more powder or undiluted solution. The tonic composition of claim 1, wherein the tonic composition further comprises any one selected from the group consisting of inorganic sources, organonutrient sources, dietary fibers and caffeine. A tonic agent having the tonic composition of any one of the preceding claims as an active ingredient. The tonic according to claim 9, which is in the form of liquid, powder, granules, tablets, gels, sol, capsules and pills. 11. The tonic according to claim 10, which is mixed with a pharmaceutically acceptable excipient. 11. The tonic according to claim 10, which is in the form of a soft drink. The tonic according to claim 10, which is in the form of a car.